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1 early-gestation (6-8 wk) human placentas are bipotential, a phenotype that is lost with increasing ge
2 2 activation results in the proliferation of bipotential adipocyte precursors (APs) and their subsequ
3   We have shown that EpCAM(+) oval cells are bipotential adult hepatic epithelial progenitors.
4 esistant Nkx3-1-expressing cells, CARNs) are bipotential and can self-renew in vivo, and single-cell
5 9 and HES1 during human embryonic pancreatic bipotential and endocrine progenitor fate choice.
6  which normally become parapineal cells, are bipotential and require Fgf8a to maintain parapineal ide
7 pos):Lin(neg):THY1(neg):DDR2(neg) cells were bipotential as the majority expressed collagen 1 alpha-1
8  utilized three cell models: the uncommitted bipotential C2C12 cells, the pre-osteoblastic cell line
9                  Implantation of these human bipotential CD34(+) progenitors into nonobese diabetic/s
10 specify hypochord from a notochord/hypochord bipotential cell population.
11 ific genes were precociously actuated in the bipotential cell populations, and some other genes were
12  mesoderm, given that this pathway acts as a bipotential cell-fate switch on equipotent progenitor po
13 r failed to provide direct evidence for such bipotential cells at the single-cell level.
14                                        These bipotential cells likely serve as a reservoir for the ep
15 Y initiates development of a testis from the bipotential cells of the early gonad.
16                      Immature thymocytes are bipotential cells that are signalled during positive sel
17 ic rat spinal cord can give rise in vitro to bipotential cells that express defining characteristics
18 within a population of notochord/floor plate bipotential cells through negative transcriptional regul
19 ions also suggest a novel mechanism by which bipotential cells throughout development can determine t
20 on of C/EBPalpha alone in stably transfected bipotential cells triggers neutrophilic differentiation,
21   Double-positive thymocytes are short-lived bipotential cells whose developmental fate is determined
22                         HPCs are known to be bipotential cells, capable of forming both hepatocytes a
23 x2/Cbfa1-expressing preosteoblasts are still bipotential cells.
24                                 Here we used bipotential CG-4 cells to examine the impact of agnoprot
25           We found that normal tip cells are bipotential, contributing to both tips and trunks.
26 del system to identify factors that regulate bipotential differentiation in the liver.
27  embryos and demonstrated their capacity for bipotential differentiation in vivo.
28                                          The bipotential differentiation of liver progenitor cells un
29                   Both domains are initially bipotential, each capable of giving rise to either neuro
30 d RapGEF2(-/-) yolk sacs indicating that the bipotential early progenitors were in fact generated in
31                    Our results indicate that bipotential endothelial/erythroid precursor cells do ind
32 hroleukemic pathology with transformation of bipotential erythro-megakaryocytic cells.
33                 Finally, we demonstrate that bipotential erythroid-megakaryocyte progenitor and CD150
34                                  We define a bipotential erythroid-megakaryocyte progenitor populatio
35 ropose that FOG-1 may modulate the fate of a bipotential erythroid/megakaryocytic precursor cell.
36 or FOG in megakaryocyte development from the bipotential erythroid/megakaryocytic progenitor.
37 ncipally regulates ductal differentiation of bipotential exocrine progenitors.
38 epatocytes can function as or be a source of bipotential facultative hepatic stem cells (hepatoblasts
39     The liver contains a population of small bipotential facultative progenitor cells that reconstitu
40  as classically described and only acquire a bipotential fate later, in more posterior regions.
41 a temporal window during which PGCs retain a bipotential fate.
42 Cs that are committed to spermatogenesis and bipotential female PGCs.
43               The K562 leukemia cell line is bipotential for erythroid and megakaryoblastic different
44              In this review we discuss their bipotential functions and the possible underpinning mech
45                                          The bipotential Ganglion Mother Cells, or GMCs, in the Droso
46 e expression of Sry in the undifferentiated, bipotential genital ridges of mammalian XY fetuses initi
47 he basis for myelin loss in HD, we generated bipotential glial progenitor cells (GPCs) from human emb
48 hways that are initially co-expressed in the bipotential gonad and subsequently become male- or femal
49 t low temperatures, the somatic cells of the bipotential gonad differentiate into Sertoli cells, the
50                                          The bipotential gonad expresses genes associated with both t
51 control of female sex differentiation from a bipotential gonad in mammals is poorly understood.
