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3 -TRAP, the intracellular folding and antigen-binding activity of a human single-chain antibody fragme
4 results suggest that EGF regulates the actin binding activity of ACTN4 by inducing tyrosyl-directed p
5 ied as selective materials for assessing the binding activity of agonist and antagonist of dopamine D
7 ylation are associated with a loss of ligand-binding activity of alpha-DG and are causal for various
8 alpha-dystroglycan glycosylation and laminin binding activity of alpha-dystroglycan in the morphants.
9 utation analyses demonstrate that the ligand-binding activity of alpha-dystroglycan is conferred prim
10 rated ROS enhanced the activation and ligand-binding activity of alphaMbeta2 integrin following N-for
11 Hippo pathway negatively regulates the actin-binding activity of Amot family members through direct p
12 help elucidate this process, we examined the binding activities of an MA mutant that stabilizes MA tr
14 we hypothesize that RNPC1 modulates the RNA-binding activity of, and cooperates with, HuR to regulat
15 demonstrate by microarray analyses distinct binding activities of antibodies and a lectin toward var
18 receptor-binding region ablated the heparin-binding activity of apoE, as determined by an in vitro h
19 ability of CRISPR-Cas12a and the competitive binding activities of aTFs for small molecules and doubl
20 s are promising leads for suppression of DNA binding activities of B-ZIP and B-HLH-ZIP transcription
25 S-/IgG immune complexes-induced ALI, the DNA binding activities of C/EBPgamma are obviously reduced.
27 for optimal DNA binding or can stimulate the binding activity of CAP variants that only transiently p
28 multidomain proteins that regulate the actin-binding activity of capping protein (CP), a major capper
29 dicate that impairment of the membrane lipid binding activity of Cb and a consequent defect in inhibi
30 10 by arsenic is associated with reduced DNA-binding activity of CCAAT/enhancer-binding protein beta
31 a point mutation (C169A) that abolishes DNA-binding activity of Cfp1 ablates the rescue activity of
32 pression of hmuO and the hrtAB genes and the binding activity of ChrA is dependent on phosphorylation
33 ity of other members of this family, the DNA-binding activity of Clp is allosterically inhibited by i
37 e at pH 7.0, for example, the phosphocholine-binding activity of CRP, which was reduced at acidic pH,
42 lis, a model Gram-positive organism, the DNA binding activity of CtsR is regulated by McsAB-mediated
44 formation about the domain structure and DNA-binding activity of D5, the poxvirus helicase-primase.
46 vivo, enzymatic (ATPase or helicase) or ATP binding activities of Dhh1 or those of any its many high
49 srupting TGFbeta signaling decreased the DNA binding activity of DNA methyltransferase DNMT1, suggest
50 tide exchange predominantly regulate the DNA binding activity of DnaA and that those with low rates o
52 mpared the previously documented microtubule binding activity of dystrophin with utrophin and analyze
54 om a variety of sources, we measured protein-binding activities of each individual compound against e
55 findings indicate that the site-specific DNA-binding activity of EBNA1 or its derivatives when expres
57 ding region for EphA2, we compared the EphA2 binding activity of EBV gH/gL and the EBV gH/gL-N(69)L/S
58 ing protein (eIF4E-BP), lowered the cap site binding activity of eIF4E and directly inhibited activit
62 Thus, it is likely that the lower ethylene binding activity of ETR1 with silver is due to fewer eth
64 -induced RPA foci formation requires the DNA-binding activity of FAAP24 but not the DNA translocase a
65 attachment had no effect on the plasminogen binding activity of FBA-tb, it competed with the natural
72 utational analysis suggest that the membrane-binding activity of Gag is a major requirement for the a
73 sion in CD4(+) T cells by regulating the DNA-binding activity of GATA-3 and limiting GATA-3 regulatio
74 ts cognate binding site can increase the DNA binding activity of GEF to Domain I, suggesting a novel
75 nt on the SMN mRNA with Gemin5, but the mRNA-binding activity of Gemin5 is dependent on SMN levels, p
78 lective pathology of CMT2D to the neomorphic binding activity of GlyRS(CMT2D) that antagonizes the VE
79 onal signaling also required the G betagamma binding activity of GRK2 but did not involve the GRK2 N-
80 mechanism that allosterically regulates DNA-binding activity of GT2-LIKE 1 (GTL1), a transrepressor
