ライフサイエンスコーパス: bloc

1 sis of lysosome-related organelle complexes (BLOCs).

2 is of lysosome-related organelles complexes (BLOCs).

3 idneys should be used as single grafts or en bloc.

4 2 locus and the capture of the cps island en bloc.

5 uncovered novel allele-specific features of BLOCs.

6 These results suggest that AP-3 and BLOC-1 act, either in concert or sequentially, to specif

7 We discuss similarities and differences of BLOC-1 activity in the biogenesis of gut granules as com

8 Deficiencies in AP-3 and BLOC-1 affect synaptic vesicle composition.

9 itive to genetic dosages of loss-of-function BLOC-1 alleles.

10 novel vesicle transport mechanism requiring BLOC-1 and AP-3 complexes for cargo sorting from neurona

11 PI4KIIalpha copurified with BLOC-1 and AP-3 in neuronal cells.

12 Dysbindin/BLOC-1 and ATP7A genetically and biochemically interact.

13 quent observations that AP-3, as well as the BLOC-1 and BLOC-2 Hermansky-Pudlak syndrome proteins are

14 BLOC-1 and BLOC-2, together with the AP-3 clathrin adapt

15 Dennis et al. report differential roles for BLOC-1 and BLOC-3 complexes in delivery and recycling of

16 hypopigmentation phenotypes associated with BLOC-1 and BLOC-3 deficiency in Hermansky-Pudlak syndrom

17 e that the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo PI4KIIalpha interact with regulator

18 BLOC-1 and Msb3 interacted in vivo, and both mutants res

19 omal sorting mechanisms mediated by AP-3 and BLOC-1 are perturbed in Hermansky-Pudlak Syndrome, a hum

20 ient mice suggesting that genetic defects in BLOC-1 are upstream of the BDNF phenotype in Mecp2 defic

21 or (GEF) of Ypt7 (the Mon1-Ccz1 complex) and BLOC-1 both localize to the same endosomes.

22 2 transport to melanosomes and indicate that BLOC-1 can cooperate with either adaptor during cargo so

23 dies expand the functional repertoire of the BLOC-1 complex and provide insight into putative molecul

24 We previously identified the hexameric BLOC-1 complex as an effector of the yeast Rab5 Vps21, w

25 that Arp2/3, dysbindin, and subunits of the BLOC-1 complex biochemically and genetically interact, m

26 ed prevalent and novel cellular roles of the BLOC-1 complex in neuronal cells by performing large-sca

27 subunits, some of which are shared with the BLOC-1 complex involved in the biogenesis of lysosome-re

28 These results indicate that the BLOC-1 complex is conserved in C. elegans.

29 Our analysis indicates that BLOC-1 complex modulates the association of PI4KIIalpha

30 and its product dysbindin, a subunit of the BLOC-1 complex, and describe a neuronal pathway modulati

31 entified 24 proteins that associate with the BLOC-1 complex, many of which were altered in content/di

32 Of importance, BLOC-1 complex, WASH complex, RhoGEF1, or PI4KIIalpha de

33 ssembles, with dysbindin, into the octameric BLOC-1 complex.

34 an be caused by mutations in subunits of the BLOC-1 complex.

35 The yeast BLOC-1 consisted of six subunits, which localized interd

36 We thus conclude that BLOC-1 controls the lifetime of active Rab5/Vps21 and th

37 We show here that BLOC-1 coordinates the kinesin KIF13A-dependent pulling

38 Human dysbindin/BLOC-1 coprecipitates with NSF and vice versa, and both

39 In fact, BLOC-1 deficiencies selectively reduced AP-3 and AP-3 ca

40 ntent in the dentate gyrus of dysbindin-null BLOC-1 deficiency and AP-3-null mice.