52  We suggest that migration of cells into the bipotential gonad may have a critical role in initiating
53                   Exogenous RA treatments at bipotential gonad stages increase germ cell number, cons
54 pression of the Y-linked gene Sry shifts the bipotential gonad toward a testicular fate by upregulati
55                       The cells in the early bipotential gonad undergo de novo organization to form t
56 ce between patterns (male and female) in the bipotential gonad.
57 first somatic lineage to be specified in the bipotential gonad.
58 that both arise from a common precursor, the bipotential gonad.
59 ertoli cells shortly after commitment of the bipotential gonads to testicular differentiation, causes
60 tis rather than ovary development from early bipotential gonads.
61 ch to promote granulocyte differentiation in bipotential granulocyte-macrophage progenitors (GMPs), i
62 ipotential progenitors to differentiate into bipotential granulocyte/macrophage progenitors and their
63  definitive erythroid (CFU-E), mast cell and bipotential granulocyte/macrophage progenitors in the yo
64 d that exhibited granulocytic, monocytic, or bipotential (granulocytic and monocytic) differentiation
65 ineage-depleted mouse bone marrow cells, and bipotential (granulocytic/monocytic) human acute myeloid
66 sion and function in human primary cells and bipotential (granulocytic/monocytic) myeloid cell lines.
67 human embryonic stem cells to define a novel bipotential hematopoietic progenitor that gives rise to
68 ngiocytes are located in ductules containing bipotential hepatic progenitor cells (HPCs).
69       These characteristics clearly identify bipotential hepatic progenitor cells in the developing h
70 FGF4 enrich the embryonic liver cultures for bipotential hepatic progenitors.
71  exhibit a similar transcriptomic profile to bipotential hepatobiliary progenitors, the latter do not
72       We utilized this information to derive bipotential hepatoblast organoids and then exploited thi
73 rs known to affect lineage commitment in the bipotential hepatoblast progenitor cell (BHPC) populatio
74                  Impaired Notch signaling in bipotential hepatoblast progenitor cells (BHPCs) dose-de
75       Thus, HBC-3 cells behave in culture as bipotential hepatoblasts and provide a model system to i
76 rovide in vivo evidence for the existence of bipotential hepatopancreatic progenitors and indicate th
77          The negative effect was observed in bipotential human cells (K562 and human erythroleukemia
78               These cells are believed to be bipotential, i.e., able to differentiate into hepatocyte
79  we discovered that Ngn3(+) progenitors were bipotential in vivo and in vitro.
80  CD34+ BM precursors can generate a post-CFU bipotential intermediate in the presence of c-kit ligand
81 vealed that one subset of multipotential and bipotential intermediate progenitors did not increase af
82  multipotential progenitor cells, as well as bipotential intermediates, manifest mixed-lineage patter
83 n can alter protein-protein interactions and bipotential lineage decisions.
84       It is widely believed that DRs contain bipotential liver progenitor cells (LPCs) that serve as
85 rived without carcinogens or mutagens, these bipotential LPC lines provide novel tools for models of
86 ber is via generation and stimulation of the bipotential megakaryocyte precursors.
87 rming capacity of the bone marrow, including bipotential megakaryocyte-erythroid colony-forming capac
88 ony-forming cells (Meg-CFCs) that arise from bipotential megakaryocyte/erythroid progenitors (MEPs).
89 eoblastogenesis and inhibits adipogenesis of bipotential mesenchymal precursors.
