ライフサイエンスコーパス: bond formation

1 ly form tetrazane dimers in solution via N-N bond formation.

2 tions to direct the enantio-determining C-CN bond formation.

3 ontinued search for improved methods for C-N bond formation.

4 aryl ring and subsequent intramolecular B-B bond formation.

5 possible reaction intermediate for thioether bond formation.

6 enetic material by catalyzing phosphodiester bond formation.

7 rt C-H bonds into C-metal bonds prior to C-C bond formation.

8 y, this is driven, at least in part, by Al-O bond formation.

9 hat bind to protein targets through covalent bond formation.

10 and the cascade is terminated by radical C-C bond formation.

11 ctions for the C11/C12, C17/C18, and C19/C20 bond formation.

12 due to kinetic barriers associated with C-F bond formation.

13 of EDO ligands in facilitating Csp(3)-Csp(3) bond formation.

14 pendent manner through increased interfacial bond formation.

15 ) bonds has been an unexplored area for C-C bond formation.

16 owed by an intramolecular oxidative N-S/N-Se bond formation.

17 r macrocycle formation through carbon-carbon bond formation.

18 nsformations, specifically for carbon-carbon bond formation.

19 idines but also represents a new type of C-N bond formation.

20 dihydrofuro[3,4-b]quinolines via C-O and C-N bond formation.

21 -oxo species, followed by azido-directed C=N bond formation.

22 ovel catalytic transformations involving P-C bond formation.

23 fluidity and dynamics may strongly influence bond formation.

24 a new catalytic manifold for metal-free C-C bond formation.

25 radical, which is responsible for subsequent bond formation.

26 eine protease and cyclization via isopeptide bond formation.

27 n-haem-iron-dependent enzymes to include N-N bond formation.

28 and may help in designing new methods of C-C bond formation.

29 despite the predicted favorability for Si-F bond formation.

30 cleophile, consistent with rate-limiting C-C bond formation.

31 veloped as a powerful tool for carbon-carbon bond formation.

32 rd subsequent enantioselective carbon-oxygen bond formation.

33 ted with pyrophosphate release and thioester bond formation.

34 insight into Ub E1 adenylation and thioester bond formation.

35 a catalyst for P-P and P-E (E = O, S, or N) bond formation.

36 the efficient proton transfer during peptide bond formation.

37 ilable for highly selective biocatalytic C-C bond formation.

38 a closed conformation required for thioester bond formation.

39 t efforts have been devoted to promoting C-C bond formation.

40 in catalytic cycles for C(sp(2) )-C(sp(3) ) bond formation.

41 n due to the nanoconfinement facilitates C-C bond formation.

42 proteins by slowing down the rate of peptide bond formation.

43 y has discouraged its use for asymmetric C-F bond formation.

44 unity also support post rate-determining C-C bond formation.

45 the MA-helices, are conducive for disulfide bond formation.

46 f the keteniminium cation and subsequent C-C bond formation.

47 ison to analogous strategies for C-N and C-C bond formation.

48 of a proton in an alkane resulting in a B-C bond formation.

49 inium moiety is critical for the desired C-C bond formation.

50 s revealed a disparate mechanism for the C-C bond formation.

51 ver the interatomic interactions that induce bond formation.

52 arbon-carbon (C-C) and carbon-nitrogen (C-N) bond formation.

53 -mediated oxidative nitrogen-selenium (N-Se) bond formation.

54 mal, photoredox-catalyzed, deformylative C-N bond formation.

55 and its ability to catalyze both C-C and C-N bond formation.

56 me MoaA accelerates the radical-mediated C-C bond formation.

57 ic and thermodynamic driving force for amide bond formation.

58 bond cleavage, and concurrent Csp(3)-Csp(3) bond formation.

59 r pathways in the visible light-mediated C-N bond formation.

60 coupling reactions, there remain challenging bond formations.

61 n-nitrogen (C-N) and one carbon-carbon (C-C) bond formations.

62 bon-oxygen (C-O) and one carbon-carbon (C-C) bond formations.

63 unprotected phenols, sorted by the types of bond formations.

64 anic reactions, for example C-C, C-N and C-O bond-formations.

