ライフサイエンスコーパス: bifunctional

1 nzymes involved in fruit color accumulation (bifunctional 15-cis-phytoene synthase, 9-cis-epoxycarote

2 mochemistry and kinetics of the oxidation of bifunctional 2-Methoxyethanol (2ME) biofuel using methyl

3 h total abstraction rate is observed for the bifunctional 2ME (4 abstraction positions) over n-butano

4 , we characterized kinetic properties of the bifunctional 5-InsP7 kinase/InsP8 phosphatase activities

5 ia the cellobiose-PTS system together with a bifunctional 6-phospho-beta-gal/glucosidase, Gan1D.

6 both activities to give insights into how a bifunctional active site catalyzes two different chemist

7 A bifunctional active site that is distinct from its methy

8 The bifunctional activity and superior durability of our Pb-

9 Our previous work demonstrated the bifunctional activity of chlamydial DapF in vitro and in

10 ic and physical methods indicated that these bifunctional additives created an interpolymeric network

11 The bifunctional AdhE enzyme is conserved in all bacterial k

12 gy to design and synthesize highly effective bifunctional air cathodes to be applied in electrochemic

13 Allylboration of ketones and imines with a bifunctional allylboron reagent is reported.

14 As such, the bifunctional allylboron reagent serves as a useful linch

15 Addition of the bifunctional allylboronate to a broad scope of ketones g

16 core trisaccharide in both organisms, and a bifunctional alpha-galactosyltransferase from CAZy famil

17 Two bifunctional alpha-phenyl-N-cyclohexyl nitrones were syn

18 The optimized bifunctional aluminum salen catalyst maintains excellent

19 Specifically, bifunctional amino reagents are used for sequential nucl

20 cascade using cinchona alkaloid-based chiral bifunctional amino-squaramide catalysts is reported.

21 We report that a bifunctional aminocyclopropenium aluminum salen complex

22 romide perovskites incorporating a series of bifunctional ammonium dications as templates which also

23 Unlike monofunctional CDDO-Me, the bifunctional analog, CDDO-Im, has a second reactive site

24 A bifunctional analogue, macropa-NCS, was conjugated to tr

25 found that a major shift in function from a bifunctional ancestor that could phosphorylate either gl

26 in vitro experiments, we show that PTPROt is bifunctional and can dephosphorylate Src both at its inh

27 We report a method to generate bifunctional antibodies by grafting full-length proteins

28 recognition and T-cell signaling domains via bifunctional antigen-specific targeting ligands, univers

29 Here, we show that CS109 cells lacking the bifunctional aPBP PBP1B (penicillin binding protein 1B)

30 We hypothesized that a bifunctional approach combining the antagonistic action

31 tic index of SERMs might be improved by this bifunctional approach.

32 al growth factor receptor (EGFR) to create a bifunctional aptamer that labels cell-surface EGFR on ma

33 e can act as a complementary approach toward bifunctional arenes along with other metal-catalyzed bor

34 paration technique by using well-established bifunctional Au-Fe3O4 nanocomposites as the separation n

35 Meanwhile, the bifunctional B-NCNT is used as the counter electrode for

36 Mtb experiments, identified Mtb Rv2498c as a bifunctional beta-hydroxyacyl-CoA lyase and that deletio

37 By developing a bifunctional biotinylated capture probe, the Friedlander

38 talysis that is enabled by a designed chiral bifunctional biphenyl-2-ylphosphine ligand.

39 This is achieved using a bifunctional bipyridine ligand bearing a pendant sulfona

40 igid planar ligand with an aromatic ring and bifunctional bond sites.

41 Described herein is a bifunctional borane/borinic acid derivative (2) in which

42 Our study showed that Houk's bifunctional Bronsted acid-hydrogen bonding model, which

43 on a multicatalytic approach that combines a bifunctional Bronsted base-squaramide organocatalyst and

44 Here, we demonstrate that a bifunctional catalase-peroxidase, MakatG1, in the locust

45 Bifunctional catalysis in zeolites possessing both Brons

46 at the nanoscale is a critical challenge in bifunctional catalysis.

