ライフサイエンスコーパス: brain-specific

1 that these changes in lipid metabolism were brain specific.

2 part of UBE3A-ATS, which overlaps UBE3A, is brain specific.

3 rminus Ca(2+) sensing domain, which appeared brain-specific.

4 type IV NRG1 protein of 66 kDa was similarly brain-specific.

5 orms are ubiquitously expressed, while G2 is brain-specific.

6 l CaM kinase domain of CASK binds to a novel brain-specific adaptor protein called Caskin 1.

7 Here, we report that the SGK1 gene encodes a brain-specific additional isoform, SGK1.1, which exhibit

8 we examined single Akt isoform, conditional brain-specific Akt1, and double Akt1/3 mutant mice in be

9 vides further insight into the mechanisms of brain-specific alternative splicing and their possible p

10 bnormal accumulation within muscle fibers of brain-specific Alzheimer type proteins.

11 we identified the G-protein coupled receptor brain-specific angiogenesis inhibitor (BAI3) as a cell s

12 Here we identify brain-specific angiogenesis inhibitor 1 (BAI1) as a rece

13 Here, we identify brain-specific angiogenesis inhibitor 1 (BAI1) as a syna

14 Here, we demonstrated that mice lacking brain-specific angiogenesis inhibitor 1 (BAI1) have seve

15 Brain-specific angiogenesis inhibitor 1 (BAI1), an orpha

16 his pathway involves the phagocytic receptor brain-specific angiogenesis inhibitor 1 (BAI1), which re

17 Two of these proteins, brain-specific angiogenesis inhibitor 1 and protein kina

18 tion between adult ADHD and the gene BAIAP2 (brain-specific angiogenesis inhibitor 1-associated prote

19 C1ql1 specifically binds to the brain-specific angiogenesis inhibitor 3 (Bai3), which is

20 g et al. show that the fifth member, BAIAP3 (brain-specific angiogenesis inhibitor I-associated prote

21 Brain-specific angiogenesis inhibitor-1 (BAI1) is an adh

22 These results advance the understanding of brain-specific angiogenic regulation, and suggest that V

23 ed RNA interference or through disruption of brain-specific Ank3 in a heterozygous knockout mouse.

24 ant difference in cerebellar expression of a brain-specific ANK3 transcript.

25 The conventional APC and brain-specific APC isoforms suppress the tumorigenic phe

26 The protein kinase Mzeta (PKMzeta), a brain-specific atypical protein kinase C isoform, is imp

27 Multiple sclerosis (MS) is brain-specific autoimmune disease mediated by T helper (

28 Here, we addressed the importance of the brain-specific auxiliary subunit of HCN1, TRIP8b, in reg

29 amyloid precursor protein, whereas tau is a brain-specific, axon-enriched microtubule-associated pro

30 significant results: non-tissue-specific and brain-specific Basenji-H3K4me3 for all traits and brain

31 We have shown that the brain-specific beta4 subunit modulates the voltage depen

32 The development of novel brain-specific biomaterials for generating mature in vit

33 l to show that lack of astrocytic laminin, a brain-specific BM component, induces BBB breakdown.

34 insoluble active zone component; and ERC2 is brain-specific but exclusively localized to active zones

35 e biochemical and functional evidence that a brain-specific, C-terminal truncated and therefore fast

36 ) of cocaine-preexposed mice and the role of brain-specific Ca(v)1.2 and Ca(v)1.3 L-type Ca(2)(+) cha

37 The blood-brain barrier (BBB) is the brain-specific capillary barrier that is critical for pr

38 Brain-specific cardiolipins accumulate in plasma early a

39 Cerebral score was derived from brain-specific cardiolipins identified in plasma of pati

40 Nine of 26 brain-specific cardiolipins were detected in plasma and

41 ith heart that allowed the identification of brain-specific cardiolipins.

42 Recent evidence suggests that the brain-specific carnitine:palmitoyl-CoA transferase-1 (CP

43 ormation of neuroprogenitor cells, whereas a brain-specific CDC42 variant, CDC42b, is essential for p

44 s delivery system with drug release into the brain-specific cell type could be useful for treatment o

45 he complex communication network between the brain-specific central clock and the tissue-specific per

46 Cytochrome P450 46A1 (CYP46A1) is a brain-specific cholesterol 24-hydroxylase responsible fo

47 These findings suggest a brain-specific cis-regulatory transcriptional effect of

48 In a mouse model, brain-specific coexpression of DNAJB6 delays polyQ aggre

49 from baseline to 24 weeks, particularly, for brain specific concerns with a trend for improvement in

50 Here, we generate a brain specific conditional knockout mouse model deficien

51 ce for the capacity of brain FAO using a pan-brain-specific conditional knockout (KO) mouse incapable

52 sex-specific impact of ELS within the human brain, specific contributions of chromosomal versus horm

53 he CAGGS promoter and was activated by using brain specific Cre-mediated recombination.

