ライフサイエンスコーパス: bicyclic

1 er in DAT interaction than the corresponding bicyclics.

2 l)pyrazine 1h with sulfonyl azides to afford bicyclic 1,2,3-thiadiazoles 8 and 1,2,3-triazoles 9 conn

3 electrocyclization cascade provides a fused bicyclic 1,2-dihydropyridine as a key intermediate.

4 elimination, and C-C and P-H bond formation bicyclic 1-benzo-dihydrophosphetes (2) with PC(3) hetero

5 rs addressing nonprimed binding regions, and bicyclic 14-mer SFTI-1 analogues blocking both, primed a

6 ree, double cyclization for the synthesis of bicyclic 2-pyridones as peptidomimetics was developed.

7 isomerization, and lactamization, to furnish bicyclic 2-pyridones in up to 98% yield with retention o

8 excellent yields were obtained for the fused bicyclic 3-aza-heterocycles.

9 ger as compared to the parent morpholine and bicyclic 3-oxa-7-azabicyclo[3.3.0]octane.

10 converged to provide short 2-step routes to bicyclic [3.2.1] or [2.2.2] L-iduronate lactones.

11 nonretinoid RBP4 antagonists, represented by bicyclic [3.3.0]-octahydrocyclopenta[c]pyrrolo analogue

12 C-C bond formation to yield spirocyclic- or bicyclic 3H-indoles or benzazepinones.

13 oadducts, which possess a basic structure of bicyclic 6-(menthyloxy)hexahydropyrano[4,3-c]pyrrol-7(6H

14 two-step approach, without isolation of the bicyclic acetal intermediates.

15 Novel bis- and tetraepoxides and bicyclic acetal products, arising from rearrangements of

16 lysis of one of the major classes of NA (the bicyclic acids) to date.

17 n of one substrate to give the corresponding bicyclic adduct in excellent yield at the gram scale.

18 -hydroxypiperidines from a readily available bicyclic adduct.

19 (2) allowing the formation of functionalized bicyclic adducts in 55-91% isolated yields (18 products)

20 rming olefin to the bridgehead carbon of the bicyclic affect the efficiency and stereochemical outcom

21 Alkynes, branched 1,3-dienes, and bicyclic alkenes were also found to be competent couplin

22 recycles HO(x), producing the corresponding bicyclic alkoxy radical (BCP-oxy).

23 or norbornadiene (NBD) readily generate the bicyclic alkyl-/alkenyl-substituted stannylenes, ArSn(no

24 trategy allows for the synthesis of storable bicyclic (alkyl)(amino)carbenes (BICAACs), which feature

25 In addition, a bicyclic allylic chloride starting material without pseu

26 Miyaura cross-coupling between racemic fused bicyclic allylic chlorides and boronic acids.

27 by cyclization of the resulting urea to give bicyclic alpha-aryl hydantoin derivatives of substituted

28 Therefore, bicyclic alpha-iminophosphonates are tools that may open

29 ionship (3D-QSAR) studies of a new family of bicyclic alpha-iminophosphonates endowed with relevant a

30 Derivatives of the fully twisted bicyclic amide 7-hypoquinuclidone are synthesized using

31 odide (1a) catalyzes the ring opening of the bicyclic amidine system of DBU (1,8-diazabicyclo[5.4.0]u

32 sfully applied to the arylation of one spiro-bicyclic amine, a class of substrates that has not been

33 lactam starting materials as well as certain bicyclic amino acid products provided insight into their

34 substrate cores ranging from cyclic to fused bicyclic and bridged bicyclic compounds.

35 A series of N(6)-bicyclic and N(6)-(2-hydroxy)cyclopentyl derivatives of

36 lkyne analogue has been further converted to bicyclic and THF ring containing derivatives with a diff

37 -catalyzed C(sp(3))-H arylation of saturated bicyclic and tricyclic amine scaffolds.