41 hinery as factors downregulated in dysbindin/BLOC-1 deficiency in neuroectodermal cells and iPSC-deri

42 ts into the metabolic consequences caused by BLOC-1 deficiency in pallid mice, which carry a null mut

43 Here, we have generated a fly model of BLOC-1 deficiency.

44 NF content was reduced in the hippocampus of BLOC-1 deficient mice suggesting that genetic defects in

45 However, here we report that AP-3 and BLOC-1 differentially regulate the composition of presyn

46 Our results demonstrate that dysbindin/BLOC-1 expression defects result in altered cellular con

47 -1- and AP-3-favoring OCA2 variants required BLOC-1 for melanosomal transport.

48 rry the cargo protein TYRP1 and that require BLOC-1 for their formation.

49 ogaster as a powerful model for the study of BLOC-1 function and its interactions with modifier genes

50 Epistatic analyses revealed that BLOC-1 function in pigment granule biogenesis requires t

51 as compared to mammalian melanosomes, where BLOC-1 has been most extensively studied for its role in

52 -3(-) and BLOC-1(-) phenotypes revealed that BLOC-1 has some functions independent of the AP-3 adapto

53 his is the first demonstration of a role for BLOC-1 in ciliary assembly and highlights the complexity

54 Consistent with the role of BLOC-1 in sorting from the endosome, we find that disrup

55 New findings include BLOC-1 interactions with the COG complex, a Golgi appara

56 Importantly, BLOC-1 interacts with the HOPS on vacuoles, suggesting a

57 We now demonstrate that BLOC-1 is an endosomal Rab-GAP (GTPase-activating protei

58 Additionally, our data show that BLOC-1 is both a Vps21 effector and an adapter for its G

59 of the Arp2/3 complex were downregulated by BLOC-1 loss of function, thus affecting actin dynamics i

60 e cellular content is sensitive to dysbindin/BLOC-1 loss of function.

61 ound 491 proteins sensitive to dysbindin and BLOC-1 loss of function.

62 Dysbindin/BLOC-1 loss-of-function alleles do not affect cell and t

63 We focused on BLOC-1 mutants affecting synapse composition and functio

64 elocalization is prevented by loss of either BLOC-1 or Msb3, but it also occurs in mutants lacking en

65 o test the hypothesis that NSF and dysbindin/BLOC-1 participate in a pathway-regulating synaptic func

66 and complex adaptive behavior in response to BLOC-1 perturbation.

67 We biochemically confirmed BLOC-1 presence in Drosophila neurons, and measured syna

68 y with an increase in the expression of both BLOC-1 related complex subunit 7 (BORCS7) and a previous

69 ks, or interactomes, downstream of dysbindin/BLOC-1 remain partially explored despite their potential

70 However, the molecular function of BLOC-1 remains unknown.

71 nterneuron markers, as well as expression of BLOC-1 subunit gene products, were affected differently

72 n glo-2 and snpn-1,or RNAi targeting 5 other BLOC-1 subunit homologues in a genetic background sensit

73 no acid identity, encode Pallidin and Snapin BLOC-1 subunit homologues, respectively.

74 BLOC-1 subunit interactions involving Pallidin and Snapi

75 We defined the distribution of the BLOC-1 subunit pallidin in human and mouse hippocampus a

76 Moreover, because BLOC-1 subunits are mutated in subtypes of the genetic d

77 Mutations in BLOC-1 subunits underlie an inherited disorder character

78 In the absence of BLOC-1 subunits, the balance between recycling and degra

79 genes encoding dysbindin and its interacting BLOC-1 subunits.

80 In metazoan cells, three complexes, termed BLOC-1 to -3, mediate protein sorting from the early end

81 BLOC-1(-) intestinal cells missorted gut granule cargo t

82 utant analysis and comparison of AP-3(-) and BLOC-1(-) phenotypes revealed that BLOC-1 has some funct

83 is of lysosome-related organelles complex-1 (BLOC-1) for ciliary delivery.

