ライフサイエンスコーパス: blood concentration

1 ed vasoactivity and increase nitrate/nitrite blood concentration.

2 venous CMT-3 dosed to obtain a 25-micromol/L blood concentration.

3 substrate, to obtain the cyclosporin target blood concentration.

4 ous Abeta concentration compared to arterial blood concentration.

5 maximizes the likelihood of achieving target blood concentrations.

6 exposure being approximately 71% of maternal blood concentrations.

7 30 min for the onset and longer for the peak blood concentrations.

8 sing mucormycosis associated with inadequate blood concentrations.

9 rly rank individuals with respect to 25(OH)D blood concentrations.

10 , few studies have examined the relation for blood concentrations.

11 h intravenous and oral fluconazole alter CNI blood concentrations.

12 ites did not affect healing or produce toxic blood concentrations.

13 cyclosporine emulsion to achieve acceptable blood concentrations.

14 han Caucasian patients to achieve comparable blood concentrations.

15 n of drugs such as lithium, leading to toxic blood concentrations.

16 al transplant recipients correlates with CsA blood concentrations.

17 the cigarette, behavioral tolerance, or THC blood concentrations.

18 sical activity (PA) can modulate sex hormone blood concentrations.

19 mined the outcomes of fetal exposure via ASM blood concentrations.

20 We measured hydroxychloroquine whole-blood concentrations.

21 at the same time as increasing GLP-2 portal blood concentrations.

22 istics are able to withstand individual drug blood concentrations.

23 with alcohol intoxication; median breath or blood concentration, 0.22% [IQR, 0.16%-0.28%]), 630 (53.

24 substantial overlap between minimum apixaban blood concentration, 12-hour area under the curve, and m

25 ty was approximately 50% inhibited at trough blood concentrations (148 microg/L); moreover, inhibitio

26 aplotype were able to withstand lumefantrine blood concentrations 15-fold higher than those with the

27 nstrated that the dose-normalized tacrolimus blood concentration after renal transplantation was asso

28 MEHP dose was chosen based on reported blood concentrations after an exchange transfusion proce

29 pancreatic enzymes and vitamins resulting in blood concentrations almost within the reference range.

30 ry outcome was within-person GLP-1 in venous blood (concentrations and area under the curve).

31 stigate the relationship between amisulpride blood concentration and central D2/3 occupancy in older

32 Accurate analysis of blood concentration and circulation half-life is an impo

33 ative microscopy-based method to measure the blood concentration and circulation half-life of any flu

34 e steroid hormone bioavailability (decreased blood concentration and increased sex hormone-binding gl

35 ignificant negative correlation between ET-1 blood concentration and IOP at the time of DH detection

36 were used to estimate threshold steady state blood concentration and occupancy required to elicit a c

37 effect of matrix metalloproteinase 7 (MMP-7) blood concentration and other demographic and clinical c

38 d a significant correlation between mean CsA blood concentration and the mean degree of inhibition of

39 , guided by close monitoring of cyclosporine blood concentrations and frequent assessments of renal f

40 rolimus, with close monitoring of tacrolimus blood concentrations and frequent assessments of renal f

41 lation was observed between tacrolimus whole blood concentrations and PDC frequencies (Spearman r=-0.

42 valuate the relation between dietary intake, blood concentrations, and retinal concentrations of caro

43 genously, (2) lower C15:0 dietary intake and blood concentrations are associated with higher mortalit

44 The lower fetal blood concentrations are likely due to active efflux tra

45 ted with many health conditions, but optimal blood concentrations are still uncertain.

46 n was seen between DC subsets and tacrolimus blood concentration at any time point.

47 Mean (+/- SD) blood concentrations at 12 and 24 months were, respectiv

48 bserved a 1,000:1 ratio between IP fluid and blood concentrations at 20 mg CsA/kg.