65 ons involving three steps, which are (1) C-C bond formation, (2) C-O bond formation, and (3) the open

66 For the C11/C12 bond formation, a stoichiometric Ni/Cr-mediated reaction

67 and particle cross-linking through disulfide bond formation accompanied by the shrinkage of the parti

68 etween the surface states during contact, or bond formation across the sliding interface.

69 escribes systems in which readily reversible bond formation allows for control of product distributio

70 The reaction relies on the C-N bond formation along with the C-C bond cleavage under me

71 e OH...O(R) and/or (H)O...H(ortho)C hydrogen bond formation along with the C-H...pai interactions see

72 , with an outer sphere mechanism for the C-N bond formation and a potentially inner sphere protodemet

73 Amide bond formation and aromatic/heteroaromatic nitro-group r

74 gen close to the oxo group to facilitate O-O bond formation and at a later stage a remote electrophil

75 We show the bond formation and bond activation at the Al sphere: thu

76 ial in both of the two-electron processes of bond formation and bond-cleavage is demonstrated.

77 5) ligand, which participates in C-H and C-C bond formation and cleavage.

78 determining step that involves oxygen-oxygen bond formation and compare it with models proposed in th

79 dditional heat to induce reversible covalent bond formation and dissociation.

80 Regulated proinsulin biosynthesis, disulfide bond formation and ER redox homeostasis are essential to

81 regions of alpha-synuclein through hydrogen bond formation and inhibits the beta-sheet formation, wh

82 oncerted amine/thiol proton transfer and C-S bond formation and instead suggest that protonated amino

83 lts from the C atom's rehybridization during bond formation and is responsible for an unexpectedly hi

84 it a key neuronal substrate associated with bond formation and maturation.

85 livered to neighboring catalytic domains for bond formation and modification.

86 talytic intermediates (S(0)-S(4)) before O-O bond formation and O(2) release.

87 w, coupling of cysteine oxidation, disulfide bond formation and structure formation in nascent chains

88 step of pol beta catalysis is phosphodiester bond formation and suggest that substrate selection is g

89 transition in tubulin that enhances lateral bond formation and thereby promotes microtubule growth a

90 nion as the intermediate responsible for C-C bond formation and ultimately ketone synthesis.

91 ulfhydration affected intraprotein disulfide bond formation and was required for the maintenance of a

92 ant biomolecules because incorrect disulfide bond formation and/or presence of cysteine-related post-

93 efficiencies that may be brought to bear in bond-formation and bond-cleavage in a benign manner.

94 locks gluten protein conformation through SS bonds formation and the free -SH are no longer able to c

95 mediated reaction involving intermediate N-I bond formation, and (3) a copper-catalyzed N-N coupling

96 s, which are (1) C-C bond formation, (2) C-O bond formation, and (3) the opening of the azlactone rin

97 ators of a pathway bifurcation (asynchronous bond formation, and a second transition state for the in

98 oatomic C-C cross-coupling, heteroatomic O-C bond formation, and cascade cyclization utilizing NO(2)

99 of the amide bond, interferes with hydrogen bond formation, and changes other properties of the pept

100 euronal ensemble increased in size following bond formation, and differences in the size of approach

101 transition, nucleotide binding, phosphoester bond formation, and dissociation steps.

102 48/45 has 16 cysteines involved in disulfide bond formation, and the correct formation is critical fo

103 t proceed by intermolecular O-B, S-B and P-B bond formation are also summarised.

104 M(NH(x) ) intermediates involved in N-N bond formation are central to ammonia oxidation (AO) cat

105 a mechanism in which C-H abstraction and C-O bond formation are merged into a dynamically coupled pro

106 ions for carbon-carbon and carbon-heteroatom bond formation are of great importance in modern chemica

107 Among all types of CDC reactions, the C-C bond formations are of prime importance in building up t

108 ng, metal complexation, and dynamic covalent bond formation) are used to tune NCT assembly as a funct

109 s permits the challenging C(sp(3))-OC(sp(3)) bond formation at a high-valent nickel center to proceed

110 arises from steric hindrance encountered in bond formation at the adjacent carbon atom.

