ライフサイエンスコーパス: bp

1 ppeared from the fossil record around 40,000 bp, after a demographic history of small and isolated gr

2 ite of El Sidron, Spain, dated around 49,000 bp, constituted a closely related kin group, making thes

3 encing produced a circular genome of 107,063 bp containing 97 open reading frames, the majority of wh

4 These three SNPs covered a region of 43,067 bp; we referred to this region as the MD/FDP locus.

5 taining a large single copy region of 82,084 bp and small single copy region of 5,272 bp.

6 The 5,097 bp of the concatenated housekeeping gene sequence from t

7 ir parents (40.7 +/- 2.5 bp/yr; 20.3 +/- 2.1 bp/yr, respectively; P < 0.0001).

8 ts obligatory carrier parents identified a 1 bp insertion (CFA20:g.33,717,704_33,717,705insT (CanFam3

9 verse reaction, the sharp kink with RAG is 1 bp away from the integration site.

10 d the open reading frame is disrupted by a 1-bp insertion, expresses very small amounts of EBNA3A usi

11 9-mediated editing with guide RNAs only 1-10 bp apart.

12 ctors (TF) function by binding to short 6-10 bp DNA recognition sites located near their target genes

13 ved SssI Control data, on both 100 bp and 10 bp windows.

14 odel engineered with a noncoding intronic 10 bp deletion (del10) in Hgf Male and female mice homozygo

15 ocytes - could adopt a helical repeat of ~10 bp/turn.

16 Using a Hgf mutant mouse with a small 10 bp deletion recapitulating a human DFNB39 noncoding vari

17 amples, with 94% of deletions larger than 10 bp, and essentially no insertions at all tested target s

18 We show that 10 bp of the CRISPR leader sequence is critical for stimula

19 ssay generated spliced RNA containing the 10 bp insertion observed in the C8alpha mRNA of affected pa

20 of which are novel and do not fall within 10 bp of existing 3'-UTR data sets and annotations.

21 ich is found by chance only once in 7x10(10) bp of genomic sequences, and can thus form a near bioort

22 and internucleosomal interactions with a 10-bp periodicity.

23 -1 nucleosomes associated with a periodic 10-bp WW signal (W = A/T).

24 extended gyrase binding motif with phased 10-bp G/C content variation, indicating that bending abilit

25 We observe the 10-bp periodic WW signal at ubiquitous promoters in other a

26 nerally follow a well-known pattern with ~10-bp periodic WW (where W is A or T) dinucleotides that os

27 e genome is 158,712 bp, smaller than 160,100 bp of the C. papaya chloroplast genome.

28 asites with homology arms as short as 80-100 bp.

29 with observed SssI Control data, on both 100 bp and 10 bp windows.

30 interactions at a high resolution (e.g. 100 bp), we developed a computational method that integrates

31 nanopore data for target DNA sequences <100 bp.

32 e of nearly perfect inverted repeats of ~100 bp near the 5' end of vlsE, and an exceedingly high conc

33 lization: large deletions (median size, ~100 bp) with little or no homology at deletion junctions.

34 We determined that 100 bp windows around MotifMap sequenced-based TF-binding pr

35 but could be restored by fusion with the 100 bp minimum transcription initiation element (TIE) of Klk

36 ed, they were widely distributed over a 1000-bp intron region downstream of J(H)3 and J(H)4 exons and

37 on consisting of a 40-70 bp poly-A and an 11 bp duplication of the exonic region preceding the poly-A

38 es, of which the most significant was a 1100-bp spanning region annotated to the calcium-binding tyro

39 aled that P. ovata plastome size was 162,116 bp and that it had typical quadripartite structure conta

40 e variant showed an in-frame insertion of 12 bp.

41 G1 first recognized a 12-bp sequence at the leader-repeat junction and performed

42 Furthermore, the successful capture of a 120 bp KRAS fragment from human plasma samples followed by r

43 ences including a major tandem repeat of 120 bp and ~1,000 germline-expressed genes.

44 e associated imaging contrast for up to 1200 bp, enabling us to quantify dsDNA length with up to 2 bp

45 We obtained ~219 million paired-end 125-bp Illumina reads from five time-courses and de novo ass

46 enced RNA-sequencing samples using long (126-bp) paired-end reads.

