ライフサイエンスコーパス: brain cell

1 diversity in gene expression profiles among brain cells.

2 ectly compare them to purified primary human brain cells.

3 ical neurons closely resembled primary fetal brain cells.

4 for functional studies upon NIR exposure to brain cells.

5 r routine non-inflammatory clearance of dead brain cells.

6 4E to increase protein synthesis in specific brain cells.

7 gical resection while sparing normal healthy brain cells.

8 etinoic acid is capable of enhancing TFEB in brain cells.

9 roglia and is thought to phagocytose damaged brain cells.

10 phocytes should reflect variation present in brain cells.

11 ted proliferation but can be induced to form brain cells.

12 of neurons, as compared with other types of brain cells.

13 ing SCZ requires studying the development of brain cells.

14 ion at the level of cell-cell contacts among brain cells.

15 n metabolism of glucose and ketone bodies in brain cells.

16 al molecules are likely exerting on specific brain cells.

17 lioma cells, but not the viability of normal brain cells.

18 ells led to the identification of individual brain cells.

19 ause CRT is required for creatine entry into brain cells.

20 pid-lowering drugs, in up-regulating TPP1 in brain cells.

21 fibroblasts, cervical cancer HeLa cells, and brain cells.

22 lic AMP, a key second messenger available in brain cells.

23 taining sialic acid-independent binding with brain cells.

24 and decreases Abeta(42) toxicity in primary brain cells.

25 ng potential binding of mhIL-13-PE to normal brain cells.

26 gered by ascorbate stimulation in kidney and brain cells.

27 assemble into ordered aggregates in affected brain cells.

28 and binding to IL4R/IL13R, present in normal brain cells.

29 zed to impede turnover of folded proteins in brain cells.

30 of mhtt protein aggregates in both islet and brain cells.

31 proinflammatory cytokines and chemokines in brain cells.

32 ionally interact with neurons and with other brain cells.

33 rous medium formed by the spaces between the brain cells.

34 ressed in normal brain cells nor in tumorous brain cells.

35 (h) CMVs in developing and mature brain and brain cells.

36 erences in sex chromosome gene expression in brain cells.

37 ction of meningioma, astrocytoma, and normal brain cells.

38 in and showed widespread infection of normal brain cells.

39 ems, they function to maintain the health of brain cells.

40 ling neural precursor cells (NPCs) and other brain cells.

41 ant free radical synthesized and released by brain cells.

42 showed relatively little infection of normal brain cells.

43 ters the molecular structure and function of brain cells.

44 stry to assay over a thousand individual rat brain cells.

45 plaques of alpha-synuclein aggregates in the brain cells.

46 ype and distinguish these neurons from other brain cells.

47 ith synthetic AuNPs for targeted delivery to brain cells.

48 lyze spatial information of various types of brain cells.

49 and challenging analyses of human and mouse brain cells.

50 ar transport mechanisms not present in other brain cells.

51 role in the tonic regulation of surrounding brain cells.

52 h is expressed on microglia as well as other brain cells.

53 filamentous inclusions of alpha-synuclein in brain cells(2,3).

54 ng cell-to-cell communication, using primary brain cells, a microfluidic device, and a multiparametri

55 o inhibit SARS-CoV-2 replication in lung and brain cells; additionally, COVID-19 clinical trials with

56 low researchers to better study how specific brain cells affect behavior in freely moving animals; ho

57 t important roles for the PMRS in protecting brain cells against age-related increases in oxidative a

58 ich scavenges complement fragments, protects brain cells against the deleterious effects of experimen

59 /- 4 mm(3); n = 14), indicating the resident brain cells also play a role.

60 Thirty percent of genes with DS-DM in adult brain cells also show DS-DM in fetal brains, indicating

61 emented creatine would be widely taken up by brain cells, although possibly less by those cells that

62 antially larger than the size and spacing of brain cells and blood vessels, is injurious and triggers

63 target cell generation including stem cells, brain cells and cardiac cells.