82 ticular mutants, we found that the porphyrin binding activity of GUN4 and Mg-chelatase contribute to
84 red to as Hand2(EDE)) that abolished the DNA-binding activity of Hand2, leaving the remainder of the
87 gest that Aurora-A modulates the microtubule binding activity of Hice1 in a spatiotemporal manner for
89 deprivation significantly suppressed the DNA-binding activities of HNF-4alpha and PPAR-alpha, and red
102 effects appear to depend on the G-quadruplex binding activity of HXDV as its non-G-quadruplex binding
104 e PAR polymer binding site abolishes the PAR binding activity of Iduna and attenuates its protective
105 evidence that the cell cycle arrest and DNA binding activities of IE2 appear to be responsible for t
108 ty, and invasion are regulated by the ligand-binding activity of integrin receptors, transmembrane pr
111 uppression activated iron-responsive element-binding activity of iron regulatory protein 1, increased
112 ed, the iron-responsive element-binding (IRE-binding) activity of iron regulatory protein 1 (IRP1) wa
114 cellular glucose deprivation reduces the RNA-binding activity of IRP2 but not IRP2-C512S or IRP2-C516
115 that Y4/31E significantly reduced the actin binding activity of K255E, T259I and S262P, dramatically
118 n (DNAm) profiles, we infer the landscape of binding activity of lung-specific transcription factors
120 ctivated HSCs have higher nuclear levels and binding activity of MafG to the antioxidant response ele
122 d the low-resolution molecular structure and binding activity of Merlin and a Merlin(S518D) mutant th
124 H melting profiles showed 24-35% of enhanced binding activity of methylxanthines during helix-coil tr
126 Mutagenesis experiments show that the RNA binding activity of Mov10 is required for HCV inhibition
127 scuss the possible implications of the lipid-binding activity of MpPR-1 family members with regard to
128 y, we discover a significant increase in RNA binding activity of MSI2 in leukemic stem cells compared
131 -type specific up/down-modulation of the DNA-binding activities of NF-kappaB, AP-1, and multiple othe
132 ylation, of p38 MAPK phosphorylation, of DNA binding activity of NF-kappaB and ATP content of Kupffer
133 hermore, IL-1alpha depletion reduced the DNA binding activity of NF-kappaB and C/EBPbeta, which stimu
135 f p65 with corresponding increase in the DNA-binding activity of NF-kappaB as detected by electrophor
137 apoptotic cell death and suppressed the DNA binding activity of NF-kappaB in a concentration depende
138 y silencing SOD and catalase reduced the DNA binding activity of NF-kappaB in the transformed cells.
141 p-Akt, VEGF, Ang-1, Bcl-2, survivin and DNA binding activity of NF-kappaB were observed in the Grx-1
143 overexpression led to an increase in the DNA-binding activity of NF-kappaB, which, in turn, led to in
146 ephrine stimulated the Ca(2+) -dependent DNA-binding activities of NFAT2, NFAT4, and Sp1 (but not Sp3
152 nd its binding with Keap1, but decreased DNA-binding activity of Nrf2 and also its binding at the pro
153 Nrf2 protein stability, compromised the DNA-binding activity of Nrf2 in a promoter-specific manner.
154 the function of both the VEGF and Semaphorin binding activities of NRP-1 has important roles in the d
155 Despite its lack of enzymatic activity, DNA-binding activity of NrtR is antagonized by the effector
156 the NS1 protein, and establish why the dsRNA-binding activity of NS1 is required for its binding to D
158 rostate cancer cells, and suppressed the DNA-binding activity of nuclear factor-kappaB (NF-kappaB) tr
159 combination gene therapy stimulated the DNA binding activity of nuclear factor-kappaB in the diabeti
163 zation) as well as scaffolding (through FACT binding) activities of OTUD5 are involved in the FACT-de
167 ParB/parS partition complex requires the DNA-binding activity of ParA, which transiently tethers the
168 Z2 nor PDZ3 nor the canonical target peptide binding activity of PDZ4 were necessary for hepatic SR-B
174 e conclude that promiscuous and specific RNA-binding activities of PRC2 in vitro are not mutually exc
177 ecognition of apoptotic T cells, whereas the binding activity of properdin in the serum appeared to b
178 ed formation is tightly regulated by the DNA binding activity of protagonist basic leucine zipper 53
180 binding assay was performed to determine the binding activity of purified allergens and allergen extr
182 estigate the functional relevance of histone-binding activity of Pygo2 in malignant progression of br
183 ancy, using compounds that stimulate the DNA-binding activity of RAD51 to promote cancer cell death.