49 icity of PFAS, little is known about whether blood concentrations at breeding sites reliably reflect

50 Miltefosine steady-state blood concentrations at the end of treatment were analyz

51 Systemic exposure to sirolimus was low, with blood concentrations below levels necessary for systemic

52 SRL and EVR were adjusted to maintain whole blood concentrations between 4 and 8 ng/mL.

53 osphate receptors.SA1P also showed different blood concentrations between patients with and without n

54 ormalized) of greatest interest were maximum blood concentration (C(max)/dose), time to reach maximum

55 ailability (F), clearance rate (CL), average blood concentration (C[av]), peak concentration (Cmax),

56 (AUC(inf) ) and maximum observed plasma (or blood) concentration (C(max) ) of cyclosporine with geom

57 harmacokinetic evaluations (maximum observed blood concentration [C(max) ], concentration before dosi

58 ulation of beta-hydroxybutyrate (BHB), whose blood concentrations can reach millimolar levels, concom

59 ration-vs.-time curve (AUC/dose), and trough blood concentrations (Co h/dose).

60 iven orally on a 28-day schedule resulted in blood concentrations comparable to those following low-d

61 ved twofold lower dose-normalized tacrolimus blood concentrations compared with CYP3A5*3/*3 homozygot

62 Sirolimus blood concentration correlated positively with dose and

63 Higher blood concentrations correlated with the achievement of

64 After a short infusion, patupilone blood concentrations declined in a multiphasic manner wi

65 cally correlated closely with the creatinine blood concentration detected by the UCLA Ronald Reagan M

66 infusion of prostacyclin to pathophysiologic blood concentrations did not reproduce such changes.

67 ped chemical similarities after weighting by blood concentrations, disease-risk citations, and number

68 experimental data to the simulated values of blood concentration for 10 target chemicals with various

69 might be sufficient to maintain therapeutic blood concentration for 4-5 days.

70 The units of blood concentration for ketamine and norketamine should

71 r area under the curve, and maximum apixaban blood concentration for patients with and without a majo

72 (RT) reaction, corresponding to an estimated blood concentration from 6.2 x 10(-5) to 6.2 x 10(1) ng/

73 All patients had PSC 833 blood concentrations greater than 1, 000 ng/mL before, d

74 were adjusted individually by assessing SRL blood concentrations, immune function, and clinical stat

75 er's epilepsy status as well as mother's ASM blood concentration in the third trimester (for children

76 We measured blood concentrations in 30 relapsed patients treated wit

77 FFQ data may usefully augment blood concentrations in estimating the intake of caroten

78 t overlap with the upper range of postmortem blood concentrations in fentanyl-related deaths.

79 Their peripheral blood concentrations in glutamate and gamma-aminobutyric

80 wever, data on the prognostic value of their blood concentrations in progressive MS (PMS) are limited

81 O) is endogenously produced in mammals, with blood concentrations in the high micromolar range in the

82 on; however, there is a need for data on TFA blood concentrations in the population.The objective of

83 was a significant delay in achieving target blood concentrations in those with at least one CYP3A5*1

84 alysis of studies comparing allopregnanolone blood concentrations in women with versus without PDS at

85 effect seen either in the time dependency of blood concentration, in the liver/splenic accumulation,

86 to the age of 12 years if the phenylalanine blood concentration is between 360 mumol/L and 600 mumol

87 apeutic index and the correlation of dose to blood concentration is poor as a result of moderate vari

88 the blood activity concentration curve, and blood concentration itself at 40 min, resulting in sever

89 ation for use of legal "per se" Delta(9)-THC blood concentration limits.

90 RIIb on LSEC, a major scavenger, keeps SIC blood concentrations low and minimizes pathologic deposi

91 hoprim-sulfamethoxazole with capillary whole blood concentrations <200 ng/mL had a 3-fold higher haza

92 Low maternal choline intake and blood concentration may be risk factors for having a chi

93 y diseases, but associations with intakes or blood concentrations may arise from other constituents o

94 B-type natriuretic peptide blood concentration measurement appears to be a sensitiv

95 Blood concentration measures provide a potential biomark

96 dosimetry method was more effective than the blood concentration method in determining the optimal ti

97 In contrast, the simple blood concentration method suggested an interval about 7

98 ts were not seen for maximum third trimester blood concentrations (n=258; adjusted parameter estimate

99 odds ratios for different exposure levels to blood concentrations normalised to a percentile scale.