64 g mechanism is electrical activity of single brain cells and cell assemblies.

65 no or negative effects of these compounds on brain cells and cognition have been found.

66 tituent in brain, is actively metabolized in brain cells and contributes to glutamine in the intersti

67 c transcripts initiated by P(N) and P(NN) in brain cells and fibroblasts, respectively.

68 in distinct populations of postmortem human brain cells and further our understanding of the regulom

69 n some patient brains, its ability to infect brain cells and impact their function is not well unders

70 yme gamma-secretase showed reduced damage to brain cells and improved functional outcome in a model o

71 ain ROS production was elevated, both in all brain cells and in repopulated microglia.

72 R-339-5p regulates BACE1 expression in human brain cells and is most likely dysregulated in at least

73 he relative contribution of iNOS in resident brain cells and peripheral leukocytes infiltrating the i

74 ripotent stem cell (hiPSC)-derived monolayer brain cells and region-specific brain organoids to SARS-

75 n sleep and wake pooled transcripts from all brain cells and showed that several genes expressed at h

76 ffering capacity under ex vivo conditions in brain cells and slices.

77 ecord in awake humans the activity of single brain cells and small cellular assemblies.

78 etection of glucose concentration changes by brain cells and subsequent release of orexigenic or anor

79 s; and (3) localizing proteasome subunits in brain cells and synapses.

80 the primary source of brain-derived Hp among brain cells and that oligodendroglia-released Hp plays p

81 ain cells more easily than it infects mature brain cells and that this preference is independent of t

82 asses the release of protein aggregates from brain cells and their uptake by neighboring cells.

83 ecretory protein profile distinct from other brain cells and to modulate microglial activation, proli

84 ated in membranes of retinal photoreceptors, brain cells, and testis, where it mediates transport of

85 m the perspective of neurons, extra-neuronal brain cells, and the systemic environment and highlight

86 hat are the consequences of staying awake on brain cells, and why is sleep needed?

87 brain barrier is formed and postnatally when brain cells are amenable to culturing.

88 evelopment in both neuronal and non-neuronal brain cells are known to exhibit subfertility due to hyp

89 Although most brain cells are postmitotic, small populations of progen

90 ich more than half of all recently generated brain cells are pruned back.

91 Astrocytes, the star-shaped brain cells, are known chemosensitive cells in the respi

92 erular preparations were not contaminated by brain cells (astrocytes, oligodendrocytes, or neurons),

93 We deleted the Mecp2 gene in ~80% of brain cells at three postnatal ages to determine whether

94 ger and longer-term effort to generate whole-brain cell atlases in species including mice and humans.

95 Beta-amyloid (Abeta) has adverse effects on brain cells, but little is known about its effects on th

96 inked proteins confer stress on all relevant brain cells, but region-specific susceptibility stems fr

97 in Drosophila, in which remote activation of brain cells by genetic means enables us to examine the n

98 a commonly used antibiotic protects cultured brain cells by reducing viral proliferation.

99 ul genetic tools available, small subsets of brain cells can be reliably manipulated, offering enormo

100 of per1 cells, which unlike other mammalian brain cells can survive and function at depolarized stat

101 elds, generated by the cooperative action of brain cells, can influence the timing of neural activity

102 Mammalian brain cells cannot synthesize riboflavin and must import

103 ion channels that are critically involved in brain cell communication Variations in genes encoding NM

104 pair is required for neural development, and brain cells contain somatic genomic variations.

105 Brain cells continuously produce and release protons int

106 broad presence of mTOR signaling in various brain cells could prevent mTOR inhibitors from achieving

107 o release glutamate, which kills surrounding brain cells, creating room for tumor expansion.

108 induced demyelination in a three-dimensional brain cell culture assay.

109 have compared Ifnb induction in mixed murine brain cell cultures by a panel of HSV1 mutants, each dev

110 rocytes as the major antioxidant producer in brain cell cultures exposed to HSV-1 stimulated microgli

111 e lactic acidosis of brain tissue leading to brain cell damage.

