ライフサイエンスコーパス: binding site

1 hen using a mutant circSamd4 lacking the PUR binding site.

2 translation can be initiated at the ribosome binding site.

3 ites, and within or close to the HA receptor binding site.

4 modeling studies suggested an extracellular binding site.

5 ed to delete critical amino acids in the ATP-binding site.

6 n the DNA-binding domain, distal to the zinc-binding site.

7 osteric, acting at a previously unidentified binding site.

8 at a site that is distinct from the receptor-binding site.

9 beta sheet core, thereby dismantling the GDP binding site.

10 residues and immediately precedes the WIPI2b binding site.

11 conserved water molecules in the bromodomain binding site.

12 ndicating that they each are part of the SLA-binding site.

13 the angiotensin I converting enzyme 2 (ACE2)-binding site.

14 a large rigid body movement of the substrate-binding site.

15 of the opposite functional antibiotic moiety binding site.

16 uction of dynamics that are localized to the binding site.

17 ures required for optimal interaction at the binding site.

18 tion at the unorthodox alpha-alpha nicotinic binding site.

19 covering the potential conformations of the binding site.

20 revealed that DPO and Ala-AA occupy the same binding site.

21 n happens at a position far from the antigen binding site.

22 that this region likely contains the glycan binding site.

23 blocking a catalytically critical ubiquitin binding site.

24 c genomic locations that correspond to PRDM9-binding sites.

25 on of the protein depending on the preferred binding sites.

26 uenced by both the number and arrangement of binding sites.

27 e mutations overlapping transcription factor binding sites.

28 been proposed to be mediated by their lysine-binding sites.

29 ched for alterations in transcription factor binding sites.

30 h multivalent scaffolds with fixed number of binding sites.

31 olecules searching for reaction partners and binding sites.

32 ibutes to the positioning of cohesin at CTCF binding sites.

33 rification, and possess deeply buried ligand-binding sites.

34 the transposon end and the generation of DNA-binding sites.

35 , we are able to accurately predict HOXA2 co-binding sites.

36 interact with LC8, many contain multiple LC8-binding sites.

37 occupancy of the transmembrane domain lipid binding sites.

38 ression of ATM from a clone lacking miR-181c binding sites.

39 se determination of biologically significant binding sites.

40 r recognition and the flexibility of protein-binding sites.

41 hrough octarepeat and nonoctarepeat (non-OR) binding sites.

42 well as loss of RUNX1 binding at RUNX1/CTCF-binding sites.

43 rminal region comprising ARL8- and kinesin-1-binding sites.

44 oxicity include its Spc42-, Spc29-, and Cmd1-binding sites.

45 res sites containing both Tn3 and Bart dimer binding sites.

46 are enhanced in nucleosomes with multiple TF binding sites.

47 calculations identified two potential ligand-binding sites.

48 hange among myriads of intermediate affinity binding sites.

49 regulatory regions and transcription factor binding sites.

50 tructurally, beta-secretase has a very large binding site (1000 angstrom) with fewer hydrophobic doma

51 Furthermore, an additional oligosaccharide-binding site 20 angstrom away from the catalytic pocket

52 ) along with transcription factors that have binding sites 5' of SLC26A9.

53 signaling, while mutagenesis of the calcium-binding site abolishes Gpr126 function in vivo.

54 e transfer required talin's C-terminal actin binding site, ABS3, but not vinculin.

55 d a synthetic Mn-porphyrin but also maintain binding site access to form high-valent oxidation states

56 Expression and binding site accessibility change for many other TFs, in

57 e MITF as a model, we show that low-affinity binding sites act as a competitive reservoir in vivo fro

58 We observed that multiple NC binding sites affected RNA packaging; of the sites teste

59 ent surface, which uncovers or blocks myosin binding sites along F-actin.

60 avenue to investigate the selectivity of the binding sites along the pore of potassium channels.

61 stent with general beta-trefoil carbohydrate-binding sites (alpha, beta), and also a unique PMT2-subf

62 zation that depend on direct competition for binding sites among protective RNA-binding proteins and

63 injury) and their effects on the ubiquinone-binding site and a connected cavity in ND1.

