ライフサイエンスコーパス: bind to

1 NSP1 binds to 18S ribosomal RNA in the mRNA entry channel of

2 gate most single transmembrane receptors for binding to 445 IgSF proteins, we identify over 500 inter

3 In addition, purified CST complex binds to 5' DNA overhangs and directly blocks MRE11 degr

4 etan treatment of Raji2R cells increased the binding to 53% +/- 3% of the parental cell line.

5 plex containing the 3'->5' RNA helicase Ski2 binds to 80S ribosomes near the mRNA entrance and facili

6 w that the small molecules ICCB-19 and Apt-1 bind to a pocket on the N-terminal TRAF2-binding domain

7 her weakly attract all chromatin or strongly bind to a randomly chosen 0.05% of nucleosomes.

8 ces IL-6 transcription through direct Twist1 binding to a conserved E-box element at the IL-6 promote

9 ithin the soluble protein calmodulin, ligand binding to a G protein-coupled receptor, and activation

10 sopressin regulates renal water excretion by binding to a G(alpha) s-coupled receptor (V2R) in collec

11 mechanism of action may be through compound binding to A kinase anchoring protein (AKAP) 1, modulati

12 teraction with the antigen is enabled by its binding to a metallic surface that serves as a source fo

13 a conformational change that mediates stable binding to a non-canonical DNA motif.

14 ional molecules consisting of one ligand for binding to a protein of interest (POI) and another to an

15 catalytic beneficial effects of a Ni(II) ion binding to a Si|PNP type surface as a result of signific

16 tin-binding proteins facilitates promiscuous binding to a wide range of different molecular targets,

17 PTPN14 binds to a C-terminal arginine highly conserved in diver

18 COVA1-16 binds to a flexible up conformation of the RBD on the sp

19 tein-Barr virus (EBV) BGLF2 tegument protein binds to a protein in the type I interferon signaling pa

20 crystal structure of the LSD1/CoREST complex bound to a 191-bp nucleosome.

21 tures of DNA-PKcs (DNA-PK catalytic subunit) bound to a DNA end or complexed with Ku70/80 and DNA in

22 -DNA complex, suggesting that Pol beta, when bound to a lesion, has a strong commitment to nucleotide

23 Moreover, in cells, MANF bound to a model ER protein exhibiting improper disulfid

24 sites enabled chemoselective and reversible binding to acetylene through the formation of metastable

25 C-87 bundled actin filaments, whereas CLIK-1 bound to actin filaments without bundling them and antag

26 n vitro, both tracers displayed preferential binding to activated hPBMCs.

27 The active sites of RFC are fully bound to adenosine 5'-triphosphate (ATP) analogs, which

28 was able to detect C. albicans cells, and it bound to Adh1 in yeast and Adh2 in hyphae among the cell

29 protein, TrkA, which closes the channel when bound to ADP and opens it when bound to ATP.

30 report the crystal structure of mouse DHX36 bound to ADP.

31 the house dust matrix, through either their binding to allergens or their autonomous modulation of i

32 tures of the IQ motif (residues 1,646-1,664) bound to alpha-actinin-1 and to apo-calmodulin (apoCaM).

33 active site (imidazolide) and can covalently bind to amino acids other than cysteine on target protei

34 s calculations to examine and rationalize CR binding to amyloids.

35 nto living cells and recover conjugates that bind to an intracellular target.

36 which functions as a stabilizer of MEILB2 by binding to an alpha-helical N-terminus of MEILB2 and pre

37 on recycling endosomes by causing increased binding to an alternative plasma membrane partner, ITSN1

38 ) changes significantly, consistent with BVM binding to an internal ring of hydrophobic side chains o

39 We find that RAC2(E62K) retains binding to an NADPH oxidase (NOX2) subunit, p67(phox), a

40 In the active state, the BBSome is bound to an Arf-family GTPase (ARL6/BBS3) that recruits

41 These proteins bind to and modulate the conformation of chromatin, ther

42 f p44/p62 complexes without XPD reveals they bind to and randomly diffuse on DNA, however, in the pre

43 They bind to and stabilize unliganded rod opsin, which in exc

44 In addition, virion binding to and subsequent infection of respiratory epith

45 ha1 receptor, and the GDNF-GFRalpha1 complex binds to and activates the transmembrane RET tyrosine ki

46 Kindlin-2, through its C-terminal region, binds to and stabilizes MafA, which activates insulin ex

47 and found one, named CLK8, that specifically bound to and interfered with CLOCK activity.

