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1 ced STEC-induced histological damage (villus blunting).
2 ing of attenuation of the mucosa with villus blunting.
3 uced histopathological damage such as villus blunting.
4 tion that is associated with moderate villus blunting.
5 tory pathways in C57BL/6 mice without villus blunting.
7 ly, DcR1 attenuates temozolomide efficacy by blunting activation of the Fas receptor pathway in p53(+
9 iosynthesis, hyperphagia, and weight gain by blunting alpha-MSH production via CB1R-induced and extra
10 the host by diminishing bacterial burden and blunting an otherwise overwhelming inflammatory response
12 ethal intestinal pathology, including villus blunting and death of intestinal crypts, and loss of lip
14 sis of epithelium and lamina propria, villus blunting and fusion, and transmural edema and hemorrhage
16 wild-type mouse podocyte and that there were blunting and widening of the minor (foot) processes in a
17 h as social withdrawal, apathy and emotional blunting) and other psychopathological symptoms (such as
18 asia, muscularis propria hypertrophy, villus blunting, and expression of inflammatory and remodeling
23 lly administered FGF2 is highly effective at blunting anxiety behavior, specifically in high-anxiety
24 DR) pathway and SETD2 mutation impaired DDR, blunting apoptosis induced by cytotoxic chemotherapy.
28 se in cardiomyocyte autophagic activity, and blunting autophagy increased the rate of aggregate accum
29 that died as well as survivors, reflecting a blunting but not complete inhibition of the inflammatory
31 ing Ca(2+) increases by 67 +/- 16%) and D2R (blunting Ca(2+) decrease by 72 +/- 17%) neurons in most
32 ttenuated responses to acute cocaine in D1R (blunting Ca(2+) increases by 67 +/- 16%) and D2R (blunti
33 ificantly improved collagen quality, thereby blunting cardiac dilatation and dysfunction after MI.
34 ity to uncertain, low-imminence threat while blunting cardiovascular and behavioral anticipatory arou
36 then kept in subsequent criteria: emotional blunting, changes in volition, and changes in social lif
38 omarker of cancer that is not subject to the blunting clonal selection effects that reduce the effica
39 that the effects of CREB over expression on blunting cocaine reward could be, at least in part, attr
40 ates silenced TSGs, revealing their role for blunting colorectal cancer cell proliferation, invasion,
41 the CTBs, which involve alternated crack tip blunting, crack deflection, twinning/detwinning and slip
42 that glycine prevents reactive arthritis by blunting cytokine release from macrophages by increasing
44 that loss of Bin1 may promote malignancy by blunting death penalties associated with oncogene activa
45 pe channel via transcriptional interference, blunting deleterious effects of mutant L-type channel ov
47 teric) adipocytes may be a novel approach to blunting detrimental fat-liver crosstalk in obesity.
48 We conclude that exogenous ATP is capable of blunting direct postjunctional alpha-adrenergic vasocons
49 ether, these results suggested that reagents blunting donor T-cell RAR signaling may possess therapeu
58 expectedly, the ALVAC-SIV/CD40L vector had a blunting effect on CD4(+) Th1 helper responses and inste
59 terregulatory responses are sensitive to the blunting effects of even short-duration prior hypoglycem
60 d assays at low levels of ADAMTS13 activity, blunting efforts to establish genotype-phenotype correla
62 PARdelta/beta phenocopies CD36 deficiency in blunting fasting induction of muscle FoxO1 and PDK4 in v
63 hanol may disrupt postsynaptic maturation by blunting feedback signaling through immature GABAARs.
