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1 neral colloids, suggesting that the V is not bioavailable.
2 ed in the eastern equatorial Pacific(30)) is bioavailable.
3 ACE inhibitory peptides that are potentially bioavailable.
4 The Caco-2 cell assay indicated that Fe is bioavailable.
5 potency, microsomal stability, and is orally bioavailable.
6 s and that only a fraction of the protein is bioavailable.
8 and safely improves 25-hydroxyvitamin D and bioavailable 25-hydroxyvitamin D levels in patients with
11 ting microbial Fe(III) reduction than highly bioavailable acetate/lactate, it ultimately has the pote
15 the conversion of atmospheric dinitrogen to bioavailable ammonia, is most commonly assayed by the re
17 approach for the development of both orally bioavailable and bioactive cyclic N-methylated hexapepti
19 imidin-5(6H)-one was identified as an orally bioavailable and brain penetrating PDE1B enzyme inhibito
21 emonstrate that these antagonists are orally bioavailable and cause pronounced beta1-mediated reducti
22 imization effort identified the first orally bioavailable and CNS penetrant glucagon-like peptide-1 r
23 in, we report the discovery of a new, orally bioavailable and CNS-penetrant metabotropic glutamate re
24 al nature allows BrC to be water-soluble and bioavailable and demonstrate light absorption at multipl
26 lusion, yerba mate polyphenols are partially bioavailable and extensively metabolized, mainly by the
27 pound 8; the compound was found to be orally bioavailable and highly effective, leading to a reductio
28 Kgp with KYT-36, a peptide-derived, potent, bioavailable and highly selective inhibitor, which is wi
29 utochthonous and allochthonous DOM is highly bioavailable and is transformed by resident microbial co
30 al ingredient and, in biscuits, it is highly bioavailable and lowers postprandial oxidised-LDL levels
31 orbed fraction and two internal fractions: a bioavailable and non-bioavailable internal fraction.
37 ents, most of the additional SOC was readily bioavailable and we observed no increase in mineral-asso
38 ester prodrug of ETX1317, ETX0282, is orally bioavailable and, in combination with cefpodoxime proxet
39 evelop a series of potent, selective, orally bioavailable, and brain-penetrant ALK2 inhibitors based
40 6827443), is a potent, low-clearance, orally bioavailable, and CNS-penetrant M1-selective PAM with mi
42 rated (selectivity index > 7,111) and orally bioavailable, and provided complete protection against l
43 rtant step in our efforts to develop stable, bioavailable, and selective inhibitors for the PADs.
44 n leading to GDC-0339 (16), a potent, orally bioavailable, and well tolerated pan-Pim kinase inhibito
45 e used a novel, potent, and selective orally bioavailable antagonist, LY2940094, to test the hypothes
46 in the development of two potent and orally bioavailable anti-fibrotic agents that were capable of d
47 a), a novel, selective, nonclassical, orally bioavailable antifolate with potent and specific inhibit
48 de that (1) pepstatin is a potent but poorly bioavailable antimalarial; (2) PfPARE is a functional es
51 ve synthetic lethality of the combination of bioavailable ATR and Wee1 inhibitors led to tumor remiss
55 omethylating compound, is not readily orally bioavailable because of rapid clearance by cytidine deam
57 pounds to identify FT-2102, a potent, orally bioavailable, brain penetrant, and selective mIDH1 inhib
60 pharmaceutical production to favor the more bioavailable but metastable Form I with limits of detect
62 have recently reported two classes of orally bioavailable C-glycosidic inhibitors of the Pseudomonas
65 onary phase, corresponding to the shift from bioavailable carbon to oligomeric lignin as a carbon sou
66 overy of these potent, selective, and orally bioavailable CCR4 antagonists, and their activity in in
68 study investigated contamination patterns of bioavailable chemicals in sediments from various sites a
69 NE-145) were identified as selective, orally bioavailable ChK1 inhibitors offering excellent in vitro
70 from mice treated with either of two orally bioavailable class I PI3K inhibitors, pictilisib or bupa
72 n of Complex I, using IACS-010759, an orally bioavailable Complex I inhibitor in clinical trials, as
73 reveal the presence of weak (and potentially bioavailable) complexes; but such measurements (particul
76 ng (mass balance) was applied to compute the bioavailable compound concentrations in cells (C(free))
77 Herein, we report NV-5138, a novel orally bioavailable compound that binds to Sestrin2 and activat
78 I=0.92), while potentially bioaccessible and bioavailable compounds acted synergistically (CI=0.43 an
79 ow applicable underlying mechanisms are with bioavailable concentrations and biological half-life.