48 -induced Kv4.2 phosphorylation triggers Pin1 binding to, and isomerization of, Kv4.2 at the pThr(607)

49 s for parent and affinity-matured antibodies bound to ARG2, with a large reorientation of the binding

50 e 1 has adenosine 5'-diphosphate (ADP)-P (i) bound to Arp2/3 complex.

51 romer arches indicates that VARP will prefer binding to assembled retromer coats through simultaneous

52 The P2K2 extracellular lectin domain binds to ATP with higher affinity than P2K1 (dissociatio

53 channel when bound to ADP and opens it when bound to ATP.

54 Interestingly, Sox9 binding to beta-catenin is enhanced in Med23(fx/fx);Wnt1

55 the EPTP-directed mAbs showed far less avid binding to brain tissue and were consistently detected i

56 p selective BET D1 inhibitors with preferred binding to BRD4 D1.

57 These sABs can bind to BRIL fused either into the loops or termini of d

58 lysis of three compounds (11a, 11d, and 11g) bound to CA II showed the validity of the adopted drug d

59 binding (CSD) motif in EphB1 prevented EphB1 binding to Cav-1 as well as Src-dependent Cav-1 phosphor

60 We demonstrate that FDL1 directly binds to CCAACC core motifs present in AD1 regulatory re

61 and thus the climate, the microbial world is bound to change and adapt as well.

62 PRDM16 binds to cis-regulatory elements and represses the expre

63 human herpesvirus-7 (HHV-7) U21 glycoprotein binds to class I major histocompatibility complex (MHC)

64 ASL(Arg1)(ICG) and ASL(Arg2)(ICG) constructs bound to cognate and wobble codons on the ribosome revea

65 ese hamster ovary cells and investigated the binding to different putative ligands (acetylated BSA [A

66 A few ligands have been reported that bind to dimeric quadruplexes, but their preclinical phar

67 ical interaction network that links effector binding to distal regions of the fold that support the g

68 ORC5.ORC3 interface that may facilitate ORC binding to DNA.

69 rmined this arrest is driven in part by Cas9 binding to DNA.

70 underlying chemistry of transcription factor binding to DNA.

71 In the initial state, RG binds to DNA and unwinds ~2 turns of the double helix in

72 However, cGAS binds to DNA irrespective of DNA sequence, therefore, se

73 ouble strand break repair by promoting 53BP1 binding to double-strand breaks.

74 At the molecular level, many MAGEs bind to E3 RING ubiquitin ligases and, thus, regulate th

75 ly, the structure reveals one hFip1 molecule binding to each ZF4 and ZF5, with a conserved mode of in

76 SidI binding to eEF1A and Lpg2505 is not mutually exclusive,

77 , multivalent interactions couple productive binding to efficient deacetylation of histones on endoge

78 nucleotide occupancy: five MCM subunits are bound to either ATPgammaS or ADP, whereas the apo MCM2-5

79 sw1 docks at the SHL2 position when ISW1a is bound to either mono- or di-nucleosomes, there are major

80 tides (EP1, -2, -3, -7 or EP9) showed strong binding to EpiSCs but not to blood immune cells.

81 in our tethering assay and increased v-SNARE binding to exocyst gain-of-function complexes.

