ライフサイエンスコーパス: blood-retinal barrier

1 schemia, neovascularization, and incompetent blood-retinal barrier).

2 ke by glucose in the cells that comprise the blood-retinal barrier.

3 pate in the induction and maintenance of the blood-retinal barrier.

4 rotein activity in cells that form the outer blood-retinal barrier.

5 disorder associated with dysfunction of the blood-retinal barrier.

6 cyte function at sites of a breakdown in the blood-retinal barrier.

7 e potential for payload transport across the blood-retinal barrier.

8 tinal cells that includes the formation of a blood-retinal barrier.

9 diseases such as DME with compromised outer blood-retinal barrier.

10 It can pass the blood-brain barrier and blood-retinal barrier.

11 h OIR, suggesting a protective effect on the blood-retinal barrier.

12 he extracellular matrix underlying the outer blood/retinal barrier.

13 tinitis, inflamed vasculature, and disrupted blood-retinal barriers.

14 optosis, thereby preserving the integrity of blood-retinal barriers.

15 lly significant increase in breakdown of the blood-retinal barrier (AGE Alb versus Alb, 8.2 vs. 1.6 n

16 n identified as an important mediator of the blood-retinal barrier alteration in diabetic retinopathy

17 l and biological factors possibly related to blood-retinal barrier alterations.

18 Consequent impairment of the outer blood retinal barrier and colonic intestinal epithelial

19 localized breakdown in the integrity of the blood-retinal barrier and aberrations in the organizatio

20 profound vascular abnormalities, loss of the blood-retinal barrier and impaired neuronal function.

21 Breakdown of the blood-retinal barrier and leakage from the retinal vascu

22 arrier (BBB), blood-spinal cord barrier, and blood-retinal barrier and play key roles in maintaining

23 role for Mvarphi-derived CD in altering the blood-retinal barrier and reveal a potential therapeutic

24 , which are a crucial component of the outer blood-retinal barrier and the damage is related to retin

25 suggests that there may be breakdown of the blood-retinal barrier and tight junction integrity in a

26 to cross RPE cell membranes (i.e. the outer blood retinal barrier) and with potential roles in certa

27 patial buffering of ions, maintenance of the blood-retinal barrier, and response to injury.

28 by ischemia, neovascularization, incompetent blood-retinal barrier, and vascular occlusion.

29 )], pericytes (anti-neural/glial antigen 2), blood-retinal barrier [anti-zonula occludens protein 1 (

30 ve acquired the ability to break through the blood-retinal barrier are thought to be causally involve

31 ecome more important during breakdown of the blood-retinal barrier, as seen after TNF-alpha treatment

32 not bind IGF-1 (IGFBP-3NB), to regulate the blood retinal barrier (BRB) using two distinct experimen

33 We hypothesized that Edn2 damages the blood-retinal barrier (BRB) and that this is mediated by

34 Diabetic retinopathy is characterized by blood-retinal barrier (BRB) breakdown and neurotoxicity.

35 Blood-retinal barrier (BRB) breakdown and related vascul

36 kostasis) within the retinal vasculature and blood-retinal barrier (BRB) breakdown and to determine w

37 an attempt to investigate the mechanisms of blood-retinal barrier (BRB) breakdown at a global level,

38 previously showed that lovastatin mitigates blood-retinal barrier (BRB) breakdown in db/db mice.

39 Blood-retinal barrier (BRB) breakdown is a hallmark of d

40 Blood-retinal barrier (BRB) breakdown is responsible for

41 ial growth factor (VEGF) protein levels, and blood-retinal barrier (BRB) breakdown of the animals wer

42 role of reactive oxygen species (ROS) in the blood-retinal barrier (BRB) breakdown that characterizes

43 Blood-retinal barrier (BRB) breakdown was quantified usi

44 The blood-retinal barrier (BRB) consists of tightly intercon

45 sophosphatidylcholine (LPC), are involved in blood-retinal barrier (BRB) damage during diabetic retin

46 es for analyzing drug transport at the inner blood-retinal barrier (BRB) do not completely retain sev

47 othelial growth factor (VEGF) contributes to blood-retinal barrier (BRB) dysfunction in several blind

48 Here, by studying functional blood-retinal barrier (BRB) formation in mice, we found

49 lop and characterize a quantitative assay of blood-retinal barrier (BRB) function in mice and to dete

50 Blood-retinal barrier (BRB) function was assayed by dete

51 he structure and integrity of the retina and blood-retinal barrier (BRB) in the eye.