47 polymorphism (T1279G) at the position -1279 bp that locates on the potential GA-responsive motif in

48 cky ends over three helical periods (100-130 bp) using single-molecule fluorescence resonance energy

49 sites, achieving replacement with up to 130-bp sequences at 6.1% efficiency.

50 PB-79 (GenBank accession no. KU901725; 1313 bp), Streptomyces sp. Kz-28 (GenBank accession no. KY000

51 esis, we used a recombinant virus with a 135-bp deletion spanning only the core CTRL2 insulator domai

52 Kz-24 (GenBank accession no. KY000533; 1367 bp) showed only 96.2% sequence similarity to S. malaysie

53 Kz-32 (GenBank accession no. KY000536; 1377 bp) and Streptomyces sp. Kz-67 (GenBank accession no. KY

54 Kz-28 (GenBank accession no. KY000534; 1378 bp), Streptomyces sp. Kz-32 (GenBank accession no. KY000

55 g or Cnr) had insertions of four related 138 bp transposable element (TE) sequences at precisely the

56 Kz-67 (GenBank accession no. KY000540; 1383 bp) showed ~89.5% similarity to the nearest type strain

57 the diffusion of various lengths (99 to 1385 bp) of single DNA molecules at rates up to 10 um(2)/s.

58 While analysis of 139 bp of mitochondrial DNA (mtDNA) has confirmed that the I

59 o J-DNA can facilitate T hydroxylation 12-14 bp downstream on the complementary strand of the J-recog

60 sembles part of the previously identified 14-bp beta2UE1 element critical for spermatocyte-specific e

61 ses revealed a VB12-riboswitch, cbiMCbl (140 bp), within the 5' UTR that controls the expression of d

62 an) circulating DNA identified a peak at 145 bp in the human DNA fragments, indicating a difference i

63 m different size bins between 20 and 892,149 bp.

64 NA fragment size with a median length of 149 bp.

65 f dsDNA and a Ctp1 tetramer footprint of ~15 bp.

66 gene that may cause GPR56 dysfunction, a 15-bp homozygous deletion in the cis-regulatory element ups

67 Mapping also revealed a ~150 bp periodic downstream sequence element (PDE) following

68 coverage) assembled from short Illumina 150 bp paired-end reads.

69 The 150 bp minimum ERalpha binding element (EBE) consists of thr

70 tradictory reports as to whether wider ( 150 bp) NDRs instead contain unstable, micrococcal nuclease-

71 ion afforded by sequencing the entire (~1500 bp) gene.

72 Mammalian antibody switch regions (~1500 bp) are composed of a series of closely neighboring G4-c

73 romatin accessibility information up to 1500 bp from the genomic region of interest.

74 op closure involving closely spaced (131-151 bp) loxP sites to investigate the in-aqueo ensemble of c

75 ed cell nuclei showed a median length of 153 bp with CC motif frequencies resembling plasma DNA from

76 ut CDEII in the former is twice as long (160 bp) as CDEII in the latter (80 bp).

77 Brg11 targets a 17-bp sequence that was found to be part of a conserved 50-

78 The nonduplicated 17-bp promoter was more common in tissue samples from popul

79 NA cleavages that are scattered across a 170-bp region and that its headful measuring device has a pr

80 To do this, we identified a 171-bp DNA sequence within multiple paralogous copies of msp

81 A derived from human chromosomes (103 vs 172 bp, p < 0.0001), corresponding to the 3(rd) percentile o

82 er, and gain of a MYB interaction with an 18-bp indel in the TAL1 superenhancer.

83 (fragments with a length between 140 and 180 bp) DNA fragments are recovered and sequenced on Illumin

84 pified by an average filament length of ~180 bp of dsDNA and a Ctp1 tetramer footprint of ~15 bp.

85 at two types of knobs, those composed of 180-bp and TR1 sequences, recruit their own novel and diverg

86 eletions of chromosomal DNA ranging from 181 bp to 49 kb.

87 dicted genes) and P. micropora NZ27 (977,190 bp, GC-content = 39.9%, 911 predicted genes) and compare

88 re of the LSD1/CoREST complex bound to a 191-bp nucleosome.

