ライフサイエンスコーパス: bone regeneration

1 that A2AR might be a novel target to promote bone regeneration.

2 improved therapeutics to achieve predictable bone regeneration.

3 r 1 muM dipyridamole (EC50 = 32 nM) promoted bone regeneration.

4 d the effect of CGS21680 and dipyridamole on bone regeneration.

5 ributions of the periosteum and endosteum to bone regeneration.

6 velopments in stem cell delivery via CPC for bone regeneration.

7 on of bone grafting materials; and 4) guided bone regeneration.

8 otent stem cell (hiPSC) seeding with CPC for bone regeneration.

9 that control the periosteal contribution to bone regeneration.

10 combinant biglycan (GST-BGN) on craniofacial bone regeneration.

11 Cs) could significantly enhance vascularized bone regeneration.

12 se cellular functions, from wound healing to bone regeneration.

13 nflammation, prevents bone loss, and induces bone regeneration.

14 ned non-bridged while the 3D scaffold guided bone regeneration.

15 mpatible and has proper biodegradability for bone regeneration.

16 tion for MSCs and EPCs dramatically promotes bone regeneration.

17 morphogenic proteins (BMPs) directly augment bone regeneration.

18 , whereas at a later time point, it enhanced bone regeneration.

19 BMP signaling can be achieved to accelerate bone regeneration.

20 concluded that smoking negatively influenced bone regeneration.

21 hey could be a viable therapeutic option for bone regeneration.

22 w their clinical and radiographic effects on bone regeneration.

23 tion control while simultaneously initiating bone regeneration.

24 both embryonic skeletogenesis and postnatal bone regeneration.

25 l pathway that may be targeted for enhancing bone regeneration.

26 hat establishes an environment for efficient bone regeneration.

27 ells indeed causes insufficiency in cortical bone regeneration.

28 dontal disease may have a negative impact on bone regeneration.

29 monstrated that radiation damage led to less bone regeneration.

30 r load-bearing bone defects and subsequently bone regeneration.

31 increased angiogenesis and markedly improved bone regeneration.

32 aracteristics influence the process of adult bone regeneration.

33 the potential to achieve rapid and enhanced bone regeneration.

34 re therapeutic applications for craniofacial bone regeneration.

35 ciated with poor clinical outcomes in guided bone regeneration.

36 chymal stromal cells (MSCs) are critical for bone regeneration.

37 ive to the currently accepted techniques for bone regeneration.

38 that synergistically interacted to stimulate bone regeneration.

39 he most recent research in the area of local bone regeneration.

40 (780 J/cm2) exhibited the greater amount of bone regeneration.

41 fect were obtained to evaluate the amount of bone regeneration.

42 branes must be in position to promote guided bone regeneration.

43 ramifications in terms of wound healing and bone regeneration.

44 IGF-I resulted in a significant promotion in bone regeneration.

45 with established techniques including guided bone regeneration.

46 part of a sequence of experiments on guided bone regeneration.

47 fic implants capable of directing functional bone regeneration.

48 d WNT signaling, leading to enhanced in vivo bone regeneration.

49 st-effective method of improving BMP-induced bone regeneration.

50 interfaces to reliable, clinically impactful bone regeneration.

51 l-free therapeutic approach for craniofacial bone regeneration.

52 ar-complete loss of callus formation and rib bone regeneration.

53 ted to mesenchymal stem cell recruitment and bone regeneration.

54 osteogenic-endothelial niche interaction in bone regeneration.

55 nts to improve cellular osseointegration and bone regeneration.

56 lication of these nanocomposites for in situ bone regeneration.

57 on of MSCs into bone cells ensuring complete bone regeneration.

58 vascularization in biomaterials relevant for bone regeneration.

59 new cell therapy approaches toward complete bone regeneration.

60 ay a major role in orchestrating large-scale bone regeneration.

61 can trigger events, such as osteogenesis and bone regeneration.

62 dicating a prominent role of DA in effective bone regeneration.