38 D as halogenated C15-acetogenin 12-membered bicyclic and tricyclic ether bromoallene-containing mari

39 luding humulene (monocyclic); caryophyllene (bicyclic); and protoilludene, pentalenene, and isocomene

40 alent drugs, we have synthesized monocyclic, bicyclic, and tricyclic compounds containing 3 as an ele

41 t of furnishing unprecedented heterometallic bicyclic architectures with a high level of constitution

42 g rise to 12 examples of nitrogen-containing bicyclic architectures.

43 The bicyclic aromatic compound was observed in a complex wit

44 ity of the transformation across a series of bicyclic aromatic heterocycles was explored.

45 actions with different nucleophiles afforded bicyclic azasugars, cyclopropanated carbohydrate, dihydr

46 Bicyclic azetidines targeting Plasmodium falciparum phen

47 mechanisms of action, including a series of bicyclic azetidines that inhibit a new antimalarial targ

48 Our findings identify bicyclic azetidines with the potential to both cure and

49 Here, we report a [3 + 3] ring expansion of bicyclic aziridines and rhodium-bound vinyl carbenes to

50 The resulting [3.1.0] bicyclic aziridines prove to be versatile synthons for t

51 ation of synthetically useful chiral [3.1.0]-bicyclic aziridines with high diastereo- and enantiosele

52 ed, the reaction with phenols proceeds via a bicyclic aziridinium intermediate leading to the stereos

53 ies (dr >99/1, (1)H NMR) via interception of bicyclic aziridinium intermediates.

54 nstrating the unprecedented influence of the bicyclic backbone unsaturation for the preparation of th

55 Starting from bicyclic beta-amino acid 3 or 5, strategies involving Cu

56 A key bicyclic beta-lactam intermediate not only serves as the

57 an anionic ring-opening polymerization of a bicyclic beta-lactam sugar monomer.

58 Cyclopropanation of the resulting bicyclic beta-lactone produces a strained housane struct

59 ing isothiourea catalysts provided access to bicyclic beta-lactone-fused, N-heterocycles in moderate

60 of this donor results in the formation of a bicyclic beta-sulfonium ion that after addition of an al

61 inhibitors, particularly avibactam-like and bicyclic boronate compounds, have potential for treating

62 Here, we show that avibactam and a bicyclic boronate inhibit L2 (serine beta-lactamase) but

63 Importantly, avibactam, but not the bicyclic boronate is deactivated by L1 at a low rate; th

64 The bicyclic boronate VNRX-5133 (taniborbactam) is a new typ

65 Bicyclic boronates are recently discovered inhibitors of

66 Different side-chain binding modes for bicyclic boronates for SBLs and MBLs imply scope for sid

67 allographic results highlight the ability of bicyclic boronates to inhibit SBLs and MBLs via binding

68 A compact and stable bicyclic bridged ketal was developed as a ligand for the

69 coupled in a B-alkyl Suzuki reaction with a bicyclic bromoenone, which was a key intermediate for th

70 e generation of alpha-ethoxyenone-containing bicyclic byproducts.

71 tion reactions were performed on a series of bicyclic C(2)-substituted pyranoside models to isolate a

72 tively easily without damage to the strained bicyclic cage.

73 nt and straightforward methodology to access bicyclic carbo- and heterocyclic scaffolds combining dif

74 ation into stereochemically dense, fused and bicyclic carbocycles containing transmutable functionali

75 antibiotics, beta-lactamase inhibitors, and bicyclic carbohydrate-beta-lactam monomers prepared by t

76 tanes as well as the construction of complex bicyclic carbon skeletons containing up to four contiguo

77 oward beta-apocarotenoids but did not cleave bicyclic carotenoids.

78 Bicyclic chiral scaffolds are privileged motifs in medic

79 e A, and intramolecular cyclizations to form bicyclic claulansine A were the key reactions.