89 ngth library (565 bp) and mini-barcodes (193 bp) contain enough taxonomic resolution to differentiate

90 ) structures of chromatosomes containing 197 bp DNA and three different human H1 isoforms, respective

91 and that only fibres with longer NRLs (>=197 bp) can more likely adopt the 1-start organisation.

92 Most HT-induced indels are 1-2 bp in size and particularly affect homopolymeric or dinu

93 We identified a 2 bp variant c.817_818GC>AA in SP6, the gene encoding the

94 t and inexpensive and can identify indels >2 bp.

95 required a terminator hairpin of at least 2 bp preceding an 3' oligoU tail of at least four uridine

96 that an extended sequencing context of +/- 2 bp is required to more completely capture the patterns o

97 ing us to quantify dsDNA length with up to 2 bp accuracy.

98 e with constituent variants falling within 2 bp distance of one another, including 18,756 variants wi

99 s in vivo, whereas the DeltaCEH and 1- and 2-bp alleles do not support telomerase function.

100 tion events involving relatively short (<200 bp) homologous sequences, where RecA-mediated recombinat

101 DNA for distances of >4 kb at a rate of ~200 bp per second at room temperature.

102 e markers (i.e. amplicons with less than 200 bp) suitable for DNA metabarcoding by evaluating the tax

103 S context in these promoters was within ~200 bp of the TSS.

104 to regulate Abd-B Here we show that an ~200-bp sequence of dHS1 from the Fab-7 boundary rescues the

105 o the regulation of ZmBCH2, we isolated 2036 bp of the 5'-flanking region containing the 263 bp 5'-un

106 This complex recognizes a conserved 21-bp GA-rich sequence motif that is enriched on the X chro

107 sequencing revealed a recessive germline 21-bp in-frame deletion in NUAK2 segregating with the disea

108 anscript of 901 nucleotides containing a 210 bp inverted fragment of the DvSSJ1 gene, the formation o

109 MinION sequencing provided 1,152,211 bp of new shark genome, increasing the number of sequenc

110 This particular 22 bp duplication within the coding region of UGT1A1 can be

111 Our data identified a short (22 bp) DNA element containing a key repressive element.

112 This 22 bp duplication causes a frame shift leading to a prematu

113 h cnr allele had a distinct insertion of 226 bp of in exon 3.

114 additional 5'-TKAN-3' motif positioned 11-23 bp downstream of the CCAAT motif, i.e. occasionally over

115 We then determined that a 23 bp region of the Widom-601 NPS is responsible for formin

116 ences flanking less well-conserved 12- or 23-bp spacers.

117 plified specific DNA fragments from dog (230 bp), duck (283 bp), buffalo (363 bp), goat (396 bp), and

118 nk bollworm cadherin gene (PgCad1) has a 234-bp insertion in exon 12 encoding a mutant PgCad1 protein

119 irs of duplex DNA at an average rate of ~240 bp/min.

120 CDEI (8 bp) and CDEIII (~25 bp) are conserved between Kluyveromyces lactis and Sacch

121 mutant mice by introducing the 129S6/SvEv 25-bp deletion Disc1 variants into the C57BL/6J strain.

122 Expecting the merged reads to be 180-250 bp in length, the appropriate e-value threshold for DIAM

123 on carp beta-actin promoter, harboring a 250-bp homologous region flanking both sides of the genomic

124 to study SCAs in vivo We have isolated a 258 bp cross-species PC-specific enhancer element that can b

125 that endogenous circRNAs tend to form 16-26 bp imperfect RNA duplexes and act as inhibitors of doubl

126 psl1 with a 260-bp deletion in its gene displayed leaf rolling in respon

127 of the 5'-flanking region containing the 263 bp 5'-untranslated region (5'-UTR) including the first i

128 We examined a 27-bp deletion (Delta27bp) within the polymorphic exon 1 th

129 084 bp and small single copy region of 5,272 bp.

130 strate targeting of an arbitrarily chosen 28 bp genomic locus at a density that approaches 1.0 (i.e.,

131 pairs activates the nickase activity, and 28-bp hybridization promotes cleavage of the target strand.