47 f the fiber-shaped zinc-air battery, i.e., a bifunctional catalyst composed of atomically thin layer-

48 a highly durable and efficient carbide-based bifunctional catalyst consisting of iron-molybdenum carb

49 The Fe3 Pt/Ni3 FeN bifunctional catalyst enables Zn-air batteries to achiev

50 between the Co3 O4 and N-rGO nanosheets, the bifunctional catalyst exhibits high activity and superio

51 arily high performance of the Fe3 Pt/Ni3 FeN bifunctional catalyst makes it a very promising air cath

52 hat the new complex Fe3 does not behave as a bifunctional catalyst, in contrast to its former congene

53 a new and readily prepared cinchona-derived bifunctional catalyst, is broad in scope, and tolerates

54 We present a series of composite bifunctional catalysts consisting of one-dimensional zeo

55 timacy criterion" for the rational design of bifunctional catalysts for the conversion of low-molecul

56 ligand cooperation (MLC) by transition metal bifunctional catalysts has emerged at the forefront of h

57 thesis of chiral thiosquaramides, a class of bifunctional catalysts not previously described in the l

58 nts the extended linear syntheses typical of bifunctional catalysts, enabling systematic variation to

59 Here we show for the first time that bifunctional CDDO-Im (in contrast to CDDO-Me), as low as

60 TRPM7 and TRPM6 were the first identified bifunctional channels to contain their own kinase domain

61 The employed approach uses a bifunctional chelator with two Abeta-interacting fragmen

62 Described herein are a series of bifunctional chelators (BFCs), L1-L5, that were designed

63 nd applications, with particular emphasis on bifunctional chelators (BFCs), which ensure secure conso

64 e design, synthesis, and characterization of bifunctional chemical ligands that induce the associatio

65 of (Ar)Pd(II) complexes using vinylBPin as a bifunctional chemical probe with Pd(II)-dependent cross-

66 Among these were the bifunctional class A PBPs, which are both glycosyltransf

67 a re-evaluation of the auxiliary role of the bifunctional class A penicillin-binding proteins (aPBPs)

68 metabolism in gymnosperms primarily recruits bifunctional class-I/II diterpene synthases (diTPSs), wh

69 The use of a bifunctional cobalt complex [Co(salophen)-HQ] as hybrid

70 re, we present the cryo-EM structure of this bifunctional complex at a resolution of 7 A using a new

71 t systems at low concentrations, we report a bifunctional complex in which the salen catalyst and an

72 in, we show that chemical fuels can assemble bifunctional components into macrocycles containing mult

73 This Perspective is focused on bifunctional compounds in which one component is a lead

74 Bifunctional compounds that are [4n + 2] pai-aromatic in

75 their application, including bioconjugates, bifunctional compounds, multitargeting molecules, chimer

76 Concerning the preparation of these bifunctional compounds, several methodologies starting f

77 inking it to the RNase inhibitor 1 forms the bifunctional conjugate 7A, which inhibits the production

78 In fungi, all six known STSs are bifunctional, containing C-terminal trans-prenyltransfer

79 In this work, bifunctional core@shell Au@Pt/Au NPs are presented as no

80 ggest the possibility that thousands or more bifunctional CRMs remain to be discovered in Drosophila

81 ensity in the native disc membranes and of a bifunctional cross-linker that preserves the native rhod

82 RNP-MaP uses a hetero-bifunctional crosslinker to freeze interacting proteins

83 succinimide, a photoactivable amino reactive bifunctional crosslinker, was used and greater than 90%

84 and theoretical studies of TxtC, an unusual bifunctional CYP involved in the biosynthesis of the EPA

85 ng domain-containing protein 9 (EFCAB9) as a bifunctional, cytoplasmic machine modulating the channel

86 Targeted protein degradation with bifunctional degraders is positioned as a remarkable gam

87 four biotin binding sites free for at least bifunctional delivery.