80 One such bicyclic compound carrying an equatorial hydroxyl group

81 toisomer along with an unusual and uncolored bicyclic compound formed through an intramolecular photo

82 assay with seven human tumor cell lines, the bicyclic compounds inhibited selectively the growth of t

83 ation tactic for the construction of diverse bicyclic compounds possessing highly functionalized cycl

84 The binding of bicyclic compounds was analyzed by molecular dynamics si

85 The structures of the obtained bicyclic compounds were reliably proved by NMR methods a

86 zolidines (BTZs) are carboxylate-containing, bicyclic compounds, considered as penicillin analogs wit

87 cally diverse structures, spanning mono- and bicyclic compounds, that either inhibited or activated M

88 ng from cyclic to fused bicyclic and bridged bicyclic compounds.

89 lbenzenes 2 provides sulfonyl oxabenzo[3.3.1]bicyclic core 4 in a cosolvent of toluene and HOAc (v/v

90 ramolecular Heck reaction to build the fused bicyclic core and a cobalt-catalyzed peroxidation to ins

91 mits more comprehensive modifications of the bicyclic core and structure-activity relationship studie

92 and stereoselective formation of the [4.3.0] bicyclic core by incorporation of a symmetrizing geminal

93 The carbapenem bicyclic core consists of a beta-lactam ring fused to a

94 yzed 5-exo-dig cycloisomerization provides a bicyclic core containing a methylenetetrahydrofuran moie

95 a viable approach to the construction of the bicyclic core of neopeltolide.

96 A novel approach toward the [5-7]fused bicyclic core of thapsigargin, a subnanomolar inhibitor

97 onist/delta-opioid receptor (DOR) antagonist bicyclic core peptidomimetics with promising analgesic a

98 lso demonstrated for the construction of the bicyclic core present in penostatin B in a concise and h

99 most known RiPPs, a tripeptide with a tight bicyclic core that appears to be cleaved from the middle

100 he structures imply conserved binding of the bicyclic core with SBLs/MBLs.

101 f its acylamino oxygen onto the boron of the bicyclic core.

102 y of the molecular scaffold by introducing a bicyclic core.

103 spontaneous 4pi-electrocyclizations to form bicyclic cyclobutenes.

104 nic acids and gives access to functionalized bicyclic cyclopentenes, which can be converted into othe

105 Oxidative transpositions of bicyclic cyclopentenones mediated by selenium dioxide (S

106 s of several nitrogen nucleophiles to chiral bicyclic dehydroalanines have been assessed effectively

107 Salinamide A belongs to a rare class of bicyclic depsipeptide antibiotics in which the installat

108 talyst-free synthesis of nitrogen-containing bicyclic derivatives through a three-bond forming proces

109 The reliable access to bicyclic derivatives was demonstrated on a 3 g scale wit

110 rated the potential postfunctionalization of bicyclic derivatives.

111 due macrocycles, and three 11- to 14-residue bicyclic designs, are close to the computational models.

112 These reactions lead to bicyclic Diels-Alder adducts that spontaneously lose N2.

113 clic dienes yields several three-dimensional bicyclic Diels-Alder adducts.

114 further intramolecularly cyclized into CF(3)-bicyclic dihydroanthracene derivatives ("helicopter"-lik

115 CF(3)-bicyclic dihydroanthracene derivatives have been studied

116 s were successfully achieved to afford fused bicyclic dihydropyridines in high yields (up to 94%) wit

117 pared in multigram quantities from the known bicyclic diketone 7 in four steps without the need for c

118 rticipation of remote esters through bridged bicyclic dioxacarbenium ions in organic solution in the

119 hosphate into a previously unknown 5,7-fused bicyclic diterpene, coined "pseudolaratriene." Combined

120 eoxystreptamine ring that carries an unusual bicyclic eight-carbon dialdose moiety.

121 yclic N-heterocycle-fused beta-lactone and a bicyclic enamine derived from in situ decarboxylation of

122 loallene D as a pentahalogenated 12-membered bicyclic ether bromoallene was synthesized by a face-sel

123 llustrated with the synthesis of a family of bicyclic fluorinated 1,3-amino alcohols.

124 t of the Al- by an Fe atom leads to a planar bicyclic frame with a terminal Al-O(*-) radical site, ac

125 onalized boronic acids to afford a cis-fused bicyclic framework containing an alpha,beta-unsaturated

126 e units embedded in an enantiomerically pure bicyclic framework is reported.

