ライフサイエンスコーパス: blood culture

1 er outpatients were less likely to receive a blood culture.

2 cardial infarction in the 365 days following blood culture.

3 values of the panel compared to myco/f lytic blood culture.

4 ndary outcome of time to positivity (TTP) of blood culture.

5 imary outcome was typhoid fever confirmed by blood culture.

6 risk of mortality with each day of positive blood culture.

7 s (24% at either time) compared with routine blood culture.

8 (secondary endpoints), and time to negative blood culture.

9 blood cultures, and 458 both respiratory and blood cultures.

10 bacteremias do not require routine follow-up blood cultures.

11 s with suspected enteric fever and performed blood cultures.

12 stem which is approved for use with positive blood cultures.

13 s with parasite antigen stimulation in whole-blood cultures.

14 r to the implementation of RDTs for positive blood cultures.

15 detection implemented directly from positive blood cultures.

16 use rapid diagnostic tests (RDT) on positive blood cultures.

17 stics was validated by comparison to matched blood cultures.

18 antibiotics given to patients with negative blood cultures.

19 ing a multiplex immunoassay or from positive blood cultures.

20 A total of 252 blood cultures, 126 in each group, were included in the

21 y to present Candida growth in all 3 sets of blood cultures (15.4% vs 45.1%; P = .005) and had less s

22 Of 4176 participants receiving blood cultures, 383 (9.2 %) yielded pathogens.

23 A total of 14,180 blood cultures (5,202 preimplementation and 8,978 postim

24 obiological clearance in the first follow-up blood cultures (92.3% vs 69.7% in positive group; P = .0

25 We implemented automatic anaerobic blood culture alongside aerobic blood cultures in a pedi

26 patients, routine inclusion of an anaerobic blood culture alongside the aerobic remains controversia

27 In 211/421 (50.0%) paired blood cultures, an organism was recovered in both cultur

28 We compared qPCR TAC results with blood culture and determined the association of qPCR wit

29 Plausibility of blood culture and next-generation sequencing results as

30 ation <90%) presenting to a clinic underwent blood culture and pneumococcal urine antigen testing (UA

31 Blood culture and T2Bacteria results were positive for t

32 Paired blood culture and T2Bacteria testing.

33 detected among those with complete testing (blood culture and UAT) was multiplied by adjusted ARI in

34 Among ARI cases, 39.0% (340/872) had both blood culture and UAT; 21.2% (72/340) had pneumococcus d

35 e cultures-6,438 respiratory cultures, 5,992 blood cultures and 458 both.

36 d clinical indicators of presumed infection (blood cultures and antibiotics) concurrent with either:

37 e blood cultures from non-S. aureus-positive blood cultures and culture-negative blood, accurately, r

38 duction of Sepsis Alert, including number of blood cultures and lactate measurements taken, percentag

39 resulted in faster FCT in those with sterile blood cultures and less relapses in culture-confirmed en

40 s study, we analysed how results of bile and blood cultures and patient data can be used for selectio

41 linically different from those with positive blood cultures and resistance patterns differ by source.

42 cant pathogens that were negative in aerobic blood cultures and supports the routine collection of bo

43 004 and June 2019 that reported the yield of blood cultures and/or their impact in the clinical manag

44 occurred within 7 days of a positive Candida blood culture, and 5628 (95% CI, 2465-8791) deaths occur

45 d variation in the criteria for collecting a blood culture, and among multiplier studies we identifie

46 nts required hospitalization, 7 had positive blood cultures, and 2 required vasopressor support.

47 ve cultures: 6438 respiratory cultures, 5992 blood cultures, and 458 both respiratory and blood cultu

48 rimary clinical specimens, including sputum, blood cultures, and pus, bacteria from 5 different phyla

49 terial culture was done on 2 sputum samples, blood cultures, and relevant extrapulmonary samples.

50 linically different from those with positive blood cultures, and resistance patterns differ by source

51 able to detect bacterial pathogens in urine, blood cultures, and whole blood and can analyze polymicr

52 e interval [CI], 1.04-3.20) and absence of a blood culture (AOR, 5.26; 95% CI, 2.56-10.00).