54 Here we show that brain-specific Crmp2 knockout (cKO) mice display molecul

55 N2 and HAPLN4) were physically linked to the brain-specific CSPG genes encoding brevican and neurocan

56 e alternative N-terminal splice forms of the brain-specific cytoplasmic protein TRIP8b and demonstrat

57 ted a new conditional knock-out mouse with a brain-specific deletion of Adk (Adk(Deltabrain)).

58 Here we test the effects of brain-specific deletion of dystroglycan, and show distin

59 EpoR knock-down animals, we demonstrate that brain-specific deletion of EpoR leads to significantly r

60 Brain-specific deletion of Mecp2 at embryonic day (E) 12

61 Brain-specific deletion of POMT2 resulted in hypoglycosy

62 uman neuropathy target esterase (NTE), and a brain-specific deletion of SWS/NTE in mice causes a simi

63 Finally, brain-specific deletion of the paternal, but not materna

64 nanoparticles with peptide ligand alters the brain specific delivery of encapsulated molecules.

65 re, these nanoplexes appear to be suited for brain-specific delivery of appropriate siRNA for therapy

66 the cell penetrating peptide TAT facilitates brain-specific delivery that is restricted to brain vasc

67 Reduction of Six3 function causes brain-specific deregulation of Nodal pathway activity, r

68 C-terminal hydrolase L1 (UCHL1) is a unique brain-specific deubiquitinating enzyme.

69 The brain-specific Disabled-1 (Dab1) functions in positional

70 Alzheimer disease (AD) has been considered a brain-specific disease characterized by the presence of

71 lthough HD has historically been viewed as a brain-specific disease, htt is expressed ubiquitously, a

72 axia, spasticity, and dystonia, hallmarks of brain-specific disease.

73 We determined whether the brain-specific disruption of the FKBP12 gene in mice alt

74 ly (Epoch-2) another set (the majority being brain specific) disrupts neurite outgrowth, synaptogenes

75 Expression analyses confirmed the brain-specific distribution of NEGR1 including strong ex

76 on of Mst1/2 fully rescued the phenotypes of brain-specific Dlg5 knockout mice.

77 Brain-specific Drp1 ablation caused developmental defect

78 Some genes show brain-specific DS-DM, while others show stronger DS-DM i

79 We conclude that the brain-specific dynamin GTPase neurolastin exhibits stres

80 he presynaptic compartment attributed to the brain-specific dynamin isoform, dynamin-1, is in synapti

81 synapses during development, and identify a brain-specific endocytic adaptor that confers spatiotemp

82 ifically in the nine autoimmune diseases and Brain-specific enhancer activities exclusively in Schizo

83 easing-level enhancer orthologues show fetal-brain-specific enhancer activity.

84 Cholesterol 24-hydroxylase (CH24H) is a brain-specific enzyme that converts cholesterol into 24S

85 CPT1c, a brain-specific enzyme with high sequence similarity to C

86 ghted an inversion on chromosome 17 plus two brain-specific eQTLs.

87 c ERCs bind to RIMs, but both ubiquitous and brain-specific ERCs bind to Rab6, a GTP-binding protein

88 Only brain-specific ERCs bind to RIMs, but both ubiquitous an

89 on to a control group of constitutive exons, brain-specific exons were often found to possess the fol

90 those derived from genes with tissue (e.g., brain)-specific expression.

91 this model we would expect that enhancers of brain-specific expression of Igf2 would lie 5' of the IC

92 Northern blot analysis revealed a brain-specific expression pattern of p200RhoGAP.

93 thern blot analysis of human BHLHB5 revealed brain-specific expression with the highest abundance in

94 ven by fusion of the promoter of a gene with brain-specific expression, TTYH1, to C19MC, the largest

95 ch disrupt insulin signaling and may cause a brain-specific form of diabetes as part of an overall pa

96 which is increasingly being recognized as a brain-specific form of diabetes.