127 The method allows for the rapid synthesis of bicyclic frameworks, generating all-carbon quaternary ce

128 sylation stereoselectivities for a series of bicyclic furanoside models have been carried out in the

129 one-pot approach to construct alpha-carbonyl bicyclic furans from easily accessible diynones is descr

130 ral information, we designed a new series of bicyclic G7 peptides that progressively constrain the st

131 This novel series of bicyclic galactopyranosides are prepared through a stere

132 In particular, bicyclic gamma-amino acids-gamma-aminobutyric acid analo

133 A general synthetic strategy to cis-fused bicyclic gamma-butyrolactones via the retro-Diels-Alder

134 ated and gamma-trifluoromethylated cis-fused bicyclic gamma-butyrolactones.

135 The fused bicyclic gamma-lactone products can be easily diversifie

136 rofuran (THF) or tetrahydropyran (THP)-fused bicyclic gamma-lactones, two privileged scaffolds often

137 Pyridine substituted with one and two bicyclic guanidine groups has been studied as a potentia

138 report a computational analysis of the [5,5] bicyclic guanidine-catalyzed asymmetric cycloaddition re

139 detailed account of the synthesis of chiral bicyclic guanidinium salts is presented.

140 of the attempted syntheses of two additional bicyclic guanidinium salts.

141 synthesis of a series of partially saturated bicyclic heteroaromatic scaffolds with enhanced sp(3) ch

142 eported on a number of structurally distinct bicyclic heteroarylsulfonamides as NaV1.7 inhibitors tha

143 used imidazole-containing 5,5- and 5,6-fused bicyclic heterocycles is described.

144 The first syntheses of privileged [5,6]-bicyclic heterocycles, with ring-junction nitrogen atoms

145 les bearing multiple bonds leading to [2.2.1]bicyclic heterocycles.

146 mI2 -H2 O, provide straightforward access to bicyclic heterocyclic scaffolds containing bridgehead ni

147 occupy an "alkyl-induced" pocket and possess bicyclic hinge-binding motifs capable of forming more th

148 iomerically enriched fluorinated benzo-fused bicyclic homoallylic amines have been synthesized throug

149 The reaction of BCP-peroxy with NO produces bicyclic hydroxy nitrate with a branching ratio <0.2%, i

150 azines and biocatalytically generated chiral bicyclic imines selectively affords either tetracyclic p

151 The key step is the activation of a bicyclic iminoglycal carbamate to generate a highly reac

152 ing from a common tetrahydrofuran-containing bicyclic intermediate and using the highly reactive brom

153 nism involving an intriguing rhodium-bridged bicyclic intermediate.

154 s it was later discovered that these bridged bicyclic intermediates can be trapped by various elimina

155 nsible for converting 8-oxogeranial into the bicyclic iridoid scaffold in a two-step reduction-cycliz

156 aza-Wittig/Ugi three-component reaction of a bicyclic isoxazolidine-derived azido-hemiacetal.

157 These synthetically versatile bicyclic isoxazolidines allowed us to obtain complex gly

158 [3 + 2] cycloaddition can be used to obtain bicyclic isoxazolidines for which we report a set of rea

159 ne rearrangement of 2,4-cyclohexadienones to bicyclic ketones was found to proceed with high enantios

160 stantial nonplanarity of the amide bond in a bicyclic lactam framework.

161 ed, starting from a common chiral nonracemic bicyclic lactam lactone (BLL).

162 able by epoxidation of carboxamide-activated bicyclic lactam substrates derived from pyroglutamate us

163 esting results, including the formation of a bicyclic lactone arising from oxidative termination of t

164 ramolecular alkoxycarbonylation to build the bicyclic lactone framework.

165 stereoselectively a five-membered ring fused bicyclic lactone, the core structure present in gracilio

166 from respective enantiopure, fused six-five bicyclic lactones.