52 p54/PSF heterodimer may contribute to normal blood-retinal barrier (BRB) induction in vivo.

53 studies, functional MRI was used to measure blood-retinal barrier (BRB) integrity after Gd-DTPA inje

54 In a subgroup of male SD rats, blood-retinal barrier (BRB) integrity was also assessed

55 In vertebrates, a blood-retinal barrier (BRB) is established by tight junc

56 Breakdown of the blood-retinal barrier (BRB) is linked to vision loss in

57 cular endothelial cells comprising the inner blood-retinal barrier (BRB) is mediated by the GLUT1 glu

58 scular permeability due to alteration of the blood-retinal barrier (BRB) is one of the major complica

59 In vivo, blood-retinal barrier (BRB) leakage was studied using th

60 nts are crucial for retinal angiogenesis and blood-retinal barrier (BRB) maturation.

61 block vascular permeability and restore the blood-retinal barrier (BRB) may lead to new therapies.

62 ngements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in disorders ranging f

63 These data suggest differences in the blood-retinal barrier (BRB) of mice and rabbits and indi

64 Blood-retinal barrier (BRB) permeability in uninfected d

65 f this study was to determine to what extent blood-retinal barrier (BRB) permeability occurred during

66 Blood-retinal barrier (BRB) permeability surface area pr

67 Its absence has been related to blood-retinal barrier (BRB) permeability through delocal

68 Loss of blood-retinal barrier (BRB) properties induced by vascul

69 The blood-retinal barrier (BRB) serves as a physiological bo

70 fect of neutrophils in the alteration of the blood-retinal barrier (BRB) was further assessed in wild

71 Uveitis is characterised by breakdown of the blood-retinal barrier (BRB), allowing infiltration of im

72 Breakdown of the blood-retinal barrier (BRB), as occurs in diabetic retin

73 ntry into the endothelial cells of the inner blood-retinal barrier (BRB).

74 trophin Dp71 gene induces a highly permeable blood-retinal barrier (BRB).

75 is important to measure the integrity of the blood-retinal barrier (BRB).

76 esion molecule (ICAM)-1 and breakdown of the blood-retinal barrier (BRB).

77 nto the deep layers of the retina and causes blood-retinal-barrier (BRB) dysfunction in mice.

78 Blood-retinal barrier [BRB] breakdown, characteristic of

79 ffected by hyperglycemia simultaneously with blood retinal barrier breakdown, suggesting that glial a

80 ular endothelial cell injury, apoptosis, and blood-retinal barrier breakdown (P<0.0001) but did not d

81 adhesion molecule-1 (ICAM-1) and results in blood-retinal barrier breakdown and capillary nonperfusi

82 receptor apoptosis, vascular telangiectasis, blood-retinal barrier breakdown and, later, intraretinal

83 IF-1alpha and VEGF increases and the related blood-retinal barrier breakdown are suppressed by inhibi

84 oteinases (MMPs) as a potential cause of the blood-retinal barrier breakdown at the onset of angiogen

85 drops significantly reduced leukostasis and blood-retinal barrier breakdown in a dose-dependent mann

86 Blood-retinal barrier breakdown in diabetic animals trea

87 dothelial cell apoptosis as a major cause of blood-retinal barrier breakdown in early diabetes.

88 Early blood-retinal barrier breakdown in experimental diabetes

89 role in the pathogenesis of blood-brain and blood-retinal barrier breakdown in vivo.