84 is of Lysosome-Related Organelles Complex 1 (BLOC-1) is a protein complex containing the schizophreni

85 is of lysosome-related organelles complex 1 (BLOC-1) is a protein complex formed by the products of e

86 is of lysosome-related organelles complex-1 (BLOC-1) is a protein complex involved in the formation o

87 is of lysosome-related organelles complex 1 (BLOC-1) required for lysosome-related organelle biogenes

88 is of lysosome-related organelles complex-1 (BLOC-1), and associated interacting proteins.

89 is of lysosome-related organelles complex 1 (BLOC-1), increased the content of characteristic synapti

90 is of lysosome-related organelles complex-1 (BLOC-1), interact with and are regulated by the lipid ki

91 is of lysosome-related organelles complex 1 (BLOC-1), which interacts with the adaptor protein comple

92 is of lysosome-related organelles complex-1 (BLOC-1)-dependent manner.

93 is of lysosome-related organelles complex 1 (BLOC-1).

94 ypic fusion and vacuole protein sorting, and BLOC-1, -2, and -3.

95 Our results imply that (1) AP-3, BLOC-1, and BLOC-3 facilitate protein sorting to lysosom

96 AP-3 was co-isolated with BLOC-1, BLOC-2, and homotypic fusion and vacuole protein

97 udlak syndrome complexes, we identified that BLOC-1, but not BLOC-2 or BLOC-3, deficiencies affect PI

98 , and down-regulation of either PI4KIIalpha, BLOC-1, or AP-3 complexes led to similar LAMP1 phenotype

99 BLOC-1, PI4KIIalpha, and AP-3 belong to a tripartite com

100 Loss-of-function alleles of BLOC-1, Pldn(pa/pa), and Muted(mu/mu) revealed that this

101 of lysosome-related organelles complex-1, or BLOC-1, proteins in these individuals.

102 To address the function of C. elegans BLOC-1, we assessed the intracellular sorting of CDF-2::

103 fecting actin dynamics in early endosomes of BLOC-1-deficient cells.

104 mory and behavioural impairments observed in BLOC-1-deficient mice.

105 However, whether AP-3-BLOC-1-dependent sorting events that control synapse mem

106 n, we examined the role for NSF in dysbindin/BLOC-1-dependent synaptic homeostatic plasticity in Dros

107 r data suggest that VAMP7 mediates fusion of BLOC-1-dependent transport carriers with melanosomes, il

108 les, our data reveal that dysfunction of the BLOC-1-KIF13A-Annexin A2 molecular network underlies the

109 dent factors in the hippocampus of dysbindin/BLOC-1-null mice.

110 However, the striatum did not exhibit these BLOC-1-null phenotypes.

111 show that Ragulator directly interacts with BLOC-1-related complex (BORC), a multi-subunit complex p

112 C-terminal domain of lyspersin, a subunit of BLOC-1-related complex (BORC), is essential and sufficie

113 Here we show that part of the BLOC-1-related complex (BORC), previously shown to regul

114 ntent and/or subcellular distribution of the BLOC-1-sensitive cargoes PI4KIIalpha, ATP7A, and VAMP7.

115 ical molecular pathways contained within the BLOC-1-sensitive proteome.

116 osome-related organelles complex (BLOC)-3 or BLOC-1.

117 , a subunit of the endosomal sorting complex BLOC-1.

118 istribution in cells or tissues deficient in BLOC-1.

119 ach neurites in cells lacking either AP-3 or BLOC-1.

120 some biogenesis requires the protein complex BLOC-1.

121 ng: LE transport regulates SV pool size, and BLOC-1/AP-3-dependent sorting fine-tunes the Ca(2+) sens

122 tion regulates SV positional priming through BLOC-1/AP-3-dependent sorting.

123 nderwent transthoracic esophagectomy with en bloc 2-field lymphadenectomy after neoadjuvant therapy w

124 le after transthoracic esophagectomy with en bloc 2-field lymphadenectomy in patients post neoadjuvan

125 nesis of lysosome-related organelle complex (BLOC)-2.