80 egression for determining both the total and bioavailable concentrations of complex chemical mixtures
81 andem with explorative chemical profiling of bioavailable concentrations of groups of legacy and emer
82 air, and in contrast, the predictions of the bioavailable concentrations of the PAH and PHC were only
85 sistent organic pollutants, POPs) to map the bioavailable contamination level of freshwater ecosystem
86 al regional heterogeneities in the levels of bioavailable contamination of metals (18 compounds) and
87 lts provide a comprehensive investigation of bioavailable contamination patterns of sediments and may
88 stablishment of multisubstance indicators of bioavailable contamination, which reliably quantify chem
91 -MS, suggesting that the particles are still bioavailable despite the heteroaggregation observed betw
94 proaches are being advocated to use high and bioavailable dietary iron sources to prevent iron defici
95 n of factors including low concentrations of bioavailable dissolved U species, slow U uptake rates fr
98 g rift sediments alter deep-ocean budgets of bioavailable DOM, creating organic-rich habitats for ben
99 ecylphosphocholine (HPC)] is the only orally bioavailable drug for the disease visceral leishmaniasis
103 d lead resulting in AT-IAP, a potent, orally bioavailable, dual antagonist of XIAP and cIAP1 and a st
105 his study aimed to determine and compare the bioavailable effect concentrations in zebrafish cell lin
107 ng and selection methods aimed at increasing bioavailable element content and improving crop growth.
112 productivity and carbon cycling by supplying bioavailable Fe to remote areas of the ocean via atmosph
113 he facility were enriched in Ra and had high bioavailable Fe(III) concentrations relative to upstream
117 iminary antileukemic activity of this orally bioavailable first-in-class lysine-specific demethylase
119 l than soaking to increase the production of bioavailable folates within the seed for human consumpti
120 the feeding regime, which could make MWCNTs bioavailable for organisms at higher trophic levels.
122 lammatory and thrombin-inhibitory actions, a bioavailable form of quercetin, like Quercetin Phytosome
129 es, or pet tags, quantitatively assessed the bioavailable FR exposures of 78 cats (>=7 y) in New York
130 rovided a significantly higher amount of the bioavailable fraction (BF) of Cur with better cytotoxici
131 Sediment-associated risks depend on the bioavailable fraction of organic chemicals and cannot be
132 ignature of wines is strongly related to the bioavailable fraction of the soil rather than to its bul
133 he use of Sr isotope composition in the soil bioavailable fraction, as assessed by 1mol/L NH4NO3, to
137 imals with Telaglenastat (CB-839), an orally bioavailable GLS inhibitor, successfully inhibits undiff
140 ly produced MeHg is important to identifying bioavailable Hg in natural systems and the interpretatio
147 s studied except for Fe, between the content bioavailable in the soil and the accumulated in both lea
148 and the iron in the white flour fraction was bioavailable in vitro, suggesting that food products mad
150 fied mitochondrial uncoupler BAM15 is orally bioavailable, increases nutrient oxidation, and decrease
151 aWO(4) precipitation resulted in loss of the bioavailable inhibitor from solution and a concurrent in
152 istry optimization resulted in 83, an orally bioavailable inhibitor molecule with remarkable selectiv
154 (CCT251921), a potent, selective, and orally bioavailable inhibitor of CDK8 with equipotent affinity
155 nes, CB-839, a potent, selective, and orally bioavailable inhibitor of GLS, suppressed cell prolifera
158 pment of MI-3454, a highly potent and orally bioavailable inhibitor of the menin-MLL1 interaction.
159 report, describing a highly specific, orally bioavailable inhibitor of the PTP oncoprotein SHP2 with
160 of the compound led to 26, a readily orally bioavailable inhibitor with potency in HWB comparable to
162 nd optimization of a class of potent, orally bioavailable inhibitors of glucose transporters, targeti
163 inent role of FB in the AP, selective orally bioavailable inhibitors, beyond our own efforts, have no
166 This can deliver substantial amounts of bioavailable iron and contribute to the fertilization of
167 ugh HIF-independent mechanisms that increase bioavailable iron as well as directly activate Fe-S synt
170 ing of staple crops to accumulate additional bioavailable iron in edible parts, thus improving the ir
171 animal scale data on how the manipulation of bioavailable iron influences the performance of a biolog
172 onstrate that cabbage was the best source of bioavailable iron out of the vegetables studied and sugg
174 ght to determine the beneficial effects of a bioavailable isoflavone and probiotic treatment against
177 pecific biokinetic slope factors, we related bioavailable lead from these sources to children's blood
179 Further SAR optimization yielded the orally bioavailable LOX inhibitor CCT365623 with good anti-LOX
180 methylenethiophenes (AMTs) as potent, orally bioavailable LOX/LOXL2 inhibitors, we report herein the
182 successful strategies to maintain access to bioavailable metal ions under conditions of extreme rest
186 et, although fish-which are a rich source of bioavailable micronutrients that are essential to human
187 of quinolinones to provide potent and orally bioavailable mIDH1 inhibitors with selectivity over wild
188 de proof-of-principle support for increasing bioavailable Mn in HD to restore autophagic function and
192 ntileukemic effects of merestinib, an orally bioavailable multikinase inhibitor with suppressive effe
