ライフサイエンスコーパス: blueprint

1 ional design using protein structures as the blueprint.

2 alters genetic information from the genomic blueprint.

3 up of neurons reveals their shared branching blueprint.

4 order of which encodes an organism's genetic blueprint.

5 ely patterned dorsoventrally by a common Dlx blueprint.

6 e, using a sequence-structure alignment as a blueprint.

7 0.4% complete high-stringency human proteome blueprint.

8 tors, patterning TFs prespecify sensory area blueprints.

9 transcription factor-mediated architectural "blueprints."

10 Instead, the innate cochlear blueprint and its actual ontogenetic variants were deter

11 This work provides a blueprint and resources for the systematic genome-wide s

12 erstanding how cells interpret their genetic blueprint and their environment during development, and

13 ith free and open sharing of detailed design blueprints and accessible development tools, rapid proto

14 All Rosetta commands, RosettaRemodel blueprints, and predictions for all datasets used in the

15 This blueprint approach, if extended to other flexible protei

16 development to be guided by both the genetic blueprint as well as the environmental context.

17 eneral design of 9-O-Ac-Sia-binding sites as blueprint, backed-up by automated ligand docking, struct

18 unique differences in levitation and density blueprints between breast, esophageal, colorectal, and n

19 Deliberate digression from this robust blueprint brought a first set of analogues into reach, w

20 hin vertebrates arises from a unique genetic blueprint by combining intrinsic cellular information wi

21 follow the anterior/posterior developmental blueprint by reading out positional information in the B

22 adenosine deamination can alter the genome's blueprint by recoding mRNAs; however, this process too i

23 further intention to align their activities (blueprint, curriculum and centre visitation) with the UE

24 This blueprint describes the consensus from the workshop, ide

25 oded by its gene sequence and that molecular blueprint designs this kinase to be regulated by subcell

26 different hematopoietic cell types from the Blueprint Epigenome project.

27 These structural insights provide a blueprint for a better molecular understanding of the pa

28 explored pocket in Hsp70 and provide a novel blueprint for a cancer-oriented development of Hsp70-dir

29 ts excellent electronic properties provide a blueprint for a potentially rich area of exploration in

30 Here, we provide step-by-step protocols as a blueprint for a terrestrial conservation genetics field

31 to the isocyanoterpene family and provides a blueprint for a very direct synthesis of DICA and relate

32 the mammalian circadian clock and provides a blueprint for advancement in chronotherapy.

33 sting that this approach may offer a general blueprint for affecting redox-neutral S(N)1 substitution

34 The genome is the blueprint for an organism.

35 hat weakens bacterial fitness and could be a blueprint for antivirulence approaches.

36 ies this therapeutic strategy, and provide a blueprint for applying systematic genetic and chemical s

37 These results are a blueprint for applying the 'node and strut' principles o

38 rather than a deficit approach and offers a blueprint for approaching the COVID-19 crisis and its af

39 Here, we present a blueprint for aromatic carbon-hydrogen functionalization

40 uch, this study begins to provide a putative blueprint for base specificity among sugar nucleotide-de

41 hibition of PrL neurons, providing a circuit blueprint for behavioral manipulations.

42 ains in defined cell types would establish a blueprint for better understanding the alteration of sig

43 This work provides a blueprint for building diverse alkaloid scaffolds and en

44 tural plasticity furnishes a next-generation blueprint for CaV channel modulation.

45 Our study provides a blueprint for characterizing the role of bacteria in the

46 logical limitations and provides a strategic blueprint for chemical production.

47 lmarks of this signaling mechanism provide a blueprint for chemical sensing in small compartments, su

48 ine with a helicene-like motif to form a new blueprint for chiral systems with large and tunable nonl

49 for embryological studies, offering a simple blueprint for chordate development.

50 Our results constitute a blueprint for circadian-based seasonal timekeeping in ve

51 ibition of the proximal cascade, providing a blueprint for combination therapy.