90 ds and ECM proteins in the fate decisions of bipotential mouse embryonic liver (BMEL) progenitor cell
91 lar markers in mutants, our data support the bipotential nature of the progenitor cells for paraxial
92 ry and sufficient to specify mesoderm from a bipotential neural/mesodermal precursor.
93 ueled by a posteriorly located population of bipotential neuro-mesodermal progenitor cells.
94                                              Bipotential neuromesoderm progenitors (NMPs) ensure axia
95 dy axis formation depends on a population of bipotential neuromesodermal cells along the posterior wa
96                         The undifferentiated bipotential NMP state is maintained when both Wnt signal
97 ls increases oligodendrocyte generation from bipotential oligodendrocyte-type-2 astrocyte/oligodendro
98        The results support the view that the bipotential optic neuroepithelium is characterized by ov
99 positional cues provided by FGF organize the bipotential optic vesicle into specific neural retina an
100 e rise to clonal oval cell proliferation and bipotential organoids, but rarely produce hepatocytes in
101                            The appearance of bipotential oval cells in chronic liver injury suggests
102 -mediated suppression of dmrt1 establishes a bipotential ovary and initiates female fate acquisition.
103 ex-determination involves establishment of a bipotential ovary that undergoes sex-specific differenti
104  to specify the identity of V2b neurons from bipotential p2 progenitors.
105                                    After the bipotential period, SOX9 was abruptly down-regulated at
106                                          The bipotential precursor cell population for pancreas and l
107  chromosome gene Sry, which controls whether bipotential precursor cells differentiate into testicula
108 tes in the fetal gonad with specification of bipotential precursor cells into male Sertoli cells or f
109 w provided evidence for the presence of this bipotential precursor in vivo, the precise mechanism for
110                               Wnt-expressing bipotential precursors already present at E11.5 are foll
111 s a myeloid differentiation switch acting on bipotential precursors and directing them to mature to g
112 oreover, induced expression of C/EBPalpha in bipotential precursors blocks their monocytic differenti
113 as been postulated to induce hemangioblasts, bipotential precursors for blood and endothelial cells.
114 ome of Notch signaling is differentiation of bipotential precursors into one cell type versus another
115 e specification of haemangioblasts, putative bipotential precursors of blood and endothelium.
116         Primordial germ cells (PGCs) are the bipotential precursors of mature gametes that commit to
117  the erythroid lineage limits development of bipotential precursors toward an endothelial fate.
118 CD9(hi)endoglin(lo) fraction, which contains bipotential precursors with characteristics of increased
119 granulosa (BPG) cells, derives directly from bipotential precursors, expresses Foxl2 early, and assoc
120 expression to HSCs and endothelium and their bipotential precursors, the haemangioblast.
121  are mast cell, monocyte, and mast/monocyte (bipotential) precursors.
122                                One PG group, bipotential pregranulosa (BPG) cells, derives directly f
123  and erythroid lineages derive from a common bipotential progenitor and share many transcription fact
124 or for these two lineages, the presence of a bipotential progenitor cell has yet to be demonstrated i
125 ive enterocytes suggested reprogramming of a bipotential progenitor cell.
126 lian sexual development commences when fetal bipotential progenitor cells adopt male Sertoli (in XY)
127 alignancy in this model and may develop from bipotential progenitor cells at an early stage of prosta
128 been any single gene that can define mammary bipotential progenitor cells, and as such it has not bee
129 rovide direct evidence that K6a(+) cells are bipotential progenitor cells, and the first demonstratio
130 eam mesodermal genes, but also by repressing bipotential progenitor genes, in part through a direct r
131 progenitors were CK-19-positive (biliary and bipotential progenitor marker) only in the presence of F
132 r) and FLK1 (a marker of hemangioblasts, the bipotential progenitor of endothelial and hematopoietic
133 that sustained Nodal signaling establishes a bipotential progenitor state from which cells can switch
134 t may be a state of competence rather than a bipotential progenitor state that exists in vivo.
135 of the mesodermal fate and repression of the bipotential progenitor state, even as cells leave the in
136 how ERY and MEG lineages arise from a common bipotential progenitor via overlapping and divergent fun
137 suggesting that transformation occurred in a bipotential progenitor.