132 c DNA fragments from dog (230 bp), duck (283 bp), buffalo (363 bp), goat (396 bp), and sheep (477 bp)

133 Our analysis revealed 296,485,284 bp in 125,715 distinct contigs present in the population

134 Crucially, 3 bp overhangs corresponding to start and stop codons are

135 grees kinks towards the minor groove, only 3 bp apart.

136 that nucleotides in the close vicinity (+/-3 bp) of methylated cytosines mutate less frequently.

137 out CCR2 allele while the other contains a 3-bp deletion, resulting in a 114I115A-to-114T conversion

138 the Escherichia coli Hfq Core bound to a 30 bp DNA, containing three 6 bp A-tracts.

139 sn2(8), referred to as monomer, contains ~30 bp duplex DNA bound along a central channel.

140 sulting in average translocation rates of 30 bp s-1, while a typical velocity of 50 bp s-1 is found i

141 istic genomic scars as insertions of 3 to 30 bp of sequence that is identical to flanking DNA ("templ

142 four Cas2 subunits and contains two DNA ~30-bp duplexes within the channel.

143 involves adaptation, the integration of ~30-bp DNA fragments, termed prespacers, into the CRISPR arr

144 established population, we sequenced a ~ 300 bp portion of the mitochondrial control region and ~ 5 M

145 as towards sites in a relatively narrow, 300 bp window downstream of the sgRNA targets.

146 Additional genetic targets included a 308-bp deletion (20%) in the prophage DNA packaging Nu1 and

147 The original 3120 bp hopper(Bd-Kah) element isolated from the Kahuku wild-

148 and terminal sequences, while a second 3131 bp element, hopper(Bd-we), isolated from a white eye mut

149 A proximal promoter sequence (-8 to +33 bp) of Frmpd1 binds to neural retina leucine zipper (NRL

150 simultaneous assays that detect TR(34) (a 34-bp tandem repeat in the promoter region), TR(46), G54W (

151 ify two abundant satellite DNAs, alpha (~340 bp) and CapA (~1,500 bp), from short-read clustering of

152 psbA qPCR assay successfully amplified a 350 bp fragment identifying six species and uncovering two n

153 sequence from P. longichromatophora (979,356 bp, GC-content = 38.8%, 915 predicted genes) and P. micr

154 cleosome arrays with linker DNA length of 36 bp and 41 bp (3.5 turns and 4 turns of DNA double helix,

155 expected for a zigzag fiber, whereas the 36-bp linkers promoted interactions between two nucleosome

156 om dog (230 bp), duck (283 bp), buffalo (363 bp), goat (396 bp), and sheep (477 bp).

157 We report a 3,370-bp insertion in a cadherin gene associated with resistan

158 assay for amplification of the P20 gene (387-bp) characteristic of CTV was first designed/optimized a

159 , duck (283 bp), buffalo (363 bp), goat (396 bp), and sheep (477 bp).

160 Individual genomic segments are flanked by 4 bp regions of similarity (CCUG).

161 Here, we show that 4 bp of core-enclosing helix is required for telomerase to

162 he relative incidence of the 256 potential 4-bp insertion/duplication mutations at position c.863_864

163 NPM1 mutations are predominantly 4-bp duplications or insertions in the terminal exon that

164 CEH mutant RNAs to TERT, we find that the 4-bp CEH RNA binds to TERT but the shorter-CEH constructs

165 Although the 8 nt that form this 4-bp stem at the base of the CEH are nearly invariant amon

166 ntergenic viral DNA fragments (less than 400 bp) containing two GREs and putative KLF binding sites p

167 mber of bases in the genome (~6200 vs. ~4000 bp), implying that they may have similar functional cons

168 rrays with linker DNA length of 36 bp and 41 bp (3.5 turns and 4 turns of DNA double helix, respectiv

169 In particular, the 41-bp linkers promoted interactions between any two nucleos

170 lved in the tyrosine metabolism showed a 410-bp duplication within the hmgA gene that results in a fr

171 With a genome size of 4248 bp and only four putative open reading frames (ORF), vB_

172 This SNP is 29 426-bp upstream of the nearest gene EOMES and in LD with add

173 ture of human PSMA in complex with A9g, a 43-bp PSMA-specific RNA aptamer, that was determined to the