167 Through key structural modifications of a bicyclic lead, stepwise gains in spectrum of inhibition

168 aesthetically pleasing Fe-Pt heterometallic bicyclic metallacycles 6a and 6b, consisting of nine com

169 unctionalized hydrindanes, where the bridged bicyclic metallacyclopentenes from intramolecular [4 + 2

170 tion of rhodium-bound carbenes with strained bicyclic methylene aziridines results in a formal [3+1]

171 a bioinspired strain-driven ring opening of bicyclic methyleneaziridines to 2-amidopentadienyl catio

172 ouble bond of the allene to yield endocyclic bicyclic methyleneaziridines with excellent stereocontro

173 A thymidine-derived bicyclic monomer, 3',5'-cyclic 3-(3-butenyl) thymidine e

174 to provide both enantiomers of this unusual bicyclic monosaccharide.

175 of Arabidopsis thaliana to a mixture of the bicyclic monoterpenes alpha-pinene and beta-pinene induc

176 of the useful and important skeleton of the bicyclic N,O-acetals is described.

177 owcased with stereoselective construction of bicyclic N-heterocycles, opens the door for future synth

178 ketones into all three topological types of bicyclic N-heterocycles: bridged, spiro-, and fused ring

179 logous amides for the efficient synthesis of bicyclic N-unprotected lactams similar to those in many

180 report identification of over 30 individual bicyclic naphthenic acids as the bicyclane hydrocarbons.

181 nimize the molecular weight to provide novel bicyclic next-generation PCSK9 inhibitor peptides such a

182 The potential of using chiral bicyclic NHC ligands that exhibit modularity was investi

183 The process provides rapid access to bicyclic nitrogenous structures resembling natural alkal

184 rculosis, there is now a renewed interest in bicyclic nitroimidazole scaffolds as a source of therape

185 Delamanid, a-first-in-class bicyclic nitroimidazole, was recently approved for multi

186 Bicyclic nitroxyl derivatives, such as 2-azaadamantane N

187 T is especially noteworthy at high pH, where bicyclic nitroxyls are inhibited by formation of an oxoa

188 signatures consistent with conversion of the bicyclic norbornane repeat units into the ring-open isom

189 acene (TIPS-BP1') dimers utilizing a [2.2.1] bicyclic norbornyl bridge have been studied-primarily us

190 non-bile acid FXR agonists that introduce a bicyclic nortropine-substituted benzothiazole carboxylic

191 cked-nucleic-acid (LNA) or constrained-ethyl-bicyclic-nucleic-acid ((S)-cEt) modifications much more

192 A bicyclic olefin was discovered as a cocatalyst in a Cp*R

193 1)-C(6) cyclization yields a highly strained bicyclic olefin whose surface chemistry was hitherto unk

194 tanones including spiro-, bridged, and fused bicyclic ones can be readily accessed.

195 cloadditions with carbonyl compounds to give bicyclic oxazolidine products in good overall yields.

196 tho-methoxycarbonylaryl isocyanates formed a bicyclic oxazolidinone, followed by a sequence of intram

197 philes displace one of the two bent bonds of bicyclic oxocarbenium ion intermediates in an antiperipl

198 e and metabolically stable nonphosphorylated bicyclic peptide as a potent and selective Pin1 inhibito

199 Fatty acid modification of the bicyclic peptide extended its circulating half-life, res

200 The bicyclic peptide had improved protease stability, and we

201 The resulting bicyclic peptide has greatly enhanced proteolytic stabil

202 re, we determined the structure of the G7-B4 bicyclic peptide in complex with the Grb7-SH2 domain, bo

203 we report the crystal structure of a stapled bicyclic peptide inhibitor G7-B1 in complex with the Grb

204 We show that this bicyclic peptide is able to remodel the aggregation proc

205 silico rational design strategy to produce a bicyclic peptide to target the C-terminal region (residu

206 A bicyclic peptide with subnanomolar affinity towards MT1-

207 Molecular simulations of the bicyclic peptide-G4 complexes corroborate the experiment

208 nce: This work demonstrates the potential of bicyclic peptides as a platform for the development of h

209 Here we demonstrate the power of bicyclic peptides as targeting probes, exemplified with

210 Selected bicyclic peptides display submicromolar affinity to G4 s

211 successfully developed for the selection of bicyclic peptides from large random-sequence libraries.