88 target receptors and can accommodate novel, bifunctional designs.

89 catalysts uncovered by these studies are the bifunctional dications 1,8-bis(xanthylium)-biphenylene (

90 We show here that elevated expression of the bifunctional DNA glycosylase, NEIL2, sensitizes breast c

91 products, which are repair intermediates of bifunctional DNA glycosylases.

92 Here we investigate the bifunctional DNA glycosylases/lyases NEIL1 and NEIL2, wh

93 coded by open reading frame 37 (ORF37), is a bifunctional early-lytic-phase protein that possesses al

94 amination has recently been achieved using a bifunctional editor (RESCUE-S) capable of deaminating bo

95 ctrocatalytic properties to Pt and RuO2 as a bifunctional electrocatalyst for ORR and OER, and hold a

96 espectively, which is comparable to the best bifunctional electrocatalyst reported in the literature.

97 that electrodeposited NiSe2 can be used as a bifunctional electrocatalyst under alkaline conditions t

98 Rational design of highly efficient bifunctional electrocatalysts based on 3D transition-met

99 oxides have been intensively investigated as bifunctional electrocatalysts because of their superior

100 e zinc-air batteries lies in the inefficient bifunctional electrocatalysts for the oxygen reduction a

101 enders the as-prepared materials as the best bifunctional electrocatalysts so far.

102 Developing bifunctional electrocatalysts with high activities and l

103 of precious-metal catalysts, especially the bifunctional electrocatalysts with high activity for bot

104 Developing low-cost bifunctional electrocatalysts with superior activity for

105 most of the reported Ni-, Co-, and Fe-based bifunctional electrocatalysts.

106 l rate-determining step to achieve excellent bifunctional electrocatalytic activity.

107 Ss/Fe-N(4) Janus material exhibits excellent bifunctional electrocatalytic performance, in which the

108 Furthermore, this bifunctional electrode can be used for highly efficient

109 ibits a voltage of 1.58 V at 30 mA cm(-2) as bifunctional electrode for water splitting, which is muc

110 on-buffering nitrosyl's role is subtler as a bifunctional electron reservoir.

111 Glyoxal (gx) is a bifunctional electrophile capable of cross-linking DNA.

112 n triploblastic bilaterians evolved from the bifunctional endomesoderm (gastrodermis) of a diploblast

113 u5Ac derivative that is modified at C-5 by a bifunctional entity composed of a complex synthetic hepa

114 The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,

115 Within this pathway, the bifunctional enzyme adenylosuccinate (ADS) lyase plays a

116 Here, we use a novel bifunctional enzyme AgeMTPT to protect linear peptides b

117 NfnII is therefore proposed to be a bifunctional enzyme and also to catalyze a bifurcating r

118 ase activities in vitro and it can work as a bifunctional enzyme capable of synthesizing glycerol dir

119 CoVs code for nsp14, a bifunctional enzyme carrying RNA cap guanine N7-methyltr

120 Mycobacterial Pol1 is a bifunctional enzyme composed of an N-terminal DNA flap e

121 This bifunctional enzyme couples the NAD(+) synthetase and gl

122 target soluble epoxide hydrolase (sEH) is a bifunctional enzyme exhibiting two different catalytic a

123 cts of the GNE gene which encodes a critical bifunctional enzyme for sialic acid biosynthesis, lead t

124 TKFC encodes a bifunctional enzyme involved in fructose metabolism thro

125 This paper demonstrates bifunctional enzyme mimicking roles of a metal-free nano

126 s the structure of the catalytic site of the bifunctional enzyme phosphoribosylaminoimidazole carboxy

127 es in Toxoplasma and Pythium by an unrelated bifunctional enzyme that assembles a distinct but struct

128 PaaZ is a bifunctional enzyme that catalyzes the ring opening of o

129 DNA2 is a bifunctional enzyme that contains both single-stranded D

130 LT) A4 hydrolase/aminopeptidase (LTA4H) is a bifunctional enzyme that converts the highly unstable ep

131 gy to utilize the functional advantages of a bifunctional enzyme.