100 Peak blood concentration of (68)Ga-PSMA-R2 was typically obse

101 Enhanced marrow perfusion, an increased blood concentration of (99m)Tc-MAG3, and marrow hyperpla

102 median age 71.2 years old) with a median B12 blood concentration of 414.8 pmol/L (as measured by auto

103 At a blood concentration of 80 pg/ml, BNP was an accurate pre

104 The blood concentration of [5-(15)N]-glutamine (microM) was

105 ALL patients by adjusting doses based on the blood concentration of active drug metabolite could sign

106 onic diseases in which low dietary intake or blood concentration of alpha-tocopherol have been implic

107 I: -0.12, -0.01; beta: 0.03; P = .01), lower blood concentration of bilirubin (B: -0.01; 95% CI: -0.0

108 often have impaired renal function, and the blood concentration of cardiac troponin often increases

109 y was paralleled by a reduction in the basal blood concentration of corticosterone.

110 ilure is characterized by an increase in the blood concentration of creatinine and nitrogenous waste

111 (AUC ratios) did not increase with the mean blood concentration of CsA, indicating a near-maximal P-

112 ation-versus-time curve and the mean maximum blood concentration of cyclosporine-both normalized for

113 s of Abs and pharmacokinetic fluctuations in blood concentration of drug are not essential to inducin

114 The blood concentration of fibrocytes expressing the chemoki

115 The blood concentration of HbF, or the number of cells with

116 in measurements to closely track the dynamic blood concentration of insulin during insulin therapy an

117 The mean trough blood concentration of ISATX247 was 120 +/- 32 ng/mL and

118 nophen-induced liver damage, assessed by the blood concentration of liver enzymes and liver histology

119 ies, rejection episodes, renal function, and blood concentration of medications.

120 iable and high-efficiency measurement of the blood concentration of most common PET and SPECT radiotr

121 ange in plasma glucose and cortisol, and the blood concentration of neutrophils (F[14, 112] = 5.13, P

122 insulin resistance appears to be an elevated blood concentration of plasminogen activator inhibitor t

123 The blood concentration of soluble CD14 (sCD14) increases du

124 , and renal impairment appeared to influence blood concentration of the drug, impacting bioavailabili

125 ells (DU145) spiked into a sample with whole blood concentration of the peripheral blood mononuclear

126 oodstream work together to amplify the total blood concentration of these tiny biomarkers.

127 timulating hormone (TSH), an increase in the blood concentration of thyroid hormone (T4), increased e

128 on of monounsaturated fatty acids and higher blood concentration of triglycerides.

129 From the literature we obtained human blood concentrations of 1,561 small molecules and metals

130 Blood concentrations of 122 persistent environmental pol

131 ntial exposures to environmental toxins, and blood concentrations of 122 persistent environmental pol

132 Whole blood concentrations of 13.5 umol/L (95% credible interv

133 ioxidants was assessed, and the summed molar blood concentrations of 14 POPs were positively related

134 Higher blood concentrations of 17-betaE, higher accumulation in

135 Blood concentrations of 19 persistent organic pollutants

136 Maintaining blood concentrations of 25-hydroxyvitamin D above 80 nmo

137 study was to evaluate the relations between blood concentrations of 36 polyphenols and TC risk in EP

138 ysis, each 1 standard deviation increment in blood concentrations of ALA was associated with a lower

139 APOE e4 did not correlate with blood concentrations of another 9 inflammatory cytokines

140 APOE epsilon4 did not correlate with blood concentrations of another 9 inflammatory cytokines

141 ring pregnancy in women with epilepsy, lower blood concentrations of antiseizure medications can have