52 Our approach provides a blueprint for combining chemical exposures linked to com

53 mental and computational strategy provides a blueprint for comparing immune cell differentiation acro

54 may be regarded as a universally applicable blueprint for comprehensive exploitation of the substant

55 Altogether, ArcPP serves as an invaluable blueprint for comprehensive prokaryotic proteomics.

56 DrugCell provides a blueprint for constructing interpretable models for pred

57 ty in this class of materials and serve as a blueprint for controlling charge transport in MOFs with

58 responsible for providing the master genetic blueprint for craniofacial development.

59 Collectively, this structure provides a blueprint for deciphering the signal transduction mechan

60 These results provide a blueprint for decoding signaling selectivity and advance

61 Our study provides a blueprint for defining pan-NLRomes.

62 These multi-dimensional datasets provide a blueprint for delineating molecular mechanisms underlyin

63 e IL-2 structure, our results offer a direct blueprint for designing precision therapeutics targeting

64 c insights into BAX inhibition and provide a blueprint for developing inhibitors of BAX activation.

65 the resulting network models will serve as a blueprint for developing next-generation therapeutic age

66 The demonstrated concept could be used as a blueprint for development of stimuli-responsive material

67 coordinated joint action, which serves as a blueprint for dialogue coordination, and the experience

68 ographic structures presented here provide a blueprint for discovery of specific inhibitors designed

69 SC pancreatic differentiation and provides a blueprint for dissection of their coding and noncoding r

70 on transport mechanism in KCCs and provide a blueprint for drug design.

71 a comprehensive, culture-independent genomic blueprint for ecosystem-wide analysis of protein functio

72 details of their generation could provide a blueprint for effective vaccination.

73 all together, this study provides a general blueprint for efficient optical screening of micro- and

74 ecified, leading to the establishment of the blueprint for embryogenesis.

75 e topology of the hexameric complex offers a blueprint for engineering IFNgamma variants to tune IFNg

76 Our results provide a blueprint for engineering molecular anchors with finely

77 These insights provide a molecular blueprint for engineering selectively potentiating thera

78 nase degrader discovery, but also provides a blueprint for evaluating targeted degradation across ent

79 for regulating anxiety states and provide a blueprint for examining how G-protein-mediated signaling

80 al and computational methods, establishing a blueprint for examining SLiM-based networks.

81 porter ion, we believe this work serves as a blueprint for expanding the multiplexing capacity of the

82 Together, our structures provide a blueprint for final assembly of a functional ribosome.

83 NKCC1 structure provides a blueprint for further probing structure-function relatio

84 We propose components of a blueprint for further research, emphasising process-base

85 ycosylation and NRF2 signaling and provide a blueprint for future approaches to discover functionally

86 ilable in fruit ripening and will serve as a blueprint for future biological endeavors.

87 atical work supports this idea and provide a blueprint for future investigations.

88 tions, the established framework serves as a blueprint for future large-scale water resource monitori

89 he novel techniques presented here provide a blueprint for future observational experiments to quanti

90 Our investigation provides a blueprint for future photosensitizer development featuri

91 of visual system regeneration and provides a blueprint for future progress in the field.

92 Here we attempt to make a blueprint for future studies in this field.

93 derstanding Tfp biology and provide a useful blueprint for future studies.

94 is rapid catalytic process provides a useful blueprint for future work in artificial photosynthesis.

95 Our work provides a blueprint for glioblastoma, integrating the malignant ce

96 PCR Experiments" (MIQE) guidelines provide a blueprint for good PCR assay design and unambiguous repo

97 ng bridge and could yield a metabolism-based blueprint for hampering Legionnaires' disease.

98 volved in dimerization yielded a mechanistic blueprint for homodimeric class I cytokine receptor acti

99 Our methods and findings provide a blueprint for how the increasing wealth of ecological, l

100 ghts into CARD9 variant proteins to create a blueprint for IBD therapeutics and recapitulated the mec

101 Our results provide a blueprint for identifying naturally long-lived states in

102 rived from metabolite datasets can provide a blueprint for improvement of water use efficiency and dr

103 ids plus six volatile molecules, providing a blueprint for improving the flavor of what has become an

104 The results presented here provide a blueprint for in-depth studies of the interactions of th

105 obabilistic tractography map as a connectome blueprint for individualized, patient-specific, determin

106 ectivity and molecular composition provide a blueprint for information processing in neural circuits.