53 Here we show that underfilled blood cultures are extremely common but that operational

54 In syndromes where blood cultures are low-yield, blood cultures can be cons

55 Routine blood cultures are recommended in syndromes with a high

56 Blood cultures are routinely collected in pairs of aerob

57 etect very low levels of parasitemia in both blood cultures as well as animal models.

58 d a systematic, standardised surveillance of blood culture-based febrile illness in 13 African sentin

59 uch an approach could complement traditional blood culture-based surveillance or even replace it in s

60 Blood culture (BC) often fails to detect bloodstream mic

61 rbapenem inactivation method [CIM] test with blood cultures [bcCIM]) were assessed on blood cultures

62 Interventions to optimize blood culture (BCx) practices in adult inpatients are li

63 ute difference in the proportion of positive blood cultures between pre- and postantimicrobial testin

64 After exclusions, 970 blood culture/biochemistry sets were analysed.

65 After exclusions, 970 blood culture/biochemistry sets were analyzed.

66 am-negative organisms from the same positive blood culture bottle.

67 med "Blood-mCIM," was evaluated using Bactec blood culture bottles (Becton, Dickinson and Company, Fr

68 d into a sterile lithium-heparin tube before blood culture bottles (diversion group) or blood culture

69 d into a sterile lithium heparin tube before blood culture bottles (diversion group) or blood culture

70 % CI: 1.74 to 6.46; p < 0.001), >=3 positive blood culture bottles (OR: 3.69; 95% CI: 1.88 to 7.23; p

71 alysis using bacterial cultures in pediatric blood culture bottles and panbacterial PCR.

72 Blood culture bottles containing antibiotic binding resi

73 y in BacT/Alert FA Plus and Bactec Aerobic/F blood culture bottles containing antibiotic binding resi

74 Blood culture bottles experimentally inoculated were use

75 c heart valve, and higher number of positive blood culture bottles in the first set of cultures were

76 pact of culture of periprosthetic tissues in blood culture bottles on laboratory workflow and cost.

77 e specimens are obtained and inoculated into blood culture bottles or four periprosthetic tissue spec

78 identification of staphylococcal species in blood culture bottles to help improve antimicrobial stew

79 species adjusted for age, sex, >=3 positive blood culture bottles, native valve disease, prosthetic

80 ning BacT/Alert FA Plus and Bactec Aerobic/F blood culture bottles.

81 on of E. coli and K. pneumoniae in anaerobic blood culture bottles.

82 r antimicrobial resistance genes in positive blood culture bottles.

83 es included bacterial culturing of pediatric blood culture bottles; 16SrDNA amplification and sequenc

84 the direct Vitek 2 AST method from positive blood culture broth for GNR bacteremia with electronic i

85 The assay was positive for all blood culture broths inoculated with CPE isolates and ne

86 lated with CPE isolates and negative for all blood culture broths inoculated with non-CPE isolates, c

87 arbapenemase activity directly from positive blood culture broths.

88 dels to analyze the probability of receiving blood culture by age, and linear regression models to an

89 tification of fungal pathogens from positive blood cultures by culture-based methods can be time-cons

90 yndromes where blood cultures are low-yield, blood cultures can be considered for patients at risk of

91 var Typhi isolates from the 2 hospitals with blood culture capability and matched patient demographic

92 particularly in settings with limited or no blood culture capacity.

93 da panel and mycolytic/fungal (myco/f lytic) blood culture collected simultaneously during hospitaliz

94 Culture negative patients had blood cultures collected at hospital attendance and were

95 dings support the routine use of ISDD during blood culture collection in the ED as a cost-beneficial

96 The routine implementation of ISDD for blood culture collection in the ED was cost beneficial c

97 on device (ISDD) when routinely utilized for blood culture collection in the emergency department (ED

98 was cost beneficial compared to conventional blood culture collection methods.

99 Low prevalence of positive blood cultures, collection of a single set of culture sp

100 the proportion of febrile cases prescribed a blood culture compared with the burden of febrile illnes

101 We enrolled 8,705 blood culture confirmed enteric fever cases: 4,873 (56%)

102 febrile illness that was either suspected or blood culture confirmed for enteric fever.