63 opontin (hOPN) in plants for inducing dental bone regeneration.

64 ells is still a challenge in stem cell-based bone regeneration.

65 for hematopoiesis, immunological memory, and bone regeneration.

66 ffold for drug delivery and stem cell-guided bone regeneration.

67 2, a growth factor currently used to promote bone regeneration.

68 ted by insufficient vascularization and slow bone regeneration.

69 ctive molecules to support wound healing and bone regeneration.

70 cially the placement of implants at sites of bone regeneration.

71 elineates their essential role in functional bone regeneration.

72 ting adenosine receptors in the promotion of bone regeneration.

73 BMP2-modified MSCs can significantly promote bone regeneration.

74 d represents a novel approach to stimulating bone regeneration.

75 t averaged 3.7+/-0.3 and 3.9+/-0.3 mm, total bone regeneration 0.8+/-0.6 and 1.5+/-0.8 mm, and total

76 he biological mechanisms underlying alveolar bone regeneration (ABR) and orthodontic tooth movement i

77 Bone regeneration after 24 weeks was evaluated by micro-

78 hibited fast biodegradation and retarded new bone regeneration after 8 weeks.

79 n clinical and/or radiographic indicators of bone regeneration after periodontal therapy.

80 stematically assess the effect of smoking on bone regeneration after periodontal treatment.

81 hat their smoking habit may result in poorer bone regeneration after periodontal treatment.

82 Smoking has a negative effect on bone regeneration after periodontal treatment.

83 has been placed on the impact of smoking on bone regeneration after treatment.

84 They have been used for orofacial bone regeneration and autoimmune disease treatment.

85 on of aspirin, markedly improved BMMSC-based bone regeneration and calvarial defect repair in C57BL/6

86 is 2-year randomized clinical trial compared bone regeneration and esthetic outcome between immediate

87 Simvastatin (SMV) assists in bone regeneration and has an anti-inflammatory effect wh

88 processes of the main cells responsible for bone regeneration and help support the positive clinical

89 ctivation of bone surfaces in the context of bone regeneration and in response to parathyroid hormone

90 critical roles in lysosomal homeostasis and bone regeneration and its mutation can lead to osteopetr

91 promoting factors and cytokines that promote bone regeneration and maturation of soft tissue.

92 mbining NELL-1 with BMP2 to improve clinical bone regeneration and provide mechanistic insight into c

93 rstand the regulatory mechanisms involved in bone regeneration and provides a mathematical framework

94 F-kappaB may have dual benefits in enhancing bone regeneration and repair and inhibiting inflammation

95 of IKKVI promoted MSC-mediated craniofacial bone regeneration and repair in vivo.

96 Promoting bone regeneration and repair of bone defects is a need t

97 Wnt-4 may have a potential use in improving bone regeneration and repair of craniofacial defects.

98 tion is a promising therapeutic approach for bone regeneration and repair.

99 sts and provide an excellent cell source for bone regeneration and repair.

100 omerase therapy may be a useful strategy for bone regeneration and repair.

101 istologic findings suggest that PRP enhanced bone regeneration and resulted in increased horizontal b

102 th more complex bone grafting such as guided bone regeneration and sinus augmentation compared with s

103 Systemic Scl-Ab administration improved bone regeneration and tended to increase cementogenesis

104 augment the endogenous osteogenic cells for bone regeneration and the treatment of bone loss.

105 e a basis for clinical strategies to improve bone regeneration and treat defects in bone healing.

106 ecan-binding growth factors inducing greater bone regeneration and wound repair than wild-type growth

107 s directed toward ridge augmentation (guided bone regeneration) and had the membranes removed either

108 d bone marrow MSC (hBMSC) seeding on CPC for bone regeneration, and (5) human embryonic stem cell (hE

109 ade, leading to improvement of SHED-mediated bone regeneration, and also upregulates TERT/FASL signal

110 ervation, guided tissue regeneration, guided bone regeneration, and sinus augmentation (P < 0.0001).