107 We provide a blueprint for initiating and executing student-led discu

108 the evolution of cooperation and provides a blueprint for intentional induction of cooperation withi

109 ngle-cell transcriptomic resource provides a blueprint for interrogating the molecular and cellular b

110 Our study provides a blueprint for investigating and prolonging drug-target k

111 Our work provides a blueprint for investigating evolutionary pressures on co

112 observations, our data point to CENP-C as a blueprint for kinetochore assembly.

113 The DiscovEHR data set provides a blueprint for large-scale precision medicine initiatives

114 Since these data contain the blueprint for life, it is imperative that we interpret i

115 ian embryo, provide access to the regulatory blueprint for mammalian organogenesis.

116 tice during the early pandemic may provide a blueprint for managing LTx in an era of continued commun

117 The key to this reaction is a conceptual blueprint for metathesis chemistry that forgoes the trad

118 Overall, this paper provides a blueprint for ML use with clinical data.

119 Finally, our study provides a blueprint for modeling viral-host protein interactions a

120 ssential biological processes and provides a blueprint for molecular mimicry that drives drug discove

121 These studies provide a blueprint for myriad N-heterocyclic methodologies.

122 This light-driven method may provide a blueprint for new approaches to catalytic homogeneous am

123 of life; in many ways they provide a general blueprint for organizing the building blocks of life.

124 This work provides a blueprint for other microtubule nucleation pathways and

125 The methods developed here provide a blueprint for parsing out the contribution of the four H

126 This work provides a structure-based blueprint for rationalizing antibody-mediated targeting

127 Our proposal is the first blueprint for realizing topological phases of matter in

128 olubilized zebrafish P2X4 receptor provide a blueprint for receptor mechanisms but unexpectedly showe

129 t pentose utilization in yeast and provide a blueprint for reprogramming transporter properties.

130 This design provides a realizable blueprint for scalable spin-based quantum computers in s

131 taining transcription factors that provide a blueprint for segmental identity along the body axis.

132 actions-but not single domains-can provide a blueprint for sensitive activation sensors within a narr

133 tion and specificity by SOCS2, and provide a blueprint for small molecule ligand design.

134 The PFKP structural blueprint for somatic mutations as well as the catalytic

135 hanisms of TRPA1 regulation, and establish a blueprint for structure-based design of analgesic and an

136 esented to the immune system, and provides a blueprint for structure-based vaccine design.

137 c objectives that serve to provide a general blueprint for sustaining the legacy of the Institute by

138 Our method represents a blueprint for systematic genetic analysis of complex tis

139 Our approach can serve as a blueprint for tackling other eruptive forest insects.

140 and inhibition in ferroportin and provide a blueprint for targeting ferroportin in pharmacological i

141 We believe that this method can serve as a blueprint for the activation of many other small molecul

142 We expect that this work will serve as a blueprint for the adaptation of ssDNA recombineering to

143 nd the approach provided here can serve as a blueprint for the analysis of traits and conditions link

144 he melanocortin system provides a conceptual blueprint for the central control of energetic state.

145 It will also serve as a blueprint for the construction of other brain-inspired m

146 mulating compounds in E. coli, and a general blueprint for the conversion of Gram-positive-only compo

147 site (H-cluster) of [FeFe]-hydrogenases is a blueprint for the design of a biologically inspired H(2)

148 works developed in this study can serve as a blueprint for the design of a broad range of tailor-made

149 typical Ni coordination, thereby providing a blueprint for the design of bio-inspired H(2) -conversio

150 ria pathogenesis, these structures provide a blueprint for the design of future anti-malarials target

151 SARS-CoV-2 S ectodomain trimer, providing a blueprint for the design of vaccines and inhibitors of v

152 ond electron transfer step, thus providing a blueprint for the development of a broad range of novel

153 They provide a blueprint for the development of advanced heterogeneous

154 activity, and modularity could be used as a blueprint for the development of electroactive and condu

155 ting to semiconducting, as well as provide a blueprint for the development of hybrid porous materials

156 These mAbs provide a blueprint for the development of improved vaccines and t

157 ng approaches, we established an integrative blueprint for the EOM functional unit.