82 ormation by extending from the cell surface, binding to exogenous DNA, and retracting to thread this

83 rediction, imaging analysis show that CXCL13 binds to extracellular matrix components in situ, constr

84 es that indicate a potential role of AeOBP22 binding to fatty acids, and that the specificity for lon

85 nly alphaKG is bound to the Fe(II)), alphaKG binding to Fe(II)-DAOCS results in ~45% five-coordinate

86 Hepcidin binding to ferroportin is coupled to iron binding, with

87 Furthermore, when bound to fibrillin, MAGP-1 retained the ability to inter

88 IgE-binding to fish tropomyosins and TPIs was demonstrated f

89 Here, we assembled core U7 snRNP bound to FLASH from recombinant components and analyzed

90 bound-state mobility based only on transient binding to flexible polymers.

91 dium containing eGFP-Wnt-3a to visualize its binding to FZD and to quantify Wnt-FZD interactions in r

92 ed DNA-binding domain that exhibits specific binding to G-quadruplex (G4) DNA structures.

93 r G-protein-modulating effect, i.e. they can bind to Galpha subunits of different classes and either

94 diverges from that in GIV and enables better binding to Galpha(s) and Galpha(q) Unlike the nucleotide

95 n of IFITM3 in neurons and astrocytes, which binds to gamma-secretase and upregulates its activity, t

96 residue in type P(O) SadP, was required for binding to Gb4 and, strikingly, was also required for in

97 ocytes with troglitazone increased PPARgamma binding to GIP-R PPREs.

98 esin from systemic subtype P(N) strains also binds to globotetraosylceramide (Gb4).

99 silico docking analysis supports allosteric binding to glutamate-gated chloride channels similar to

100 -binding domain in GluN1 is more closed when bound to glycine and glutamate relative to what is obser

101 The DNA-AuNPs can bind to GO in a concentration- and time-dependent manner

102 Nickel binding to H. pylori NikR (HpNikR) induces an allosteric

103 1 insert in mouse neuroligin-1 increases its binding to heparan sulphate, a modification on neurexin.

104 srupting peptide that is inactive when VI is bound to hexon trimers.

105 ng to ProQ and negative determinants against binding to Hfq.

106 We compared plasma antibody binding to HIV antigens between 51 nontransmitting mothe

107 IV, they did not respond to or eliminate FDC bound to HIV.

108 analysis demonstrated that EBV peptides can bind to HLA-E and block inhibition of NK cell effector f

109 fferent protein scaffolds were engineered to bind to hRBP4 when loaded with the orally available smal

110 sp90-organizing protein (HOP) preferentially bound to HSPA1L, and the Hsp110 nucleotide-exchange fact

111 ter, the nanoMIPs were observed to deform at binding to HTR: while no relevant changes were observed

112 a novel quinoline core ligand, BMPQ-1, which bound to human telomeric G-quadruplex multimers over mon

113 tructure of the non-ubiquitinated ID complex bound to ICL DNA-which we also report here-we show that

114 he IFNARs proximal complex is assembled upon binding to IFN is poorly understood.

115 ring human memory B cells are constitutively bound to IgA.

116 ins a nuclear localization signal (NLS) that binds to importin and is required for its function durin

117 identify various RREs in mRNAs that FMRP may bind to in vivo.

118 c electron microscopic (cryo-EM) maps, limit binding to incoming monomers, and flatten the terminal s

119 n-containing SOCS box protein 2 (SPSB2) that binds to iNOS, and selective ligands for AGRP-binding me

120 Binding to Ins(1,4,5)P(3) receptors [Ins(1,4,5)P(3)R] an

121 Moreover, extracellular SQSTM1 binds to insulin receptor, which in turn activates a nuc

122 versible, non-toxic, and attributable to the binding to integrins on the surface of epithelial cells.

123 These studies show that PGC-1alpha binds to intronic RNA sequences, some of them controllin

124 cluster that, upon oxidation, promotes FBXL5 binding to IRP2 to effect its oxygen-dependent degradati

125 Several small molecules activate PKM2 by binding to its intersubunit interface.

126 Pi promoted beclin 1 binding to its negative regulator BCL2, which impairs au

127 rapidly internalized and degraded following binding to its receptor and initiation of signaling.

128 indings expand the current models of insulin binding to its receptor and of its regulation.