97 In this study we have identified the first brain-specific function for a neuronal adaptor complex.

98 pected, suggesting that Mints 1 and 2 have a brain-specific function related to APP that is not execu

99 Here, we present BaiHui, a brain-specific functional gene network built by probabil

100 for schizophrenia and autism genes within a brain-specific functional interaction network.

101 The brain-specific gamma isoform of protein kinase C (Prkcc)

102 -specific expansion, and many viper TEs show brain-specific gene expression along with their nearby g

103 mannosyl glycan core structures and that its brain-specific gene expression is regulated by epigeneti

104 tical projection tomography to rapidly image brain-specific gene expression patterns in 3D at cellula

105 y machine-learning approach based on a human brain-specific gene network to present a genome-wide pre

106 Many gene loci, including that of Myc and a brain-specific gene, are anchored by the SATB1 network a

107 ed target sites in a number of pancreas- and brain-specific genes consistent with its restricted expr

108 er methylation and evolution patterns (e.g., brain-specific genes evolve slowest, whereas testis-spec

109 Furthermore, we show that the codon usage of brain-specific genes has been selectively preserved thro

110 pG density regions, and were associated with brain-specific genes related to neuronal plasticity.

111 stitutions in humans than in chimpanzees for brain-specific genes relative to other genes in the geno

112 ere is little overlap among the five sets of brain-specific genes, none of them supports human accele

113 expressed in the brain and other organs, and brain-specific genes.

114 on and neuronal function, thereby increasing brain-specific genetic mosaicism.

115 Combining a brain-specific genetic Xist ablation with short-term 5-a

116 the transgene is under the influence of the brain-specific GFAP promoter.

117 Collybistin is a brain-specific guanine nucleotide exchange factor (GEF)

118 al synapses is critically dependent upon the brain-specific guanine nucleotide exchange factor Collyb

119 Kalirin is a brain-specific guanine-nucleotide exchange factor (GEF)

120 Furthermore, the two brain-specific HAPLN genes (HAPLN2 and HAPLN4) were phys

121 Knockout (KO) of the brain-specific HCN-channel auxiliary subunit tetratricop

122 otorized) Myo10 protein was deleted, but the brain-specific headless (Hdl) isoform (Hdl-Myo10) was st

123 SIRT1 deacetylates the brain-specific helix-loop-helix transcription factor NHL

124 gamma-Hydroxybutyric acid (GHB) binding to brain-specific high-affinity sites is well-established a

125 cription factors glucocorticoid receptor and brain-specific homeobox factor.

126 ected POU domain transcription factor Brn3b (brain-specific homeobox/POU domain protein 3b) plays suc

127 n 20, retinoid-related orphan receptor beta, brain-specific homeobox/POU domain protein 3b, Ets varia

128 ive regulator for exon splicing, whereas the brain-specific homolog of PTB, termed nPTB, promotes exo

129 PTBP1 and its brain-specific homologue polypyrimidine tract-binding pr

130 Using brain-specific IkappaB kinase beta knockout mice, it was

131 We now show that SynCAM is a brain-specific, immunoglobulin domain-containing protein

132 Expression of ATP1B4 genes is brain-specific in teleost fishes, whereas it is predomin

133 Brain-specific inactivation of these genes individually

134 Severe brain-specific inflammation and demyelination in DRB1*03

135 Although mechanisms leading to brain-specific inflammation and T cell activation have b

136 Both exogenous and brain-specific inhibitors of CaMKII accelerate voltage-d

137 Taken together, the current studies on the brain-specific insect P450 involved in deltamethrin resi

138 tivity, we established where and when in the brain specific internal knowledge conceptually interpret

139 At 22 months of age, brain-specific Irs2 knockout mice were overweight, hyper

140 The brain-specific isoform carnitine palmitoyltransferase 1C

141 However, it is unclear whether the brain-specific isoform CPT1C, which is located in the en

142 carnitine palmitoyltransferase 1C (CPT1C), a brain-specific isoform located in the endoplasmic reticu

143 The brain-specific isoform neuroplastin-65 co-localizes with

144 le complex, in particular the homolog to the brain-specific isoform of CPT1C which functions as a hyp

145 phin complex, the localization of the 71-kDa brain-specific isoform of dystrophin was assessed by imm

146 gion of tryptophan hydroxylase-2 (TPH2), the brain-specific isoform of the enzyme responsible for the

147 Pak5 (p21-activated kinase 5) is a brain-specific isoform of the group II Pak kinases whose

148 Synaptotagmin IV (Syt IV) is a brain-specific isoform of the synaptotagmin family, the

149 FX4_v3 (regulatory factor X4 variant 3) is a brain-specific isoform of the transcription factor RFX4.

150 e first produced an antibody against TPH2, a brain-specific isoform of tryptophan hydroxylase (seroto

151 hin RGS9-1 that differs in sequence from the brain-specific isoform RGS9-2.