174 We deleted 430 bp, encompassing one of the ERalpha-binding sites, there

175 rmethylated oncological region (THOR), a 433-bp genomic region encompassing 52 CpG sites located imme

176 amilies and a large genomic deletion (36,445 bp) encompassing exons 2-7 of TRPM1 present in 13 Ashken

177 lysis of the GALGT2 promoter identified a 45-bp region containing a TFAP4-binding site that was requi

178 In addition to that, we identified about 450 bp (upstream of their transcription start site) of the a

179 For a cDNA of ~450 bp, about half of the expressed proteins were multimeric

180 s we engineer a miniature AAV encoding a 465 bp lambda bacteriophage DNA (AAV-lambda465), enabling se

181 was 122,561 bp, which is similar to 122,474 bp in the closely related European larch (Larix decidua

182 falo (363 bp), goat (396 bp), and sheep (477 bp).

183 Our approach uses short homology of 24-48 bp to drive targeted integration of DNA reporter cassett

184 ociated with early fruit maturity, and a 487-bp deletion in the promoter of PpMYB10.1 is associated w

185 ime PCR detection assay, resulting in an 490 bp amplicon with a consistent melting temperature (T(m)

186 inii var. chinensis (complete genome 122,492 bp), and L. occidentalis (partial genome of 119,680 bp),

187 ostmortem brain and blood found (i) the 4977 bp 'common deletion' was neither the most frequent delet

188 lysis and identified large indels (50 to 499 bp) and CNVs (500 bp and larger) in these accessions.

189 mTOR pathway protein expression (raptor, 4e-bp-1, and p70S6K proteins) along with enhanced muscle po

190 The 5'-flanking 0.4k bp region of Klk1b21 gene responded as an ERalpha AF-1-d

191 riod close to the helical turn of DNA (~10.5 bp).

192 as twice that of their parents (40.7 +/- 2.5 bp/yr; 20.3 +/- 2.1 bp/yr, respectively; P < 0.0001).

193 se-dependent integration, highlighted by a 5-bp duplication of the host genome.

194 A 52-bp deletion (type I mutation) and a 5-bp insertion (type II mutation) are the most frequent ge

195 of 30 bp s-1, while a typical velocity of 50 bp s-1 is found in the absence of pausing.

196 ignificantly longer than the extension on 50 bp of homology.

197 f the MHC and 22368 variants smaller than 50 bp, 49% more variants than a mapping-based benchmark.

198 icant binding inhibition occurring within 50 bp of the nucleosome dyad.

199 substrates tandemly in vivo, each with a 50-bp footprint.

200 that was found to be part of a conserved 50-bp motif, termed the ADC-box, upstream of ADC genes invo

201 icrohomology recombination requiring only 50-bp regions flanking the target gene.

202 llite DNAs, alpha (~340 bp) and CapA (~1,500 bp), from short-read clustering of sequencing datasets f

203 ed large indels (50 to 499 bp) and CNVs (500 bp and larger) in these accessions.

204 A 52-bp deletion (type I mutation) and a 5-bp insertion (type

205 lar mass of 62.7 kDa); dsRNA2 dsRNA is 1,524 bp in length with an ORF that encodes 434 amino acids (m

206 the transcription start site (distance: 542 bp) than to the start codon (distance: 704 bp), which co

207 the assembled chloroplast genome was 122,561 bp, which is similar to 122,474 bp in the closely relate

208 We are able to quantitatively detect a 563 bp fragment of genomic DNA of Mycobacterium avium subspe

209 onstrated that both full-length library (565 bp) and mini-barcodes (193 bp) contain enough taxonomic

210 tochondrial genome, which consists of 16,569 bp of DNA with a cytosine-rich light (L) strand and a he

211 Based on a new six-gene data set (5707 bp) for 92 taxa including Oxyporinae (outgroup), represe

212 ifferential methylation in the -1058 to -587 bp regulatory region of FCGRT contributes to FcRn expres

213 nly identify the germline microhomology (1-6 bp) anticipated to prime such slippage in one-third of F

214 be genetically encoded to replace existing 6 bp stem elements at virtually any location within an RNA

215 We thus replaced internal 6 bp RNA stems that supported loop regions with 6 base-tri

216 The modest 6 bp stem binding footprint of bPNA+ makes the hybrid stem

217 ore bound to a 30 bp DNA, containing three 6 bp A-tracts.

