ライフサイエンスコーパス: brainstem

1 spinal regions, such as the motor cortex and brainstem.

2 lexes controlled by neuronal circuits of the brainstem.

3 ic cancer resident in the pons region of the brainstem.

4 on of microbubbles and FUS sonication at the brainstem.

5 ngue, olfactory epithelium, whisker pads and brainstem.

6 tria terminalis, amygdala, diencephalon, and brainstem.

7 nhibition in the adult human spinal cord and brainstem.

8 and not HO-1, progressively decreased in the brainstem.

9 phrine, dopamine or serotonin, mainly in the brainstem.

10 ic systems which impact motor systems of the brainstem.

11 medial nucleus of the trapezoid body in the brainstem.

12 gus nerve and thereby signal directly to the brainstem.

13 ry through its descending projections to the brainstem.

14 s, as well as in some specific nuclei in the brainstem.

15 ontaneous recovery in regions other than the brainstem.

16 reduced volumes of cerebellum, midbrain, and brainstem.

17 sory representations, including thalamus and brainstem.

18 ory neurotransmission in the spinal cord and brainstem.

19 ub for respiratory chemoreception within the brainstem.

20 t information to the cochlear nucleus of the brainstem.

21 regions of the central brain structures and brainstem.

22 to spinal-projecting premotor neurons in the brainstem.

23 ates neurons in the brain regions beyond the brainstem.

24 uning distribution observed in the mammalian brainstem.

25 ation of the autonomic nervous system in the brainstem.

26 contains only a small set of neurons in the brainstem.

27 xpression of rLFPs across the pontomedullary brainstem.

28 ults show the highest IS accumulation in the brainstem.

29 frontal cortex, hippocampus, cerebellum, and brainstem.

30 ted kinase 1 (Tak1) is over-activated in the brainstem.

31 neurons of the retrotrapezoid nucleus in the brainstem(4-6) and pH homeostasis by kidney proximal tub

32 arly Parkinson's disease was observed in the brainstem (52%; P = 0.018).

33 5-HT(3A)R in the gastrointestinal tract and brainstem, acting as effective anti-emetic agents.

34 evidence an impact of top-down modulation of brainstem activity on the variability in speech-in-noise

35 The mean concentration of 800CW-BSA in the brainstem after FUSIN delivery decreased from 0.5 h to 4

36 c deletion of serotonin (5HT) neurons in the brainstem also prevented arousal from hypercapnia.

37 of InCO(2); and 4) there were few changes in brainstem amine levels following 24 h or 30 d of increas

38 We apply this approach to the adult murine brainstem and achieve a precise alignment of projections

39 greater in the hippocampus, cerebellum, and brainstem and APP protein level was greater in cerebellu

40 oimaging in the basal ganglia, thalamus, and brainstem and by a loss of motor skills and delayed deve

41 At G135, ethanol-exposed fetuses had reduced brainstem and cerebellum volume and water diffusion anis

42 es were found in the pallidum, hypothalamus, brainstem and cerebellum.

43 tion of neuronal networks formed between the brainstem and cerebellum.

44 lower risk of subsequent attacks except for brainstem and cerebral events, with an overall relative

45 litis, area postrema attacks and less common brainstem and cerebral events.

46 Performance ranged from 0.96 +/- 0.01 (brainstem and cerebrum) to 0.74 +/- 0.06 (internal capsu

47 WPNs and SPNs are ubiquitous in the brainstem and diencephalon, areas that together contain

48 pharmacological inhibition primarily in the brainstem and genetic microglia-selective deletion of Ta

49 ty was mitigated by stimulation of ascending brainstem and intralaminar thalamic connections.

50 y an efferent pathway that descends from the brainstem and makes transient direct synaptic contacts w

51 ittle attention has been paid to the role of brainstem and midbrain areas that process sound informat

52 essential advance to record from neurons in brainstem and spinal cord in moving animals.

53 Brain, brainstem and spinal cord portions of the corticospinal

54 in the corticospinal tracts along the brain, brainstem and spinal cord portions to explain physical d

55 Labeling throughout the brainstem and spinal cord were very similar for the two

56 type, higher psychosine levels in the rodent brainstem and spinal cord, and a significantly shorter l

57 ated in multiple ganglia associated with the brainstem and spinal cord.

