ライフサイエンスコーパス: bioconjugation

1 l chemistry, and chemical biology (e.g., for bioconjugations).

2 group or carboxylic acid moiety) for further bioconjugation.

3 ng rapid, stable, and chemoselective protein bioconjugation.

4 tegy for achieving ligation, attachment, and bioconjugation.

5 to the bay region for the purpose of further bioconjugation.

6 ules onto the gold nanoparticles followed by bioconjugation.

7 icability for pH responsive surfaces and for bioconjugation.

8 st prompts use in both general synthesis and bioconjugation.

9 reporter and an activator molecule to assist bioconjugation.

10 nctional groups, which were used for surface bioconjugation.

11 l containing activated carbonate polymer for bioconjugation.

12 cles may find many potential applications in bioconjugation.

13 for efficient synthesis of nanoparticles for bioconjugation.

14 can be attached to a target compound through bioconjugation.

15 netic incorporation of cysteine residues for bioconjugation.

16 se in biochemistry, pharmacology and peptide bioconjugation.

17 .g., light-absorbing antennas and groups for bioconjugation.

18 ve yet to be applied to the field of protein bioconjugation.

19 o meet the requirements of practical protein bioconjugation.

20 l parameters for tuning precision in protein bioconjugation.

21 lic reagents enable practical strategies for bioconjugation.

22 ached to monoclonal antibodies via dendrimer bioconjugation.

23 s, medicinal chemistry, polymer science, and bioconjugation.

24 ses (PALs) are particularly useful tools for bioconjugation.

25 -forming reactions are crucial for efficient bioconjugation.

26 the most favorable in vivo properties after bioconjugation.

27 fs, including isotope labels and handles for bioconjugation.

28 compatible library of protein substrates for bioconjugation.

29 (455/650 nm) for rapid site-specific protein bioconjugation.

30 gy an important alternative to maleimides in bioconjugation.

31 n a single cysteine using classical cysteine bioconjugation.

32 thods play an increasingly important role in bioconjugation.

33 sm towards enabling site- and chemoselective bioconjugation.

34 ications ranging from polymer fabrication to bioconjugation.

35 ts its practice in certain situations, e.g., bioconjugation.

36 as also been applied to peptide labeling and bioconjugation.

37 acrylic reagents for chemoselective cysteine bioconjugation.

38 uperior to off-protein rates of many current bioconjugations.

39 sis of the recently developed boron-mediated bioconjugations.

40 lick editors (CEs) leverage the 'click'-like bioconjugation ability of HUH endonucleases with single-

41 ed ring systems, with applications including bioconjugation agents.

42 malignancies, their target, composition and bioconjugation, along with preclinical and clinical outc

43 ogy contexts, Reps are the basis for HUH-tag bioconjugation and a critical adeno-associated virus gen

44 mical and optical properties of NIR-II dyes, bioconjugation and biological behavior of NIR-II dyes, w

45 ars, relying on innovations in the fields of bioconjugation and bioorthogonal click chemistry, new ch

46 isn -tags at the protein termini allow rapid bioconjugation and consequent purification through compl

47 ch second- and third-generation catalysts in bioconjugation and in cellular applications are highligh

48 e ]( *) is not significantly perturbed after bioconjugation and is available as a phototrigger of tyr

49 the innovative use of these unique tools in bioconjugation and nanomaterial synthesis.

50 the innovative use of these unique tools in bioconjugation and nanomaterial synthesis.

51 ediates, the methodology has been applied to bioconjugation and peptide labeling.

52 chains is critical to advance the fields of bioconjugation and peptide pharmaceuticals.

53 amely the thiol-ene photo-click reaction for bioconjugation and photocleavage reactions that allow fo

54 NAs can serve as tools for both non-covalent bioconjugation and structure-function nucleation.

55 pproaches - including chemical modification, bioconjugation and the use of nanocarriers - which aim t

56 BDSA and basic sites to facilitate gas-phase bioconjugation and to reduce charge sequestration and in

57 nable efficient highly selective thiol-thiol bioconjugations and cysteine modification of peptides.