212 Bicyclic peptides have great therapeutic potential since

213 scribe the development of de novo G4-binding bicyclic peptides selected by phage display.

214 Bicycles are constrained bicyclic peptides that represent a promising binding mod

215 xample of a computational approach to design bicyclic peptides to target specific epitopes on disorde

216 al molecular insights into G4 recognition by bicyclic peptides via the precise positioning of amino a

217 e rapid tumor penetration characteristics of bicyclic peptides, coupled with high potency and chemica

218 ysiologic conditions to yield monocyclic and bicyclic peptides.

219 egy was applied to generate a cell-permeable bicyclic peptidyl inhibitor against the NEMO-IKK interac

220 nolic compound or it can rearrange to form a bicyclic peroxy intermediate that subsequently undergoes

221 the effective production rates of phenol and bicyclic peroxy radical (BCP-peroxy) are experimentally

222 The structures of bicyclic phospholene oxide and two sultones were establi

223 ived Salinospora sp. bacterium and contain a bicyclic phosphotriester core structure, which is a rare

224 A synthetic strategy to fused bicyclic piperidines-building blocks for medicinal chemi

225 on nucleophile with carbon dioxide to give a bicyclic product by P-CH(2) attack on CO(2) combined wit

226 The bicyclic product can also form from PPh(3) using the bro

227 vor the tricyclic product over the undesired bicyclic product resulting from diene metathesis.

228 r the preparation of both enantiomers of the bicyclic product with near-identical stereocontrol.

229 Two (of four possible) bicyclic products are selectively formed by addition of

230 Furthermore, the bridged bicyclic products can be diversely functionalized throug

231 The bridged bicyclic products can be further functionalized or deriv

232 In addition, N-tethered bicyclic products further transformed into tricyclic com

233 A prototropic shift leads to the observed bicyclic products in what can be viewed as an interrupte

234 propyl moiety, affecting only one of the two bicyclic products initially formed.

235 ctrophilic activation of double bonds in the bicyclic products with m-CPBA is an efficient method for

236 moiety linked to the 4-position afforded the bicyclic products, which possess three stereogenic cente

237 ates, including lactams, which lead to spiro-bicyclic products.

238 kynes leads to alpha-methoxyenone-containing bicyclic products.

239 affording mirror-image forms of the desired bicyclic products.

240 Over the years, we have reported covalent bicyclic prolyl oligopeptidase inhibitors that were high

241 on mechanism en route to the 5,7-trans-fused bicyclic pseudolaratriene scaffold.

242 ta-amino amides and esters, pyrazolones, and bicyclic pyrazolidinones.

243 perative potency effects of the biphenylene, bicyclic pyrrolidine (Aoc), and methyl-threonine structu

244 preparation of various derivatives from the bicyclic pyrrolidine products.

245 llory reaction path can be altered to obtain bicyclic rather than tricyclic products.

246 inhibitors: cytochalasin B, a nine-membered bicyclic ring fused to a 14-membered macrocycle, which h

247 condensation precedes pyrrole annulation and bicyclic ring fusion.

248 Analogues with a bicyclic ring I carrying equatorial amino or hydroxyl gr

249 polynorbornene (VA-PNB), which has strained bicyclic ring repeat units along the polymer backbone.

250 ot all iridoids share the exact five- to six-bicyclic ring scaffold of the Catharanthus iridoids.

251 This transformation was further extended to bicyclic ring substrates, providing the opportunity to e

252 Novel bridged bicyclic ring systems are accessible from the diol, alph

253 ructure, e.g., monocyclic nonanolide core or bicyclic ring systems with a bridging THF ring.

254 nt three-step synthesis of a series of fused bicyclic s-[1,2,4]triazolo[1,5-a]pyridines 1 was accompl

255 he design and synthesis of a novel promising bicyclic scaffold for FKBP51 ligands.