132 tool for in vivo validation of an essential bifunctional enzyme.

133 ile maintaining a monolithic AMA fold of the bifunctional enzyme.

134 -PFKs), specific glucokinases (ADP-GKs), and bifunctional enzymes (ADP-PFK/GK).

135 VIH1/2 are bifunctional enzymes able to generate and break-down PP-

136 They are bifunctional enzymes containing a trans-esterase activit

137 Aldehyde/alcohol dehydrogenases (ADHEs) are bifunctional enzymes that commonly produce ethanol from

138 er chlorinate or hydroxylate C4 and (ii) two bifunctional enzymes that normally hydroxylate one carbo

139 hlamydia trachomatis genome encodes multiple bifunctional enzymes, such as DapF, which is capable of

140 d WarB have structural similarities with the bifunctional Escherichia coli lipopolysaccharide (LPS) O

141 Bifunctional FAD synthetases (FADSs) fold in two indepen

142 We report a crystal structure of the bifunctional FEN/EXO-POL apoenzyme that reveals the posi

143 The bifunctional flavoenzyme proline utilization A (PutA) ca

144 We report a bifunctional fluorescent probe that combines a rhodium m

145 y of target capture in immunoassays, using a bifunctional fusion protein construct which incorporates

146 Bifunctional fusion protein design has been widely utili

147 usly, we proposed a novel application of the bifunctional fusion protein design through the introduct

148 In this study, a bifunctional gallium ion immobilized magnetic pertriflat

149 code TrpF specialists, HisA specialists, and bifunctional generalists.

150 res of an array of reported enantioselective bifunctional HBD catalysis through an iterative statisti

151 However, thus far, no bifunctional HBED chelator capable of direct conjugation

152 reby introduce HBED-NN as a structurally new bifunctional HBED chelator for direct click coupling.

153 adiometal-based radiopharmaceuticals bearing bifunctional HBED chelators are powerful radiotracers fo

154 Bifunctional HBED chelators make strong complexes with t

155 KatG is a bifunctional, heme-dependent enzyme in the front-line de

156 f the sensor histidine kinases belong to the bifunctional HisKA family, displaying both kinase and ph

157 hosphatase activity of the largest family of bifunctional histidine kinases in response to the change

158 The bifunctional human enzyme phosphoribosylaminoimidazole c

159 Bifunctional hydrogen bond donor (HBD) catalysis exempli

160 that can be used for future applications of bifunctional hydrogen bond donor catalysis.

161 The use of a bifunctional iminophosphorane (BIMP) superbase was found

162 A bifunctional iminophosphorane (BIMP)-catalysed enantiose

163 Bifunctional iminophosphorane catalysts are found to use

164 Consistently, Corin, a bifunctional inhibitor of HDACs and LSD1, potently inhib

165 In this study, a new class of bifunctional inhibitors of bacterial ureases, important

166 ry and establish AcrIIA13-AcrIIA15 as unique bifunctional inhibitors of SauCas9.

167 A series of first-generation bifunctional inhibitors was achieved through structure-b

168 All but one of its neurites were bifunctional, innervating thalamocortical and local inte

169 C-terminal pyrophosphatase domain of Asp1, a bifunctional inositol pyrophosphate (IPP) kinase/pyropho

170 by the convergent union of an enimide with a bifunctional iodoether.