126 ranule biogenesis requires the activities of BLOC-2 and a putative Rab guanine-nucleotide-exchange fa

127 These studies show that, although BLOC-2 and exocyst cooperate in WPB formation, only exoc

128 However, BLOC-2 and exocyst showed very different effects on VWF

129 Depletion of BLOC-2 caused misdirection of cargo-carrying transport t

130 Although BLOC-2 depletion impaired exocytosis, exocyst depletion

131 Depletion of the exocyst complex phenocopied BLOC-2 depletion, resulting in immature WPBs.

132 These results support a model in which BLOC-2 functions to direct recycling endosomal tubular t

133 vations that AP-3, as well as the BLOC-1 and BLOC-2 Hermansky-Pudlak syndrome proteins are essential

134 Immunoprecipitation of BLOC-2 identified the exocyst complex as a binding partn

135 ed predominantly with the HPS-5 component of BLOC-2 in normal human melanocytes.

136 omplexes, we identified that BLOC-1, but not BLOC-2 or BLOC-3, deficiencies affect PI4KIIalpha inclus

137 ore, releasates of immature WPBs from either BLOC-2 or exocyst-depleted endothelial cells lacked high

138 t melanocytes from mouse HPS models to place BLOC-2 within a cargo transport pathway from recycling e

139 sis of lysosome-related organelle complex-2 (BLOC-2) (HPS-5), BLOC-3 (HPS-1), and adaptin-3 (HPS-2).

140 biogenesis of lysosomal related organelle-2 (BLOC-2) functions in the biogenesis of platelet dense gr

141 ubtypes result from mutations in subunits of BLOC-2, a protein complex with no known molecular functi

142 AP-3 was co-isolated with BLOC-1, BLOC-2, and homotypic fusion and vacuole protein sorting

143 BLOC-2, AP-3, and AP-1 coimmunoprecipitated with Rab38 a

144 steady state levels of known cargoes of the BLOC-2, AP-3, and AP-1 pathways, the melanin-synthesizin

145 BLOC-2, AP-3, AP-1, and clathrin partially colocalized w

146 BLOC-1 and BLOC-2, together with the AP-3 clathrin adaptor complex,

147 uring melanosomes; in contrast, tubules from BLOC-2-deficient cells were shorter in length and made f

148 In BLOC-2-deficient melanocytes, the melanosomal protein TY

149 ome-related organelles, we hypothesized that BLOC-2-dependent endolysosomal trafficking is essential

150 al for WPB biogenesis and sought to identify BLOC-2-interacting proteins.

151 orms of VWF, demonstrating the importance of BLOC-2/exocyst-mediated endosomal input during VWF matur

152 eys not recovered, 21 not transplanted, 8 en bloc, 23 with extrarenal organs, and 6 with missing reco

153 esis of lysosome-related organelles complex (BLOC)-3 or BLOC-1.

154 esis of lysosome-related organelles complex (BLOC)-3, and patients with BLOC-3 or AP-3 deficiency dev

155 elated organelle complex-2 (BLOC-2) (HPS-5), BLOC-3 (HPS-1), and adaptin-3 (HPS-2).

156 ing Rab-32 or its nucleotide exchange factor BLOC-3 are permissive to S. Typhi infection and exhibit

157 New work identifies BLOC-3 as a guanine nucleotide exchange factor for two R

158 In addition, we show that BLOC-3 can promote specific membrane recruitment of Rab3

159 earlier work, we found that a subunit of the BLOC-3 complex inhibits loading of Argonaute (Ago) prote

160 al. report differential roles for BLOC-1 and BLOC-3 complexes in delivery and recycling of melanosoma

161 tation phenotypes associated with BLOC-1 and BLOC-3 deficiency in Hermansky-Pudlak syndrome variants.

162 Our results imply that (1) AP-3, BLOC-1, and BLOC-3 facilitate protein sorting to lysosomes to suppor

163 Mammals lacking BLOC-3 have impaired formation of melanosomes, a type of

164 We now demonstrate that BLOC-3 is a Rab32 and Rab38 guanine nucleotide exchange

165 In this paper, we show that BLOC-3 is required for biogenesis of Drosophila LROs cal

166 These characteristics indicate that BLOC-3 might function as a Rab9 effector in the biogenes

167 receptor CRTH2, which trafficked normally in BLOC-3 mutant HPS.