129 from Francisella novicida as it inspects and binds to its DNA target.

130 IFN-gamma binds to its receptor on Leishmania-infected macrophages

131 F4AP, a radiofluorinated analog of 4AP, also binds to K(V)1 channels and can be used as a PET tracer

132 rate that while CTCF is required for cohesin binding to KSHV, they have very distinct effects, with c

133 periments and found a lower amount of KChIP3 bound to Kv4.2 in the presence of CLN3.

134 changes in PCSK9 required for high-affinity binding to LDL particles.

135 s "wobble") of lipophilic probes transiently bound to lipid membranes, revealing that Nile red's (NR)

136 icles including oligomers and microfilaments bound to lipid vesicles.

137 ng complexes are formed, whereas MG does not bind to malaswitches alone.

138 Crm proteins from different orthopoxviruses bound to membrane-associated TNF and dampened inflammato

139 ins are abundant cytoplasmic proteins, which bind to membranes that expose negatively charged phospho

140 osomes revealed that the Aster-B GRAM domain binds to membranes in a cholesterol concentration-depend

141 nd SNARE-assembly complex, and the Rab Ypt7, bound to membranes by either C-terminal prenyl groups (Y

142 roline-arginine-rich sequence within the LCD binds to microtubules and targets condensation of LEM2 t

143 different miRNAs or when the two sites were bound to miRNAs loaded into two different AGO paralogs,

144 We demonstrated that Grh remains bound to mitotic chromosomes, a property shared with oth

145 Unexpectedly, two phospholipids are bound to MlaFEDB, suggesting that multiple lipid substra

146 The ability of these toxins to target and bind to motor nerve terminals is a key factor determinin

147 We also found that many RBPs can bind to multiple distinctly different motifs.

148 Some orthosteric agonists bind to multiple sites on a receptor, but current analyt

149 It bound to multiple bioactive phosphoinositides in vitro.

150 However, monovalent UCA Fabs bound to MuSK but did not have measurable pathogenic cap

151 d that WD repeat-containing protein 5 (WDR5) binds to MYC and is a critical cofactor required for the

152 ing reactivator, monoxime RS194B, reversibly bound to native and venomous agent X (VX)-inhibited huma

153 nd Listeria monocytogenes strain EGD-e while bound to native-like lipid membranes.

154 as been proposed to also contribute to toxin binding to neurons by interacting with lipid membranes (

155 We further demonstrate that n-apo AI binds to neutrophils and monocytes, with preferential bi

156 yl sulfonamides that exhibit a novel mode of binding to non-bromodomain and extra terminal domain (no

157 d for these sugars both in free solution and bound to nonhydrolytic proteins, where for the most part

158 TC1 and SA4503 likely have off-target binding to NR2B in vivo.

159 e synthesized peptides were tested for their binding to nSH3/cSH3.

160 -terminal Zalpha1 and Zalpha2 domains, which bind to nucleic acids in the Z-conformation.

161 ripts accumulate in nuclear speckles and are bound to Nxf1.

162 E binding to one peptide on Ara h 5 and IgG4 binding to one Ara h 9 peptide were greater in PS than i

163 IgE binding to one peptide on Ara h 5 and IgG4 binding to on

164 blast HS genetically to make it incapable of binding to OPG.

165 During late M-phase of the cell-cycle, Cdc6 binds to ORC and the ORC-Cdc6 complex loads in a multist

166 Interactome analysis detects no significant binding to other STATs or additional off-target proteins

167 i) 18F-AV-1451, a radioligand with increased binding to pathologically affected regions in tauopathie

168 viral transcription by cleaving capped mRNA bound to PB2.

169 This phosphorylation event reduced eIF2alpha binding to PERK and selectively attenuated downstream si

170 Escherichia coli MlaFEDB in an apo state and bound to phospholipid, ADP or AMP-PNP to a resolution of

171 ipathic N-terminal helix of CPn0678 mediates binding to phospholipids in both the plasma membrane and

172 oth types of SadP are shown to predominantly bind to pig lung globotriaosylceramide (Gb3).