152 roduce several isoforms, including the major brain-specific isoform, BPAG1a.

153 metabolism, we generated mice lacking these brain-specific isoforms (alphadelta knockout [alphadelta

154 lyses suggesting that classes II and III are brain-specific isoforms of NRG3.

155 the finding that NRG3 classes II and III are brain-specific isoforms predicted by rs10748842 risk gen

156 JNK3, a brain-specific JNK isoform, is activated under oxidative

157 Here, we report the cloning of actinfilin, a brain-specific Kelch protein, which interacts with F-act

158 esis under energy stress conditions, whereas brain-specific kinase (BRSK) promotes the establishment

159 ed a Cre-Lox strategy to generate 11betaHSD2 brain-specific knockout (Hsd11b2.BKO) mice, measuring bl

160 nd correlates of the male phenotype in Usp9x brain-specific knockout mice, and further resolve loss o

161 y the neuronal function of S1P, we generated brain-specific knockout mouse models in which S1P-lyase

162 have linked the Rbfox1 gene to autism, and a brain-specific knockout mouse revealed a critical role f

163 Oga (DeltaBr), a mouse brain-specific knockout of Oga, was also scanned to asse

164 Brain-specific knockout of Sirt1 results in exacerbation

165 Here we demonstrate that mice with a brain-specific knockout of the insulin receptor (NIRKO m

166 In summary, we show that brain-specific leptin signaling is sufficient to reverse

167 Here we identify a brain-specific, leucine-rich-repeat protein with high af

168 tag (EST; AA331381) originally reported in a brain-specific library, Pitx3, and CBP, were confirmed t

169 ipid binding proteins or were present in the brain-specific list of tissue-enriched genes identified

170 The expression of TOX2 and a brain-specific long noncoding RNA RP1-269M15.3 in fronta

171 Furthermore, whole-brain-specific loss of Atg7 leads to presynaptic accumul

172 rate that the c.548G>T mutation results in a brain-specific loss of presenilin function due to decrea

173 of the FLNA poison exon in NPCs and causes a brain-specific malformation.

174 t analysis and inter-association analysis on brain-specific markers, and 2) identification of previou

175 odimer complex, indicating the presence of a brain-specific mechanism for ADAR3 dimerization.

176 Using both conventional and brain-specific Mef2d KO (Mef2d (-/-)) mouse lines, we de

177 Delta-catenin is a brain-specific member of the adherens junction complex t

178 Here we show that delta-catenin, a brain-specific member of the p120 catenin subfamily, for

179 Cyclin-dependent kinase 5 (Cdk5) is a brain-specific membrane-bound protein kinase that is act

180 somal loci display developmentally regulated brain-specific methylation patterns which are lost in Sm

181 Bl6J mice led to increased expression of the brain-specific microRNA miR-128b, which disrupted stabil

182 Dysregulated expression of miR-219, a brain-specific microRNA, has been observed in neurodevel

183 A recent study has shown that miR-134, a brain-specific microRNA, is present in dendrites where i

184 Here we show that a brain-specific microRNA, miR-134, is localized to the sy

185 ponse binding protein (CREB) expression by a brain-specific microRNA, miR-134.

186 t lamin C expression, is down-regulated by a brain-specific microRNA, miR-9.

187 In our previous study, we have shown that brain-specific microRNA-124 (miR-124) is significantly d

188 Here, we identify a brain-specific microRNA-miR-128-that represses NMD and t

189 he brain is low and is regulated by miR-9, a brain-specific microRNA.

190 ce of a putative binding site for miR-338, a brain-specific microRNA.

191 emoval of prelamin A transcripts by miR-9, a brain-specific microRNA.

192 ng of the mechanisms regulating the level of brain-specific microRNAs.

193 ng studies showed that NXF proteins bound to brain-specific microtubule-associated proteins (MAP) suc

194 We found that brain-specific miR-124 is expressed in microglia but not

195 expression of a family of miRNAs, including brain-specific miR-124a.