64 ginating in the peripheral C-terminal ligand binding site and culminating in pore opening.

65 citrate of crystallization at the nucleotide binding site and exhibits structural features common to

66 tom linker only interacts with the substrate-binding site and functions as a substrate.

67 receptor-induced exposure of the co-receptor binding site and fusion elements.

68 ormational flexibility, together with ligand-binding site and interaction mechanisms.

69 WEW, which encodes a coiled-coil, nucleotide-binding site and leucine-rich repeat protein (CNL).

70 al structures have revealed a specific Na(+) binding site and molecular dynamics (MD) simulation stud

71 ility: it modulates exposure of its receptor-binding site and subsequently undergoes complete structu

72 antiferromagnetic coupling between the metal binding site and terminal oxo ligand during the C-H acti

73 ecause an ancient linkage between the oxygen binding site and the multimerization interface was alrea

74 ctive GABA(A)R modulators acting via the BZD binding site and their potential clinical indications.

75 hosphorylation, contains the secondary eIF4E-binding site and three other phospho-sites, whose mechan

76 GSDMB colocalized with IFN regulatory factor binding sites and associated with GSDMB expression, asth

77 or performed to obtain their binding energy, binding sites and correlation with sweetness index.

78 chies, osmolytes, coupling between different binding sites and coupling between ligand binding and co

79 target genes based on their proximity to ANT binding sites and differential expression in response to

80 ture.ORG for further investigation of glycan-binding sites and glycan structures.

81 p of pairwise interactions between 171 miRNA-binding sites and identified synergistic and redundant e

82 , including closure of neurodevelopmental TF binding sites and increased expression and binding capac

83 ctural features, such as RNA-binding-protein binding sites and reactivity differences at single-nucle

84 nged epitope residues confirmed the antibody-binding sites and revealed strongly reduced IgE reactivi

85 ermining features in proteins with conserved binding sites and to translate this knowledge into the d

86 peak calling correspond to annotated protein-binding sites and/or have stable predicted secondary str

87 g of transcriptional HbF repressors or their binding sites and/or regulating epigenetic intermediates

88 KIIalpha promoter and microRNA-128 (miR-128) binding sites, and labeled CaMKIIalpha(+) cells with nat

89 dominantly located at five reported antibody-binding sites, and within or close to the HA receptor bi

90 We found that indels within the Morpholino binding site are indeed able to suppress both zygotic an

91 lycomb repressive complex occupancy and CTCF binding sites are associated with cancer-specific gene d

92 These composite binding sites are built into existing scaffold proteins

93 l, this work demonstrates that non-coding AR binding sites are frequently mutated in prostate cancer

94 The binding sites are identified as Cys13, Cys15, Cys19, Cys

95 AR surfaces are sequestered and the PX lipid-binding sites are occluded.

96 nalysis of the data allowed pinpointing CodY-binding sites at close to single-nucleotide resolution.

97 ally identify ZMAT3-regulated RNAs and their binding sites at nucleotide resolution in intact colorec

98 s of their conservation across species, CTCF binding sites at TAD boundaries are subject to stronger

99 RT forms a symmetric dimer with two (p)ppGpp binding sites at the dimer interface.

100 signal analyses reveal co-localization of TF binding sites based on inferred cis-regulatory modules (

101 tting from the pH-responsiveness of WP5, the binding site between G and WP5 changes in an acidic envi

102 smembrane domains 1 and 2 and the allosteric binding site between transmembrane domains 2 and 3.

103 The structure reveals a composite binding site bridging over three domains of one capsid p

104 d or in chromosomal DNA, containing the same binding site but with a different reporter.

105 that occur upon occupation of the substrate-binding site by an active site-directed inhibitor.

106 eractions by disrupting each predicted miRNA-binding site by CRISPR-Cas9 genome editing in C. elegans

107 nal repression of Wapl through a single Pax5-binding site by recruiting the polycomb repressive compl

108 esistant mutant despite some crowding in the binding site by the glutamates.

109 ds on a conserved cysteine in its nucleotide binding site (C20).