112 resulted in an increase in mortality and in brain cell death (TUNEL positive cells) throughout the w

113 r to and continued for 48 h after hypoxia on brain cell death and systemic haematological changes com

114 urrent moderate hypoglycemia had 62-74% less brain cell death and were protected from most of these c

115 LPS alone did not increase brain cell death at 48 h, despite evidence of neuroinfla

116 trix signaling and homeostasis, MMPs trigger brain cell death.

117 nd the cerebellum, which points to potential brain cell dedifferentiation.

118 orts is also important for understanding how brain cells derived from diverse human genetic backgroun

119 Here, we review the molecular properties of brain cells derived from patients with neurodegenerative

120 of intact Cln1(-/-) mice as well as cultured brain cells derived from these animals with a thioestera

121 abundantly expressed in specific individual brain cells, despite being hard to detect in bulk sample

122 FGFR1 affects brain cell development by two distinct mechanisms.

123 In response to ischemia, damaged/necrotic brain cells discharge factors that polarize MPhi to a M1

124 enlarged brains with an increased number of brain cells, displaying marked runting and developmental

125 ify regulatory elements that drive conserved brain cell diversity.

126 bral ischemia, and refers to the swelling of brain cells due to the entry of water from the extracell

127 A picture is emerging to suggest that brain cells, due to their nonproliferative nature, may b

128 The chromatin landscape of human brain cells encompasses key information to understanding

129 al single-cell catalog of ~220,000 zebrafish brain cells encompassing 12 stages from embryo to larva.

130 monemia have shown that ammonium is toxic to brain cells especially astrocytes and neurons.

131 of the genes coding for SOCS-3 and PTP-1B in brain cells, examined their sensitivity to hormone actio

132 The lack of live human brain cells for research has slowed progress toward unde

133 roup comparisons of normal and disease model brain cells for the whole brain at a high spatial resolu

134 ning is critical for neural development, and brain cells frequently contain somatic genomic variation

135 ing hematoma absorption and protecting other brain cells from ICH-induced damage.

136 ion-induced apoptosis is reduced in cortical brain cells from MAO A-deficient mice compared with WT.

137 First, aneuploidy was found in brain cells from MAPT mutant transgenic mice expressing

138 TLD, we measured aneuploidy and apoptosis in brain cells from patients with MAPT mutations and identi

139 hich glucose and oxygen are delivered to the brain cells from the vascular system.

140 the interferon pathway protects normal human brain cells from VSV infection while maintaining the vul

141 ated, although to a lower degree than in the brain cells from which they were derived.

142 rive one kind of specialized cell (such as a brain cell) from another, more accessible, tissue (such

143 u inclusions form first in a small number of brain cells, from where they propagate to other regions,

144 ine (hmC) maps revealed that hmC marks fetal brain cell genomes at putative regulatory regions that a

145 Changes in other brain cells (glia) across the sleep-wake cycle and their

146 ing effects of gonadal secretions, XY and XX brain cells have different patterns of gene expression t

147 ent of mitochondria in neurogenesis in human brain cells have not been well explored.

148 In a dataset of over 1.3 million mouse brain cells, Hopper detects a cluster of just 64 macroph

149 tosine methylation between spermatogenic and brain cells, identifying 223 new candidate tissue-specif

150 ruses can infect and replicate and spread in brain cells if not blocked by interferon-stimulated gene

151 In parallel work with cultured primary human brain cells, IFN and poly(I:C) treatment reduced hCMV in

152 Similar to the case with cultured brain cells, IFN treatment of the developing brain in vi

153 ble gliomas without evident damage to normal brain cells in all 24 mice assessed.