158 volution of antigen receptors, and provide a blueprint for the experimental reconstruction of protein

159 nd physiological experiments have outlined a blueprint for the feedforward flow of activity in cortic

160 Therefore, our work provides a blueprint for the functional annotation of diverse bacte

161 logy for immunoengineering and can provide a blueprint for the future development of personalized, au

162 tunities available for progress, providing a blueprint for the future of cystic fibrosis care.

163 The reported method constitutes a blueprint for the high-throughput screening and future d

164 findings from the neural field can provide a blueprint for the identification of new molecular mechan

165 ow information written into genes provides a blueprint for the initiation and orchestration of progra

166 The overall approach provides a general blueprint for the integration of carbene catalysis with

167 ing of retinal inputs provides an anatomical blueprint for the integration of visual features in the

168 nge inhibition of the reactants--that sets a blueprint for the location of the stereocilia.

169 This work provides a blueprint for the next generation of rapid microbial ide

170 ent techniques: an algorithm for computing a blueprint for the overall strategy, an algorithm that fl

171 l agenda for child health and wellbeing as a blueprint for the practice of paediatrics and child heal

172 These examples sketch a blueprint for the preparation of new metal-organic conta

173 PhotoETP thus provides a blueprint for the production of small-molecule class B G

174 e almost totally unknown, yet they provide a blueprint for the radiation of land plant forms.

175 Notably, this study provides a blueprint for the rational design and application of non

176 ution-based precursor approach creates a new blueprint for the rational design and controlled synthes

177 We provide a blueprint for the realization of 16-plex reagents with 1

178 vegetative growth, but serves as the genetic blueprint for the somatic macronucleus (MAC), which is r

179 map of fetal liver haematopoiesis provides a blueprint for the study of paediatric blood and immune d

180 rgent strategy was developed that provides a blueprint for the synthesis of many of the small yet com

181 ults strongly support the role of titin as a blueprint for the thick filament and the arrangement of

182 staining procedures, and could be used as a blueprint for the virtual staining of tissue images acqu

183 iad other short peptide motifs and provide a blueprint for therapeutic applications in a variety of c

184 signs described here may serve as a possible blueprint for therapeutic development in fields other th

185 mune system, this ISG network may serve as a blueprint for therapeutic targeting of cellular systems

186 intrinsic ORF mRNA structure encodes a rough blueprint for translation efficiency.

187 nesis and tumor pathophysiology, providing a blueprint for understanding diverse astrocyte contributi

188 The structural mechanism is a blueprint for understanding how phytochromes connect to

189 the importance of the coelacanth genome as a blueprint for understanding tetrapod evolution.

190 netic analysis of arenaviral GP1s provides a blueprint for understanding the discrete structural clas

191 racterized by NMR, and provides a structural blueprint for understanding the function of this channel

192 The D. alkenivorans genome provides a blueprint for understanding the genetic systems involved

193 ivity, structure, and genotype may provide a blueprint for understanding the mechanisms governing tem

194 s charge state and may furnish a methodology blueprint for understanding the redox and magnetic behav

195 The mutational landscape provides a blueprint for understanding the specificity of the inter

196 The MacB architecture serves as the blueprint for understanding the structure and mechanism

197 attributes of T44625, this report provides a blueprint for understanding the successful zoonotic pote

198 These observations provide a structural blueprint for understanding unique aspects of TRP channe

199 ctively, the results of this study provide a blueprint for using metabolomics as a platform to identi

200 The maps can serve as blueprints for biological experiments in those model org

201 These surface structures encompass different blueprints for capsids with the same number of structura

202 f antidepressant action in SERT, and provide blueprints for future drug design.