65 Gi subfamily to decrease intracellular cAMP, blunting glucose-stimulated insulin secretion (GSIS).
66 te to further T cell recruitment and that by blunting glutamate-mediated platelet activation, graft s
67 f intestinal epithelial architecture (villus blunting, goblet cell hyperplasia, and increased epithel
68 e H(dAc) vaccine granted greater efficacy in blunting heroin analgesia in murine behavioral models co
70 effects on T-cell activation, with IFN-beta blunting IFN-gamma-induced upregulation of epithelial ce
73 monstrated on over-activation induced reward blunting, illustrating the symptom-specificity of its ac
75 ]; SCZ: +1.8% [11%]; P = .01); a generalized blunting in dopamine release in SCZ involving most extra
76 n gluconeogenesis, bile diversions promote a blunting in hepatic glucose production, whereas intestin
78 findings in knockout mice, we propose that a blunting in P2Y2 receptor expression or activity is a ne
79 to moderate to severe villous shortening and blunting in the duodenum and jejunum of WT-PEC-inoculate
80 on errors in the midbrain, and the degree of blunting in the encoding of prediction errors in the ins
83 ention of TonEBP, resulting in a substantial blunting in transcription of important osmotic stress re
86 duodenal and colonic mucosa including villus blunting, increased lamina propria and intraepithelial l
90 sed the frequency of Ca(2+) pulsars, whereas blunting IP(3) production, blocking IP(3)Rs, or depletin
92 BA A pathways can play a significant role in blunting key autonomous nervous system, neuroendocrine,
93 xcess FAs toward TAG storage in LDs, thereby blunting lipotoxicity-associated insulin resistance.
94 ical support for the notion that exogenously blunting M1 signaling (pharmacologically or with cortica
97 ered in these symptoms but also in affective blunting, motor retardation, and passive or apathetic so
98 Antitumor activity was not diminished by blunting murine natural killer activity, suggesting that
100 genescell envelope proteinase (SpyCEP), thus blunting neutrophil-mediated killing and enabling ingres
101 d grafts are lost upon PT-Cy administration, blunting NK cell alloreactivity in this transplantation
102 re needed to address whether the physiologic blunting observed here might be a useful correlate of ap
103 t apical dendritic atrophy might result in a blunting of 5-HT- and hypocretin-induced excitatory resp
105 xerts its antidepressant efficacy, via rapid blunting of aberrant sgACC hyper-reactivity to positive
108 low CYP11B1/CYP11B2 selectivity resulted in blunting of adrenocorticotropic hormone-stimulated corti
110 reased CaMKII activity may contribute to the blunting of agonist-evoked arrhythmias in the atrial myo
111 During hypoglycemia on day 2, DHEA prevented blunting of all neuroendocrine, autonomic nervous system
112 the forearm and leg, it does not appear that blunting of alpha-adrenergic responsiveness is the cause
117 rmal baroreflex function as indicated by the blunting of baroreflex sensitivity (BRS) following the a
119 vity of calcium-dependent force development, blunting of both PKA-dependent calcium desensitization,
121 ted the hypothesis that (1) aging involves a blunting of cAMP diurnal rhythmicity in the SCN; (2) adm
122 Greater BMI was associated with generalised blunting of cardiovascular (HR:beta = -0.50 bpm x unit(-
123 f cytokine-mediated Akt/FOXO inhibition, and blunting of cathepsin-L-mediated lysosomal protein break
124 reactivity to stress, leading to a relative blunting of cortisol stress reactivity in G allele genot
127 mically tractable approach for the effective blunting of cytokine storm, leading to the improvement o
128 SNX1 in RPT cells from NT subjects led to a blunting of D(5) R agonist-induced increase in cAMP prod
130 eading to accumulation of exogenous 5-HT and blunting of endogenous 5-HT axonal outgrowth specificall
131 r restricted protein, of the ewe can produce blunting of endothelial-dependent and -independent relax
132 tecedent hypoglycemia results in significant blunting of essential neuroendocrine (glucagon, insulin,
133 anxiety disorders and is associated with the blunting of GH in those children relative to that of com
134 by Homer proteins, and it was found that the blunting of group I mGluR-induced glutamate release and
138 treated diabetic mice was associated with a blunting of hyperglycemia-induced monocytosis and reduce
139 , endotoxin tolerance also can lead to fatal blunting of immunological responses to subsequent infect
141 mechanisms, including central sensitization, blunting of inhibitory pain pathways, alterations in neu
143 e, while high-fat feeding resulted in a full blunting of insulin-stimulated glucose transport in the
144 estruction of the epithelial barrier, severe blunting of intestinal villi, and recruitment and activa
145 oderate hypoglycemia can produce significant blunting of key neuroendocrine and metabolic counterregu
147 ments demonstrated that the hypoxia-mediated blunting of M-CPT I gene expression occurs at the transc
149 coupling helps to explain the age-associated blunting of maximal exercise EF, and its underlying mech
150 lenged through FcepsilonRI had a significant blunting of mediator release compared with nontreated ce
153 Lower postprandial LGD in obese subjects and blunting of MPS responses to amino acids suggest that ob
154 fied troponin confirmed that this cTnC-G159D blunting of myofilament desensitization results from alt
155 lymorphonuclear leukocyte efferocytosis, (2) blunting of NF-kappaB activation, and (3) a reduction in
156 le inactivation of linear ubiquitination and blunting of NF-kappaB nuclear translocation in response
157 be mediated, in part, through SIRT3-directed blunting of NLRP3 inflammasome assembly and activation.