58 redox or fluorescent labeling, as well as in bioconjugations and modulation of interactions of DNA wi

59 these heterocycles as reaction catalysts, in bioconjugation, and as new-drug chemotypes and bioisoste

60 em integrates yeast display, enzyme-mediated bioconjugation, and fluorescence-activated cell sorting

61 c and other boron heterocycles in catalysis, bioconjugation, and medicinal chemistry.

62 modern chemistry, including drug discovery, bioconjugation, and nanoscience.

63 e development, synthesis, scope of reaction, bioconjugation, and synthetic comparisons of four new ch

64 The development and bioconjugation applications of a novel Diels-Alder-based

65 w potential as benchtop reagents for diverse bioconjugation applications.

66 ought to expand the toolbox for a variety of bioconjugation applications.

67 ing massively parallel HUH-tag barcoding and bioconjugation applications.

68 Here, we present a palladium-based bioconjugation approach for the site-specific introducti

69 The ionic liquid bioconjugation approach led to discovery of a novel trip

70 nts a significant departure from the current bioconjugation approach of using a non-targeted fluoroph

71 ins site-specifically using a chemoenzymatic bioconjugation approach.

72 The nonaqueous bioconjugation approaches allow access to numerous chemi

73 a quartz slide was investigated with several bioconjugation approaches and an immunoassay for detecti

74 ostructured morphology and functionality for bioconjugation are essential to realise the concept of a

75 New methods for residue-selective bioconjugation are highly sought to expand the toolbox f

76 prediction of their coupling efficiencies in bioconjugations, as demonstrated in reductive amination

77 ht on the state-of-the-art technology of DNA bioconjugation assays in DNA biosensor, DNA barcode, DNA

78 Synthetic bioconjugation at cysteine (Cys) residues in peptides an

79 Herein, we report a bioconjugation-based approach for intracellular protein

80 gnetic beads are embedded in the ECM through bioconjugation between the streptavidin-coated beads and

81 erstanding of several key factors, including bioconjugation, bioanalytical techniques, biotransformat

82 ant not only for expanding the repertoire of bioconjugation but also for the application of olefin me

83 - and alkynyl-pyridine reagents not only for bioconjugation, but also as warheads for covalent inhibi

84 nstrated here is the substrate scope of this bioconjugation by attaching a variety of tags, such as N

85 library peptide selected to rapidly undergo bioconjugation, by using electron paramagnetic resonance

86 Although conventional lysine-directed bioconjugation can be used to yield conjugates for radio

87 of the acetylene allows the presentation of bioconjugation cargo to the enzyme for (18)F labelling.

88 o anti-albumin nanobodies via site-selective bioconjugation chemistries prolongs the circulation of t

89 rgeting probes (e.g., antibodies), multistep bioconjugation chemistries, different delivery strategie

90 the broader use of data-driven approaches to bioconjugation chemistry and other chemical biology appl

91 Bioconjugation chemistry has been used to prepare modifi

92 Successful bioconjugation chemistry of Abs via a bifunctional polye

93 most common points of attachment for protein bioconjugation chemistry through acid-base reactivity(3,

94 xpertise ranging from synthetic materials to bioconjugation chemistry to immunology.

95 ntial of electrochemistry for chemoselective bioconjugation chemistry.

96 mer synthesis, polymer-polymer coupling, and bioconjugation, demonstrating significant potential for

97 equivalent of a second thiol to give further bioconjugation, demonstrating that bromomaleimides offer

98 oor aryl nitriles are promising reagents for bioconjugation due to their high electrophilicity and se

99 , a significant portion of the boron-enabled bioconjugations exhibit rapid reversibility and accordin

100 ed through a sonication-mediated method with bioconjugation flexibility.

101 The sequence of site-selective bioconjugation followed by bioorthogonal bond cleavage w

102 idates for in vitro and in vivo non-covalent bioconjugation, for imaging and delivery applications, a

103 (125)I-labeled triazoles functionalized with bioconjugation groups, fluorescent dyes, and biomolecule

104 robust utility of the aldehyde product as a bioconjugation handle in recombinant proteins.