196 functional studies showed that silencing of brain-specific miR-134 using antisense oligonucleotides

197 Mammalian brain-specific miR-9 and miR-124 have been implicated in

198 It is known that brain-specific miR-9 is controlled transcriptionally; ho

199 One brain-specific miRNA, miR-124a, decreases the levels of

200 NMDA receptor signaling reduces levels of a brain-specific miRNA, miR-219, in the prefrontal cortex

201 iR-124, the most abundant and well-conserved brain-specific miRNA, was exclusively present presynapti

202 , including a large polycistronic cluster of brain-specific miRNAs, are DNA-methylated and are bound

203 Here, we examine the role of two brain-specific miRNAs, miR-219 and miR-132, in modulatin

204 eins in controlling the expression levels of brain-specific miRNAs.

205 ges in cytoplasmic calcium and activation of brain-specific, mitochondrial MICU3.

206 ormed an extensive characterization of a new brain-specific model of severe forms of RASopathies, the

207 Using the same, highly regulatable brain-specific model, here we report PI3K-dependent mech

208 Thus, our study suggests that brain-specific modulation of PIP2 may offer a therapeuti

209 lated transcription coactivator 1 (TORC1), a brain-specific modulator of CREB activity.

210 understanding of neuroprotective therapy and brain-specific monitoring for critically ill pediatric p

211 morphism analysis confirmed that a prominent brain-specific mutation constituted approximately 10% of

212 Brain-specific mutations defined several families of rel

213 The patterns of brain-specific mutations in these families were consiste

214 The fundamental role of the brain-specific myelin transcription factor 1-like (MYT1L

215 freshly isolated astrocytes the presence of brain-specific Na+-dependent inorganic phosphate cotrans

216 mRNA in situ hybridization of brain-specific Nav subunits revealed the expression of N

217 eq) data, we were able to connect identified brain-specific ncRNAs with their cell types of origin.

218 plex activity but also identifies TRIM9 as a brain-specific negative regulator of the NF-kappaB pro-i

219 raging these genome-wide predictions and the brain-specific network, we demonstrated that the large s

220 In the post-embryonic Drosophila brain, specific neuron types derive from specific progen

221 e report the identification in mouse of four brain-specific novel paternally expressed transcripts an

222 Our data suggest that type IV is a unique brain-specific NRG1 that is differentially expressed and

223 Brain-specific Orai1 and STIM1 knockout (KO) mice exhibi

224 A (BPA, a plastics monomer), induces strong brain-specific overexpression of aromatase.

225 r signaling in the central nervous system by brain-specific overexpression of the human IL-1 receptor

226 several ion channels and the CACNA1A gene, a brain-specific P/Q-type calcium channel gene associated

227 The brain-specific PACSIN 1 is enriched at synapses and has

228 The brain-specific paternal expression from the ICR shows me

229 imal spinal cord pathology further confirmed brain-specific pathology.

230 Here we show hierarchial forms of a brain-specific phage-derived peptide (herein as NanoLiga

231 atase non-receptor type 5 (PTPN5, STEP) is a brain specific phosphatase that regulates synaptic funct

232 gnaling through phospholipase Cgamma and the brain-specific PKC variant protein kinase M zeta (PKMzet

233 olyadenylation signal being nearly absent at brain-specific polyA sites.

234 We show that these iPSCs express brain-specific portions of the transcripts driven by the

235 Neurogranin (Ng) is a brain-specific postsynaptic calmodulin-binding protein i

236 Neurogranin (Ng) is a brain-specific, postsynaptically located protein kinase

237 B'beta is a brain-specific PP2A regulatory subunit that mediates dep

238 d then according to their involvement in the brain-specific PPI network and proposed new regulatory s

239 s and revealed 22 GWAS genes involved in the brain-specific PPI network.

240 of brain areas and developmental stages and brain-specific promoter and enhancer annotations.

241 we have produced transgenic mice bearing the brain-specific promoter of the human FGF1 gene joined to

242 The WAVE-1 isoform is a brain-specific protein expressed in variety of areas inc

243 loss of the ANKS1B-encoded protein AIDA-1, a brain-specific protein highly enriched at neuronal synap

244 Sustained activation of the brain-specific protein kinase C (PKC) isoform protein ki

245 lusively, the part of SYNE1 encoding CPG2, a brain-specific protein localized to excitatory postsynap

246 We identified the brain-specific protein MICU3 as a critical driver of thi

247 roteomic screen, we have identified NETO2, a brain-specific protein of unknown function, as an intera

248 hed protein tyrosine phosphatase (STEP) is a brain-specific protein phosphatase that regulates a vari