111 aa-tRNAs failing to undergo peptide bond formation at the end of accommodation corridor pass

112 hly regiospecific to proceed a selective C-N bond formation at the endo-nitrogen of 2-aminoheteroaren

113 es, demonstrating unprecedented control over bond formation at the nanoscale.

114 he last observable intermediate prior to O-O bond formation at the oxygen-evolving complex (OEC) of P

115 hich is constructed by consecutive disulfide bond formation between a large number of peptide fragmen

116 nzymes that catalyze oxidative carbon-sulfur bond formation between cysteine derivatives and N-alpha-

117 No disulfide bond formation between cysteine groups on the protein an

118 hrough coordination chemistry, (ii) covalent bond formation between existing pendant groups and incom

119 Al(3+) nanoparticle system based on hydrogen bond formation between liraglutide and TA and stabilized

120 Although a high temperature can promote the bond formation between metal atoms and the substrate wit

121 imal configuration in the molecule, hydrogen-bond formation between N-H and I (iodine) assisted the p

122 In our study, we used disulfide bond formation between pairs of engineered cysteines to

123 fold that catalyzes ATP-dependent isopeptide bond formation between the amino group of free glutamate

124 The mutational disruption of covalent bond formation between the receptor and the targeting li

125 us pneumoniae adhesin and enables isopeptide bond formation between two peptide tags: DogTag and Snoo

126 r the subsequent reaction step of isopeptide bond formation between two ubiquitin molecules.

127 tion, isobutene elimination, and C-C and P-H bond formation bicyclic 1-benzo-dihydrophosphetes (2) wi

128 lution of both of these contributions to the bond formation/breaking process.

129 rategies for optimizing the rate of covalent bond formation by a reversibly bound inhibitor (k(inact)

130 pper-catalyzed example of intermolecular C-O bond formation by allene hydrofunctionalization.

131 Here, we report that covalent bond formation by an aryl sulfonyl fluoride electrophile

132 hodologies via metal-catalyzed carbon-carbon bond formation by chelation-assisted C-H activation will

133 demonstrate selective promotion of the Au-C bond formation by controlling the bias applied across th

134 eviously showed that disruption of disulfide bond formation by Disulfide Disrupting Agents (DDAs) kil

135 RNAs was found to reduce the rate of peptide bond formation by three orders of magnitude in a well-de

136 C-C bond formation by transition metal-catalyzed C-H activat

137 An attractive strategy for C-Se bond formation by Ullmann-type copper(I)-promoted cross-

138 en atom transfer (HAT)-mediated free radical bond formations (C20-C2 and C20-OH, respectively) that a

139 molecules via transition metal-catalyzed C-O bond formation can be achieved in the presence of a care

140 energy loss generally include both chemical bond formation (chemisorption) and nonbonding interactio

141 The subsequent C3-O bond formation completes the epoxide installation.

142 ive C-C and C-O bond cleavage, carbon-carbon bond formation, deoxydehydration, haloperoxidase, cyanat

143 Pair-bond formation depends vitally on neuromodulatory signal

144 examples proceeding via initial C-B and N-B bond formation dominating this field thus both are discu

145 that exhibits an unusually fast rate of C-C bond formation driven by exquisite complementarity of th

146 effect of metal-metal and axial metal-ligand bond formation drives the critical Pd dimerization react

147 rom the notion that G units are prone to C-C bond formation during lignin biosynthesis, resulting in

148 del ER protein exhibiting improper disulfide bond formation during reductive ER stress but did not bi

149 r details of selective CO(2) binding and C-C-bond formation during the catalytic cycle of nature's mo

150 rview on recent progress in enantioselective bond formations enabled by Ni- and Cu-catalyzed manifold

151 to monitor individual bond-dissociation and bond-formation events occurring locally in chemical reac

152 h a high diastereoselectivity of further C-C bond formation facilitate a rapid access to spiro[oxindo

153 uring the initial encounter corresponding to bond formation for a range of different bonds; the resul

154 onditions, rates and/or endpoints of peptide-bond formation for the cognate (8-oxoG*C) and near-cogna

155 Tandem C-N bond formation for the oxidative annulation of indolines

156 al role of the initial reversible C-C single bond formation for the synthesis of crystalline 2D CPs.