105 duced, flavin-catalyzed method that installs bioconjugation handles on a broad range of bioactive N-a

106 sites, we also sought to identify different bioconjugation handles that can be coincorporated into p

107 pression systems and the mutually compatible bioconjugation handles they incorporate, we demonstrate

108 lative modules, bioorthogonal functions, and bioconjugation handles.

109 mide amine substitution to alternative amine bioconjugation handles.

110 Protein bioconjugation has been a crucial tool for studying biol

111 vinyl sulfone reagent for cysteine-selective bioconjugation has been developed.

112 of robust surface attachment chemistries for bioconjugation has limited their uptake in biomedical di

113 oups suitable for derivatization and protein bioconjugation have also been developed.

114 On the other hand, stable bioconjugations have been developed that display fast ki

115 lenging, and in vivo bacterial conjugations (bioconjugations) have emerged as manufacturing alternati

116 Successful bioconjugation hinges upon the ability of an oligosaccha

117 cope and limitations of olefin metathesis in bioconjugation, however, remain unclear.

118 Hence, control over their bioconjugation impacts science at the chemistry-biology-

119 nitiated reaction that can achieve patterned bioconjugation in a highly chemoselective manner.

120 Achieving chemoselective protein bioconjugation in aqueous media is challenging, especial

121 This strategy has been used extensively for bioconjugation in vitro and for protein-protein conjugat

122 Advantages of this approach for AuNP bioconjugation include: (1) initial formation of highly

123 to introduce functional groups suitable for bioconjugation into natural products and pharmaceuticals

124 In general, QD bioconjugation is completed within 1 day, and multiplexe

125 The potential of this novel bioconjugation is demonstrated through the preparation o

126 y concepts surrounding their preparation and bioconjugation is provided given the defining role these

127 s) against protein drugs by immunomodulatory bioconjugation is reported.

128 ic methodologies and applications, including bioconjugation, labelling, surface functionalization, de

129 a general strategy that combines synthesis, bioconjugation, linker technology, site-directed mutagen

130 or small drug molecules, process impurities, bioconjugation linkers, stealth polymers, and small prot

131 ct synthesis, drug discovery, radiolabeling, bioconjugation, materials, and fine chemical synthesis.

132 Here we report a simple and rapid protein bioconjugation method based on a one-step ligand exchang

133 Key advantages of this bioconjugation method include (1) the use of air-stable

134 A highly efficient protein bioconjugation method is described involving addition of

135 Bioconjugation methodologies have proven to play a centr

136 lly combining robust site-specific phosphine bioconjugation methods and a lipid-binding protein (SCP-

137 Cs employing novel mAb, payload, linker, and bioconjugation methods are also included.

138 Site-selective bioconjugation methods are valuable because of their abi

139 hly specific antibodies and well-established bioconjugation methods for modification of these antibod

140 The described microwave-assisted bioconjugation methods give an opportunity to synthesize

141 Site-specific protein bioconjugation methods have enabled the development of n

142 Site-specific bioconjugation methods offer exceptional uniformity in p

143 Stochastic bioconjugation methods were used to append deferoxamine

144 tagging works with a range of site-selective bioconjugation methods with proteins tagged at the C-ter

145 s expansion of the toolbox of site-selective bioconjugation methods.

146 particles and proteins used in the different bioconjugation mixtures (1:1, 2:1, and 3:1 QD:Ab molar r

147 pharmacokinetics, facilitating site-specific bioconjugation, modulating Fc interactions, and creating

148 MOF mesopores, including succinimidyl ester bioconjugation moieties that allow for straightforward c

149 uoride require (18)F-labeled prosthetics for bioconjugation more often with cysteine thiols or lysine

150 We demonstrate controlled in vivo bioconjugation of a targeted intracellular protein to se

151 The study provides a means of characterizing bioconjugation of AgNPs with aptamers and assessing biom

152 turing methods are based on the nonselective bioconjugation of cytotoxic drugs to lysine and cysteine