142 Elevated blood concentrations of asymmetric dimethylarginine (ADM

143 Compared with men with high blood concentrations of beta-carotene or cholesterol-adj

144 In this study, telaprevir increased the blood concentrations of both cyclosporine and tacrolimus

145 Elevated blood concentrations of BR, especially in the neonatal p

146 temic hyperinflammation defined by increased blood concentrations of C-reactive protein or ferritin w

147 h our study raises the possibility that high blood concentrations of caffeic, 3,4-dihydroxyphenylprop

148 Blood concentrations of cardiac troponin above the 99(th

149 of prospective studies of dietary intake and blood concentrations of carotenoids and breast cancer ri

150 assessment has compared dietary intake with blood concentrations of carotenoids and breast cancer ri

151 Blood concentrations of carotenoids are more strongly as

152 Blood concentrations of carotenoids have been proposed a

153 In contrast, the summary RR for blood concentrations of carotenoids was 0.78 (95% CI: 0.

154 ve SSB consumption (independent variable) to blood concentrations of ceramides (C16:0, C22:0, and C24

155 eing oxidative stress and alterations in the blood concentrations of compounds that influence oxidati

156 Elevated blood concentrations of corticosterone (CORT), an adrena

157 or weakness combined with large increases in blood concentrations of creatine kinase), new-onset diab

158 Blood concentrations of CsA at 15 min after the 45-min i

159 ung disease, is predicted by the circulating blood concentrations of CXCL13.

160 found no clear relationship between specific blood concentrations of Delta(9)-tetrahydrocannabinol (D

161 In contrast to EPA and DHA, blood concentrations of DPA were not correlated with die

162 Blood concentrations of ferritin, transferrin receptor,

163 associations of toenail selenium levels with blood concentrations of fibrinogen, high-sensitivity C-r

164 Blood concentrations of folate and UMFA were measured wi

165 ere assessed for their association with cord blood concentrations of folate and UMFA.

166 ctive study, we determined maternal and cord blood concentrations of folate and unmetabolized folic a

167 RTE or SUP increases usual daily intakes and blood concentrations of folate and vitamin B-12.

168 ogic studies indicate that higher intakes or blood concentrations of folate are associated with a low

169 High blood concentrations of folic acid may be related to dec

170 w nanomolar concentrations, corresponding to blood concentrations of free genistein attained after di

171 ile, there was a significant increase in the blood concentrations of glial fibrillary acidic protein

172 se FGF19 ortholog) fail to properly maintain blood concentrations of glucose and normal postprandial

173 Blood concentrations of high-sensitivity C reactive prot

174 findings from observational studies relating blood concentrations of hyperinsulinemia markers to brea

175 T cells of wild-type (N) mice, have elevated blood concentrations of IgE, IgG1, and eosinophils; enha

176 ale epidemiological studies demonstrate that blood concentrations of immunoreactive insulin predict t

177 Overall, these results emphasize that blood concentrations of individual long-chain polyunsatu

178 a cascade of events associated with abnormal blood concentrations of insulin, glucose, or lipids that

179 Blood concentrations of interleukin 1ra (IL-1ra), IL-6,

180 Whole-blood concentrations of ISATX247 and cyclosporine, compl

181 Blood concentrations of ketamine and its metabolites dur

182 This new model predicts mean daily blood concentrations of key hormones during a contracept

183 sh consumption or dietary omega-3 PUFAs with blood concentrations of lead, cadmium, methyl mercury, a

184 ssociations of mixtures of omega-3 PUFAs and blood concentrations of lead, cadmium, selenium, and met

185 FAS concentrations and birth weight and cord blood concentrations of leptin and adiponectin using dat

186 examined whether pregnancy or umbilical cord blood concentrations of leptin and/or adiponectin a) pre

187 Blood concentrations of lipoproteins and lipids are heri

188 uggest that higher dietary intake and higher blood concentrations of lutein are generally associated

189 er suppression of spermatogenesis, and lower blood concentrations of luteinising hormone at baseline.