103 medical, nonmedical, and indirect costs per blood culture-confirmed case incurred by patients and th

104 ompared with 10 000 per arm for trials using blood culture-confirmed cases.

105 uce sample sizes, compared with trials using blood culture-confirmed cases; (3) whether the rate of c

106 e analyzed clinical and laboratory data from blood culture-confirmed enteric fever cases enrolled in

107 Of the 8705 blood culture-confirmed enteric fever cases enrolled, we

108 nical features do not accurately distinguish blood culture-confirmed enteric fever from other febrile

109 caregiver information for 1029 patients with blood culture-confirmed enteric fever or with a nontraum

110 disease severity were variably predictive of blood culture-confirmed enteric fever.

111 rticipants (163 in each arm); 87 (26.7%) had blood culture-confirmed enteric fever.

112 s to determine the primary outcome, which is blood culture-confirmed S. Typhi illness.

113 In sum, 53-193 blood culture-confirmed typhoid cases occurred annually

114 vaccination to measure the rate reduction of blood culture-confirmed typhoid fever in the vaccination

115 Blood culture-confirmed typhoid fever occurred in 7 part

116 time for studies reporting the incidence of blood culture-confirmed typhoid fever.

117 as associated with a significant decrease in blood culture contamination in patients undergoing blood

118 o reduce the clinical and economic impact of blood culture contamination in terms of microbiology, ph

119 Blood culture contamination leads to unnecessary interve

120 Blood culture contamination results in increased hospita

121 t cases, the bacteria isolated in diagnostic blood culture corresponded to the genera in the gut micr

122 tering antimicrobial agents before obtaining blood cultures could potentially decrease time to treatm

123 Blood culture data were available from 2008 (n=2267/7638

124 In the validation cohort, there were 50,514 blood culture days, with 3,762 cases of bacteremia (7.5%

125 There were 252,569 blood culture days-defined as nonoverlapping 24-hour per

126 Accelerate Pheno blood culture detection system (AXDX) provides identific

127 age, 65.6 years; 62.8% men) and had repeated blood cultures drawn after initiation of antimicrobial t

128 apy significantly reduces the sensitivity of blood cultures drawn shortly after treatment initiation.

129 d clinical indicators of presumed infection (blood culture draws and antibiotic administrations) and

130 All hospitalized patients who received a blood culture during hospitalization.

131 severe sepsis or septic shock and a positive blood culture during their hospital encounter with eithe

132 s is necessary to prevent overutilization of blood cultures during patient surges, and laboratories s

133 uate the utilization and diagnostic yield of blood cultures during the COVID-19 pandemic to determine

134 frequencies of approximately 30% whereas in blood cultures, enterobacterales predominated (56% compa

135 In the seven days following index blood culture, excluding recurrent events, there were 89

136 Blood cultures experimentally inoculated with Enterobact

137 e blood culture bottles (diversion group) or blood cultures first and then lithium heparin tube (cont

138 e blood culture bottles (diversion group) or blood cultures first and then lithium-heparin tube (cont

139 any low- and middle-income countries utilize blood culture for diagnostic purposes and to inform trea

140 at a hospital may reduce the sensitivity of blood culture for enteric fever, with implications for b

141 re is still considerable value in performing blood culture for individuals reporting antibiotic use.

142 ence of myocardial infarction 365 days after blood culture for Staphylococcus aureus.

143 in 64.7% and 46.7% of patients with positive blood cultures for P. aeruginosa and Escherichia coli, r

144 tpatients, of whom 2116 (10.1%) had positive blood cultures for S. Typhi and 297 (1.4%) had positive

145 ed a retrospective cohort analysis of 88,201 blood cultures from 28,011 patients at a multicenter net

146 be distinguishes clinical S. aureus-positive blood cultures from non-S. aureus-positive blood culture

147 ptibility testing (AST) results within 8h of blood culture growth.