157 disordered copper structures facilitate C-C bond formation from CO(2) and that electrochemical nanoc

158 This approach is able to deconvolute Fe-N bond formation from complex carbonization and nitrogen d

159 Enzymes also catalyze C-C bond formation from weakly C-H acidic substrates; howeve

160 roup of Li and others to describe direct Y-Z bond formations from Y-H and Z-H bonds under oxidative c

161 clization, and one-pot C-O bond cleavage/C-N bond formation furnished the pentacyclic scaffold.

162 N(2) extrusion followed by radical C-C bond formation generates the cyclopropane product.

163 lds with satisfactory yields via C-C and C-N bond formation has been developed.

164 ar dynamics revealed that altered end-to-end bond formation has effects extending toward the central

165 e-pot, three component reaction by two C-S-C bond formations has been developed.

166 doxime dehydratase, cis-trans isomerase, N-N bond formation, hydrazine formation and S-S formation, a

167 ion/desulfurization and subsequent disulfide bond formation in a one-pot process.

168 Multiple bond formation in a single operation through a cascade o

169 he rate-limiting step is most likely the C-C bond formation in agreement with the DFT calculations of

170 remote beta -, gamma-, and delta-C(sp(3))-N bond formation in aliphatic alcohols using mild basic co

171 effectively combined with an ensuing step of bond formation in an enantioselective fashion, then it w

172 standing of the mechanisms underlying social bond formation in anthropoid apes.

173 successfully promoted intersubunit disulfide bond formation in HeV F.

174 ults provide the first working model for C-S bond formation in isopenicillin N synthase and indicate

175 Dimethylation then enables selective C-O bond formation in multiple intermediates.

176 sparaginyl ligase (PAL) and catalyze Asx-Xaa bond formation in near-neutral conditions.

177 udy in detail the mechanism of carbon-carbon bond formation in Ni bipyridine- and diketonate-based ca

178 and the mechanisms underlying biological N-N bond formation in primary metabolism and how the associa

179 corresponding to disulfide and non-disulfide bond formation in protein aggregates, was markedly enhan

180 nds participate in the stereocontrolling C-C bond formation in the form of activated substrates, resp

181 ation reaction mechanism suggests facile C-N bond formation in the radical cation leading to a 5-exo

182 atform for efficient catalytic carbon-carbon bond formation in the synthesis of benzene.

183 e(V) =O species proposed to initiate the O-O bond formation in water oxidation reactions remained und

184 on of carbon-centred radicals that allow C-C bond formation in water.

185 These strategies allow C-C bond formations in a regioselective manner to synthesize

186 - endo-dig mode with two new carbon-selenium bonds formation in a one-pot procedure.

187 tic reactions, ranging from acylation to C-C bond formation, in which peptides have been successfully

188 emical and biophysical data reveal that -N=C bond formation involves two cycles of Fe/2OG enzyme cata

189 taking advantage of the fact that reversible bond formation is a characteristic feature of COFs.

190 Disulfide bond formation is a common mechanism to stabilize a prot

191 Disulfide bond formation is a critical post-translational modifica

192 Transition-metal-catalyzed sp(2) C-N bond formation is a reliable method for the synthesis of

193 wo complementary groups assures that the C-C bond formation is assisted by the flow of electron densi

194 camer transitions and intersubunit disulfide bond formation is more complex than previously thought.

195 unctional is still challenging as reversible bond formation is one of the prime prerequisites for the

196 ring proofreading, particularly when peptide bond formation is slow, which may serve to increase both

197 er, the most plausible mechanism for the O-O bond formation is the water nucleophilic attack to singl

198 iX enzymes, we reveal the first step, N5-C1' bond formation, is contingent on the presence of a dimet

199 of their role(s) in the mechanism of peptide bond formation, it is remarkable that the purposeful alt

200 The rate of covalent bond formation ( k(inact)) does not correlate with elect

201 al addition to an alkene with subsequent C-C bond formation leading to 2,1-carboamination products.

202 hanism by which a blue-light driven covalent bond formation leads to a global conformational change r

203 This bond formation leads to an increase of the conductance b

204 investigated the interplay between disulfide bond formation, lipids, and pH in the folding and activi

205 ity of the electrophiles needed for covalent bond formation makes control of selectivity difficult.