138 ge committed (unipotential) and uncommitted (bipotential) progenitor cells exerting different repopul
139 ted the molecular steps during maturation of bipotential progenitors along both alveolar lineages and
140                                        These bipotential progenitors arise along the entire extent of
141 k between committed alphabeta thymocytes and bipotential progenitors for normal gammadelta T cell dif
142  closely related to liver stem cells, act as bipotential progenitors for the two main hepatic lineage
143                    There are fewer committed bipotential progenitors in C/EBPalpha(-/-) FL, whereas m
144  the generation of different cell types from bipotential progenitors in order to facilitate orderly a
145   The subsequent selection of fate from such bipotential progenitors is then governed by lateral inhi
146 n vertebrates, pancreas and liver arise from bipotential progenitors located in the embryonic gut end
147 erein that mice lacking Foxo1, -3, and -4 in bipotential progenitors of osteoblast and adipocytes (ex
148 training effect of FOXOs on Wnt signaling in bipotential progenitors suggests that FOXO activation by
149 show that megakaryocytes arise from CD150(+) bipotential progenitors that display both platelet- and
150     CD140a(+) cells were isolated as mitotic bipotential progenitors that initially expressed neither
151 l mesoderm fate, or if transplanted into the bipotential progenitors that normally give rise to somit
152 iver (hepatocytes, cholangiocytes, and their bipotential progenitors) are heritably labeled at high e
153  The erythroid lineage was arrested early in bipotential progenitors, which did not give rise to matu
154 method for generating large numbers of these bipotential progenitors-known as hemangioblasts-from hum
155 tic lineages, suggesting that they represent bipotential progenitors.
156 cision tree involves initial coactivation of bipotential properties followed by gradual shifts toward
157 nt for this process, they do not explain the bipotential result.
158                            Patterning of the bipotential retinal primordia (the optic vesicles) into
159 ogenin 3 can redirect the differentiation of bipotential secretory progenitors to endocrine rather th
160           In fact, PGCs form well before the bipotential somatic gonad is specified.
161 nation, an oocyte-derived signal acts on the bipotential somatic gonad to promote the female-specific
162           We found that TCF21(lin) cells are bipotential somatic progenitors present in fetal testis
163 els and that ectopic expression of Wnt10b in bipotential ST2 cells suppresses expression of CCAAT/enh
164                                       At the bipotential stage of development (embryonic day or E14.5
165 how strong RA responses in germ cells at the bipotential stage of gonad development.
166 e that early gonocytes are in a dual poised, bipotential state in which Rbpms2 acts as a binary fate-
167 d that early cardiogenic mesoderm contains a bipotential stem cell that can give rise to both the myo
168 e in early biliary lineage commitment of the bipotential stem cells and also seems to be important in
169             These lesions show properties of bipotential stem cells and co-express markers of epithel
170 lted in loss of CK19 immunoreactivity of the bipotential stem cells.
171 determination results from the commitment of bipotential supporting cells to Sertoli or granulosa cel
172 view considers the unusual plasticity in the bipotential system of sex determination and some of the
173 d "oval cells," have long been thought to be bipotential, that is, produce both biliary ducts and hep
174           We suggest that TRbeta2 controls a bipotential transcriptional state to promote cone divers
175 genous estrogen feminizes the medulla of the bipotential turtle gonad by inhibiting SOX9 expression.
176 troduction of constitutively active Fes into bipotential U937 cells induced the appearance of fully d
177            In mammals, Sry expression in the bipotential, undifferentiated gonad directs the support
178 t a common progenitor exists that can remain bipotential up to its final mitotic division.
179       These findings suggest the presence of bipotential valve progenitor cells with ability to diffe
180 I and DLP demonstrated that both regions are bipotential with respect to primitive and definitive hem
181 alf of the c-kitLo B-lineage precursors were bipotential, yielding myeloid and lymphoid progeny, wher

 
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