148 community acquisition, persistently positive blood cultures, >72 h of fever, or foreign body material

149 The use of rapid diagnostic tests (RDTs) for blood cultures has become standard of care in the United

150 entification of microorganisms from positive blood cultures has improved clinical management and anti

151 ted by a rapid-diagnostics platform, BioFire blood culture identification (BCID), with unknown clinic

152 he GenMark Dx ePlex investigational use only blood culture identification fungal pathogen panel (BCID

153 The GenMark Dx ePlex Blood Culture Identification Gram-Positive (BCID-GP) Pan

154 Obtaining blood cultures immediately before a dose and utilizing r

155 These data support the practice of drawing blood cultures immediately before an antibiotic dose to

156 [LAM], urine Xpert MTB/RIF, or tuberculosis blood culture in 79.6% of deaths versus 60.7% of survivo

157 The test showed 93.7% agreement with blood culture in a cohort of 350 patients with a sepsis

158 ociated with a cost savings of $272 (3%) per blood culture in terms of overall hospital costs and $28

159 ic anaerobic blood culture alongside aerobic blood cultures in a pediatric emergency department (ED)

160 culture contamination in patients undergoing blood cultures in an Emergency Department setting.

161 of T2Bacteria compared with a single set of blood cultures in diagnosing proven, probable, and possi

162 toreactivity present at the time of positive blood cultures in patients with Gram-negative and Gram-p

163 encing of 162 isolates obtained from patient blood cultures in Scotland.

164 atients, which supports the judicious use of blood cultures in the absence of compelling evidence for

165 ndividual data of 523 patients with positive blood cultures included in 13 trials, in which patients

166 The sensitivity of blood cultures increases with the volume of blood collec

167 Mean times from start of blood culture incubation to positivity and species ident

168 this Raman-based method could potentially be blood-culture independent, thus saving precious time in

169 with higher sensitivity and specificity than blood culture, indicating that patients might benefit fr

170 which overwhelmed the capacity of automated blood culture instruments.

171 Early confirmation that a blood culture is negative could shorten antibiotic cours

172 Blood culture is not widely available in endemic setting

173 Blood culture is the current standard for diagnosing bac

174 ity of microbiological results from positive blood cultures is essential to enable early pathogen-dir

175 garding indications for initial or follow-up blood cultures is limited.

176 ibiotic management in patients with positive blood cultures is safe remains understudied.

177 Rapid identification from positive blood cultures is standard of care (SOC) in many clinica

178 Blood culture isolates from enrolled patients were teste

179 s poor with a coverage of bacterial bile and blood culture isolates in 51 and 69%, respectively.

180 e determined the whole-genome sequences of 4 blood culture isolates of Staphylococcus aureus and 2 co

181 The most common blood culture isolates were Streptococcus pneumoniae (24

182 parin tubes for diversion prior to obtaining blood cultures lead to a 60% decrease in contamination.

183 ine microbiologic diagnostic methods such as blood culture leading to considerable under-diagnosis of

184 parin tubes for diversion prior to obtaining blood cultures led to a 60% decrease in contamination.

185 aureus (34%) and P. aeruginosa (17%), while blood cultures most commonly grew S.

186 %) and Pseudomonas aeruginosa (17%), whereas blood cultures most commonly grew Streptococcus pneumoni

187 ncluded 5157 CA-SABSI cases matched to 10146 blood culture negative cases.

188 tected capsule from blood samples for 32% of blood culture negative melioidosis patients in both coho

189 th T2Candida panel positive and myco/f lytic blood culture negative results, while 6 patients had T2C

190 tive (aOR 4.6, 95% CI, 2.1-10.0; p < .01) or blood culture-negative (aOR 2.9, 95% CI, 1.2-6.9; p = .0

191 In blood culture-negative endocarditis (BCNE), 22% of cases

192 Moraxella osloensis should be tested in blood culture-negative endocarditis.

193 f preterm birth and is defined by a positive blood culture obtained after 72 h of age.