203 tralizing antibody responses, might serve as blueprints for HIV-1 vaccine design.

204 In addition to providing blueprints for Hmox1 expression in mice that provide nov

205 rovide high-fidelity, single-cell resolution blueprints for Hmox1 expression throughout the body of m

206 Natural products serve as chemical blueprints for most antibiotics in clinical use.

207 for dynamic ion selectivity and provide the blueprints for new therapeutic agents.

208 , we hope that our approach will provide the blueprints for new visualizations of other longitudinal

209 se of genomics methods to reveal the genetic blueprints for not one but dozens of plant species, as w

210 s are crucial for gene regulation, providing blueprints for the assembly of transcriptional machinery

211 ogical systems provide attractive reactivity blueprints for the design of challenging chemical transf

212 tanding of the biological world by providing blueprints for the evolutionary and functional diversity

213 zers, can inform vaccine design by providing blueprints for the induction of similar bNAb responses.

214 crystal chemistry and are regarded as ideal blueprints for the rational design and construction of m

215 dge-transitive nets are regarded as suitable blueprints for the successful practice of reticular chem

216 The amino acid sequence of a protein is the blueprint from which its structure and ultimately functi

217 ersification of proteomes beyond the genomic blueprint; however it is infrequently used among animals

218 ng can be directly inferred by examining its blueprint in embryos.

219 bat retina conforms to the general mammalian blueprint, in which light signals of intensities above r

220 rns in a recent WHO research and development blueprint initiative for emerging infectious diseases.

221 s they allow the establishment of structural blueprints inspired by natural photosynthetic organisms

222 s essential to maintain and to translate the blueprints into functional sensory area properties in co

223 t as a linear entity within cells where this blueprint is actually utilized.

224 REVIEW: Epigenetics dictate how the genetic blueprint is ultimately expressed and, therefore, is fun

225 an increasing threat to human health on the Blueprint list of viruses likely to cause major epidemic

226 rget article continues a critique of genetic blueprint models of development that suggests reconsider

227 As part of the NIH Blueprint Neurotherapeutics Network project we undertook

228 y 42 human healthy blood epigenomes from the BLUEPRINT, NIH ROADMAP and ENCODE consortia by their cel

229 Numerous blueprints now exist for stabilizing the simplest type o

230 ich has policy implications for the national blueprint of ecological civilisation and preparation for

231 belian quasiparticles and can be seen as the blueprint of fractional topological order.

232 = 218, r > 0.9999, eFDR < 0.001) revealed a blueprint of gene expression specific to each pregnancy.

233 n a cell-specific manner, but also provide a blueprint of how a tissue-specific molecule might be con

234 amino acid sequence of a protein encodes the blueprint of its native structure.

235 The human genome encodes the blueprint of life, but the function of the vast majority

236 Besides its role as the blueprint of life, DNA can also alert the cell to the pr

237 nitors are rapidly organized into a scalable blueprint of lost structures.

238 In sum, our results sketch out a blueprint of mammalian connectomes consisting of species

239 tensively characterize the resulting in vivo blueprint of metabolism in human blood by integrating it

240 the embryonic body axis, giving rise to the blueprint of organ formation.

241 In-depth characterization of the blueprint of SC-niche crosstalk, as well as understandin

242 This blueprint of synaptic sharing provides an efficient way

243 in mammalian and yeast cells that serve as a blueprint of TA protein insertion.

244 nergistically to provide a unique structural blueprint of the assembly process of this intricate mole

245 Together, these findings provide a blueprint of the brain mechanisms by which neutral third

246 These findings provide a blueprint of the developmental events associated with es

247 Although the cellular blueprint of the ENS is mostly in place by birth, the fu

248 We map out a blueprint of the genetic architecture of rice (Oryza sat

249 ory, mission, and structure, and present the blueprint of the new Institutional Representatives progr

250 ubtypes relies heavily on defining a lineage blueprint of the normal human breast.