153 Finally, the SuFEx bioconjugation of iminosulfur oxydifluorides to amine-ta

154 The effective bioconjugation of inorganic nanoparticles to the molecul

155 Such reactions allow for stoichiometric bioconjugation of micromolar cysteine within minutes or

156 and high-density and orientation-controlled bioconjugation of nanobody-SpyCatcher fusion proteins on

157 in the optical observation, fabrication, and bioconjugation of nanometer-sized gold or silver colloid

158 The bioconjugation of organometallic complexes with peptides

159 maleimide group is a widely used reagent for bioconjugation of peptides, proteins, and oligonucleotid

160 We introduce the bioconjugation of polymers synthesized by RAFT polymeriz

161 Engineering and bioconjugation of proteins is a critically valuable tool

162 erein we report an umpolung strategy for the bioconjugation of selenocysteine in unprotected peptides

163 eveloped protocols for functionalization and bioconjugation of single-walled carbon nanotubes (SWNTs)

164 Currently, bioconjugation of SNO-OCTs to a desired target is achiev

165 highlights the most exciting developments in bioconjugation of synthetic hydrogels targeted to tissue

166 alixarene-based coating enabled the covalent bioconjugation of the SARS-CoV-2 Spike Protein via the c

167 We demonstrate bioconjugation of the squaraine Pdots and employ the Pdo

168 A covalent bioconjugation of these AuNCs with the desired antibody

169 Surface functionalisation and bioconjugation of these hybrid nanoparticles and nanocom

170 Here we report a redox-based strategy for bioconjugation of tryptophan, the rarest amino acid, usi

171 c anticancer vaccine 2 has been prepared via bioconjugation of unimolecular pentavalent construct 1-c

172 ncorporating novel chemical modifications or bioconjugations of a variety of moieties including pepti

173 rms on demand with the help of sophisticated bioconjugation or radiolabeling techniques.

174 Then, after evaluating how bioconjugation parameters influenced biotin density and

175 talysis to develop a site-selective tyrosine bioconjugation pathway that incorporates bioorthogonal f

176 ch we observed known metabolic oxidation and bioconjugation pathways and turnover rates.

177 o-antibody ratios (DARs) for their impact on bioconjugation, pharmacokinetics (PK), siRNA delivery, a

178 The utility of this new bioconjugation platform in a drug discovery setting is h

179 The broad utility of the bioconjugation platform was further corroborated by the

180 thesis and has also numerous applications in bioconjugation, polymer synthesis, material science, and

181 For this purpose, a reproducible bioconjugation procedure for preparing gold biohybrid na

182 to give a suitable labeling reagent for this bioconjugation process, which enables modification of pe

183 nti-ALP) were immobilized using carbodiimide bioconjugation process.

184 These proteins can be subjected to different bioconjugation processes to form single-domain antibody-

185 protein, are expected to improve large scale bioconjugation processes.

186 Herein we report a site-selective methionine bioconjugation protocol that uses photoexcited lumiflavi

187 osed amine groups in the initial step of the bioconjugation protocol.

188 ate stable ADTAs, which could facilitate new bioconjugation protocols.

189 hese new thaumatin variants are amenable for bioconjugation, providing chemical biology tools for tha

190 es provide the basis for the design of novel bioconjugation reactants or fluorogenic labeling agents.

191 rk, we report an electrochemically activated bioconjugation reaction as a mild, reagent-free strategy

192 Monitoring of the bioconjugation reaction between fluorescein isothiocyana

193 ss analytical technology (PAT) for real-time bioconjugation reaction monitoring.

194 e for comprehensive ADC characterization and bioconjugation reaction monitoring.

195 fatty acid synthase with a highly selective bioconjugation reaction provides a biomimetic route for

196 After due optimization of such bioconjugation reaction, a molar ratio 1:3 (antibody:AuN

197 can be chemically modified using a standard bioconjugation reaction, showing mass transportation wit

198 tuned to maximize fluorogenic efficiency in bioconjugation reactions and reveal that strained alkyne

199 Site-selective chemical bioconjugation reactions are enabling tools for the chem

200 Novel bioconjugation reactions have been heavily pursued for t

201 erstanding and predicting reaction rates for bioconjugation reactions is fundamental for evaluating t

202 mended for monitoring the progression of the bioconjugation reactions on protein and antibody substra

203 evelopment of highly efficient and selective bioconjugation reactions that operate under mild, biomol

204 Thus, bioconjugation reactions using DIBAC can be carried out

205 A growing cluster of bioconjugation reactions were realized by tapping into t

206 Maleimide groups are used extensively in bioconjugation reactions, but limited kinetic informatio

207 go-release strategies and organelle-specific bioconjugation reactions.