256 The exo- or endo-selectivity of bicyclic scaffolds depends on the selection of the base

257 to the identification of multiple 5,6-fused bicyclic scaffolds that bind to the same allosteric tunn

258 of the newly synthesized 6,5- and 7,5-fused bicyclic scaffolds was then investigated to obtain vario

259 ion, and position within the molecule of the bicyclic scaffolds were assessed virtually.

260 es a distinct approach for accessing [3.2.2] bicyclic scaffolds which are challenging to prepare thro

261 oriented synthesis of an array of cyclic and bicyclic scaffolds with polyhydroxylated appendages with

262 t, we described the optimization of a fused, bicyclic screening hit for potency, selectivity, and phy

263 ar reaction of a range of fused- and bridged-bicyclic secondary amines with a broad set of heteroaren

264 acterized plant STSs by forming unified 15/5 bicyclic sesterterpene intermediates.

265 d allenes, which provides a distinct [4.2.1]-bicyclic skeleton containing two quaternary carbon cente

266 The rigid bicyclic skeleton of 2,4-methanoprolines allowed us to f

267 rally diverse scaffolds, ranging from simple bicyclic skeletons to complex polycyclic systems and nat

268 elded access to novel types of diastereopure bicyclic spiramycin derivatives containing tetrahydrofur

269 Caged (or bridged) bicyclic structural elements offer a variety of diverse

270 Carbocyclic decalin is a ubiquitous bicyclic structural motif.

271 It contains a bicyclic structure composed of a large macrocycle and a

272 Surprisingly, the generated bicyclic structure featuring three stereocenters was a m

273 onverted into a conformationally constrained bicyclic structure through the formation of a pair of di

274 Despite the intrinsic constraints of the bicyclic structure, we demonstrate that their synthesis

275 ing of repeating units of fairly rigid fused bicyclic structures and alkenes separated by freely rota

276 Spiro- and bridged bicyclic structures are in demand for their sp(3)-rich f

277 termediates, which involves the formation of bicyclic structures from large Criegee intermediates con

278 s to construct aziridine/oxazolidinone-fused bicyclic structures.

279 recently described a nitroimidazopyrazinone bicyclic subclass with promising antitubercular and anti

280 reversible beta-hydride elimination from the bicyclic substituted aryl/alkyl stannylenes 2a or 2b and

281 , and biological characterization of a novel bicyclic-substituted hydroxyphenylmethanone 17beta-HSD2

282 Bicyclic-substituted piperidine ring derivatives of naph

283 someric quinolinone sulfonamide inhibitors [ Bicyclic sulfonamide compounds as sodium channel inhibit

284 followed by ring expansion to generate novel bicyclic sulfones.

285 database, Paquette's sultams (i.e., bridged bicyclic sultams with a bridgehead nitrogen atom) were o

286 nlocked the path to alternate monocyclic and bicyclic synthons representing the basis of a myriad of

287 pping from benzoxazine to chroman and indane bicyclic system followed by thiazole replacement on sulf

288 pansion of our approach, morphing the fused, bicyclic system into a novel monocyclic pyrimidinone sca

289 the 3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl bicyclic system were potent (TTK IC50 < 10 nM, HCT116 GI

290 on (respectively, axial or equatorial to the bicyclic system).

291 can be substituted at every position of the bicyclic system.

292 )one, afforded a number of pyrrolidine-based bicyclic systems.

293 This resulted in a shift from our original bicyclic tetrahydroquinoline core to a monocyclic benzyl

294 The fused bicyclic thiazolo[5,4-d]thiazole heterocycle allows the

295 ntadiene structure awaits, reached through a bicyclic transition state.

296 to proceed through highly ordered cyclic or bicyclic transition states, leading to remarkable levels

297 perimentally unidentified class of condensed-bicyclic triazolo-thiadiazoles targeting PTP1B and its a

298 Condensed-bicyclic triazolo-thiadiazoles were synthesized via an e

299 lated heterocycles, or related products with bicyclic unit.

300 uence of related substrates allows access to bicyclic uracil derivatives.