251 are coming closer to obtaining a structural blueprint of the polyadenylation machinery that explains

252 To establish a molecular blueprint of this dynamic complex, we first mapped the a

253 Having an accurate blueprint of this regulation is essential for understand

254 ermittent fluctuations in the wall stress, a blueprint of turbulence in the vicinity of the boundarie

255 intain a harmonic family in light of genetic blueprints of individual couples.

256 s not only extended our understanding of the blueprints of many plant species but has also revealed t

257 bout the genetic landscape and architectural blueprints of various cancers.

258 and revealed individual-specific chromatin "blueprints" of neurons that, in part, relate to genetic

259 ell lineage and establish a high-resolution 'blueprint' of their development.

260 Deoxyribonucleic acid (DNA) is the blueprint on which life is based and transmitted, but th

261 nes to generate organelles with unique lipid blueprints on which they assemble replication complexes

262 Such structures of prion polymorphs serve as blueprints on which to evaluate the potential impact of

263 bundles as intended, matching the connectome blueprint previously defined.

264 His goal of outlining the blueprint principles for a universal model of reading is

265 pired by the relatively simple morphological blueprint provided by batoid fish such as stingrays and

266 We assert that nature's blueprint provides the fundamental principles for vastly

267 Overall, we argue that our approach, as a blueprint, provides both a general framework and the pre

268 Based on the natural system blueprint, several research efforts have investigated pa

269 Our blueprint should be readily reproducible by research tea

270 nesses that opponents have identified in the blueprint strategy.

271 t these circuits are part of the fundamental blueprint that all vertebrates use to select actions and

272 ided DNA recognition and provide a molecular blueprint that has facilitated structure-guided function

273 Nevertheless, we lack a developmental blueprint that integrates the molecular determinants of

274 While desmosomes have a molecular blueprint that is similar to that of adherens junctions,

275 We outline a conceptual blueprint that provides direct and atom economical acces

276 preting maps without an underlying cellular 'blueprint'; this could be supplied using contrast agents

277 We then utilized this gea net as a blueprint to design and assemble another MOF (gea-MOF-2)

278 energy conversion, and the scheme provides a blueprint to guide future campaigns to establish synthet

279 rector with developing a focused and concise blueprint to guide the use of limited funding over the n

280 n nondynamic transcriptomes and to provide a blueprint to identify gene regulatory network involved i

281 Our approach offers a blueprint to objectively study functional and energetic

282 for Arabidopsis and maize, which serves as a blueprint to reduce the bioinformatic complexity associa

283 prioritizing cell lines according to natural blueprint to streamline functional applications.

284 Altogether, we provide a blueprint to study the impact of SNVs derived from genet

285 Our data provide a blueprint to understand how conventional RGCs and ipRGCs

286 compared with mouse and provides a molecular blueprint to understand human embryogenesis and its rela

287 ace of ookinetes and provides the structural blueprints to design next-generation immunogens.

288 of voltage sensing and establish structural blueprints to design selective Nav channel antagonists.

289 Natural structures provide blueprints to overcome this, however this approach intro

290 RA as a potential resource in retrosynthetic blueprints to reach highly challenging targets.

291 sed the four-bundle tractography 'connectome blueprint' to plan surgical targeting in 11 participants

292 o bioconjugation this methodology provides a blueprint toward the development of photoredox catalysis

293 s discovery by refining and transmitting the blueprints using DNA mutations autonomously.

294 As a blueprint, we chose a mechanism typical of influenza A v

295 With these design principles as a blueprint, we experimentally constructed artificial pola

296 Because of their distinctive genomic blueprint, we propose the classification of these giant

297 Using this synthetic blueprint, we were able to produce natural products on a

298 al condition categories from the examination blueprint, which balances examination content by conside

299 ction of our brain are governed by a genetic blueprint, which reflects dynamic changes over the histo

300 s that assume a topology or other structural blueprint will often fail.