188 ore, arginine methylation fine-tunes the RNA-binding activity of REF such that the RNA-protein intera
189 egulate the phosphorylation level or the DNA-binding activity of response regulators such as Spo0F, i
193 xpressed had the general single-stranded DNA binding activity of RPA complexes, unlike the telomere-s
194 hat inhibits the in vitro and cellular ssDNA-binding activity of RPA, prevents cell cycle progression
195 inhibition of NF-kappaB signaling or the DNA-binding activity of RPA1 abrogates the pro-survival feat
197 on of RPT6 with XopJ is dependent on the ATP-binding activity of RPT6, but proteolytic cleavage addit
200 readouts allowed us to characterize the DNA-binding activity of SaCas9 and to optimize its sgRNA sca
201 uted across the adjacent introns and the RNA binding activity of Sam68 are necessary to repress the S
203 r factor 1, which is able to enhance the DNA binding activity of several transcription factors throug
204 APE1's redox activity stimulates the DNA-binding activity of several transcription factors, inclu
205 we have developed assays to measure the DNA binding activity of Shelterin complexes in human cell ex
209 neutralize the Fcgamma and the V(H)3(+) Fab binding activities of SpA and provide protection from st
212 s in kratom, we compared the opioid receptor binding activity of speciofoline, mitragynine, and 7-hyd
215 concentrations of SsoRal3 increase the ssDNA binding activity of SsoRadA approximately 9-fold and als
216 nds directly to the DBD and inhibits the DNA-binding activity of STAT3 both in vitro and in situ but
218 cells indicated that the promiscuous antigen-binding activity of subset #8 mAbs could lead to signifi
221 nd neurofilaments, and decreased microtubule-binding activity of tau in the brains of streptozotocin-
223 sion of Leish4E-IP2 also display reduced cap-binding activities of tested LeishIF4Es, and decreased g
224 chanism by which the 5mC hydroxylase and DNA binding activities of Tet3 cooperate to control target g
225 g pERK expression also declined the promoter binding activity of TFII-I to the GRP78 promoter and in
231 eting of the complex relies on the chromatin binding activities of the MRG15 (MRG stands for mortalit
233 ted form of B. subtilis GS regulates the DNA-binding activities of the TnrA and GlnR nitrogen transcr
235 njugation methods retained most of the EphB4 binding activity of the antibodies (83.85% +/- 3.82%, 76
240 This is likely mediated by a novel lipid binding activity of the first BRCA1 C terminus domain of
241 ng the telomeric single-stranded DNA (ssDNA)-binding activity of the human telomeric protein POT1 ind
246 hysically interact with and modulate the DNA-binding activity of the major mitochondrial nucleoid, DN
248 initiation, it can be expected that the DNA binding activity of the mitochondrial transcription fact
249 at the binding of NSm affects the nucleotide binding activity of the NB-ARC-LRR in vitro, while Sw-5b
250 It is generally accepted that global DNA binding activity of the NF-kappaB avian reticuloendothel
251 y complementary roles in determining the DNA-binding activity of the NF-kappaB proteins encoded by th
252 fied that at least some component of the LPS binding activity of the PACs is via the lipid A moiety.
255 e enriched at hotspots determined by the DNA binding activity of the rapidly evolving zinc finger arr
257 high levels in mammalian cells, retained the binding activity of the respective parental Fv domains a
260 urthermore, the data establish that the zinc-binding activity of the S100A12 protein represses the ac
262 imparted by Tbf1 can be overcome by the DNA-binding activity of the single-stranded DNA-binding prot
265 A) for characterization of the integrity and binding activity of the three mAbs in the drug product.
267 We examined the expression, structure, and binding activity of the two major S. aureus fibronectin-
271 recognition by Itk highlights a nonclassical binding activity of the well-studied SH2 domain providin
273 fic B-cell populations and the sequences and binding activities of their antibodies before and during
274 ral basis of the alterations in the receptor binding activities of these mutants is also discussed.
277 el to further examine the porin and integrin-binding activities of this OMP as they relate to B. burg
279 osphorylation of PRH by CK2 inhibits the DNA binding activity of this protein and dephosphorylation r
281 y disrupting the double-stranded RNA (dsRNA)-binding activity of TLR3 ablated the chemokine/cytokine
284 pes of structures, we evaluated the in vitro binding activities of two well-characterized DNA repair
285 s biochemical analysis revealed that the DNA-binding activity of UAF1 is indispensable for enhanced R
286 In support of the observed host membrane binding activity of VapA, we also found that rVapA(32-18
289 his study, we sought to characterize the RNA binding activity of VP6 and its functional relevance.
291 ere we describe the conformations and ligand binding activities of water-soluble and membrane-bound B
295 performed to examine the transactivation and binding activities of WT, mutant, and chimeric AIREs on
297 These data suggest that the intrinsic DNA-binding activities of XRCC4 and XLF may be subject to re