208 iable azido (18) F-arene clickable agent for bioconjugation reactions.

209 useful for the detailed study of a number of bioconjugation reactions.

210 s reagents for high-yielding oligonucleotide bioconjugation reactions.

211 poration of an aldehyde group for orthogonal bioconjugation reactions.

212 tet-Spengler (PAPS) an attractive choice for bioconjugation reactions.

213 pholipids using abiotic but highly selective bioconjugation reactions.

214 t and highly selective cysteine conjugation (bioconjugation) reactions that are rapid and robust unde

215 -rich heteroaromatics, carbocycles, and as a bioconjugation reagent.

216 result, the developed organometallic Au(III) bioconjugation reagents enable selective labeling of Cys

217 nthesis of isotopomeric Rhodamine dye-linked bioconjugation reagents enabled direct labeling of surfa

218 the development of new methionine-selective bioconjugation reagents with tunable adduct stabilities.

219 es represent one of the most widely employed bioconjugation reagents.

220 Bioconjugation relies upon an oligosaccharyltransferase

221 been synthesized for numerous applications, bioconjugation remains a challenge, often resulting in d

222 The bioconjugation results were confirmed by MS and Western

223 ing, amenability to quantitation, and facile bioconjugation schemes.

224 ellular delivery, and flexible chemistry for bioconjugations should generate broad applications of th

225 ogen, selenium, oxygen, and carbon arylative bioconjugation strategies and their applications to modi

226 Bioconjugation strategies are essential for enhancing me

227 Many bioconjugation strategies for DNA oligonucleotides and a

228 be advantageous to design materials that use bioconjugation strategies that do not affect bioactivity

229 Bioconjugation strategies using biotin-avidin interactio

230 As radiochemists explore alternative bioconjugation strategies, this article considers their

231 regioselectivity issues which limit existing bioconjugation strategies.

232 otential for advancing polymer materials and bioconjugation strategies.

233 leveraged to expand the repertoire of glycan bioconjugation strategies.

234 e considerations for choosing an appropriate bioconjugation strategy and targeting moiety.

235 the area of PEGylation as the most important bioconjugation strategy are also summarized.

236 an unprecedented "tag and modify" selective bioconjugation strategy based on DCvC.

237 Further, the bioconjugation strategy can be applied to a model protei

238 tablishes a unique chemoselective, traceless bioconjugation strategy for the selective enrichment of

239 the cell penetrating peptide-photosensitiser bioconjugation strategy is a promising and versatile app

240 A bioconjugation strategy is reported that allows the deri

241 A novel bioconjugation strategy leading to ultrastable gold nano

242 This unprecedented bioconjugation strategy targets these under-utilized ami

243 Finally, this reaction is applied as a novel bioconjugation strategy to link biologically active mole

244 lishes a unique chemoselective "unclickable" bioconjugation strategy to site-specifically modify prot

245 o-coupling reaction, and the utility of this bioconjugation strategy was further illustrated by gener

246 This dual bioconjugation strategy was used to generate a highly fl

247 nd modular synthesis to small-molecule model bioconjugation studies and proof-of-principle bioorthogo

248 powerful approach for site-specific protein bioconjugation, synthesis and semisynthesis of proteins

249 organoboron reagents have been evaluated for bioconjugation, targeting the reactivity of either nativ

250 Our bioconjugation technique exploits the electrophilic reac

251 from a rotaxane synthesis tool into a useful bioconjugation technique.

252 ajor challenges with conventional N-terminal bioconjugation techniques are the lack of universal sequ

253 od for rapid synthesis of the target Pcs and bioconjugation techniques for labeling of the oligonucle

254 as seen a remarkable growth in the number of bioconjugation techniques in chemistry, biology, materia

255 came one of the most important and efficient bioconjugation techniques in the 1990s and this century.