173 bited or genetically ablated, Gbetagamma can bind to PLCbeta but does not elicit Ca(2+) signals.

174 PTBP1 promotes displacement of UPF1 already bound to potential substrates.

175 We find that PHF19 interacts with PRC2 and binds to PRC2 targets on chromatin.

176 MTG16 also bound to previously reported enhancer regions of genes r

177 fq depends both on positive determinants for binding to ProQ and negative determinants against bindin

178 We show here that CP33B is bound to psbA mRNA in vivo, as was shown previously for

179 Both proteins bind to Psi RNA primarily as dimers, but to a control RN

180 Now, by directly manipulating E7 binding to PTPN14 and using a PTPN14 knockout rescue exp

181 coexpressed in intestinal crypt stem cells, bind to R-spondins (RSPOs) with high affinity, and poten

182 nal domains of OPG, which is responsible for binding to RANKL, the exact biological functions of the

183 n VP1, a broad range of GAG oligosaccharides bind to recessed regions between VP1 capsomers.

184 (rhPRG4) devoid of core 2 structures did not bind to recombinant galectin-3.

185 arations of IVIg were tested for IgM and IgG binding to red blood cells (RBCs) from wild-type (WT), a

186 ed by DNA-binding transcription factors that bind to regulatory gene regions, an elegant alternative

187 is constitutively present in healthy tissues bound to resident cells via its high-affinity receptor,

188 These defective RNAs bind to retinoic acid-inducible gene I (RIG-I) and initi

189 et charge and lower hydropathy and prefer to bind to RNA.

190 Additionally, ARF6 binds to RPH3A and enhances the interaction between the

191 ressor complex and that HDAC3 preferentially binds to RUNX1 rather than to AML1-ETO in t(8;21) AML ce

192 precipitation (ChIP) assays with low dox, AR binding to sARE-containing enhancers increased, whereas

193 Bound to self-DNA/RNA, LL37 licenses autoreactivity by s

194 fe (~ 24 hours) in mice, suggesting possible binding to serum components.

195 rved for estradiol but not testosterone, IPI binding to SHBG was reduced by ~20-fold in the presence

196 ly 70% of RBPs for which we obtained a motif bound to short linear sequences, whereas ~30% preferred

197 , and WDR41 is a beta-propeller protein that binds to SMCR8 such that the whole structure resembles a

198 Ca(2+)-free synaptotagmin-1 binds to SNARE complexes anchored on PIP(2)-containing n

199 well-established that transcription factors bind to specific DNA sequences using a combination of ba

200 , KH2, and RGG domains, which are thought to bind to specific RNA recognition elements (RREs).

201 t is involved in DNA replication by directly binding to specific motifs within their promoters.

202 ion is controlled by the MatP protein, which binds to specific sites (matS) within ter, and interacts

203 ly in the presence of host factor PCBP2 that binds to stem-loop IV of the IRES.

204 of 11s and related thieno[3,2-d]pyrimidines bound to STK17B revealed a unique P-loop conformation ch

205 Interestingly, C3G bound to talin and promoted the interaction of talin wit

206 associated with more effective and selective binding to target proteins compared to planar compounds

207 uclear receptors (NRs), NR2F2 and NR2C2, can bind to (TCAGGG)(n) variant repeats within telomeres and

208 frared light sensitivity using gold nanorods bound to temperature-sensitive engineered transient rece

209 ) recovered tRNAs that overlapped with those bound to TET2 in cells.

210 In these studies, miRs predicted to bind to the 3'-UTR of mouse MR were profiled by qRT-PCR

211 structure reveals that two Rab33B molecules bind to the diverging alpha-helices of the dimeric Atg16

212 These EMC subunits also bind to the ER-resident fusion machinery component synta

213 The fragments discriminately bind to the interface of 14-3-3 with the recognition mot

214 nist picrotoxinin, TETS has been proposed to bind to the noncompetitive antagonist (NCA) site in the

215 00B-3p, and MIR200C-3p, as miRNAs that might bind to the occludin 3'UTR.