110 argets that contain preferred small molecule binding sites can be identified from sequence, allowing

111 nded to more realistic buffers with multiple binding sites characterized by cooperative Ca(2+) bindin

112 hat suggest that PLB interacts with multiple binding sites, conferring dynamic responsiveness to chan

113 s expressed Na(v) channels with modified TTX binding sites, conferring extreme physiological resistan

114 ity determining regions (CDRs) that increase binding site conformational diversity.

115 tyrosine to phenylalanine substitution at a binding site could be detected.

116 the following: (i) large scale differential binding sites (DBS) were available for only H3K4me3 in t

117 and efficacy at three discrete neurosteroid-binding sites determine whether a neurosteroid has poten

118 ally, the motif stringency of XBP1s promoter binding sites dictates XBP1s's ability to drive 12-h rhy

119 Mutating both half GR binding sites did not significantly reduce GR- and KLF4-

120 association with its Cebpa promoter-proximal binding site during adipogenesis.

121 sites were lost, whereas new pS22-Lamin A/C-binding sites emerged in normally quiescent loci.

122 tein and beta-arrestin2 compete for the same binding site even though their recruitment leads to much

123 icularly to the NBDs and its putative ligand-binding sites face the transporter to likely modulate AT

124 ecause DapF (Ct) utilizes a shared substrate-binding site for both racemase and epimerase activities,

125 on strategy, we determined the preferred DNA-binding site for CDA-KLF1.

126 inus of the peptide chain, distinct from the binding site for Lipid II.

127 To date, a binding site for P on L had not been described.

128 ction of channels presenting a high-affinity binding site for PF-05089771 and suggesting that combina

129 Here, we functionally characterize a binding site for the 3' vRNA and cRNA promoters.

130 omes, removing the glycan cap and exposing a binding site for the Niemann-Pick C1 (NPC1) receptor.

131 The other cluster is adjacent to the binding site for two COPII components, SEC31 homolog A C

132 reds of thousands of energetically favorable binding sites for a target ligand.

133 recipitation-tiling array experiments to map binding sites for ABI3 globally.

134 Modeling studies unveil the specific binding sites for acetylene capture as well as the inter

135 during infection without the need to evolve binding sites for antisilencing proteins at each foreign

136 his assay allows distinction of two separate binding sites for BODIPY-cyclopamine on the SMO transmem

137 d TRPM8 structures have uncovered unforeseen binding sites for both cooling agonists and membrane lip

138 5 can form oligomers that possess additional binding sites for C3b in FHR5.

139 omplexes and a competitive loss of available binding sites for glyphosate-functionalized poly(ethylen

140 as simultaneously, suggesting two different binding sites for H2A/H2B and H3/H4.

141 hromatin accessibility at PPARgamma and EBF2 binding sites for key thermogenic genes.

142 roscopy (cryo-EM) structures reveal that the binding sites for PF 06882961 and GLP-1 substantially ov

143 n autoantibodies endowed with stereospecific binding sites for phospholipids.

144 mes and shape genome regulation by harboring binding sites for regulatory factors.

145 ciating domain (TAD), rich in enhancers with binding sites for retinal transcription factors.

146 ition model was used to determine overlap of binding sites for several inhibitory and potentiating st

147 dered non-druggable because they do not have binding sites for small drug-like ligands.

148 reporter assay (MPRA) libraries composed of binding sites for SOX2, POU5F1 (OCT4), KLF4, and ESRRB.

149 We identify binding sites for substrate K(+) and Cl(-) ions, demonst

150 ment of single nucleotide variants in active binding sites for TEAD4 (P = 6 x 10-11) and its binding

151 ty in the particles and a total of 13 unique binding sites for the LHCIs around the PSI core.

152 DNA binding sites for the transcription factors are closely

153 ronment-specific eQTLs reveals enrichment of binding sites for two transcription factors.

154 matic mutations have different effects on TF binding sites from different TF families on a cancer-typ

155 Identifying local similarities in binding sites from distant proteins is a major hurdle to

156 low concentrations of each Q-SNARE, showing binding site functionality.

157 First, we fine-mapped its GCN5 binding sites genome-wide and then used several global m

158 To characterize RNA-capsid binding sites genome-wide within mature RNA virus partic

159 ting scaffold proteins matching the intended binding site geometry with high accuracy.