218 Haplotype analysis revealed that a rare 6-bp natural deletion of lysine-glycine codons, endemic to

219 HNARs are spanning over 600 bp, featuring high in vivo and predicted in vitro nucleo

220 The 15,603 bp long mitochondrial genome of S. microneptunus is AT-r

221 sive array of long repeat sequences (65-6499 bp) that are associated with CNV, LOH, and chromosomal i

222 s varies sinusoidally with a period of 10.65 bp and energetic cost of 1.37 KBT for sites that are pos

223 their length ranges from 161,501 to 162,669 bp.

224 d L. occidentalis (partial genome of 119,680 bp), we identified 110 genes, 34 of which represented tR

225 equences revealed that dsRNA1 dsRNA is 1,683 bp in length with an open reading frame (ORF) that encod

226 Here, we characterize a human-specific 69 bp variable number tandem repeat (VNTR) in the last intr

227 terized and consist entirely of imperfect 69-bp terminal inverted repeats characteristic of the Foldb

228 distinct dissociation kinetic rates for a 7 bp duplex in which one G-C basepair is mutated to an A-T

229 integration sites, with a median length of 7 bp.

230 Owing to the promiscuity of the 7 bp overlap sequence in its att sites, active 'attB' site

231 ipperkes: an insertion consisting of a 40-70 bp poly-A and an 11 bp duplication of the exonic region

232 Therefore, regulation of the telomere and 70 bp repeat R-loop levels is important for the balance bet

233 cumulation of R-loops at the telomere and 70 bp repeats, providing an intrinsic mechanism for local D

234 n, stabilized R-loops are observed at the 70 bp repeats and immediately downstream of ES-linked VSGs

235 ) where VSG genes are flanked by upstream 70 bp repeats and downstream telomeric repeats.

236 containing two loxP sites in cis and 900-700 bp 5'/3' homology arms.

237 s containing a rat proglucagon promoter (700 bp) driving enhanced green fluorescent protein (AAV GCG-

238 Within the 785,701-bp genome, we used sequence rewriting to reduce the numb

239 2 bp) than to the start codon (distance: 704 bp), which corresponds to open chromatin, especially in

240 Rats with a monoallelic deletion of 71 bp in exon 1 (Delta 71 rats) showed decreased BMPRII exp

241 The size of the genome is 158,712 bp, smaller than 160,100 bp of the C. papaya chloroplast

242 in the prophage DNA packaging Nu1 and a 730-bp insertion of the green fluorescent protein gene downs

243 RNA was extracted and sequenced (75 bp paired-end) from bronchial lymph nodes.

244 topancreas, has a circular genome of 119,754 bp in length, and encodes a predicted 106 open reading f

245 revealed that the presence/absence of a 766-bp sequence in NaLIS underlies the variation of linalool

246 CDEI (8 bp) and CDEIII (~25 bp) are conserved between Kluyveromy

247 ing >35 internal loop:loop complements of >8 bp.

248 ions, and 2) among those mutations, those <8 bp apart are significantly more likely to match microhom

249 ion of 3 ribonucleotides upstream and 7 or 8 bp of dsRNA downstream of the cleavage site, and bacteri

250 e show that C/EBPbeta binds the methylated 8-bp element with modestly-increased (2.4-fold) binding af

251 his protein specifically binds to repeated 8-bp motifs on the plasmid sequence, following a mechanism

252 as long (160 bp) as CDEII in the latter (80 bp).

253 osome-sized (fragments with a length of <=80 bp) and mononucleosome-sized (fragments with a length be

254 trand exchange, the extension afforded by 82 bp of homology is significantly longer than the extensio

255 We used DNA barcoding of a ~ 830 bp fragment from the SSU rDNA to identify the kleptoplas

256 RNA genes, 22 transfer RNA genes and an 834 bp intergenic region assumed to be the D-loop.

257 identified 375 total inversions between 859 bp and 92 Mbp, increasing by eightfold the number of pre

258 yielded closed genome sequences of 1,914,862 bp, identical in length and sequence identity.