171 This bifunctional isocyanide was found to undergo mild cyclod

172 fulfil previously published criteria for any bifunctional kinase/phosphatase to exhibit concentration

173 The last enzyme of the pathway, bifunctional L-histidinol dehydrogenase (HDH, EC 1.1.1.2

174 use biotinylated anti-bacteria antibodies as bifunctional linkers (BLs) to mediate the aggregation of

175 A bifunctional macrocycle, with hydrogen bond donors at on

176 peptide c[E(4)W(5)C] pHLIC was conjugated to bifunctional maleimide-NO2A and radiolabeled with (64)Cu

177 This bifunctional marker was efficiently cleaved during virus

178 n YFP and mCherry because of cleavage of the bifunctional marker, which manifested as a marked shift

179 This bifunctional material shows enantioselectivity luminesce

180 lfonic acid functionalized material and with bifunctional materials (SBA-15 type and macroporous) con

181 we designed a labeling strategy based on the bifunctional mCherry-2xCL-YFP-Vpr construct, in which 2x

182 The alternative bifunctional mechanism is verified by combined electroch

183 The DFT study supports a bifunctional mechanism with the alkoxo complexes 8a and

184 It can be detrimental to the HOR as per the bifunctional mechanism, as the AM(+) destabilizes the OH

185 that PS1 regulates Abeta levels by a unique bifunctional mechanism.

186 that PS1 regulates Abeta levels by a unique bifunctional mechanism.

187 uced precious metal usage, opportunities for bifunctional mechanisms via spillover, and higher resist

188 We report the design of a bifunctional metal-organic layer (MOL), Hf(12) -Ru-Co, c

189 Bifunctional Mo complexes, [CpMo(CO)(kappa(3)-P2N2)](+)

190 as a model, we identified a highly specific bifunctional molecule able to mediate the engulfment and

191 The hetero-bifunctional molecule QC-01-175 was designed to engage b

192 ned from the pyridazinone template to enable bifunctional molecule synthesis, and affinity enrichment

193 of these variants could be used to design a bifunctional molecule with affinity for albumin and a se

194 The bifunctional molecule, 1-pyrenebutanoic acid succinimidy

195 t protein, and exhibit several features of a bifunctional molecule, including the hook-effect, turnov

196 Here, we report a rationally designed bifunctional molecule, piperazinium iodide (PI), contain

197 induced protein degradation with photoactive bifunctional molecules are discussed.

198 onists, to date it remains unprecedented for bifunctional molecules that bring proteins together, suc

199 Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that recruit an E3 ligase to a ta

200 ysis-TArgeting Chimeras (PROTACs) are hetero-bifunctional molecules that recruit an E3 ubiquitin liga

201 y effective way of using rationally designed bifunctional molecules to simultaneously enhance the dev

202 75 repeat units long (28 kDa) from a single bifunctional monomer and Cu(I) .

203 These data demonstrate that bifunctional MOP/NOP agonists, which may have therapeuti

204 y reported the development of a long-acting, bifunctional MOR agonist/delta-opioid receptor (DOR) ant

205 n reaction, nitrogen reduction reaction, and bifunctional/multifunctional electrocatalysis, along wit

206 atalyses enantioselective cycloaddition as a bifunctional NADPH-dependent reductase/Diels-Alderase.

207 n this direction, we have designed the first bifunctional nanobiosensor for chemokine screening and d

208 perspectives on further development of these bifunctional nanocrystals into a viable platform for inv

209 ems to demonstrate the capabilities of these bifunctional nanocrystals to monitor chemical reactions

210 Bifunctional nanocrystals with integrated plasmonic and

211 Thus, the bifunctional nature of ROC provides the RA-based signali

212 stable under all conditions, preserving the bifunctional nature of the catalyst.

213 Here we report the design of a catalytic, bifunctional nitrile template that binds a heterocyclic

214 Molecular metal/NH bifunctional Noyori-type catalysts are remarkable in tha

215 ylation of the N-H functionality within M/NH bifunctional Noyori-type catalysts leads to detrimental

216 All known CoVs encode a bifunctional nsp14 protein which possesses ExoN and guan

217 vation by ORE1 of its downstream target gene BIFUNCTIONAL NUCLEASE1 (BFN1).