168 ganelles complex (BLOC)-3, and patients with BLOC-3 or AP-3 deficiency develop pulmonary fibrosis.

169 molecular functions of the Hps1-Hps4 complex BLOC-3 remain mysterious.

170 Silencing of the BLOC-3 subunits Hps1 and Hps4 results in the mislocaliza

171 BLOC-3 therefore defines a novel Rab GEF family with a s

172 reveals a specific and strong interaction of BLOC-3 with the GTP-bound form of the endosomal GTPase,

173 sis of lysosome-related organelle complex 3 (BLOC-3).

174 is of lysosome-related organelles complex-3 (BLOC-3).

175 we identified that BLOC-1, but not BLOC-2 or BLOC-3, deficiencies affect PI4KIIalpha inclusion into A

176 educed virulence, which is fully restored in BLOC-3-deficient mice.

177 -13Ralpha2 as a consequence of dysfunctional BLOC-3-dependent membrane trafficking.

178 ARE recycling from melanosomes as a critical BLOC-3-dependent step, and likely explain the distinct h

179 rom defects in a mysterious protein complex, BLOC-3.

180 the absence of any other protein as part of BLOC-3.

181 on is dependent on the RAB38 exchange factor BLOC-3.

182 Teeth with defects were excised en bloc and analyzed by microcomputed tomography (microCT)

183 were repeated, and the teeth were removed en bloc and prepared for histomorphologic analysis.

184 Clones containing en bloc and promoter deletions that consistently displayed

185 The coagulation zones were excised en bloc and sectioned into approximately 4-mm slices for me

186 ace forms before Ca(2+) triggering, moves en bloc as Ca(2+) influx promotes the interactions between

187 y (DBS)) is placed over RTN in an ex-vivo en bloc brain and changes in cation concentration in the di

188 and subsequently transferred to proteins en bloc by an OTase.

189 rench and by eventual alignment with eastern bloc Communist countries, thus isolating much of his wor

190 mor extirpation via either en-bloc or non-en-bloc complete resection based on FS analysis is associat

191 n of Rab32 or of an essential component of a BLOC complex was sufficient to allow S. Typhi to survive

192 urvive in macrophages from mice defective in BLOC components.

193 oss 3 groups: complete resection achieved en-bloc (CR-EB), complete resection achieved non-en-bloc (C

194 (CR-EB), complete resection achieved non-en-bloc (CR-NEB), and IR.

195 scores to match 148 en bloc with 581 non-en bloc deceased donor recipients (matching variables: tran

196 ith increased frequency as single (SK) or en bloc (EBK) kidneys.

197 All patients had undergone transthoracic en bloc esophagectomy, with a median of 27 resected lymph n

198 wed 6 to 8 weeks later by a transthoracic en bloc esophagectomy.

199 All patients underwent an en bloc esophagectomy.

200 eocortical enhancers did not originate by en bloc exaptation of transposons.

201 En bloc excision of these lesions was successful and avoide

202 ordomas of the mobile spine and sacrum is en-bloc excision with wide margins and postoperative extern

203 three patients were surgically extracted en bloc for histologic and microcomputed tomography (micro-

204 essels and draining lymph nodes) obtained en bloc from 72 individual donors.

205 n of Poh1, which removes ubiquitin chains en bloc from proteasomal substrates prior to their degradat

206 Resections were en bloc, full thickness, and had complete margins.

207 suppressed during gaze saccades made with en bloc, head and body together, rotations.