58 a located adjacent to multiple levels of the brainstem and spinal cord.

59 tribution of polySia immunoreactivity in the brainstem and thoracolumbar spinal cord, to compare the

60 ate the reconstructed tracts, the MR-scanned brainstem and three additional brainstems were sectioned

61 lesions scattered throughout the cerebellum, brainstem, and basal ganglia.

62 egmental nucleus (RMTg) arising from cortex, brainstem, and habenula that drive triply dissociable RM

63 e alpha-syn pathology along the spinal cord, brainstem, and midbrain by 16 weeks post-injection.

64 ain regions (orbitofrontal cortex, striatum, brainstem, and thalamus) that lie in the trajectories of

65 similar group of Pdyn+ neurons in the human brainstem, and we define the efferent and afferent proje

66 acial eye-blink startle electromyography and brainstem- and amygdala-specific functional magnetic res

67 Two deaths were related to brainstem anesthesia.

68 pulation of neurons in the vagal ganglia and brainstem are activated via the gut-brain axis to create

69 Owing to its location, the nerves of the brainstem are closely related with vascular structures.

70 rons, including cranial motor neurons of the brainstem, are frequently organised as nuclei.

71 H(+) leads to constriction of vessels in the brainstem area that controls respiration.

72 eral thalamic nuclei) and both neocortex and brainstem ascending reticular activating system (ARAS) n

73 sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first l

74 channels in and out of the cell membrane in brainstem astrocytes contributes to their role as centra

75 investigated the mechanosensory signaling in brainstem astrocytes, as these cells reside alongside th

76 ific correlation pattern was detected in the brainstem, at a location consistent with noradrenergic c

77 have allowed researchers to compare how the brainstem auditory and vestibular nuclei develop in embr

78 tifies a new pathway of connectivity between brainstem auditory neurons and indicates that MOC neuron

79 ut whiskers and transmitted centrally to the brainstem (barrelettes), the thalamus (barreloids), and

80 PSD-95 was reduced in the brainstem, basal ganglia, neocortex, and cerebellum with

81 ism in the medial temporal lobe, cerebellum, brainstem, basal ganglia, thalami, and orbitofrontal and

82 atures of cortical neurons projecting to the brainstem before binge drinking predicted the ultimate e

83 ology caused by uncontrolled invasion of the brainstem by inflammatory monocytes and neutrophils.

84 However, the interactions of these brainstem centers with each other and with the spinal lo

85 terminating in the respiratory and autonomic brainstem centers.

86 Involvement of the brainstem, cerebellum or both is common in MOGAD but usu

87 Isolated attacks involving the brainstem, cerebellum or both were less frequent in MOGA

88 ve cell-based assay and (3) MRI lesion(s) of brainstem, cerebellum or both.

89 lar vagal airway sensory neurons wire into a brainstem circuit with ascending projections into the su

90 g dorsal cochlear nucleus, a cerebellar-like brainstem circuit.

91 damental computational processes in auditory brainstem circuitry and to a more holistic understanding

92 Leveraging unique brainstem circuitry, we show in vitro evidence for refle

93 is a major source of inhibition in auditory brainstem circuitry.

94 ent and ion channel deregulation of auditory brainstem circuits, to impaired neuronal plasticity and

95 or motor deficits, often as a consequence of brainstem compression or syringomyelia (SM).

96 V VS without or with only mild symptoms from brainstem compression, SRS can be recommended as the pri

97 olivocochlear (MOC) efferent neurons in the brainstem comprise the final stage of descending control

98 lial Tak1 in the brain, and particularly the brainstem, contributes to the pathogenesis of obesity-as

99 We suggest that brainstem control of locomotion is mediated by two pathw

100 control TNF production, revealing a role for brainstem coordination of immunity.

101 in cortical regions, striatum, thalamus and brainstem correlated with longer disease duration (P < 0

102 Phosphocreatine in brainstem correlated with respiratory dysfunction and di

103 assess IS concentrations in the cerebellum, brainstem, cortex, hypothalamus, and striatum with hippo

104 Recordings of brainstem DC potential and neuronal activity, cardioresp

105 rding concepts such as 'whole brain' versus 'brainstem' death, and the intersection of BD/DNC and rub

106 in which neuronal GALC expression influences brainstem development that is critical for KD pathogenes

107 pulation of GABAergic neurons in the ventral brainstem, distinguished by prodynorphin expression, whi

108 opulation of inhibitory neurons in the mouse brainstem, distinguished by their expression of prodynor

109 ate that cholinergic neurons residing in the brainstem DMN control TNF production, revealing a role f

110 Neurons residing in the brainstem dorsal motor nucleus (DMN) project in the vagu

111 ated syndromes (optic neuritis, myelitis and brainstem encephalitis), but rarely in MS.