216 r analysis revealed that BZR1 could directly bind to the promoter of RESPIRATORY BURST OXIDASE HOMOLO

217 es a conformational change that allows gD to bind to the regulatory complex gH/gL, which then activat

218 Glucocorticoid receptor (GR) and STAT3 bind to the same genomic regulatory regions, which were

219 These alarmins bind to the Toll-like receptor 4 and prime the nod-like

220 endent on multiple replisome components that bind to the ubiquitin ligase SCF(Dia2).

221 development, since antibodies to NS1 do not bind to the virion, thereby eliminating the risk of ADE.

222 ions, and provide new insights on antagonist binding to the A(2A) AR, an emerging target in immuno-on

223 in accumulation in the dark and enhance PIF4 binding to the ABI5 promoter, but negatively regulate PI

224 navirus 2 (SARS-CoV-2) is initiated by virus binding to the ACE2 cell-surface receptors(1-4), followe

225 enza IgG monoclonal antibodies for selective binding to the activating Fcgamma receptor FcgammaRIIa r

226 , resulting in its nuclear translocation and binding to the Axin1 promoter.

227 ently by promoting oligomerization involving binding to the C-terminal region.

228 Gangliosides relieve this block, binding to the capsid at low pH and facilitating a late

229 titers of nasal wash antibodies, especially binding to the central conserved domain.

230 CH-3-8 binding to the colchicine-binding site in tubulin protei

231 Binding to the decoding site of the eukaryotic ribosomes

232 radation rate of HO2 are independent of heme binding to the HRMs.

233 pparent hydricity, which encompasses formate binding to the Mn, is considered.

234 ucture through the ubiquitin of one protomer binding to the other protomer in a reciprocal fashion.

235 otes immunostimulatory secondary necrosis by binding to the phagocytic marker phosphatidylserine on d

236 neutrophils and monocytes, with preferential binding to the proinflammatory monocyte subtype and part

237 t and alpha-methylstyrene render the si-face binding to the Rh-center more preferred over the re-face

238 While binding to the same consensus motif, their DNA-binding s

239 thambutol inhibits arabinosyltransferases by binding to the same site as both substrates in EmbB and

240 switch during CD4SP development, via direct binding to the Satb1 P2 promoter.

241 changes in the capacitance induced by ligand binding to the serotonin transporter and to the glycine

242 cant fluorescence enhancement upon selective binding to the transport protein serum albumin in PBS bu

243 They further show that substrate binding to the WW domain simultaneously alters interdoma

244 Additional data indicate that although MDIMP binds to the closed state of the channels, it has more p

245 Ric-8A binds to the exposed Galpha beta sheet and switch II to

246 ased the IC(50) value, suggesting that MDIMP binds to the extracellular side of the pore.

247 We found that T-cadherin binds to the globular domain of adiponectin, relying on

248 e cellular protein complex known as retromer binds to the L2 capsid protein and sorts incoming virion

249 tic protein kinases, and that MOB1A directly binds to the LegK7 kinase domain.

250 T analysis, we demonstrate that SWG directly binds to the lipid-binding cavity of OSBP.

251 ocalizes to the nucleus where it selectively binds to the mRNA processing protein, heterogeneous nucl

252 atrix-ESCRT interaction is replaced when Gag binds to the plasma membrane.

253 c-Myc binds to the promoter of the MTR4 gene and is important

254 nscriptional factor downstream from MEK/ERK, binds to the promoter region of VE-cadherin (chip assay)

255 HDL NPs are a cholesterol-poor ligand that binds to the receptor for cholesterol-rich HDLs, scaveng

256 Our data suggest that synaptotagmin-1 binds to the SNARE complex through the primary interface

257 racterization, and utilization of a CDP that binds to the transferrin receptor (TfR), a native recept

258 Our results showed that MAb binds to the virus surface spike, allowing it to undergo

259 NSs bound to the carboxyl-terminal SPRY subdomain of TRIM21,

260 an isosceles triangle of three [2]-rotaxanes bound to the central triangle while the [3]-rotaxane 4 c

261 ]-rotaxane 4 contains only two [2]-rotaxanes bound to the central triangle.