154 evaluation of the effects of oHSVs on normal brain cells in animal models is needed to enhance our un

155 TLR3 protein is present in brain cells in early embryonic stages of development, an

156 We also found that very few of these brain cells in male hybrids are in S phase, as determine

157 interplay of breast cancer cells and native brain cells in metastasis is poorly understood and rarel

158 um signaling tunes numbers of differentiated brain cells in regenerative growth and tissue remodeling

159 Transduction of rat brain cells in situ with a lentiviral vector expressing

160 the ovaries on the structure and function of brain cells in the mouse.

161 ect on the viability and plasticity of major brain cells in the presence or absence superparamagnetic

162 ls and virally infected target Ag-presenting brain cells in vivo during an antiviral brain immune res

163 occurred in primary cell cultures, embryonic brain cells in vivo, and cells in healing skin wounds an

164 her demonstration of their ability to target brain cells, in vivo bioluminescence imaging revealed th

165 led to quantifying populations of different brain cells, including myelin-forming oligodendrocytes.

166 the absence of both centrosomes and the SAC, brain cells, including neural stem cells, experience mas

167 Thus, upon infection, resident brain cells induced a breadth of innate immune responses

168 A genome, which replicates only in the first brain cell infected, as corroborated with ultrastructura

169 Ags released by neurocytotoxic Abs or other brain cell injury, and the resulting immune complexes st

170 mutations contribute functional diversity to brain cells is a long-standing question.

171 The intense osmotic stress sustained by brain cells is believed to be the major risk factor for

172 Time course, in vivo imaging of brain cells is crucial to fully understand the progressi

173 Transgenic manipulation of subsets of brain cells is increasingly used for studying behaviors

174 Deletion of SOCS-3 from brain cells is known to protect mice from diet-induced o

175 ow extensive methylation patterns vary among brain cells is unknown and bipolar methylated genomic lo

176 otein (apo) E4 is expressed in many types of brain cells, is associated with age-dependent decline of

177 als released into the circulation by damaged brain cells lead to activation of systemic immunity, fol

178 ze vesicles and induce cytotoxicity in a rat brain cell line.

179 ta, albeit initially from only two cancerous brain cell lines for a limited number of epigenetic mark

180 ction of HIV regulatory proteins in infected brain cells may contribute to neurological damage.

181 igate SARS-CoV-2 infection susceptibility of brain cells, mechanisms of virus-induced brain dysfuncti

182 toward efflux of specific proteins from the brain, cell-mediated immune responses, and other mechani

183 Phospholipids in the brain cell membranes contain different polyunsaturated f

184 ochondrial dysfunction, methods for studying brain cell metabolism at high spatial resolution are nee

185 s that Mn transport into/distribution within brain cells mimics that of other biologically relevant m

186 determining behavioral output, or can other brain cells modulate behavior?

187 etary (poly)phenols may cross the BBB, reach brain cells, modulate microglia-mediated inflammation an

188 previously shown that CMV infects developing brain cells more easily than it infects mature brain cel

189 inguishing and quantitatively characterizing brain cell morphologies noninvasively.

190 es to explore the possibility of quantifying brain cell morphology noninvasively.

191 The transfected brain cells near the injection site appeared to be mostl

192 be the generation of ketones, which provide brain cells (neurons and astrocytes) with an energy sour

193 These markers are not co-expressed in normal brain cells nor in tumorous brain cells.

194 Brain cells normally respond adaptively to bioenergetic

195 tric assay, based on the analysis of unfixed brain cell nuclei, to study whether p75(NTR)-dependent n

196 restored brain:body proportion by increasing brain cell number through epimorphosis or decreasing bra

197 ll number through epimorphosis or decreasing brain cell number through tissue remodeling (morphallaxi

198 due to the cellular changes in blood and/or brain cell number, activation state and their cytokine/g

199 lantation, we demonstrated that adult monkey brain cells, obtained from cortical biopsies and kept in

200 1) upon HIV-1 infection and its elevation in brain cells of AIDS patients with dementia.

201 cible pluripotent stem cells (iPSCs)-derived brain cells of ApoE4(+/+) AD subjects while inhibiting m

202 tegration of human oncogenes into endogenous brain cells of immunocompetent mice.