112 rences in spike transmission in the auditory brainstem (endbulb of Held).

113 we assessed effects of brainstem seizures on brainstem function and respiration in male and female mi

114 data can facilitate better understanding of brainstem gliomagenesis and classification, and guide fu

115 Brainstem gliomas are a heterogeneous group of tumors th

116 53 loss to accelerate development of diffuse brainstem gliomas that recapitulated human DIPG gene exp

117 ic and genomic analyses on a large cohort of brainstem gliomas, including Diffuse Intrinsic Pontine G

118 e neocortex, limbic structures, and auditory brainstem, glutamatergic nerve terminals corelease zinc

119 osterior limb of internal capsule), level of brainstem, grey- white matters on levels of centrum semi

120 f dnSNARE in astrocytes of the ventrolateral brainstem had no effect.

121 Traditionally, the brainstem has been seen as hardwired and poorly capable

122 The brainstem has been shown to be affected by photoperiodic

123 ume, leading to augmented cerebral pressure, brainstem herniation, and death.

124 sing the Dice coefficient for the regions of brainstem, hippocampus, and cortex.

125 insic immunity can account for forebrain and brainstem HSE, respectively.

126 The lateral superior olive (LSO), a brainstem hub involved in sound localization, integrates

127 mechanism for autism-like behaviours and the brainstem hypoplasia seen in some individuals with mutat

128 licate a modulatory pathway centering on the brainstem (i.e., nucleus reticularis pontis caudalis) an

129 tion in cerebral peduncles, midbrain, and/or brainstem in MRI scans.

130 mic Arc and the ventrolateral medulla of the brainstem in normal-weight male Wistar rats.

131 (AP) and nucleus tractus solitarius (NTS) of brainstem including the NTS neurons immunoreactive to do

132 rvous system and branchiomotor nuclei in the brainstem including the RTN, had a similar distribution

133 neurons leads to decreased neuronal firing, brainstem inflammation, motor and respiratory deficits,

134 These putative brainstem inputs (PBIs) are broadly tuned and exhibit de

135 spinal interneurons are the main targets for brainstem inputs adjusting gait (Danner et al., 2017).

136 , excitatory responses evoked by sensory and brainstem inputs are reduced in MNs of presymptomatic mu

137 ng presynaptic potentials from broadly tuned brainstem inputs can be recorded concurrently with posts

138 orters 1 and 2 denoting a specific source of brainstem inputs.

139 nd motor features in the medial hypothalamic-brainstem instinctive network.SIGNIFICANCE STATEMENT Alt

140 of Parkinson disease (PD) suggests that the brainstem is a convergent area for the propagation of pa

141 The brainstem is an important interface between upper motor

142 t that, in addition to the hypothalamus, the brainstem is essential for non-rapid eye movement (NREM)

143 Thus, the presence of ITD maps in the brainstem may reflect a local optimum in evolutionary de

144 at astrocytes are integral components of the brainstem mechanisms that process afferent information a

145 s in males and sudden death at infant age by brainstem-mediated cardiorespiratory arrest.

146 le-unit studies at the level of the auditory brainstem, midbrain, and cortex of aged animals.

147 jections to distinct areas and nuclei in the brainstem, midbrain, thalamus, and the somatosensory cor

148 anglia and through descending projections to brainstem motor circuits.SIGNIFICANCE STATEMENT Meso-die

149 ons receive direct input from the cortex and brainstem motor nuclei and are required for corrective m

150 Functionally tuned brainstem neurons for different actions serve as importa

151 et proto-oncogene (RET) signaling complex in brainstem neurons that mediates GDF15-induced weight los

152 t, and 5-HT(+) neurons within graft and host brainstem neurons were transsynaptically labeled by inje

153 aturation of immature T-box-brain-1 positive brainstem neurons.