111 ains unclear, however, whether cells used in bone regeneration applications produce a material that m

112 gn and application of SF-based scaffolds for bone regeneration are discussed.

113 Safe, effective approaches for bone regeneration are needed to reverse bone loss caused

114 defect height and area, membrane height, and bone regeneration area, showed high correlations among t

115 Bone regeneration (area) was 2-fold greater in cGTR site

116 ination growth factor cement (GFC) on guided bone regeneration around dental implants.

117 locally applied alendronate sodium on guided bone regeneration around dental implants.

118 rimary closure and delayed loading to ensure bone regeneration around implants were not critical in t

119 PTH 1-34 (cys-PTH 1-34) was shown to enhance bone regeneration around implants.

120 ic viability and function, implying enhanced bone regeneration around NAC-treated inorganic biomateri

121 s study was to evaluate osseointegration and bone regeneration around nonsubmerged or submerged impla

122 neration than the scaffold alone and as much bone regeneration as BMP-2, a growth factor currently us

123 hat half-dose gene of Fgf-9 markedly reduced bone regeneration as compared with wild-type.

124 polymer matrix (gene activated matrix) using bone regeneration as the endpoint in vivo.

125 CGS21680 and dipyridamole markedly enhanced bone regeneration as well as BMP-2 8 wk after surgery (6

126 eased gingival HIF-1alpha protein levels and bone regeneration, as compared to mice treated with vehi

127 logical analyses revealed significantly more bone regeneration at 2 and 4 weeks post-injury.

128 Although there was no difference in bone regeneration at 4 weeks, at 8 weeks there was a sig

129 microarchitectural cues that promote in situ bone regeneration at locations distant from existing hos

130 The BioCer implant promoted bone regeneration at nonosseous sites, and bone bonding

131 t to evaluate the effects of HFDDS on guided bone regeneration at sites with 1.5-mm peri-implant defe

132 ft substitutes, barrier membranes for guided bone regeneration, autogenous and allogenic block grafts

133 cts were treated with FDBA, differing guided bone regeneration barrier membranes, and PCTG.

134 cells (hiPSC) represent a powerful tool for bone regeneration because they are a source of patient-s

135 tion of cytokines even before the process of bone regeneration begins.

136 BMPs facilitate periodontal bone regeneration but also are implicated in causing too

137 promise of dental pulp stem cells (DPSCs) in bone regeneration, but less is known about the regenerat

138 Because dipyridamole promotes bone regeneration by an A2AR-mediated mechanism we deter

139 cycline in the form of natrosol-based gel on bone regeneration by examining critical defects in rat c

140 on, which translate into more robust in vivo bone regeneration by neural crest-derived cells.

141 This clinical study compared the bone regeneration capacity of a commonly used GTR proced

142 We concluded that the bone regeneration capacity of Cox-2KO MDSCs was impaired

143 study investigates a comprehensive model of bone regeneration capacity of dypiridamole-loaded 3D-pri

144 lds resulted in a significant improvement in bone regeneration compared to PEI-pBMP-2 embedded in col

145 ted matrices promoted significantly enhanced bone regeneration compared to PEI-plasmid DNA (BMP-2)-ac

146 mplant defects did not significantly enhance bone regeneration compared to the carrier, polyglactin m

147 Bone regeneration continues to be a challenge due to the

148 6-deficient mice, which have both a nail and bone regeneration defect.

149 ment of mesenchymal stem cell (MSC) directed bone regeneration during in vivo assays is dependent on

150 Although there are several methods of bone regeneration, each has limits.

151 the osteogenic potential of Nell-1 to induce bone regeneration equivalent to BMP-2, whereas immunohis

152 ccelerates xenograft resorption and enhances bone regeneration, especially in the early stages of bon

153 an embellishment of this paper and describes bone regeneration experiments in 18 adult male Macaca mu

154 Bone regeneration following injury is initiated by infla

155 s that provide more predictable and improved bone regeneration for bone defect repair in oral and max

156 ling have or may have in periosteal-mediated bone regeneration, fostering the path to novel approache

157 n materials have also been applied in guided bone regeneration (GBR) and root coverage procedures wit

158 e long-term outcomes and the need for guided bone regeneration (GBR) are still topics of debate.