160 sed Residue neighborhood Strategy to Predict binding sites (GRaSP), a novel residue centric and scala

161 Two series of ligands targeting the lysine binding sites have been recently described, which are mo

162 hanism of the Ealpha and its downstream CTCF binding site (here named EACBE) in dynamic chromatin reg

163 human and preclinical species within the ATP binding site highlights a single amino acid (I960 -> V)

164 A second orthogonal DNA binding site identified in the mEndoG structure accommod

165 ed occupancy of binding sites, regardless of binding site identity and positioning.

166 of both the allosteric ligands and receptor binding sites important for these allosteric activities.

167 sion encoding a Nab1 translational repressor binding site in a CAO knockout line it was possible to c

168 is, suggesting a potential role for this BH3-binding site in BAK activation.

169 ar switch involving a highly conserved anion binding site in CK1.

170 A/6B via a region homologous to the receptor-binding site in Clostridioides difficile toxin B (TcdB),

171 We validated the miR-744 binding site in the 3' untranslated region (UTR) of PELI

172 overlapped spatially, revealing a conserved binding site in the central cavity of the viral polymera

173 We further identified an AR binding site in the promoter/enhancer region of BMI1, an

174 CH-3-8 binding to the colchicine-binding site in tubulin protein was confirmed by tubulin

175 To this end, we identified an NF-kB-binding site in USP7, ubiquitin-like domain 2, that sele

176 d PMO-based SBOs complementary to the let-7c binding site in UTRN 3'UTR, with the goal of inhibiting

177 ng enabled the identification of a potential binding site in VISTA for NSC622608.

178 Nonetheless, mutating the morpholino binding sites in both maternal and zygotic genes can asc

179 PSF30-hFip1 complex in vitro, and both hFip1 binding sites in CPSF30 can support polyadenylation.

180 ed a ChIP-Seq experiment that identified ANT binding sites in developing flowers.

181 -CL can readily and reliably identify capsid binding sites in genomic viral RNA by detecting crosslin

182 explains the requirement for convergent CTCF binding sites in loop formation.

183 d small oligomers by virtue of the number of binding sites in one polymer being an integer multiple o

184 e searches resulted in only 13 similar metal binding sites in other proteins, indicative of the raren

185 We also discover ectopic HIF binding sites in repeat regions which are normally methy

186 step, we sought to identify potential 14-3-3-binding sites in the APN sequence.

187 that overexpressed RUNX1 could bind putative binding sites in the HSV-1 genome, repress numerous vira

188 olocalization with the PIF proteins at their binding sites in the promoters of PIF Direct Target Gene

189 tions of amino acid side chains altering RNA binding sites in the RRM.

190 urthermore, there are functionally redundant binding sites in viral RNA.

191 imary probe the DNA-binding species with the binding site inactivated and eGFP as a calibration stand

192 at multiple medications compete for the same binding sites, indicating possibilities for undesirable

193 ering such a selective multivalent metal ion binding site into target macromolecules for structural a

194 exhibit functional binding when the ZIC DNA binding site is embedded in a multiple transcription fac

195 eful structural analysis beyond the antibody binding site is required to develop a more efficacious a

196 l change on the other face (second potential binding site), leading to a negative allosteric effect.

197 Using TR ChIP-seq peaks or imputed TR binding sites, Lisa probes the chromatin models using in

198 ecycline binds at the canonical tetracycline binding site located in the decoding center of the small

199 1-to-2 stoichiometry with two distinct FtsX-binding sites located within an antiparallel coiled coil

200 cing antibody-like molecules with an antigen binding site made up of 2 kappa variable domains.

201 V-1-infected humanized mice but elicited CD4-binding site mutations that reduced viral fitness.

202 small-molecule "anchor" groups to a specific binding site of a target biopolymer.