154 Our results indicate that brainstem NI GABAergic cells are essential for controlli

155 h redundancy and Kv3.3 dominance between the brainstem nuclei involved in sound localization.

156 vides the first evidence of synaptic loss in brainstem nuclei involved in the pathogenesis of Parkins

157 One of the brainstem nuclei involved in the regulation of anxiety i

158 inotopic projection of the neural image onto brainstem nuclei reveals features of the neural image in

159 re we examined the contribution of two lower brainstem nuclei that could be implicated in CO(2) and h

160 us, ventral striatum, thalamus, and specific brainstem nuclei, coactivates in response to diverse exp

161 eys spectral information from the cochlea to brainstem nuclei, the inferior colliculi, and the thalam

162 ubcortical regions, such as the thalamus and brainstem nuclei, which mediate complex interactions wit

163 lation of the superior colliculus from other brainstem nuclei.

164 us of the trapezoid body (MNTB), an auditory brainstem nucleus critically involved in sound localizat

165 urs, which include birds and crocodiles, the brainstem nucleus laminaris (NL) developed into the crit

166 eathing, rhythm generation is localized to a brainstem nucleus, the preBotzinger Complex (preBotC).

167 spontaneous glutamate release in an auditory brainstem nucleus, while suppressing evoked release.

168 g the RTN, had a similar distribution in the brainstem of adult macaques compared to adult rats.

169 esencephalic locomotor region and the caudal brainstem of mice involved in the initiation and control

170 the miR-378-3p level in Be(2)C cells and the brainstem of the morphine tolerant mice, contributing to

171 he preferred ITD of neurons in the mammalian brainstem often lies outside the physiological range and

172 Brainstem or cerebellar involvement occurred in 62/185 (

173 n relatively broad brain networks beyond the brainstem, our data suggest that acupuncture at this acu

174 the ascending arousal system, including the brainstem parabrachial neurons, which promote arousal in

175 OKR is acquired through recurrent cerebellum-brainstem parallel loops in which the cerebellum adjusts

176 ive/defensive responses via hypothalamic and brainstem pathways (eg, periaqueductal grey).

177 The brainstem pathways that drive MOC function are poorly un

178 0.9% of neuromyelitis optica patients (18.1% brainstem periventricular/periaqueductal, 32.7% periepen

179 everal months after a subtotal excision of a brainstem pilocytic astrocytoma.

180 ights into the limits of physiology-mediated brainstem plasticity during the development of the audit

181 In females, whole brainstem, pons and medulla volumes individually mediate

182 icated and frequently spatially intermingled brainstem populations essential for action diversificati

183 amidal pathway for control over midbrain and brainstem premotor structures.

184 is defensive behavior via the recruitment of brainstem premotor targets, whereas ablation of OXT neur

185 ivation were acquired in a rat working heart-brainstem preparation during baroreflex and chemoreflex

186 on phrenic and vagal nerves in the perfused brainstem preparation.

187 ainstem tissue in single arterially perfused brainstem preparations with respect to the ongoing respi

188 ting the developmental processes of auditory brainstem presynaptic terminals is critical to understan

189 al retrograde tracing approach to map direct brainstem projections to the putative location of pF(L)

190 ion within the brain (r = 0.31, P < 0.0001), brainstem (r = 0.45, P < 0.0001) and spinal cord (r = 0.

191 Among the brainstem raphe nuclei, the dorsal raphe nucleus (DR) co

192 All areas except the brainstem recovered.

193 This is regulated by a brainstem reflex pathway.

194 s, and the mesencephalic locomotor region, a brainstem region that controls locomotion in a graded fa

195 he mesencephalic locomotor region (MLR) is a brainstem region well known to initiate and control loco

196 ei, which are sensitized by migraine-related brainstem regions and simultaneously suppressed by inhib

197 inson's disease, supporting the relevance of brainstem regions and their genetic architectures in com

198 lei and lateral parabrachial nucleus, and in brainstem regions associated with autonomic function, in

199 ase, detailed information regarding specific brainstem regions is lacking.

200 Brainstem regions support vital bodily functions, yet th

201 veral respiratory and nonrespiratory related brainstem regions that could contribute to the complex m

202 oup, but RTN has very limited projections to brainstem regions that regulate arousal (locus ceruleus,

203 ctivation of nerve fibers terminating in the brainstem respiratory center.