190 tem disorders have been associated with high blood concentrations of manganese.

191 d its connection to disease, we sought human blood concentrations of many chemicals, along with their

192 containing thiomersal does not seem to raise blood concentrations of mercury above safe values in inf

193 In the presence of blood concentrations of Mg(2+) , a PhoQ mutant bound mor

194 notherapy resulted in elevated and sustained blood concentrations of MIS, which significantly inhibit

195 ancy (maternal PKU), untreated phenylalanine blood concentrations of more than 360 mumol/L need to be

196 MGDF at 0.5 micrograms/kg/d produced similar blood concentrations of Mpl-ligand and platelets as 10 t

197 Blood concentrations of mutant ATXN3 were high before an

198 Because blood concentrations of n-3 (or omega-3) fatty acids (FA

199 wever, they had metabolic acidosis, elevated blood concentrations of Na(+) and Cl(-), reduced blood p

200 ncreased folic acid intake leads to elevated blood concentrations of naturally occurring folates and

201 The increased blood concentrations of NE and neutrophil extracellular

202 Higher blood concentrations of organochlorine compounds were no

203 Blood concentrations of oxaliplatin were similar in the

204 Associations between cord blood concentrations of p,p -DDE and PCBs and sperm diso

205 type of cytochrome P450 3A4 displayed higher blood concentrations of parent (inactive) cyclophosphami

206 We investigated whether umbilical cord blood concentrations of perfluorooctane sulfonate (PFOS)

207 We also found that high blood concentrations of perfluorooctanoate (PFOA) (media

208 ociations between maternal or umbilical cord blood concentrations of perfluorooctanoic acid and perfl

209 Blood concentrations of Phe across time were not signifi

210 de and B-type natriuretic peptide) and lower blood concentrations of plasminogen activator inhibitor-

211 relationship between case:control status and blood concentrations of pneumoproteins (surfactant prote

212 Blood concentrations of polychlorinated biphenyl (PCB)-1

213 by liquorice (Glycyrrhiza glabra); decreased blood concentrations of prednisolone when taken with the

214 The secondary outcome was blood concentrations of prothrombotic factor plasminogen

215 Patients who developed neuropathy had lower blood concentrations of riboflavin, vitamin E, selenium,

216 plementation, and iron status as measured by blood concentrations of several indicators.

217 pon oral dosing in rats, CAGE increased peak blood concentrations of SRF by 2.2-fold.

218 nzyme 3A4 (CYP3A4), and inhibition increases blood concentrations of statins that are metabolized by

219 From these, blood concentrations of substances of interest were anal

220 The dose-normalized blood concentrations of tacrolimus at 3 months after ren

221 There is marked heterogeneity in blood concentrations of tacrolimus following standard bo

222 contribute to interindividual variability in blood concentrations of the active metabolite of dabigat

223 wined phenomena that are associated with low blood concentrations of the anti-inflammatory and "endog

224 rapeutic drug monitoring in achieving target blood concentrations of the immunosuppressive drugs duri

225 In a pharmacokinetics study, the blood concentrations of the radiolabeled antibodies decr

226 immune cells and moderately correlated with blood concentrations of these cytokines/chemokines in cl

227 Blood concentrations of these drugs may rise to harmful

228 Blood concentrations of these TAT-NSF peptides rapidly d

229 tect LDL from oxidation, and high intakes or blood concentrations of these vitamins have been linked

230 olesterol-adjusted vitamin E, those with low blood concentrations of these vitamins were 2.5 times as

231 olybrominated diphenyl ethers (PBDEs) reduce blood concentrations of thyroid hormones in laboratory a

232 lind, placebo-controlled trial, we evaluated blood concentrations of total arsenic, InAs, MMAs, and D

233 Seven months after surgery, blood concentrations of total bile acids, taurocholic ac

234 Elevated blood concentrations of total homocysteine (tHcy) have b

235 all comparison diets combined for changes in blood concentrations of total, low-density lipoprotein,

236 ian birth cohort (n = 743), we measured cord blood concentrations of tumor necrosis factor (TNF), TNF

237 ed furosemide; and slower in those with high blood concentrations of unmeasured anions (all, p < .05)

238 Blood concentrations of vitamin B-12, folate, homocystei

239 ntake, vitamin C supplementation, and higher blood concentrations of vitamin C are associated with lo

240 t compared with the lowest tertile of lutein blood concentration or intake.