90 Blood-retinal barrier breakdown is markedly increased wi

91 ry cytokines that initiate neuronal loss and blood-retinal barrier breakdown seen in diabetic retinop

92 y produces a transient worsening of diabetic blood-retinal barrier breakdown via an HIF-1alpha-mediat

93 Blood-retinal barrier breakdown was assessed using (3)H-

94 Diabetes-induced blood-retinal barrier breakdown was dose-dependently inh

95 Blood-retinal barrier breakdown was induced in rats with

96 Spatially, early blood-retinal barrier breakdown was localized to the ret

97 Blood-retinal barrier breakdown was quantified using the

98 circulation with an anti-platelet antibody, blood-retinal barrier breakdown worsened in the diabetic

99 rrent study, diabetic vascular permeability (blood-retinal barrier breakdown) is demonstrated to resu

100 elial growth factor (VEGF) triggers diabetic blood-retinal barrier breakdown, and (2) identify the si

101 n apoptosis, oxidative stress, inflammation, blood-retinal barrier breakdown, and neuroprotection.

102 the diabetic retinal vasculature results in blood-retinal barrier breakdown, capillary nonperfusion,

103 iabetic retinal vasculature results in early blood-retinal barrier breakdown, capillary nonperfusion,

104 adhesion molecule-1 levels, leukostasis, and blood-retinal barrier breakdown, in a relevant animal mo

105 sening of diabetic retinopathy, specifically blood-retinal barrier breakdown, that follows the instit

106 cell death and serves, in part, to suppress blood-retinal barrier breakdown.

107 appaB DNA-binding activity, leukostasis, and blood-retinal barrier breakdown.

108 urs, endothelial cell injury ensues, as does blood-retinal barrier breakdown.

109 ocyte adhesion, endothelial cell injury, and blood-retinal barrier breakdown.

110 yte adhesion and endothelial cell injury and blood-retinal barrier breakdown.

111 ch reduced leukocyte adhesion and suppressed blood-retinal barrier breakdown.

112 the isotope-dilution method for quantitating blood-retinal barrier breakdown.

113 approach in the treatment of early diabetic blood-retinal barrier breakdown.

114 as the isotope-dilution method for measuring blood-retinal barrier breakdown.

115 model by determining retinal leukostasis and blood-retinal barrier breakdown.

116 titating vascular leakage and especially the blood-retinal barrier breakdown.

117 xtracted and assayed for leukocyte adhesion; blood-retinal barrier breakdown; VEGF, TNF-alpha, IL-1be

118 etinopathy increases the permeability of the blood-retinal barrier, but the specific vessels that bec

119 TGF-beta may contribute to breakdown of the blood-retinal barrier by stimulating endothelial cell MM

120 Blood-retinal barrier cells are known to exhibit a massi

121 racteristics of tight junctions in the outer blood-retinal barrier change during embryonic developmen

122 Macular oedema typically results from blood-retinal barrier disruption.

123 GF) plays a crucial role in breakdown of the blood-retinal barrier due to hyperpermeability in diabet

124 ivo was demonstrated that was accompanied by blood-retinal barrier dysfunction.

125 ontributing to the pathologic progression of blood-retinal barrier dysfunction.

126 agenase-like activity that may contribute to blood-retinal barrier dysfunction.

127 ssion of pathologic retinal angiogenesis and blood-retinal barrier dysfunction.

128 diabetic retinopathy and macular edema, the blood-retinal barrier fails to function properly, and th

129 ibitor (HDACi), ITF2357, in regulating outer blood-retinal barrier function and investigates the unde

130 Impaired blood-retinal barrier function leads to macular edema th

131 ivo Fluorescein angiography indicated normal blood-retinal barrier function.

132 enhanced apoptotic cell death, and impaired blood-retinal barrier function.

133 erentially contribute to the inner vs. outer blood-retinal barrier function.