208 a case series of adult patients receiving en-bloc heart-liver transplantation (HLTx), describe techni

209 etrospective review of patients receiving en-bloc HLTx over 18 months, with clinical follow up to 1 y

210 En-bloc HLTx technique is a safe and effective strategy, de

211 satisfactory when transplanted as SKs or en bloc; however, the absence of an aortic patch in SK tran

212 genomes are transmitted from cell-to-cell en bloc in membrane-bound PS vesicles instead of as single

213 und along Kcnq1ot1, interrupting a biallelic BLOC in the Kcnq1-Cdkn1c domain.

214 re capable of removing neoplastic lesions en bloc in the upper gastrointestinal tract.

215 e segment from chromosome 15 was inserted en bloc into the second intron of the RARA gene on chromoso

216 whereas broad local enrichment of H3K27me3 (BLOC) is a domain-wide feature at imprinted clusters.

217 ient and death-censored graft survival of en bloc kidney (EBK) and split kidney (SpK) transplants fro

218 tudy is to compare graft survival (GS) of en bloc kidney (EBK) from young pediatric donors to other d

219 En bloc kidney donors were on average younger (12+/-10 vs.

220 consisted of 195 recipients of pediatric en bloc kidney grafts throughout a 10-year period.

221 ted with vascular thrombosis of pediatric en bloc kidney grafts.

222 c single kidney transplant (SKT, n=3712), en bloc kidney transplant (EBK, n=1517), or adult standard

223 cellent long-term outcome after pediatric en bloc kidney transplantation from donors weighing less th

224 Pediatric en-bloc kidney transplantation into adult recipients is an

225 pact later renal function after pediatric en-bloc kidney transplantation into adults.

226 there has been hesitancy in transplanting en bloc kidneys from donors weighing less than 10 kg due to

227 En bloc kidneys from pediatric donors have been considered

228 elp stratify patients receiving pediatric en bloc kidneys into risk categories for vascular thrombosi

229 Use of pediatric en bloc kidneys should be encouraged continuously to addres

230 thogenicity locus presumably acquired via en bloc mobilization from a direct predecessor of equine pV

231 y-associating domains (TADs) that undergo en bloc movements, and identify dynamically coupled distal

232 ive morbidity and mortality rates, and an en bloc multivisceral resection should be performed in pati

233 ed seventy-one patients had transthoracic en bloc (n = 161) or transhiatal esophagectomy (n = 10) for

234 ormed to compare outcomes after pediatric en bloc (n=20, mean donor weight 11.4 kg), standard criteri

235 weight, 27 kg); SCDKT (n=283); pediatric en bloc (n=21), living-donor (n=275), and extended criteria

236 my, complete tumor extirpation via either en-bloc or non-en-bloc complete resection based on FS analy

237 omplete resection of the tumour mass with en-bloc organ resection as necessary.

238 Ancestry aligned to these regional blocs, overlapping with both the parasite's origin and w

239 Then, the cysts were en bloc-passaged, attached to culture surface, and grew, fo

240 Conversely, en bloc pediatric kidney transplant was more common in the

241 graft losses can be minimized when using en bloc pediatric kidneys from donors weighing less than or

242 lthough pancreaticoduodenectomy (PD) with en-bloc portal vein/superior mesenteric vein (PV/SMV) resec

243 rhythmic inspiratory activity in isolated en bloc preparations even after acidic or serotonergic stim

244 llowed to extend membrane protrusions in the BloC-Printing device for 3 h, multiple biophysical chara

245 BloC-Printing has a minimum turnaround time of 0.5 h, a

246 In light of this discovery, BloC-Printing may serve as a rapid and high-throughput c

247 ing technique, termed "Block-Cell-Printing" (BloC-Printing), allows for convenient, precise, multiple

248 re, primary neurons are also compatible with BloC-Printing.

249 find that it removes chains from cyclin B en bloc, proceeding until a single chain remains.

250 Compared with non-en bloc recipients, en bloc recipients had lower 1-y graft survival (78.9% vers

251 En bloc recipients had superior 10-y patient (89.0% versus

252 he increased risk of 1-y graft loss among en bloc recipients only appeared in the oldest era.