206 P-C bond formation may occur via substrate insertion into th

207 d the natural macrocycle tether of disulfide bond formation, metal-mediated or lactam group addition

208 The applicability of this direct C-O bond formation method is shown by synthesizing several m

209 However, the key step of the C-C bond formation needed for the generation of C(2) product

210 of 23S rRNA in regions critical for peptide bond formation now enables the direct ribosomal incorpor

211 A stepwise mechanism with C-C bond formation occurring first is supported by computati

212 Mechanistic studies indicate that the C-N bond formation occurs via a syn amino-palladation mechan

213 omputational studies indicate that C-halogen bond formation occurs via an S(N)Ar pathway, and phosphi

214 ylbenzylamines, however, effective ortho-C-C bond formation of free primary and secondary benzylamine

215 ay platform using the spontaneous isopeptide-bond formation of the SpyTag:SpyCatcher system to displa

216 he energetics of charge accumulation and O-O bond formation on a model haematite (110) surface.

217 that only become activated towards covalent bond formation on binding a specific protein.

218 literature by direct MS analysis: C=C double bond formation on saturated fatty acids, covalent adduct

219 orward solid-phase approaches based on amide-bond formation or a Cu(I)-catalyzed azide-alkyne click (

220 wide range of transformations through either bond formation or bond cleavage at sulfur.

221 labeling of octreotide either through amide-bond formation or by CuAAC reaction.

222 tching between homolytic and heterolytic H-H bond formation pathways through molecular engineering, i

223 ner-approach ensemble and its expansion upon bond formation potentially make it a key neuronal substr

224 ploits an inverted sequence and promotes C-C bond formation prior to deprotonation.

225 The palladium-catalyzed C-N bond formation proceeds in excellent yields, using an un

226 support for a pathway in which carbon-carbon bond formation proceeds via a radical-chain process wher

227 emained elusive for decades because the Fe-N bond formation process always convolutes with uncontroll

228 sence of p-toluenesulfonic acid for the C-Se bond formation process.

229 highly reactive fragment ions for selective bond formation processes and may pave the way for the us

230 an action proceed successfully, billions of bond formation processes have to be mastered exclusively

231 ranslational processing, incorrect disulfide-bond formation, protein aggregation, changes in gene exp

232 e derivatives DA1-DA4 could catalyze the C-N bond formation reaction between activated aryl halides a

233 ons for a photocatalytic decarboxylative C-O bond formation reaction that provides rapid and facile a

234 ameworks and their (001) facets seed the C=C bond formation reaction to constitute 2D sp(2) carbon-co

235 -1 (MmOGOR), which catalyzes a carbon-carbon bond formation reaction.

236 l materials; therefore, methodologies of C-S bond formation reactions are desirable in synthesis.

237 ciated with several bond cleavage as well as bond formation reactions in one pot.

238 Number of bond activation and bond formation reactions occur in selective sequence via

239 Ni, Co, Fe, and Mn catalysts for C-N and C-C bond formation reactions with alcohols and amines using

240 lly known have been our contributions in C-C bond formation reactions, hydrogen-atom transfer from wa

241 other three through judiciously selected C-C bond formation reactions.

242 reported transition-metal-free carbon-carbon bond formation reactions.

243 toward aryl C-S bond-formation reactions.

244 -catalyzed chemical reactions, including C-C bond formation, reduction, and oxidation reactions.

245 protein folding switch coupled to disulfide bond formation regulates chaperone-mediated retention ve

246 amines that strategically deviate from amide bond formation remains both a challenge and an opportuni

247 Thus, proteins involved in disulfide bond formation represent good targets for the developmen

248 ly destabilizing or preventing the disulfide bond formation required for proper protein function.

249 osphate leaving group is required for C6-C3' bond formation, resembling pyrophosphate initiated class

250 tams through two geminal C-C bond or two C-N bond formations, respectively.

251 I)-catalyzed ipso chloro displacement to C-N bond formation resulting in a more modular and straightf

252 olar effects in the transition-state for C-N bond formation/ring-opening.

253 In addition to phosphodiester bond formation, RNA polymerase II has an RNA endonucleas

254 ng step, which changes at high pH to the O-O bond formation step.