194 Sensitivity of blood cultures obtained after initiation of antimicrobia

195 ive bile duct cultures and 197 corresponding blood cultures obtained from 348 consecutive patients wi

196 110 VREfm isolates from gastrointestinal and blood cultures of 24 pediatric patients undergoing chemo

197 Although inclusion of anaerobic blood cultures only recovered 2 (0.69%) obligate anaerob

198 if either sputum Gram stain, sputum culture, blood culture, or the immunochromatographic (ICT) BinaxN

199 ict blood culture results at the time of the blood culture order using routine data in the electronic

200 tics are likely to reduce the sensitivity of blood culture, our findings indicate that there is still

201 Patients with >=1 positive blood culture over a 15-month period were grouped by neg

202 All adult septic patients with positive blood cultures over a 7-year period were included in the

203 All adult septic patients with positive blood cultures over a period of 7 years were included in

204 d to inform a diagnostic approach to relieve blood culture overutilization.

205 were assumed to be true positives missed by blood culture, per-patient specificity of T2Bacteria was

206 asked about recent antibiotic use and had a blood culture performed.

207 survey dates to caregivers of patients with blood culture positive cases at enrollment and 6 weeks l

208 their urine were slightly more likely to be blood culture positive for enteric fever; however, the e

209 AT assay accurately distinguished Australian blood culture positive melioidosis patients from Austral

210 ents had T2Candida panel negative and myco/f blood culture positive results.

211 Two infants with blood culture positive sepsis were excluded, and the dat

212 .5; p < .01) and TB qPCR-positivity, whether blood culture-positive (aOR 4.6, 95% CI, 2.1-10.0; p < .

213 The majority (>90%) of blood culture-positive typhoid cases remain unobserved i

214 kine concentrations and also associated with blood culture positivity and 28-day mortality risk.

215 infections (seroefficacy trials) rather than blood culture positivity as a study endpoint may be usef

216 Blood culture positivity results for true pathogens and

217 Over the whole study period, blood culture positivity was 11%, and next-generation se

218 Blood culture positivity was 48.6%, most commonly Staphy

219 evaluate the effect of antimicrobial use on blood culture positivity, adjusted for markers of diseas

220 ine and multiple organ dysfunction severity, blood culture positivity, and 28-day mortality, was conf

221 d the association between antibiotic use and blood culture positivity.

222 gation for cryptococcal disease with LPs and blood cultures, prompt ART initiation, and more intensiv

223 ely recruited children <17 years of age with blood culture-proven sepsis due to Streptococcus pneumon

224 n aged >=28 days and <17 years admitted with blood culture-proven sepsis.

225 uld consider these factors when implementing blood culture RDTs.

226 from 2008 (n=2267/7638, 30%), with positive blood cultures recorded in 42% (950/2267).

227 ecovered 7.6% (349/4,615), whereas anaerobic blood cultures recovered 6.6% (286/4,363).

228 res in the postimplementation phase, aerobic blood cultures recovered 7.6% (349/4,615), whereas anaer

229 lithium-heparin tube prior to aspiration of blood culture reduces contamination.

230 lithium heparin tube prior to aspiration of blood culture reduces contamination.

231 etermine if earlier confirmation of negative blood culture result would shorten antibiotic treatment.

232 formance of select clinical features against blood culture results among outpatients using mixed-effe

233 o develop machine learning models to predict blood culture results at the time of the blood culture o

234 When compared to 5 day blood culture results from both the control and test sam

235 seline risk factors may influence subsequent blood culture results.

236 seline risk factors may influence subsequent blood culture results.

237 ivors longitudinally and recorded subsequent blood culture results.

238 s (FBC) (RR 0.80, 95% CI 0.69-0.92 I2 = 0%), blood cultures (RR 0.82, 95% CI 0.68-0.99; I2 = 0%) and

239 py for fermenting, gram-negative bacteria in blood culture(s) if they were afebrile for 24 hours with

240 The Cognitor Minus test, performed on blood culture samples after 12 hours incubation has a ne

241 Blood culture samples collected at 10 United States site

242 es collected residual, deidentified positive blood culture samples for analysis.

243 To this end, clinical blood culture samples from patients with bloodstream inf

244 detects 15 fungal targets simultaneously in blood culture samples positive for fungi by Gram stainin

245 September 2018 - April 2020, enrolling 7,716 blood culture samples routinely collected in patients wi

246 Incubation of S. aureus-positive blood culture samples with the P2&3TT probe resulted in

247 by bi-directional PCR/sequencing of residual blood culture samples.