253 lant Recipients to identify 149 pediatric en bloc recipients transplanted from October 1, 1987 to Dec

254 Compared with non-en bloc recipients, en bloc recipients had lower 1-y graft

255 versus 39.9%; P = 0.04) compared with non-en bloc recipients.

256 h albendazole was instituted and surgical en bloc removal of the cyst was obtained, allowing the pati

257 cosal resection was developed to increase en-bloc resection (less residual disease) of a flat colorec

258 En-bloc resection (P = 0.005) but not resection margin stat

259 s includes local resection (EA or SA) and en bloc resection (pancreaticoduodenectomy).

260 22.9%; PTx and hemithyroidectomy: 24.1%; en bloc resection 15.7%; others 37.3%] and complications of

261 En bloc resection and reconstruction of involved vessels is

262 ve lymph-nodes, who may be candidates for en bloc resection and/or neoadjuvant treatment.

263 Most agree that en bloc resection entails a significant morbidity and morta

264 eness and safety of TAMIS and ESD for the en bloc resection of large non-pedunculated rectal lesions.

265 En-bloc resection of large, flat dysplastic mucosal lesions

266 went extended radical pelvic surgery with en bloc resection of the sciatic or femoral nerves at a sin

267 al time, but is promising due to the high en-bloc resection rates and the very low recurrence rates.

268 ophageal cancer and its treatment with an en bloc resection.

269 e become available for minimally invasive en bloc resections of large non-pedunculated rectal lesions

270 Nine months after surgical correction, en bloc resections were obtained and examined histologicall

271 En bloc sciatic and femoral nerve resection can be performe

272 e achieved after pelvic exenteration with en bloc sciatic nerve resection.

273 pelvic resections, 68 patients (9.5%) had en bloc sciatic or femoral nerve resection.

274 En-bloc specimens containing the graft and soft tissue were

275 detection of synapses from conventionally en-bloc stained 3D electron microscopy image stacks.

276 To avoid this problem, we tested several en bloc staining techniques to contrast tissue in serial se

277 ively to UA in negative staining (NS), in en bloc staining, and post sectioning staining (PSS) of bio

278 this step with other classic heavy metal en bloc stains, including uranyl acetate (UA), lead asparta

279 The 5-year graft survival after en bloc, standard deceased, and LDKT were 92%, 70%, and 88%

280 from a pediatric donor without using the en bloc technique.

281 to a polyisoprenyl donor, followed by the en bloc transfer of the glycan to particular asparagine res

282 n undecaprenyl diphosphate and subsequent en bloc transfer of the glycan to serine residues of select

283 rase (OST), the enzyme that catalyzes the en bloc transfer of the oligosaccharide onto the acceptor a

284 nd attached to Cys(820) before stochastic en bloc transfer to the target protein.

285 smatch, cold ischemia time, and double or en bloc transplant.

286 The outcomes after en bloc transplantation from young donors weighing less tha

287 udies examining the long-term outcomes of en bloc transplantation in children are few.

288 En bloc transplantation of small pediatric kidneys in child

289 En bloc transplantation of small pediatric kidneys in child

290 ank test and examined survival benefit of en bloc transplantation versus remaining on the waiting lis

291 After multivariate adjustment, en bloc transplantation was associated with superior patien

292 We reviewed 20 pediatric en-bloc transplants performed at our institution between 20

293 tions, and urine leak was seen in 1 of 20 en bloc transplants.

294 En bloc venous and/or arterial resection was required in 12

295 es in general, transport multiple virions en bloc via infectious extracellular vesicles, 100~1000 nm

296 Pancreata were removed by en bloc viscerectomy from 65 female Landrace pigs.

297 A maternally biased BLOC was found along the H19-Igf2 domain.

298 Bone resection en bloc was performed in 8.2% of patients (n = 106), and 22

299 ed that the left-handed dimer gets tilted en bloc, whereas conformational transitions to alternative

300 We used propensity scores to match 148 en bloc with 581 non-en bloc deceased donor recipients (mat