203 n binding site of lidocaine and the external binding site of aryl sulfonamides may have synergistic a

204 The Rab33B binding site of Atg16L1 comprises 20 residues and immedi

205 nd is only partially dependent on the glycan-binding site of CRT, which is generally relevant to subs

206 Taken together, our data indicate that the binding site of EphA2 on EBV gH/gL is at least in part p

207 onance (NMR)-based studies revealed that the binding site of FHL1 in CHIKV nsP3 HVD overlaps that of

208 use intact proteins to show that the lysine-binding site of K2(hPg) is a major determinant of the ac

209 In the proposed model, the N-terminal actin-binding site of leiomodin can act as a "swinging gate" a

210 ations of agents targeted to the pore-region binding site of lidocaine and the external binding site

211 ng the receptor inactive state, the putative binding site of Mg(2+) on the MOP receptor, as well as t

212 ctivity when targeting the peptide substrate binding site of NTMT1/2.

213 osteroid pregnenolone sulfate (PES), but the binding site of PES on the NMDAR and the molecular mecha

214 he single canonical conserved 3' UTR miR-290-binding site of Pfn2 or overexpression of the Pfn2 open

215 kets within the adenosine triphosphate (ATP) binding site of PI3Kgamma.

216 s bound with high affinity with the effector-binding site of Ras in an active conformation.

217 its analogues bind to the central substrate-binding site of SERT, stabilize the outward-open conform

218 We show that the binding site of SrmB is unperturbed by SrmB deletion, bu

219 ogical approaches, we have characterized the binding site of the cellular FHL1 protein in CHIKV HVD a

220 dicts that indole docks perfectly to the ATP binding site of the GyrB subunit.

221 the positions were located near the receptor binding site of the HA protein, as they are in the HA pr

222 ant in which aspartate residues in the metal-binding site of the polymerase domain were replaced by a

223 a challenge to identify the specific targets/binding sites of BACE1.

224 ractions between C(2) H(2) molecules and the binding sites of FeNi-M'MOF.

225 In this study, we have explored binding sites of host proteins, which are specific partn

226 logue to occupy both substrate- and cofactor-binding sites of NTMT1, but the bisubstrate analogue wit

227 sion and splicing QTLs and are enriched with binding sites of RNA-binding proteins, RNA structure-cha

228 We show that budding yeast Ty3/Gypsy co-opts binding sites of the essential meiotic transcription fac

229 at interact in a one-to-one fashion with the binding sites of the other polymer.

230 r being an integer multiple of the number of binding sites of the other.

231 We compared binding sites of TRAMP components with multiple nuclear

232 ability analysis, we evaluated the potential binding sites of TTP to 3'-untranslated regions (3'-UTR)

233 he efficiency of the method by mapping metal-binding sites of Zn(7-x)MT species using a bottom-up MS

234 t binding peptide was solved by NMR, and its binding site on Cdc42 was determined.

235 llar C-ring protein FliM have an overlapping binding site on FlhG, their binding depends on the ATP-d

236 promising the ability to predict the retinol binding site on RBP4 when adopting this proteolysis with

237 ese studies reveal a previously unknown zinc-binding site on the surface of the ADAR1 deaminase domai

238 tated and translated over potential "target" binding sites on F-actin where the corresponding interac

239 We also identified crucial antibody binding sites on factor B, including one correlated to d

240 eletion likely creates more available TDP-43 binding sites on Malat1 and subsequent TDP-43 aggregatio

241 u(2+) We also demonstrate that multiple zinc-binding sites on tau are involved in the LLPS-promoting

242 usion of the excess of twist through the two binding sites on the DNA molecule and, simultaneously, p

243 uggest that PhMAX2A and PhD53A have distinct binding sites on the SL receptor and that its flexibilit

244 hell and the structure defines two metal ion binding sites, one in each domain.

245 hylated context, either deletion of the CTCF binding site or depletion of RAD21 cohesin complex prote

246 Disruption of the NAD(+)-binding site or the ARM-TIR interaction caused constitut

247 ed in this way often contain multiple ligand binding sites or modification sites, which can operate t

248 ds typically rely on existing small molecule binding sites or protein scaffolds with existing shape c

249 l key structural information, e.g., lectin's binding site orientation, binding mode, and interbinding

250 This analysis revealed that SA1 and SA2 binding sites overlap significantly with R-loops.

251 The amicetin binding site overlaps significantly with that of the wel

252 bound MHB can be correlated to the change of binding site polarity and that a tyrosine to phenylalani

253 tarting protein structures on the results of binding-site prediction, so the dataset contains a minim