160 in myogenic tone are two further findings: a blunting of paxilline-induced increase in myogenic tone
162 ing day 1 euglycemia resulted in significant blunting of plasma epinephrine, norepinephrine, glucagon
163 s loss in human immobilisation, and includes blunting of post-prandial increases in muscle protein sy
164 nges with tumor burden included the complete blunting of postprandial MPS (0.038 +/- 0.004%/h in the
165 of procollagen alpha1(I) messenger RNA, and blunting of profibrogenic activities of transforming gro
166 urrent and/or antecedent hypoglycemia causes blunting of protective counterregulatory responses, know
168 zolid toxicity that needs to be confirmed is blunting of reactive mitochondrial biogenesis and unfold
171 DNA damage, synergistic tumor cytotoxicity, blunting of self-renewal, and strong anti-tumor response
172 (increased onset and deactivation rates) and blunting of sensitivity also engendered by RGS protein a
175 and defective regeneration with significant blunting of signal transducer-and-activator of transcrip
176 weight early pubertal girls have significant blunting of sleep-related LH production, which is the fi
177 ex in the brain at rest (t = 5.63) predicted blunting of smoking cue responses in the medial orbitofr
178 nding, and suggest that inflammation-induced blunting of SN responses to hippocampal novelty signals
179 als, we observed a pronounced and persistent blunting of stress-induced DA release in the right PFC b
180 and substance dependence showed significant blunting of striatal DA release, in contrast to what has
181 cked by DA receptor antagonism, CB1-mediated blunting of suprathreshold fear memory was rescued by in
182 present results suggest that hypoxia-induced blunting of sympathetic vasoconstriction in skeletal mus
184 n in intake was accompanied by a conditioned blunting of the accumbens dopamine response to the sacch
185 ailure of D(5)R to internalize and bind GTP, blunting of the agonist-induced increase in cAMP product
188 odeoxyuridine uptake, which was confirmed by blunting of the cell growth rate of infected cells compa
190 ent stress in mice resulted in a significant blunting of the corticosterone response during pregnancy
191 s, we found that aging was associated with a blunting of the diurnal rhythm and a significant linear
193 find that acute stress leads to circuit-wide blunting of the DRN output, while the SSRI fluoxetine no
196 l of the host immune response and indicate a blunting of the immune mechanism in humans and animals.
197 ignificance of which is reflected by similar blunting of the in vivo bone resorption marker tartrate-
198 his protection correlated with a significant blunting of the induction of PAI-1 caused by ethanol/LPS
200 ic excitability of BLA pyramidal cells and a blunting of the medium component of the afterhyperpolari
202 roved resuscitation may be attributable to a blunting of the nuclear factor-kappa B and interleukin-6
203 ntial termination is unlikely) resulted in a blunting of the odds ratios; however, a trend for parity
204 jection fraction (HFrEF) is characterized by blunting of the positive relationship between heart rate
205 creasing renin response to insulin predicted blunting of the renal vasodilator response to insulin in
206 om recent large clinical trials confirm that blunting of the renin-angiotensin system through either
210 uals with APOC3 knocked out displayed marked blunting of the usual post-prandial rise in plasma trigl
211 st prominently, and, when silenced, observed blunting of the ventilatory response to inhaled CO2Tac1-
213 ontinuous LPS was reflected in a significant blunting of transcription factor activation and cytokine
214 ron microscopy confirmed mild shortening and blunting of villi in the duodenum and jejunum of the TC-
215 dothelial cell hypertrophy of blood vessels, blunting of villi, and lacteal dilatation with lymphocyt
217 , and recent therapeutic approaches aimed at blunting or reverting detrimental protumorigenic phenoty
220 ing day 1 euglycemia resulted in significant blunting (P < 0.05) of ANS (epinephrine, norepinephrine,
221 Antecedent hypoglycemia produced widespread blunting (P < 0.05) of neuroendocrine, ANS, and metaboli
224 may be useful dietary supplements capable of blunting postprandial glycaemia in humans, including tho
226 lso normalized abnormal mechanosensing while blunting progressive chamber hypertrophy in Duchenne mus