204 mal models, initiates apnea upon invasion of brainstem respiratory centers.

205 ed MORs from neurons in two key areas of the brainstem respiratory circuitry (the Kolliker-Fuse nucle

206 ess more pro-inflammatory cytokines in their brainstem respiratory control nuclei, exhibit a higher r

207 d that the compartmental organization of the brainstem respiratory network is sufficient to generate

208 (MORs) are widely distributed throughout the brainstem respiratory network, but the mechanisms underl

209 stic emission (TEOAE) and automated auditory brainstem response (AABR).

210 ion in wave I of the suprathreshold auditory brainstem response (ABR) and reduced number of synapses

211 mal hearing function as assessed by auditory brainstem response (ABR) measurements, and their otolith

212 e no significant differences in the auditory brainstem response (ABR) thresholds between mutant rats

213 ant synaptopathy and a reduction in auditory brainstem response (ABR) wave-I amplitude.

214 tive electrophysiological test, the auditory brainstem response (ABR).

215 Previously we showed that the auditory brainstem response to running speech is modulated by sel

216 that only the attentional modulation of the brainstem response to speech was significantly related t

217 vs 6% of early awakeners), absent motor and brainstem responses (38% vs 11%; 23 vs 4%, respectively)

218 acoustic emissions (DPOAEs) and the auditory brainstem responses (ABRs) across the entire range of te

219 Wave III of auditory brainstem responses (which represents synchronized activ

220 anges in mouse hearing by recording auditory brainstem responses before and following exposure to noi

221 on of the SGNs in vivo, we measured auditory brainstem responses in K(Na)1.1/1.2 double knockout (DKO

222 All HA-tagged genotypes had auditory brainstem responses not significantly different from tho

223 n product otoacoustic emissions and auditory brainstem responses.

224 ks of age as measured by tone burst auditory brainstem responses.

225 ions of the serotonergic raphe nuclei of the brainstem reticular formation, with three discrete subre

226 ortex included development of connections to brainstem reticulospinal neurons; these projections pers

227 Analysis of the cerebellum and brainstem revealed a reduced granule cell layer and a re

228 These changes implicate the brainstem's breathing circuitry which we confirm by loca

229 Brainstem SD occurred during all spontaneous fatal seizu

230 We show that brainstem seizure-related medullary SD is followed by lo

231 mice, that apnea is induced when spontaneous brainstem seizure-related spreading depolarization (SD)

232 To study this, we assessed effects of brainstem seizures on brainstem function and respiration

233 al chemoreception is the process whereby the brainstem senses blood gas levels and adjusts homeostati

234 tracing from the intestinal wall identifies brainstem sensory nuclei that are activated during micro

235 For macrocyclic GBCAs, the DCN-to-brainstem SI ratios did not significantly differ from th

236 The brainstem, situated in the posterior fossa, connects the

237 -cell patch-clamp experiments in acute mouse brainstem slices at postnatal days (P) 4 and 11 during p

238 al recordings from identified MOC neurons in brainstem slices from mice of either sex to demonstrate

239 l recordings of NTS neurons, from horizontal brainstem slices of male and female SST-yellow fluoresce

240 Whole-cell patch recordings from brainstem slices of mice of both sexes were performed.

241 ell, patch clamp recordings were obtained in brainstem slices.

242 , the most prominent source of inhibition in brainstem sound-localization circuitry.

243 To study the central effects of LLTS, four brainstem (SP5, NAb, NTS, and RVLM) and two forebrain si

244 evious model, we propose a connectome of the brainstem-spinal circuitry and suggest a mechanistic exp

245 trocyte-specific Trpa1 disruption in a mouse brainstem-spinal cord preparation impedes the amplitude

246 We postulate that brainstem spreading depolarization (SD), previously asso

247 This scientific commentary refers to 'Brainstem spreading depolarization and cortical dynamics

248 the pedunculopontine nucleus (PPN), a small brainstem structure considered as a locomotor center, is

249 of major discoveries regarding how this tiny brainstem structure exerts such varied and significant i

250 n of the superior colliculus, a sensorimotor brainstem structure, in de novo PD patients compared to

251 mechanistic explanation of the operation of brainstem structures and their roles in controlling spee

252 Although brainstem structures are likely to be affected early in

253 ined neural circuits, including midbrain and brainstem structures, at unprecedented depths of up to 7

254 overlapping as well as distinct thalamic and brainstem structures.