218 st together with a N,N'-bistosyl urea as the bifunctional nucleophile and N-fluorocollidinium tetrafl

219 These data establish OsCAldOMT1 as a bifunctional O-methyltransferase predominantly involved

220 Bifunctional organocatalysis combining covalent and nonc

221 talysis, cooperative organo/metal catalysis, bifunctional organocatalysis, dicyanoalkylidene activati

222 an unsaturated basic amine, facilitated by a bifunctional organocatalyst designed to stabilize a carb

223 alization of silyl-diene enol ethers under a bifunctional organocatalyst provokes a dramatic change i

224 catalyzed by a cinchona alkaloid-squaramide bifunctional organocatalyst was studied using density fu

225 Herein, we report an advanced bifunctional oxygen electrocatalyst consisting of porous

226 uses significant carbon-support corrosion of bifunctional oxygen electrocatalysts.

227 free multi-sensing air electrode (MSAE) with bifunctional oxygen reduction and evolution activities,

228 experimental results verify the existence of bifunctional oxygen vacancies in the 2D black In(2) O(3-

229 Our newly discovered bifunctional oxygen-independent pathway, widespread in b

230 This work establishes a bifunctional oxygen-independent salvage pathway for 5'-d

231 entities, the divisome, the elongasome, and bifunctional PBPs.

232 he peptidoglycan cell wall is synthesized by bifunctional penicillin-binding proteins such as PBP1b t

233 nt CLE peptide hormones leads to a synthetic bifunctional peptide that exerts activities beyond the o

234 vely, this study presents the selection of a bifunctional peptide-based anti-infective agent and its

235 rate to caffeate in lignin biosynthesis as a bifunctional peroxidase that oxidizes both ascorbate and

236 sors or (iii) overproducing PBP1A, a related bifunctional PG synthase.

237 New bifunctional phase transfer agents were synthesized and

238 n reaction catalyzed by a chiral enantiopure bifunctional phosphine.

239 ns of different proton transport pathways of bifunctional photoacid 7-hydroxyquinoline (7HQ) in water

240 ly curing a mixture of diols and triols with bifunctional phthalic anhydrides.

241 tituted 3-vinyl-1,2,4-triazines, as original bifunctional platforms for the domino conjugate addition

242 ye can be stably conjugated to a mAb using a bifunctional platinum(II) linker.

243 zole linked maleimide-based single molecular bifunctional probe 1 has been synthesized for the colori

244 This bifunctional probe, which is also detectable with fluore

245 icacy at MOR and DOR, accessing a variety of bifunctional profiles while maintaining high affinity an

246 ntiviral activity of antibodies reflects the bifunctional properties of these molecules.

247 and double-KO cell lines revealed that the D-bifunctional protein (HSD17B4) and the peroxisomal ABC t

248 Prevotella nigrescens contains a distinctive bifunctional protein comprising a 3-deoxy-d-arabino hept

249 The bifunctional protein kinase-endoribonuclease Ire1 initia

250 It is a bifunctional protein resulting from the fusion of a G-pr

251 d L. major genes (FKP40 and AFKP80) encoding bifunctional proteins with kinase/pyrophosphorylase acti

252 Additionally, bifunctional proteolysis targeting chimeras (PROTACs) co

253 Hetero-bifunctional PROteolysis TArgeting Chimeras (PROTACs) re

254 phthalic anhydride derivatives were used as bifunctional reactants in systems with varied stoichiome

255 channel gating, we perform cross-linking by bifunctional reagents of multiple predicted pairs of cys

256 and optimized a synergic system based on two bifunctional reagents, a thiosemicarbazide-functionalize

257 tors called signaling and antigen-presenting bifunctional receptors (SABRs) in a cell-based platform

258 redox targeting reactions of LiFePO4 with a bifunctional redox mediator, 2,3,5,6-tetramethyl-p-pheny

259 entified silencers and reveals that they are bifunctional regulatory sequences that also act as gene

260 Here, we have tested a bifunctional resistance gene for its suitability as a se

261 tilizing a biological circuit generated by a bifunctional retinoid oxidoreductive complex (ROC).