227 gy depletion activates AMPK (Threonine 172), blunting protein synthesis and mTOR signaling, culminati
228 ironmental enteropathy (EE) refers to villus blunting, reduced absorption, and microbial translocatio
230 o, vulnerability to ethanol-induced receptor blunting requires elements of an intact brain environmen
231 Further, the mechanism for adrenocortical blunting resides at the level of the adrenal cortex rath
234 gulated patterns of sleep and wakefulness by blunting serotonergic signaling in the lateral hypothala
235 epsin-induced cleavage of SIRT 1 in EPCs and blunting SIPS and apoptotic cell death induced by releva
237 ced hypercortisolemia may be responsible for blunting subsequent sympathoadrenal responses to hypogly
238 is that nitric oxide (NO) is responsible for blunting sympathetic alpha-adrenergic vasoconstriction i
239 We studied the role of nitric oxide (NO) in blunting sympathetically evoked muscle vasoconstriction
244 ngs demonstrate a quality control checkpoint blunting terminal PC differentiation by eliminating thos
246 e to increase the uptake of avid substrates, blunting the ability of investigators to measure clinica
247 ainst functional gp120/gp41 trimers, thereby blunting the ability of particles to elicit neutralizing
249 elial system, suppressing erythropoiesis and blunting the activity of erythropoiesis stimulating agen
250 improved carbohydrate and lipid metabolism, blunting the AEA-induced increase in gene expression of
253 ty of MAs to alpha1AR vasoconstriction while blunting the attenuation of sympathetic vasoconstriction
254 e micropores prevents further drug delivery, blunting the clinical utility of this unique transdermal
256 creasing p65 nuclear translocation, although blunting the degradation of IkappaBalpha was due, at lea
260 ffector cells, but suppression was dominant, blunting the expansion of naive tumor-specific T cells a
261 alysis suggests that FGF21 acts primarily by blunting the growth hormone/insulin-like growth factor-1
264 fic humoral and cellular immune responses in blunting the immunogenicity of a rAd5-Env vaccine in mic
265 eases in luminal diameter have the effect of blunting the impact of flow velocity on microvillous she
266 ffects under these conditions, significantly blunting the increase in all these parameters caused by
267 PA1 protected mice from peritoneal fibrosis, blunting the increases in peritoneal collagen by 65.4 an
269 ved ASLN in mice through immunoregulation by blunting the MAPK (ERK, JNK)-mediated priming signal of
272 ocytes via a STAT5-dependent pathway, and by blunting the proinflammatory effects of IL-17 on its tar
274 tly inhibited PVM-elicited cytokine storm by blunting the PVM-specific CD8(+) T cell response, result
277 ilarly, and (2) TNF-alpha decreases force by blunting the response of muscle myofilaments to calcium
278 ed and modulated the hydrologic inputs of N, blunting the rise in coastal N sources during the early
279 in schizophrenia by disrupting learning and blunting the salience of rewarding events, and contribut
281 effects on perioperative pulmonary function, blunting the surgical stress response and improved analg
282 ssociated with a nonsignificant trend toward blunting the survival improvement associated with early
283 and melanoma, documenting its involvement in blunting the susceptibility of tumor cells to lysis by a
284 e expression and activity of NOS1 via SGLT1, blunting the TGF response and promoting glomerular hyper
285 ents recruitment of Bim or Bax to lysosomes, blunting the TRAIL-induced lysosome membrane permeabiliz
287 nt nitric oxide (NO) in the macula densa and blunting the tubuloglomerular feedback (TGF) response, t
289 below 10%) effectiveness of interventions in blunting the ZIKV transmission from symptomatic cases to
290 e and maternal immunization coverage and 30% blunting, the incidence among neonates (0-2 months) is r
293 hrough increased 4E-BP1 inhibitory activity, blunting this mechanism may represent a novel therapeuti
294 xpression correlated with mortality, whereas blunting TLR gene and protein expression correlated with
295 th following glutamate exposure probably via blunting toxicity from delayed calcium deregulation.
296 flammatory processes to help clear tumors by blunting tumor neovascularization and restoring immunosu
298 function may impair RGS2 activation, thereby blunting vascular relaxation and contributing to hyperte
300 ical changes in ill animals included villous blunting with sloughing of epithelial cells, submucosal