159 atic review we evaluate the effect of guided bone regeneration (GBR) at the time of IIP on crestal bo

160 , and bovine bone mineral on vertical guided bone regeneration (GBR) in rabbit calvarium.

161 affold as a biomaterial for obtaining guided bone regeneration (GBR) in vivo.

162 Guided bone regeneration (GBR) is a similar procedure used to a

163 Guided bone regeneration (GBR) is a viable treatment for osseou

164 Guided bone regeneration (GBR) is a widely used procedure for a

165 let-derived growth factor (rhPDGF) in guided bone regeneration (GBR) is debatable.

166 ation is often performed as part of a guided bone regeneration (GBR) procedure.

167 quality of the new bone formation in guided bone regeneration (GBR) procedures with different titani

168 cularization underlies the success of guided bone regeneration (GBR) procedures.

169 rimary soft tissue closures following guided bone regeneration (GBR) procedures.

170 to virtual dental implants following guided bone regeneration (GBR) surgery and evaluate the influen

171 may enhance bone formation following guided bone regeneration (GBR) techniques alone or in combinati

172 bone height and width created during guided bone regeneration (GBR) to augment alveolar ridges is no

173 Guided bone regeneration (GBR) using a non-absorbable barrier h

174 t the amount of healed bone following guided bone regeneration (GBR) with demineralized freeze-dried

175 ntial of this technique--often called guided bone regeneration (GBR)--to regenerate bone defects in t

176 morphology on the clinical outcome of guided bone regeneration (GBR).

177 Synthetic, resorbable scaffolds for bone regeneration have potential to transform the clinic

178 For in vivo bone regeneration, HCCS-PDA or HCCS particulates with or

179 Bone regeneration (height) was significantly increased i

180 e alpha V beta 3-vitronectin is important in bone regeneration, hence the compounds were also tested

181 he difficulty in achieving spatially uniform bone regeneration in 3D.

182 two previous studies of periosteum-mediated bone regeneration in a common ovine model, it was shown

183 r angle defect, which is used to investigate bone regeneration in a nonload-bearing area, and the inf

184 Deficient bone regeneration in aged mice could only be returned to

185 eliable and predictable methods to stimulate bone regeneration in alveolar bone defects.

186 ld enhance bone marrow stromal-cell-mediated bone regeneration in an osseous defect.

187 ng platform is proposed to assist functional bone regeneration in cases of larger bone defects, inclu

188 ped calcium phosphate cement used to promote bone regeneration in craniofacial defects was examined t

189 cell-CPC constructs are highly promising for bone regeneration in dental, craniofacial, and orthopedi

190 dy shows that treatment with SA-PAE enhances bone regeneration in diabetic rats and accelerates bone

191 e effect of polymer-controlled SA release on bone regeneration in diabetic rats where enhanced inflam

192 bjective of this pilot study was to evaluate bone regeneration in mandibular, full-thickness, alveola

193 one substitutes or growth factors to enhance bone regeneration in membrane-protected defects.

194 imordial bone thus plays a critical role for bone regeneration in MSFA, particularly in the molar reg

195 egeneration in diabetic rats and accelerates bone regeneration in normoglycemic animals.

196 P-2) is an osteoinductor frequently used for bone regeneration in oral and maxillofacial surgery.

197 M) has been extensively studied and used for bone regeneration in oral and maxillofacial surgery.

198 Efforts to enhance bone regeneration in orthopedic and dental cases have gr

199 ical, histologic, and radiographic effect on bone regeneration in patients with AgP.

200 GF-2) could be an effective way of promoting bone regeneration in patients with diabetes.

201 and retrospective clinical studies assessing bone regeneration in smokers and non-smokers after perio

202 The impaired bone regeneration in the Cox-2KO MDSCBMP4/GFP group is a

203 us strategies have been developed to promote bone regeneration in the craniofacial region.