255 he occipital cortex, as well as thalamic and brainstem structures.

256 ssumed to manifest in subcortical limbic and brainstem structures.

257 y processing nuclei, and additional specific brainstem, subcortical, and cortical areas.

258 ts including the auditory thalamus, auditory brainstem, superior colliculus, and periaqueductal gray.

259 tayed in a coma for several months following brainstem surgery, but finally was discharged home with

260 ogy, as well as the time of occurrence after brainstem surgery, contributed to the diagnosis of HOD.

261 nnection in a female rabbit, and an auditory brainstem synapse in a female gerbil.

262 ritical for signaling the maturation of this brainstem synapse.

263 e neocortex, limbic structures, and auditory brainstem, synaptic zinc is released from presynaptic te

264 al population events to its hypothalamic and brainstem targets.

265 ed partial recovery of thalamo-occipital and brainstem-thalamic connectivity, with values more closel

266 lationship can be found in the somatosensory brainstem, thalamus, and cortex of rats and mice, where

267 identified discrete groups of neurons in the brainstem that connect a sensory integrative area with d

268 l populations in the medial hypothalamus and brainstem that encode defensive responses to a rat preda

269 pot', is a small nucleus located deep in the brainstem that provides the far-reaching noradrenergic n

270 Within the brainstem, the high SIV load and inflammation, along wit

271 SIV RNA expression was highest in the brainstem throughout infection, and it associated with n

272 196-364 electrode sites within 8-10 mm(3) of brainstem tissue in single arterially perfused brainstem

273 m hundreds of electrode sites in a volume of brainstem tissue while monitoring the respiratory motor

274 activate and modulate the MOC somata in the brainstem to drive these cochlear effects are poorly und

275 e peptide-1 (GLP1) signaling from the caudal brainstem to the hypothalamus and limbic forebrain.

276 ordings in macaque monkeys, we show that the brainstem transiently modulates hippocampal network even

277 tine gliomas (DIPGs) are incurable childhood brainstem tumors with frequent histone H3 K27M mutations

278 concentration of drug within the SU-DIPG-17 brainstem tumours compared to controls.

279 atergic presynaptic terminal in the auditory brainstem undergoes developmental changes to support the

280 mporary BBB opening within the normal murine brainstem using MRgFUS following intravenous (IV) admini

281 had stable (optic radiations) or decreasing (brainstem, ventral pons) white matter volumes.

282 in the distribution of fibers, especially in brainstem vocal-acoustic nuclei and other sensory integr

283 olumes and lower depressive scores, and that brainstem volume mediates the seasonality of depressive

284 We detect genetic overlap between brainstem volumes and eight psychiatric and neurological

285 photoperiod days are associated with larger brainstem volumes and lower depressive scores, and that

286 d was found to be positively correlated with brainstem volumes.

287 however, consistent with C1's projections to brainstem wake-promoting structures.

288 nctional channels in neurons of the auditory brainstem was examined from the physiological perspectiv

289 microglia-specific activation of Tak1 in the brainstem was sufficient to cause an impairment in BA fu

290 SB non-displaceable binding potential in the brainstem were associated with increased Movement Disord

291 ed Ca(2+) responses in astrocytes of the rat brainstem were blocked by (1) antagonists of connexin ch

292 he MR-scanned brainstem and three additional brainstems were sectioned for polarized light imaging (P

293 outcome of 800CW-BSA was the highest at the brainstem when T(lag1) was 0.5 h, which was on average 2

294 xidative phosphorylation was detected in the brainstem where DeltaGATP and phosphocreatine were reduc

295 are overlapping, and did not investigate the brainstem where they separate.

296 ols that measure neural activity across this brainstem-wide circuit are lacking.

297 ime, that only the I-PI transition engages a brainstem-wide network, and that rLFPs during the PI-E2

298 ributed NREM sleep-regulating circuit in the brainstem with a common molecular property.

299 of distribution were found in rat and mouse brainstem with differences evident in DH.

300 ubunits are highly expressed in the auditory brainstem, with little or no mRNA for Kv3.2 or Kv3.4.