259 Both are encoded by a single 870-bp open reading frame that exhibits genetic polymorphism

260 erence unique insertions spanning 18,048,877 bp, some of which disrupt exons and known regulatory ele

261 esponds to the break site for a large (3,895 bp) deletion observed in mitochondrial disease patients.

262 ciation of short DNA duplexes of 7, 8, and 9 bp.

263 orted RNP formation but produced a stable ~9 bp R-loop that could not activate DNA cleavage.

264 ressor (Bcor) gene, most commonly within a 9-bp "hotspot" in Bcor exon 8.

265 A CRISPR/Cas9-generated rat model, with a 9-bp deletion within the hotspot analogous to a human dele

266 A 9-bp insertion in Prupe.4G186800, which encodes a NAC tran

267 The resulting high-resolution (9-bp) map shows uniform absolute occupancies.

268 lonal origin and successive expansions of 90-bp-exon LRR genes.

269 y frequently found physically adjacent to 90-bp exon/intron repeat units of the youngest LRR genes.

270 The youngest 90-bp exon LRR genes in T. thermophila are concentrated in

271 ranslocation processivity from 1750 to >9000 bp before helicase disassociation, suggesting that more

272 At 80,923 bp, I. nocturnus now holds the record for the largest an

273 presents 80-nm-sized particles and a 44,924-bp dsDNA genome encoding for 74 predicted proteins.

274 ng CRISPR/Cas9 technology, we generated a 94 bp out of frame deletion in exon 1 of Kcnk3 gene and cha

275 CLN3 with the most prevalent mutation, a 966 bp deletion spanning exons 7-8, affecting ~ 75% of patie

276 mutant of the KNOX1 mutant brevipedicellus (bp) that we termed flasher (fsh), which promotes stem an

277 n-state observation of a Hoogsteen (G-C(+) ) bp in a DNA:protein complex under solution conditions wi

278 hat a certain fraction of DNA lesions at C:G bp was indeed repaired in an error-free manner via Brca2

279 a previous assignment of a G-C(+) Hoogsteen bp in the complex, and indicate that Hoogsteen bps do in

280 es revealed that cytokinin levels are low in bp, but fsh restores cytokinin levels to near normal by

281 h suppressor are significantly lower than in bp, which is likely due to elevated expression of JA ina

282 cles can lead to artefacts (10(-6) mutations/bp).

283 erse mutations encompassing a 643-base pair (bp) deletion (100% efficiency), a stop codon insertion (

284 ribe a novel mutation within a 15 base pair (bp) region of the PDE3A gene and define this segment as

285 APN2 also suppresses 2-base pair (bp) slippage mutagenesis in RNH201-deficient cells.

286 t folate-associated DMR was a 400-base pair (bp) spanning region annotated to the LGALS3BP gene.

287 rtant, highly variable, 5 million base-pair (bp) region where diploid assembly is particularly useful

288 insert sequences of up to 2,049 base pairs (bp), including enhancers and promoters, into the rice ge

289 and deletion (5,464) calls >=50 base pairs (bp).

290 han or equal to approximately 60 base-pairs (bp) are required for DvSSJ1 insecticidal activity.

291 estimate a mutation rate (3.38 x 10(-6) per bp per generation) that is two orders of magnitude highe

292 een the 180-s/bp images and the 30- and 10-s/bp images reconstructed using the clinical protocols, wh

293 lesion SUV(max) were found between the 180-s/bp images and the 30- and 10-s/bp images reconstructed u

294 on physicians' willingness to adopt the 60-s/bp images in clinical practice.

295 s showed minimal deviation (~5%) in the 60-s/bp images.

296 lity assessment was conducted using the 60-s/bp images.

297 PET acquisition at 180 s per bed position (s/bp).

298 The reliance on only a single bp with the 3' nucleotide of the acceptor together with

299 We reveal that single-bp changes, including in the 12RSS spacer, can significa

300 ctivation of its core promoter, localized to bp -160 to +42 within the proximal 5' flanking region of