204 itro, and suggest a therapeutic strategy for bone regeneration in the future.

205 By studying a model of large-scale bone regeneration in the lower jaw of adult zebrafish, w

206 ple one-dimensional time-dependent model for bone regeneration in the presence of a bioresorbable pol

207 The increased vascularity and bone regeneration in the pVHL mutants were VEGF dependen

208 r without rhTGF-beta1, significantly enhance bone regeneration in the rat calvaria defect model.

209 here was a significant (P <0.05) increase in bone regeneration in the VEGF-Alg-treated defects.

210 oblast differentiation in vitro and inducing bone regeneration in vivo when compared with its closely

211 gulates mineralization in vitro and promotes bone regeneration in vivo.

212 e new US morphometric parameters to quantify bone regeneration in vivo.

213 These data suggest that bone regeneration, in contrast to homeostatic bone turno

214 that each pathway has in periosteal-mediated bone regeneration, in this review we analyze the status

215 result in complications, such as inadequate bone regeneration, inflammatory reactions, and wound inf

216 Bone regeneration involves a series of events in a coord

217 Bone regeneration is a complex process and the clinical

218 Bone regeneration is a complex process, that in vivo, re

219 Bone regeneration is a dynamic, multistage process requi

220 Bone regeneration is an indispensable procedure for impl

221 Guided bone regeneration is commonly applied to attenuate the c

222 Alveolar bone regeneration is frequently necessary prior to place

223 Guided bone regeneration is frequently performed to augment def

224 The microenvironment of bone regeneration is hypoxic.

225 Bone regeneration is mediated by skeletal stem/progenito

226 ailure of commonly used materials for guided bone regeneration is rare; however, different batches of

227 Unfortunately, the science of bone regeneration is still in its infancy, with all curr

228 how that although VEGF alone did not improve bone regeneration, it acted synergistically with BMP4 to

229 ng beta tricalcium phosphate (beta-TCP) as a bone regeneration material with either platelet rich fib

230 epresents an advancement towards a synthetic bone regeneration matrix.

231 Premature membrane exposure for guided bone regeneration may result in complications, such as i

232 y induces new bone formation in the alveolar bone regeneration model.

233 e collagen sponge (ACS) in a vertical guided bone regeneration model.

234 Part I included the alveolar bone regeneration model.

235 anisms driving the fibrous scaffold mediated bone regeneration must be understood.

236 e delivery of multiple growth factors to the bone regeneration niche, specifically 1) dual growth fac

237 Bone regeneration occurs as a series of events that requ

238 uates age-related bone loss, and accelerates bone regeneration of aged rodents.

239 TR) techniques have been reported to enhance bone regeneration of molar furcation defects.

240 rate that MSC and pericytes have significant bone regeneration potential in an atrophic non-union mod

241 Desirable antibacterial effects, bone regeneration potential, and tumor growth suppressio

242 A staged guided bone regeneration procedure prior to the implant install

243 A guided bone regeneration procedure was performed to protect the

244 ane has been shown to be effective in guided bone regeneration procedures and in treating periodontal

245 ollagen matrix is commercially available for bone regeneration procedures.

246 matrix material has been used clinically in bone regeneration procedures.

247 ducing the different tissues involved in the bone regeneration process.

248 Bone regeneration was tested in the guided bone regeneration rat calvaria model.

249 hat 10% doxycycline gel had a good effect on bone regeneration regarding the filling of critical defe

250 in a three-dimensional microenvironment for bone regeneration remains a challenge.