262 10-16 degrees in the orientation of a single bifunctional rhodamine molecule attached to a regulator

263 We identified a novel bifunctional riboflavin kinase/regulator (RbkR), which c

264 mechanistic insight enabled the design of a bifunctional ROAMP-reversible addition-fragmentation cha

265 eversible-deactivation chain transfer in the bifunctional ROCOP system to demonstrate precise molecul

266 t of new therapeutic entities because of its bifunctional role as a biomarker and effector protein.

267 chanism in which the ClBcat reagent serves a bifunctional role by sequentially activating the alkyne,

268 findings support the notion that SbnI has a bifunctional role contributing precursor OPS to SB synth

269 Using a bifunctional SAM containing PEG moieties and a tethered

270 ucture of the ferroconcrete, a high-strength bifunctional scaffold has been developed by combining su

271 rk, we designed benzoselenazolone as a novel bifunctional selenide reagent for both off- and on-DNA C

272 ere we describe a class of readily available bifunctional silyl ether-based cyclic olefins that copol

273 In this study, we design and synthesize a bifunctional small molecule by conjugating the neuramini

274 proteasome-mediated degradation of BRD4 by a bifunctional small molecule linking the KEAP1-Nrf2 activ

275 Targeted protein degradation, using bifunctional small molecules (Protacs) to remove specifi

276 Here, we show the development of hetero-bifunctional small molecules capable of selectively targ

277 ulate microRNAs (miRNAs) biogenesis by using bifunctional small molecules that consist of a pre-miRNA

278 ed from electron paramagnetic resonance of a bifunctional spin label (BSL) to build and refine atomis

279 With bifunctional squaramide catalyst, the desired tetralone

280 employing a very low loading of 1 mol % of a bifunctional squaramide organocatalyst.

281 alogues was achieved using L-proline derived bifunctional squaramide which outperformed commonly used

282 Novel supported chiral bifunctional squaramides have been easily prepared start

283 ures are assembled by iterative couplings of bifunctional stannyl amine protocol (SnAP) reagents and

284 ced with polymers and surfaces, but suitable bifunctional stoppering groups are lacking.

285 Herein, we introduce a bifunctional supramolecular modulator, 1,2,4,5-tetrafluo

286 Initially self-reproduction of the bifunctional surfactants is observed, but once it reache

287 r assembler is a supramolecular aggregate of bifunctional surfactants produced by the reaction of two

288 ased enzyme engineering of DHPAAS results in bifunctional switching between aldehyde synthase and dec

289 the PG synthesis regulator LpoA, its cognate bifunctional synthase, PBP1A, and different endopeptidas

290 erivatives can be clicked with a fluorescent bifunctional tag that allows multidimensional HPLC purif

291 fination of thiazole derivatives utilizing a bifunctional template in an intermolecular fashion.

292 he overall process was catalyzed by a chiral bifunctional thiourea catalyst through a sequential conj

293 ereomeric P-chiral beta-aminophosphine-based bifunctional thioureas displayed significantly different

294 xes, found in most eukaryotes, to the single bifunctional TIM complex present in trypanosomes.

295 or glycolysis and gluconeogenesis, including bifunctional unidirectional fructose 1,6-bisphosphate al

296 Chiral bifunctional urea-catalyzed asymmetric direct hetero-Die

297 ExoS is bifunctional, with an amino-terminal RhoGAP and a carbox

298 In contrast Cel12A, a bifunctional xyloglucanase/cellulase, induced creep with

299 rimidines through the expression of a single bifunctional yeast fusion gene, cytosine deaminase/uraci

300 fiber networks, and restored by treatment of bifunctional Zn(II)-terpyridine-capped PEO to redisperse