193 mplications of these dynamics on the fate of bioavailable N in coastal environments susceptible to in
194 rees C of warming, which probably restricted bioavailable N supply and arbuscular mycorrhizal contrib
196 en human-like Neu5Gc-deficient mice were fed bioavailable Neu5Gc and challenged with anti-Neu5Gc anti
197 icient mice immunized against Neu5Gc and fed bioavailable Neu5Gc developed a much higher incidence of
198 e invention of MLN9708 (ixazomib), an orally bioavailable next-generation proteasome inhibitor with i
199 e discovery of potent, selective, and orally bioavailable NHE3 inhibitors with 13d as best compound,
200 hemeridae) was reduced in sites with greater bioavailable Ni, but accounting for Fe oxide-bound Ni gr
202 ial sodium channel activation, reductions in bioavailable nitric oxide, increased vascular remodeling
205 ction to ammonium (DNRA), determines whether bioavailable nitrogen is removed as N(2) gas or recycled
206 ies in the availability of fixed and readily bioavailable nitrogen relative to phosphate (P) in the s
207 fixation by cyanobacteria supplies critical bioavailable nitrogen to marine ecosystems worldwide; ho
209 e fashion, and although oil does not provide bioavailable nitrogen, phosphorus or iron, there are eno
210 Biological N2 fixation is a major input of bioavailable nitrogen, which represents the most frequen
212 inetics, prompting the development of orally bioavailable, nonsteroidal SERDs, currently in clinical
213 ors assessed the effects of the first orally bioavailable Npt2a inhibitor (Npt2a-I) PF-06869206 in no
214 tory mucins represent a potentially abundant bioavailable nutrient source, although we have recently
218 e sediments harbored large concentrations of bioavailable organic carbon that fueled anaerobic microb
219 ectly bioavailable P (phosphate), indirectly bioavailable P (phosphatase-hydrolyzed P) and nonbioavai
221 We show that acidification can increase bioavailable P deposition over large areas of the globe,
223 a significant, long-term source of in-stream bioavailable P that contributes to a legacy of wildfire
228 tributary inputs contained higher levels of bioavailable particulate P (NAIP) - these effects were a
229 ions in RBA results and revealed that highly bioavailable Pb (hydroxy)carbonate (indicative of Pb-bas
233 cles can dramatically increase the amount of bioavailable phosphorus (P) deposited on the surface oce
234 turn, further decreased anoxic recycling of bioavailable phosphorus to the water column, promoting t
236 were initially conducive to the drawdown of bioavailable phosphorus, they also permitted a limited d
237 ation for food crops can lead to presence of bioavailable phthalic acid esters (PAEs) in soils, which
240 scovery of two potent, selective, and orally bioavailable PI3Kdelta inhibitors, 1 (AM-8508) and 2 (AM
241 scovery of two potent, selective, and orally bioavailable PI3Kdelta inhibitors, 6a (AM-0687) and 7 (A
246 ril-resistant rhinoviruses) and OBR-5-340, a bioavailable pyrazolopyrimidine with proven in vivo acti
247 oups, led to the discovery of potent, orally bioavailable pyridine-based macrocyclic FXIa inhibitors.
250 ration, and selectively protecting otherwise bioavailable, reduced organic compounds such as lipids a
252 he identification of JNJ-53718678, an orally bioavailable RSV inhibitor that was shown to be efficaci
253 idence of so far unreported depletion of the bioavailable Se pool, a plausible driving mechanism of d
254 onitoring technique to integrate the risk of bioavailable sediment-associated chemicals in aquatic en
255 unambiguously discriminate low from high Fe bioavailable seeds in these closely related maize variet
256 ibe GDC-0810, a novel, non-steroidal, orally bioavailable selective ER downregulator (SERD), which wa
257 porting a pathophysiological role, no orally bioavailable selective TRPC6 inhibitor has yet been deve
259 ing support for the determination of free or bioavailable sex steroid concentrations in medicine, and
260 roup previously developed a series of orally bioavailable small molecule activators of PP2A, termed S
262 characterization of GDC-0994 (22), an orally bioavailable small molecule inhibitor selective for ERK
263 was realized with the approval of the orally bioavailable small molecule PI3Kdelta inhibitor idelalis
264 litus (T2DM) motivated our search for orally bioavailable small molecules that can activate the GLP-1
268 igated by examining the effects of an orally bioavailable, small molecule p75NTR ligand, LM11A-31, on
275 Here, we describe a water-soluble, orally bioavailable synthetic sphingolipid, SH-BC-893, that tri
276 companion animals and further indicates that bioavailable TDCIPP exposures are associated with feline
278 obalamin is several orders of magnitude less bioavailable than cobalamin to several B12-dependent mic
279 metal sulfide phases were considerably less bioavailable than metal contaminants introduced to sedim
283 and can provide useful predictions of metal bioavailable to benthic organisms in dynamic sediment en
284 Overall, sediment-bound Cs is sufficiently bioavailable to deposit-feeding polychaetes, and macrofa
285 Hg(SR)(2) complexes as the immediate species bioavailable to fish, and that these complexes transform
288 of oceanic primary production by making N(2) bioavailable to planktonic communities, in the process i
291 eported that inorganic polyphosphate was not bioavailable to the model diatoms Thalassiosira weissflo
298 otics decreases miR-204, increases Sirt1 and bioavailable vascular nitric oxide, and improves endothe
299 water suggested that the NaHCO(3)-P pool was bioavailable, whereas NaOH-P and HCl-P pools were recalc