203 H2S3 and H2S were produced from 3 MP in the brain cells of wild-type mice but not 3MST knockout (3MS

204 We hypothesized that spatial variation in brain cell organization and/or pathway expression levels

205 al to the control of motor activity, whereas brain cells other than forebrain neurons (likely glial c

206 he infected tumor cells, but not of infected brain cells outside the tumors.

207 explored, potentially fundamental aspects of brain cell physiology.

208 ime that PEGylated nanoparticles evade major brain cell populations - a phenomenon which will enhance

209 We identify the brain cell populations that are most susceptible to ZIKV

210 on-free, transient NIR photonic approach for brain cells possesses remarkable potential to add new di

211 Investigations were performed with brain cell preparations obtained from 9 donors.

212 Chronic hyperglycemia also decreased brain cell proliferation in most neurogenic niches throu

213 ain psychotropic drug-induced actions on SVZ brain cell proliferation.

214 the TRalpha selective agonist CO23 increased brain cell proliferation; whereas, treatment with the TR

215 ulted from the methylation differences among brain cells rather than from asymmetric DNA methylation

216 microanatomy of immune clearance of infected brain cells remains poorly understood.

217 y-state level, with an impact on surrounding brain cells, remains unknown.

218 The survival and function of brain cells requires uninterrupted ATP synthesis.

219 us, neural cell lines and heterogeneous, rat brain cells, respectively.

220 pend completely on an external supply (e.g., brain cells, roots and seeds).

221 solution studies and an improved modeling of brain cell shapes and mechanical properties, could help

222 port that ATP levels, the energy currency of brain cells, show a surge in the initial hours of sponta

223 Discrete populations of brain cells signal heading direction, rather like a comp

224 vealed that contributions from nonneoplastic brain cells significantly influence the expression patte

225 this promotes the pain phenotype and, in the brain, cell survival or differentiation.

226 was in the range 3.0-4.1, and increased with brain cell swelling after water intoxication.

227 l ADC was reduced in both groups (indicating brain cell swelling).

228 tive disorders, if and how LTL is related to brain cell telomere shortening, and whether telomere sho

229 ML) is caused by the infection of particular brain cells, termed oligodendrocytes, by the JC virus.

230 t Al-Abeta42 would have more ready access to brain cells than Abeta42.

231 ectivity for killing GBM cells versus normal brain cells than VSV with wild-type M protein.

232 brain, and that cause mosaics of monoallelic brain cells that differentially express wild-type and mu

233 activation and identified a critical pair of brain cells that induces the entire feeding sequence whe

234 persensitive (DH) sites within the PWS-IC in brain cells, then identified transcription factor bindin

235 exposure may interfere with the activity of brain cells, thereby generating behavioral and cognitive

236 OI analyses confirmed that the propensity of brain cells to accumulate excessive iron as a function o

237 ockout model that allows CoA regeneration in brain cells to be evaluated and describe two new series

238 resting condition.SIGNIFICANCE STATEMENT For brain cells to communicate with each other, neurons rele

239 HSF1 plays a crucial role in the response of brain cells to prenatal environmental insults and may be

240 nd interleukin-1 alpha (IL-1alpha) stimulate brain cells to yield increased levels of LG3.

241 In a previous study on autologous brain cell transplantation, we demonstrated that adult m

242 We examined cultures for brain cell type and changes in cell type caused by exper

243 AKT has three isoforms, AKT1/AKT2/AKT3, with brain cell type-specific expression that may differentia

244 ctive infection in at least one normal mouse brain cell type.

245 linear messenger RNA expression or estimated brain cell-type proportions.

246 Brain cell-type specific expression profiling libraries

247 ingle-nucleus methylomes expand the atlas of brain cell types and identify regulatory elements that d

248 ation and induction strategies for the major brain cell types and providing perspective into integrat

249 All major brain cell types can now be differentiated from iPSCs, w

250 with organoid systems, and teratoma gut and brain cell types correspond well to similar fetal cell t

251 the complex interactions that occur between brain cell types during neurodegeneration.