249 hed protein tyrosine phosphatase (STEP) is a brain-specific protein tyrosine phosphatase that opposes

250 Here we show that Jerky is a brain-specific protein with a high expression level in n

251 We identified a brain-specific protein, which has been previously termed

252 Combinations of brain-specific proteins increase the sensitivity and spe

253 ing can be achieved by detection in blood of brain-specific proteins that extravasate when these endo

254 Previously, we showed that brain-specific PTP1B(-/-) mice are protected against hig

255 Rim1, a brain-specific Rab3a-binding protein, localizes to the p

256 SynGAP is a brain-specific ras GTPase-activating protein that is an

257 resent study shows for the first time that a brain-specific receptor, GABA(B)R2 is present in human n

258 In excitatory synapses of the brain, specific receptors in the postsynaptic membrane l

259 t of antioxidant response and be inherent to brain-specific regions.

260 Such risk might be selective to brain-specific regions.

261 normal vision, Drosophila-like 2 (ELAVL2), a brain-specific regulator of RNA stability, as presumptiv

262 The role of brain-specific regulatory subunits in neuronal different

263 al inflammation on the brain, and reported a brain-specific response characterised by increased trans

264 ted as peripheral biomarkers and may reflect brain-specific responses to smoking exposure.

265 We describe a brain-specific RhoGAP splice variant, BARGIN (BGIN), whi

266 Topics examined include brain-specific risk factors, such as bacterial infection

267 set of broadly expressed (the majority) and brain-specific risk genes disrupts cell proliferation, n

268 In brain, specific RNA-binding proteins (RBPs) associate wi

269 fically expressed in the brain, suggesting a brain-specific role in mRNA metabolism.

270 in is a multidomain protein that serves as a brain-specific serine protease.

271 only expressed the ubiquitous mRNA isoform, brain-specific SGCE mRNA and epsilon-sarcoglycan protein

272 However, no brain-specific signature sequence was identified.

273 lude elements of the IC, suggesting that the brain specific silencing of Ube3a is due to multiple alt

274 It has been proposed that brain-specific silencing of the paternal UBE3A allele is

275 n this issue of Cell, Chang and Guarente use brain-specific SIRT1 knockout mice and transgenic mice o

276 Here, we developed a brain-specific Slc6a8 knockout mouse (Slc6a8-/y) as an a

277 cificity, blood-based studies may not detect brain-specific smoking-related DNAm differences that may

278 We validated our muscle-specific and brain-specific splice forms for known genes.

279 The brain-specific splice variant of Cdc42 (bCdc42) terminat

280 RGS9-2, a brain-specific splice variant of the RGS9 gene, is highl

281 Here, we show that cpg2 is a brain-specific splice variant of the syne-1 gene that en

282 ArgBP2, and its brain-specific splice variant, nArgBP2, are interactors

283 however, the precise contribution of the two brain-specific subunits Ca(v)1.2 and Ca(v)1.3 remains mo

284 TATEMENT Sulfotransferase 4A1 (SULT4A1) is a brain-specific sulfotransferase highly expressed in neur

285 In summary, we demonstrate here that brain-specific suppression of AMPKalpha2 isoform impairs

286 Syntaphilin is a brain-specific syntaxin-binding partner first characteri

287 ), we characterized mice with whole-body and brain-specific targeted deletion of Mrap2, both of which

288 l genetic redundancy between Src and Fyn for brain-specific targets suggests that these two kinases m

289 Recent development of an inducible brain-specific Tat transgenic mouse model has made it po

290 Cutting edge brain-specific therapies, capable of circumventing the p

291 In addition, we identified a brain-specific transcript containing a novel, alternativ

292 The brain-specific transcription factor POU3F2 (POU domain,

293 iated with sequence-dependent binding of the brain-specific transcription factors EMX2 and NKX6-1.

294 e findings suggest the novel hypothesis that brain-specific transcription of Ube3a-ATS is regulated b

295 oup; P=0.25), although the number of days of brain-specific treatments (e.g., administration of hyper

296 In contrast, late disruption of brain-specific Trpm7 after embryonic day 10.5 does not a

297 The brain-specific tyrosine phosphatase, STEP (STriatal-Enri

298 ature DG granule cells (GCs) or by prolonged brain-specific VEGF overexpression culminating in extens

299 h water channels, we studied the extent of a brain-specific water channel, aquaporin-4 (AQP4), using

300 Here we describe the generation of a brain-specific XBP-1 conditional KO strain (XBP-1(Nes-/-