255 into coupling N(2) and H(2) cleavage and N-H bond formation steps together, highlight the importance

256 sidues in pairs is a result of the disulfide bond formation system, which functions to oxidize pairs

257 (2)-chiral element is close to where the C-C bond formation takes place in cyclizations of 1,6-enynes

258 several carbon-carbon and carbon-heteroatom bond formations taking place in one pot.

259 to identify new moieties capable of cysteine bond formation that are differentiated from commonly emp

260 ed a high degree of reversibility in the C-N bond formation that negatively impacted enantioselectivi

261 the phosphanido moiety to accomplish the P-C bond formation, the key role of the hydride ligand in 1

262 Rather surprisingly, C-C bond formation through "intermolecular" radical addition

263 tion, oxidative C-C bond cleavage and triple bond formation through a putative allene intermediate.

264 e asymmetric Tsuji allylic alkylation is C-C bond formation through a seven-membered pericyclic trans

265 experimental mechanistic studies support C-F bond formation through vinyl cation intermediates, with

266 ond of an iPr substituent and by C-C and P-C bond formation to a new isomer of phosphaallenes, 10, wh

267 renoid intermediate that can engage in C-NAr bond formation to construct functionalized N-heterocycle

268 hod relies on thermodynamically favored Si-F bond formation to generate a carbanion, therefore enabli

269 ibe a system for photochemical carbon-carbon bond formation to make 2-oxoglutarate by coupling CO(2)

270 transformations can shift from carbon-carbon bond formation to proton transfer to the catalyst's conj

271 hrough loose transition states, with minimal bond formation to the nucleophile and bond cleavage to t

272 inetics provide strong evidence for hydrogen bond formation to Y191(*) by His232/Glu232.

273 fold faster, permitting multiple turnover NP bond formation to yield NP-DNA strands from the correspo

274 ed by productive and selective C-NAr and C-C bond formation to yield spirocyclic- or bicyclic 3H-indo

275 state followed by two rotations and a final bond formation transition state.

276 leveraged to enable challenging H(3)C-CF(3) bond formation under mild conditions.

277 lexes with Selectfluor results in C(sp(2))-F bond formation under mild conditions.

278 ropiolic acid substrate, a cascade three C-C bond formation via an uninterrupted C-H functionalizatio

279 This is the first example of alkyl-alkyl bond formation via cross-coupling of an alkyl amine deri

280 ities of metal ion coordination and hydrogen bond formation via its NH moiety.

281 deuterium-labeled acetate 1h corroborate C-N bond formation via outer-sphere addition.

282 accomplish this abiological carbon-nitrogen bond formation via reactive iron-bound carbonyl nitrenes

283 o the transition state region; then, the P-O bond formation via the donation of electron density of t

284 ing lower permeabilities reported by others, bond formation was insufficient to balance drag forces o

285 The mechanism of the C-N bond formation was probed via initial rate kinetic analy

286 All sigma-bond formations were found to proceed through highly ord

287 -C bond desaturation, aromatization, and C-C bond formation, were also observed.

288 he second channel results from transient C-H bond formation, where H atoms lose 1 to 2 electron volts

289 provides sufficient space even for disulfide bond formation which can guide protein folding.

290 res a high overpotential associated with O O bond formation, which dominates the energy-efficiency of

291 the underlying substrate was due to hydrogen bond formation, which outcompeted electrostatic repulsio

292 zing the single kinetic step: first, the C-C bond formation, which takes place via donation of electr

293 ned and site-selective carbon-nitrogen (C-N) bond formation, while a photoredox- and cobalt-based cat

294 cis-selectivity is a result of selective C-C bond formation, while subsequent steps appear to influen

295 complex exclusively undergoes C(sp(3) )-OAc bond formation, while the Ni(III) analogue forms the C(s

296 iven by reversible binding prior to covalent bond formation, while the reversible covalent PROTACs dr

297 on through C-terminal adenylation, thioester bond formation with an E1 catalytic cysteine, and thioes

298 ns of cis-1,2-diol moieties, followed by C-C bond formation with net retention of configuration, are

299 c pathway becomes slower than phosphodiester bond formation with the APC DNA sequence but not with a

300 s by distinguishing late stage key strategic bond formations within the underlying Aspidosperma core