252 We investigated which brain cell types express MLC1, compared developmental ex

253 he mood disorders, particularly in the mouse brain cell types implicated by the expression patterns o

254 zing detailed metabolic changes of different brain cell types in response to neurotoxins.

255 eplicates in and may be neurotoxic to normal brain cell types in vivo is poorly understood.

256 Metabolic specialization among major brain cell types is central to nervous system function a

257 whether coordinated growth among these major brain cell types is required for neural development.

258 Several brain cell types represent possible sources of NO.

259 nt likely arises from an interaction of many brain cell types that follow distinct developmental path

260 lMapper makes accurate predictions for human brain cell types that have never been isolated, and can

261 e expression was annotated to occur in other brain cell types were altered.

262 ntal retardation protein (FMRP) in different brain cell types, especially in non-neuron glial cells,

263 ApoE is abundantly expressed in multiple brain cell types, including astrocytes, microglia, and v

264 iad of biological processes in virtually all brain cell types, including neurons.

265 ely induce NQO1 in neurons, as well as other brain cell types, may be able to unlock the neuroprotect

266 s of allele-specific Ube3a expression in key brain cell types, thereby improving our understanding of

267 Across six major brain cell types, we identified transcriptionally distin

268 les by all the major (immune and non-immune) brain cell types.

269 rge number of interactions between different brain cell types.

270 derstanding their diverse roles in different brain cell types.

271 development has lagged behind that of other brain cell types.

272 ssue across two developmental epochs and two brain cell types.

273 d ligand-receptor interactions in nearly all brain cell types.

274 Notch pathway in normal and malignant human brain cell types.

275 The spheroids used here were composed of six brain cell types: Astrocytes, pericytes, endothelial cel

276 number of times and differentiate to normal brain cell types; whereas NBCs can divide an unlimited n

277 ng genes specifically expressed in different brain cell-types.

278 analyzed protein turnover rates in cultured brain cells under basal neuronal activity and found that

279 xosomes was demonstrated by their binding to brain cells under laminar flow conditions as well as the

280 en fluorescent protein-CIP (AAV9-GFP-CIP) to brain cells via intracerebroventricular infusion in amyl

281 Brain cells viability and plasticity were analyzed using

282 a indicated that neuronal PD-L1 signaling in brain cells was important for GBM patient survival.

283 The chromosomal repertoire of individual brain cells was then assessed by chromosome counting, sp

284 e the developmental potential of adult human brain cells, we applied conditions favoring the growth o

285 Using knock-out mice and primary brain cells, we connect a key pattern recognition recept

286 ng result was obtained: human frontal cortex brain cells were found to display "DNA content variation

287 Labeled brain cells were localized within known gustatory region

288 pernatant obtained from virus-infected fetal brain cells were measured simultaneously in microbead-ba

289 tly cross the blood brain barrier and target brain cells when applied to neurogenetic disorders such

290 lized predominantly in the nucleus of normal brain cells, whereas in primary brain tumors NRP/B was a

291 enuated the infection of all primary control brain cells, whereas most glioblastoma cell lines treate

292 The NEP was performed in microglial (MG) brain cells, which are highly sensitive for neuro-viral

293 erentiation of brain tumor cells from normal brain cells with a contrast signal ratio over 100.

294 arrier (BTB) and targeting specific types of brain cells with drug release into the cell cytoplasm.

295 he presence of extra centrosomes, and larval brain cells with extra centrosomes can generate metastat

296 By culturing human brain cells with physiological microenvironmental cues,

297 he development, differentiation, and loss of brain cells, with broad implications for the epilepsies

298 as the appearance of pathological tau inside brain cells, with cognitive impairments evident in virtu

299 in the DNA, is a common phenomenon in human brain cells, with potential functional consequences.

300 r calcium is essential to the functioning of brain cells, yet the phenomenology and mechanisms involv