241 Venous blood concentrations or transpulmonary gradients were an

242 in the mean values between plasma and whole blood concentrations (p < .0004; n = 19; paired t-test).

243 with increasing third-trimester maximum ASM blood concentrations (PE, -7.8 [95% CI, -12.6 to -3.1];

244 Tissue uptake was expressed relative to the blood concentration (percentage of injected activity per

245 Elevated BMP10 blood concentrations predict atrial fibrillation (AF), A

246 Thus, blood concentrations prior to egg laying still reflected

247 Peak cobalt whole blood concentrations ranging between 9.4 and 117 mug/L w

248 ice overexpressing human Abeta, the brain-to-blood concentration ratio increased with time due to int

249 th a half-life of 3 to 6 hr and maximum drug blood concentration reached after 0.5 to 1 hr), treatmen

250 markers of metabolic dysfunction with higher blood concentrations reported in obese and diabetic indi

251 of SRL or EVR, targeting similar therapeutic blood concentrations, shows comparable efficacy and safe

252 dietary genistein before implantation led to blood concentrations similar to those measured in genist

253 Blood concentrations spanned 11 orders of magnitude and

254 irment was compared to baseline Delta(9)-THC blood concentrations, subjects with the highest baseline

255 sure and higher likelihood of subtherapeutic blood concentration than does IV administration.

256 ine dialysis patients displaying much higher blood concentrations than the two healthy control subjec

257 ties of many compounds lie within achievable blood concentrations, these results offer an invaluable

258 Blood concentration time curves showed a biexponential d

259 This likelihood was assessed using a maximum blood concentration to in vitro response ratio approach

260 on, including measurements of serial hs-cTnT blood concentrations twice: once using the uniform 99th

261 ated by fitting its predictions of cisplatin blood concentration versus time to measurements made up

262 aximum concentration (t(max), area under the blood concentration-vs.-time curve (AUC/dose), and troug

263 concentration [T(max) ], and area under the blood concentration-vs.-time curve [AUC]) occurred on da

264 The time that the blood concentration was >10 times the half maximal effec

265 The mean maximum blood concentration was 292 ng/mL for temsirolimus and 3

266 Arterial blood concentration was derived from the PET scans by dr

267 Peak vector blood concentration was observed for 4-7 days, and type

268 The average calcineurin inhibition at trough blood concentrations was 80 +/- 11% for ISATX247 and 48

269 al administration was sufficient to maintain blood concentrations well above the IC(50).

270 CQ blood concentrations were below the therapeutic level in

271 m quantitative imaging of (111)In, and (90)Y blood concentrations were determined from (90)Y in seria

272 A total of 1711 tacrolimus whole blood concentrations were evaluated.

273 SRL, but not EVL blood concentrations were inversely correlated with urin

274 er approximately 90 d of dosing, mean cobalt blood concentrations were lower in men than in women.

275 xposure time windows and environmental toxin blood concentrations were separately fit by logistic reg

276 Efficacy is related to blood concentrations, which are determined mainly by hep

277 rfluorononanoate (PFNA) correlated well with blood concentrations, while perfluorooctanoate (PFOA) an

278 contrast medium results in its satisfactory blood concentration with potentially good image quality.

279 ol) showed clear linear trends of increasing blood concentrations with higher self-reported supplemen

280 Fast and accurate determination of oxycodone blood concentration would enable personalized dosing and