248 ips sent for culture: a 6-fold decrease from blood culture sampling trends.

249 eous liver drainage, both abscess fluids and blood cultures showed neither bacterial growth nor micro

250 ular panels directly applicable to blood and blood culture specimens, next-generation metagenomics, a

251 ith blood cultures [bcCIM]) were assessed on blood cultures spiked with 185 different molecularly cha

252 Etiology was defined by blood culture, Streptococcus pneumoniae urinary antigen

253 mate burden are limited to a small number of blood-culture surveillance studies, largely from densely

254 Automated blood culture systems have shown promise as alternatives

255 as Resistome test and VERIGENE gram-negative blood culture test) could identify susceptibility to 2 n

256 entification of fungal pathogens in positive blood cultures that may allow for earlier antifungal int

257 Blood cultures, the gold standard for diagnosing bloodst

258 als presenting to the hospitals and obtained blood cultures to evaluate for enteric fever.

259 eline period with the EOS calculator period, blood culture use decreased from 14.5% to 4.9% (adjusted

260 als in March 2020 led to a sharp increase in blood culture utilization, which overwhelmed the capacit

261 le outpatients and the proportion prescribed blood culture varied by hospital.

262 Between June 2002 and December 2018, a blood culture was collected from 54 748 children aged <=

263 Blood culture was done on 76 cases; 8 (11%) were positiv

264 epal, and Pakistan, and enrolled patients if blood culture was prescribed by the treating physician.

265 Recovery of true pathogens from blood cultures was approximately 7 h faster than recover

266 he order of blood draws for biochemistry and blood cultures was randomized.

267 Using blood cultures, we investigated children presenting with

268 Demographic, clinical data and blood cultures were collected.

269 Blood cultures were conducted at the discretion of the t

270 bapenemase production directly from positive blood cultures were developed applying a concentration a

271 A total of 516 201 blood cultures were evaluated over 40 months.

272 433 paired T2Candida panel and myco/f lytic blood cultures were identified.

273 Six percent of 1,044 positive blood cultures were NB-PC.

274 Positive blood cultures were observed in less than half of patien

275 y enrolled 200 patients per hospital in whom blood cultures were obtained and intravenous antibiotics

276 Blood cultures were obtained before and within 120 minut

277 Blood cultures were obtained from all suspected cases.

278 1427 patients for whom blood cultures were ordered as standard of care.

279 lapping 24-hour periods in which one or more blood cultures were ordered.

280 A total 89643 pediatric blood cultures were performed, and 10621 pathogens were

281 Preantimicrobial blood cultures were positive for 1 or more microbial pat

282 Postantimicrobial blood cultures were positive for 1 or more microbial pat

283 Blood cultures were positive for Klebsiella oxytoca.

284 Blood cultures were sampled in hospital-admitted patient

285 Paired blood cultures were taken in the Critical Care Unit at a

286 n active antibiotic for at least 2 days when blood cultures were taken, and subsequent episodes in th

287 esults from culture-based diagnostics (e.g., blood culture) were obtained.

288 cians should use this panel as an adjunct to blood cultures when making a definitive diagnosis of can

289 amples were collected for histopathology and blood cultures where available.

290 These tests may lack sensitivity (eg, blood culture, which is only positive in a small proport

291 centers, we selected patients with positive blood cultures who underwent surgery during the active p

292 In contrast to blood culture with a positivity rate of 33% at sepsis on

293 The rate of negative blood cultures with a positive T2Bacteria result was 10%

294 as clearly detectable for S. aureus-positive blood cultures with bacterial loads as low as ~ 7,000 co

295 g the catchment area population reported all blood cultures with Candida, and a standard case definit

296 BSIs were positive blood cultures without known contaminants.

297 tics were associated with a 45% reduction in blood culture yield and approximately 20% reduction in y

298 Most positive blood cultures yielded a pathogen (409/549 [74.5%]), pre

299 ion of the probe with non-S. aureus-positive blood cultures yielded essentially background fluorescen

300 A case was initially defined via a blood culture yielding Bcc in a SNF resident receiving i