254 hing the cytoplasm, the peptide occupies its binding site prior to the transition from initiation to

255 ' mechanism in which enhancers with specific binding sites promote rapid Cdk8-dependent Notch turnove

256 mon dependence on gating state with distinct binding sites raises the possibility that inhibition by

257 viruses, most substitutions in the receptor binding site (RBS) resulted in viable virus, but virus r

258 the specific amino acids around the receptor binding site (RBS) that were important in elicitation of

259 best explained by the predicted occupancy of binding sites, regardless of binding site identity and p

260 t for smaller oligonucleotides the number of binding sites remained unchanged with pressure rise whil

261 entric and scalable method to predict ligand-binding site residues.

262 ntified and characterized a canonical 14-3-3-binding site (site 1) within the flexible, structurally

263 eatures the prealigned binding partners with binding sites still partially surrounded by solvation sh

264 tential strain-specific transcription factor binding sites (TFBS).

265 al cis-eQTL SNVs are more likely to alter TF binding sites than rare SNVs in the human population.

266 Hrd3 and Yos9 jointly create a luminal binding site that recognizes glycosylated substrates.

267 The protein has two binding sites that compete for the cA4 ligand, a canonic

268 mer species, where each consists of repeated binding sites that interact in a one-to-one fashion with

269 chrome reductases also possess atypical heme-binding sites, the NrfA nitrite reductase (CXXCK) and th

270 ust exert rather strong constraints on their binding sites; they must block the diffusion of the exce

271 tides ('msR4Ms') designed to mimic the CXCR4-binding site to MIF, selectively bind MIF with nanomolar

272 find that proton transport from the central binding site to the lumen has a microsecond timescale, r

273 ydrogen-bond networks connecting the quinone-binding site to the transmembrane subunits are found to

274 mation integrated from many widely separated binding sites to determine how a gene is transcribed?

275 contribution of the individual modification/binding sites to the activation process, and how their i

276 NMR titrations mapped 3-O-S binding sites to the microtubule binding repeat 2 (R2) a

277 rvations explain how the orientation of CTCF binding sites translates into genome folding patterns.

278 ression of mgrA and identify a probable ArlR-binding site (TTTTCTCAT-N(4) -TTTTAATAA).

279 also discover a distant (25 angstrom) ligand-binding site unique to SARS-CoV-2, which can alternative

280 Vinculin binding sites (VBSs) from different nonhomologous actin-

281 ivergent cluster adjacent to the SEC31/SEC23-binding site was critical for this SAR1B function.

282 y of in silico methods to detect and predict binding sites was proposed as they can be scalable, fast

283 As there are no cysteines near the eIF4E cap binding site, we developed a covalent docking approach f

284 Moreover, resistance mutations within each binding site were overcome by the inhibition of the oppo

285 scription factors (TF) were identified whose binding sites were enriched or depleted in mutations.

286 ient fibroblasts, a subset of pS22-Lamin A/C-binding sites were lost, whereas new pS22-Lamin A/C-bind

287 Approximately 93% of the BSA binding sites were occupied in the BSA-CYG complex throu

288 indicates that this enzyme has a single SAM binding site, which at this stage is occupied by cystein

289 tructures and identify two conserved mannose-binding sites, which are consistent with general beta-tr

290 ibody because it, like the antibody, has two binding sites, which both selectively bind with GCSF lig

291 are predicted to have reduced numbers of ATP-binding sites, which potentially alters receptor functio

292 activity is reduced at transcription factor binding sites, while methylation turnover is elevated in

293 was consistent with the presence of a single binding site with a binding free energy of -24 kJ/mol.

294 We also identified two distal quinone-binding sites with bound quinones.

295 l molecules and constitutes a rich subset of binding sites with immense potential diagnostic and ther

296 The binding site within the beginning of the coding sequence

297 covered an evolutionarily conserved let-7-5p-binding site within the chicken Chd7 gene and its human

298 8 forms a dimeric structure with four Zn(2+) binding sites within each subunit: a highly conserved pr

299 on-coding RNA gene Gm15441 through PPARalpha binding sites within its promoter.

300 n that they independently probe specific ion binding sites within the selectivity filter.