256 Integrating the emerging advancements in bioconjugation techniques, DNA nanostructures can be rea

257 the exponential growth of new site-selective bioconjugation techniques, however very few methods have

258 Many common bioconjugation techniques, however, are inefficient, non

259 Three different bioconjugation techniques, reductive amination, amidatio

260 er a broad pH range and accessible to simple bioconjugation techniques, such as avidin-biotin binding

261 specific modification through tyrosine-based bioconjugation techniques, which leave the sensitive net

262 nt of multifunctional materials via standard bioconjugation techniques.

263 rface functionalization and develop flexible bioconjugation techniques.

264 hich rely heavily on robust and reproducible bioconjugation techniques.

265 Bioconjugation technologies have revolutionized the prac

266 A core design element in bioconjugation technology is a chemical reaction that ca

267 With the availability of a novel bioconjugation technology it is expected that multivalen

268 After bioconjugation, the imaging agent appeared to be stable

269 Upon bioconjugation, the nanoprobes are magnetically focused

270 Their nanoparticle surfaces for versatile bioconjugation, their adaptable photophysical properties

271 As a fundamentally new approach to bioconjugation this methodology provides a blueprint tow

272 ort a strategy for chemoselective methionine bioconjugation through redox reactivity, using oxaziridi

273 We describe the effect of bioconjugation to colloidal Au nanoparticles on protein

274 d amino acids on virus capsids for uses from bioconjugation to crystal growth.

275 ult stem cells, and merging 3D printing with bioconjugation to fabricate hydrogels with anatomical ar

276 ET nanoprobes and the possibility of in vivo bioconjugation to FPs and combined nanoprobe-FP FRET sen

277 able, and site-specific antibody and protein bioconjugation to native or engineered methionines.

278 Site-selective bioconjugation to native protein residues is a powerful

279 nometallic-based methods for oligonucleotide bioconjugation to other biomolecules.

280 optical traps, we demonstrate how efficient bioconjugation to otherwise nonstick surfaces can benefi

281 t is beyond the scope of existing methods in bioconjugation to permit tagging of the "seemingly untag

282 concept, highlighting targeted intracellular bioconjugation to QDs, suggests that many cytoplasmic pr

283 ic carbene (NHC)-gold(I) complexes and their bioconjugation to the CCRF-CEM-leukemia-specific aptamer

284 ed carrier proteins, making it an attractive bioconjugation tool for next generation vaccine developm

285 r biomedical applications, but approaches to bioconjugation typically show insufficient efficiency an

286 "Click" chemistry bioconjugation using a poly(ethylene glycol) (PEG)-modif

287 isms that allow the use of these reagents as bioconjugation warheads, as central pieces of linker str

288 Successful bioconjugation was confirmed by the use of fluorescent t

289 used azacyclononyne IC9N-BDP-FL for in vitro bioconjugation was exemplified by labeling and visualiza

290 ology for covalent biomolecule modification (bioconjugation), we have developed a method that exploit

291 oaddition (SPAAC) reagents for bioorthogonal bioconjugation, we integrated two common approaches: the

292 and kinetic profiles of these boron-enabled bioconjugations, which reveals structure-reactivity rela

293 l process within PDCD can be inhibited after bioconjugation with a quencher-linked peptide.

294 the surface of Au@Pt NPs allowed their easy bioconjugation with antibodies, while the high catalytic

295 ies of PG9 and PG16 were further enhanced by bioconjugation with aplaviroc, a small-molecule inhibito

296 d to demonstrate facile applicability toward bioconjugation with biotin.

297 peptides are engineered with a Cys site for bioconjugation with maleimide-terminated chromophores, w

298 Due to their convenient bioconjugation with peptides/antibodies, NIR-II molecula

299 rves as a novel reaction solvent for protein bioconjugation without noticeable loss of the biomolecul

300 -F bond resulted in a noteworthy increase in bioconjugation yields, with excellent chemo-selectivity.