134 in the cells comprising the inner and outer blood-retinal barriers: human retinal pigment epithelial

135 icrovascular disorder characterized by inner blood-retinal barrier (iBRB) breakdown and irreversible

136 port for fluids and solutes across the inner blood-retinal barrier (iBRB).

137 nce leukocytes cannot gain entry through the blood-retinal barrier, illustrating that microglia play

138 , through neutrophil recruitment, alters the blood-retinal barrier in diabetic retinopathy and, thus,

139 ricyte interactions during alteration of the blood-retinal barrier in diabetic retinopathy.

140 lity with implications for alteration of the blood-retinal barrier in diabetic retinopathy.

141 l pigmented epithelium (RPE) forms the outer blood-retinal barrier in the eye and its polarity is res

142 th diabetes and induces the breakdown of the blood-retinal barrier in vitro.

143 th diabetes and induces the breakdown of the blood-retinal barrier in vitro.

144 derangements observed in the diabetic inner blood-retinal barrier in vivo.

145 retinal thickness, intraocular pressure, and blood retinal barrier integrity.

146 l layer thickness, intraocular pressure, and blood retinal barrier integrity.

147 tion-dependent manner and that loss of inner blood-retinal barrier integrity induced by diabetes cont

148 We used retinal angiography to study blood-retinal barrier integrity.

149 fic systemic antibodies through the impaired blood-retinal barrier is higher in patients with neovasc

150 Alteration of the blood-retinal barrier is the hallmark of this disease, c

151 helium (RPE), which helps maintain the outer blood-retinal barrier, is a local source for ET-1 and wh

152 olic parameters, key inflammatory mediators, blood-retinal barrier junction molecules, retinal struct

153 cations of diabetes is the alteration of the blood-retinal barrier, leading to retinal edema and cons

154 A may have a protective effect against outer blood-retinal barrier leakage associated with diabetic r

155 tein, the vitreous-plasma protein ratio, and blood-retinal barrier leakage by 3-, 1.7-, 3.1-, and 2.7

156 nd retinal PGE2 secretion, VEGF protein, and blood-retinal barrier leakage were estimated.

157 abetes-induced elevations in PGE2, VEGF, and blood-retinal barrier leakage.

158 Disruption of the outer blood-retinal barrier (oBRB) is a central feature of ret

159 , but transporters for DHA uptake across the blood-retinal barrier or retinal pigment epithelium have

160 ansport, phagocytosis and formation of outer blood-retinal barrier, or possible involvement of JN exp

161 Choroidal contribution or blood-retinal barrier permeability surface area product

162 hese results suggest that astrocytes enhance blood-retinal barrier properties, at least in part by in

163 rowth factor (VEGF)-induced breakdown of the blood-retinal barrier requires protein kinase C (PKC)bet

164 in ICAM-1, leukostasis, and breakdown of the blood-retinal barrier, suggesting that NOX2 is primarily

165 igmented epithelial (RPE) cells maintain the blood-retinal barrier, sustain retinal photoreceptor cel

166 d Fpn is expressed in cells constituting the blood-retinal barrier, the authors tested whether the re

167 litis" based on fundamental knowledge of the blood-retinal barrier, the neurovascular unit, and patho

168 lay important roles in the alteration of the blood-retinal barrier through proteolytic degradation of

169 ining retinal homeostasis and regulating the blood-retinal barrier through secreted factors.

170 There is no evidence of a blood-ocular or blood-retinal barrier to activated T cell blasts.

171 protein [anti-GFAP]) and to investigate the blood-retinal barrier using the tight junction markers z

172 onditions in the subretinal space, the outer blood-retinal barrier was disrupted by compromising reti

173 udy, the potential side effects on the outer blood-retinal barrier were examined.

174 at is highly enriched at the blood-brain and blood-retinal barriers, where it mediates Na(+)-dependen

175 esis during development and formation of the blood-retinal barrier, which is linked to significant do

176 lature itself that results in opening of the blood-retinal barrier with or without retinal vascular o