251 Bone regeneration requires coordinated anabolic and cata

252 surgery (60 +/- 2%, 79 +/- 2%, and 75 +/- 1% bone regeneration, respectively, vs. 32 +/- 2% in contro

253 mation, the recruitment of immune cells, and bone regeneration, resulting in delayed fracture healing

254 enesis coupled with its ability to stimulate bone regeneration revealed a potential therapeutic role

255 Cell-based bone regeneration strategies offer promise for traumatic

256 Here, we use bone-regeneration successes to highlight cartilage-regen

257 dent accumulation of Treg cells and alveolar bone regeneration, suggesting a novel approach for regai

258 ed within 3-D constructs may be employed for bone regeneration techniques, such as onlay and sinus gr

259 narrow ridges without the use of membranes, bone regeneration tends to be inferior on the side of th

260 ial bone defect, promoted significantly more bone regeneration than the scaffold alone and as much bo

261 regulate fracture repair are contrasted with bone regeneration that occurs during distraction osteoge

262 In the realm of therapeutic bone regeneration, the defect or injured tissues are fre

263 linical animal models for local and systemic bone regeneration, the synergistic effect of Nell-1 with

264 or fused fiber construct may be suitable for bone regeneration therapy for dental implants.

265 On the other hand, APR promoted alveolar bone regeneration through enhancing osteogenic different

266 a cell/GF-free, one-step surgery for in situ bone regeneration, thus demonstrating high potential for

267 m our laboratory described the use of guided bone regeneration to fill large bone voids in the mandib

268 m our laboratory described the use of guided bone regeneration to fill large bone voids in the mandib

269 onstrated no significant differences between bone regeneration treated with lyophilized AdBMP-2 befor

270 VBA was performed via guided bone regeneration using titanium mesh and allografts.

271 in muscle-derived stem cell (MDSC)-mediated bone regeneration utilizing a critical size calvarial de

272 reviously used this procedure to investigate bone regeneration, vascularization and infection prevent

273 NELL-1/Nell-1 can promote orthotopic bone regeneration via either intramembranous or endochon

274 n addition, contour augmentation with guided bone regeneration was able to establish and maintain a f

275 In this case presentation, guided bone regeneration was achieved around an immediate endos

276 The 1,4-DPCA/hydrogel-induced increase in bone regeneration was associated with elevated expressio

277 Bone regeneration was evaluated 1, 2 and 3 months post-i

278 After 12 weeks, calvarial bone regeneration was evaluated radiographically, histol

279 application of barrier membranes to promote bone regeneration was first described by Hurley et al. i

280 Ddr2 expression during calvarial bone regeneration was measured using Ddr2-LacZ knock-in

281 d or lost the ePTFE membrane, the percent of bone regeneration was reduced in group A.

282 -DPCA/hydrogel on Treg cell accumulation and bone regeneration was reversed by AMD3100, an antagonist

283 Bone regeneration was tested in the guided bone regenera

284 Guided bone regeneration was the intervention most commonly app

285 To measure bone regeneration, we implanted virally transduced BLK c

286 Neovascular growth and bone regeneration were quantitatively evaluated 3 wk aft

287 vitro osteogenic differentiation and in vivo bone regeneration when compared with either CD105(high)

288 glass biomaterials have positive effects on bone regeneration when used for repair of bone defects.

289 the effects of TiO(2) nanotube surfaces for bone regeneration will be discussed.

290 eveloped in this article, future advances in bone regeneration will likely incorporate therapies that

291 Current gene therapy approaches for bone regeneration will then be summarized, including rec

292 gents often fail to achieve rapid endogenous bone regeneration with high quality.

293 ons distant from existing host bone, whereas bone regeneration with inert titanium implants was confi

294 teins may be a powerful tool for stimulating bone regeneration with significant potential for clinica

295 nt MSCs, the hydrogel's elasticity regulated bone regeneration, with optimal bone formation at 60 kPa

296 e effect of local delivery of alendronate on bone regeneration within peri-implant defects.

297 e area of bone tissue engineering focuses on bone regeneration within sterile, surgically created def

298 e laser treated specimens showed evidence of bone regeneration within the ablation defect regardless

299 Bone regeneration within the defects increased in all gr

300 study, it is hypothesized that BMP2-mediated bone regeneration would be positively affected by simult