262 ET to study the conformation of RNA duplexes bound to the core also shows bending.

263 otently neutralizing mAbs that cooperatively bound to the ebolavirus glycoprotein (GP).

264 hich are six coordinate when only alphaKG is bound to the Fe(II)), alphaKG binding to Fe(II)-DAOCS re

265 f pore formation for the CDC intermedilysin, bound to the human immune receptor CD59 in a nanodisc mo

266 gh a process mediated by resident calmodulin bound to the intracellular C-terminal segment of the Glu

267 I) (crypt)(OTf)(2) ][OTf] with two triflates bound to the metal encapsulated in the crypt.

268 -arrestin2 stabilized by phosphorylated muOR bound to the morphine and D-Ala(2), N-MePhe(4), Gly-ol]-

269 enously purified human canonical BAF complex bound to the nucleosome, generated using cryoelectron mi

270 uring scale formation, calcium is frequently bound to the Pb(II) phosphate crystal lattice structure,

271 Then this b-e-g-f complex is bound to the preformed F(1)-c(8) module by subunits OSCP

272 itro and in vivo assays showed that TubZIP28 bound to the promoter of cytosolic AGPase and enhanced b

273 ed by the nuclear receptor NR4A1/Sp1 complex bound to the proximal germinal center (GC)-rich region o

274 riant contained seven amino acid changes and bound to the RBD 170-fold more tightly than wild-type AC

275 her report the cryoEM structure of human CMG bound to the replisome hub AND-1 (CMGA).

276 ted Schizosaccharomyces pombe Arp2/3 complex bound to the S. pombe NPF Dip1 and attached to the end o

277 uctural properties of several ACE2 orthologs bound to the SARS-CoV-2 spike protein.

278 re we report X-ray crystal structures of MEK bound to the scaffold KSR (kinase suppressor of RAS) wit

279 , we also present a structure of this domain bound to the substrate diC8-PI(3,4,5)P(3), providing the

280 1 and MdGH3-2, respectively, by specifically binding to their promoters.

281 To test for MeCP2 binding to these motifs in vivo, we analysed human neuro

282 Massive SRSF7 binding to these sites and its oligomerization promote t

283 s, which bind NC with exothermic energetics, binding to these sites occurs endothermically due to con

284 ation during reductive ER stress but did not bind to this protein during nonreductive ER stress.

285 bition of cathepsin-G, we crystallized EapH1 bound to this protease, solved the structure at 1.6 angs

286 SteD bound to TMEM127 and enabled TMEM127 to interact with an

287 Epitope mapping suggested that the antibody bound to TNFR2 through a natural cross-linking surface a

288 Because STING directly binds to TRIF, we identified the STING-interacting domai

289 Results: LW223 binding to TSPO was not susceptible to the rs6971 geneti

290 ulin); 5) is competitive with paclitaxel for binding to tubulin but not with vinblastine, crocin, or

291 s even after the removal of the compound; 3) binds to tubulin [dissociation constant (K(d)) 0.4 +/- 0

292 ces can form double duplexes by simultaneous binding to two complementary DNAs, one to the base seque

293 e structure reveals a tetrameric IN assembly bound to two molecules of the phosphatase via a conserve

294 terial ribosome silencing factor (RsfS) that binds to uL14 protein onto the large ribosomal subunit a

295 corporation, and additionally, we show that, bound to UvrC, the [4Fe4S] cofactor is susceptible to ox

296 endothelial growth factor A (VEGF-A) and its binding to VEGFRs is an important angiogenesis regulator

297 and pro-metastatic effects through directly binding to Vimentin and competitively abrogating Trim16-

298 Besides binding to well-established receptors, an extended loop

299 Several proteins that bind to Xist RNA have recently been identified, includin

300 ancement, further information on germline Ab binding to ZIKV and the maturation process that gives ri