ライフサイエンスコーパス: break

1 age of another intact DNA duplex through the break.

2 RP-1 allostery to promote release from a DNA break.

3 r of response for cellular DNA double-strand break.

4 sters or individual single- or double-strand breaks.

5 otoxic stresses that cause DNA double-strand breaks.

6 ne H2AX, a known marker of double-strand DNA breaks.

7 mismatch repair and increased double-strand breaks.

8 er formation of programmed DNA double-strand breaks.

9 ian cells without donor DNA or double-strand breaks.

10 kbone phosphate positions, and single-strand breaks.

11 es at low basal levels and is induced by DNA breaks.

12 emory of recently repaired DNA single-strand breaks.

13 damage response (DDR) upon DNA double-strand breaks.

14 by promoting 53BP1 binding to double-strand breaks.

15 target sites without inducing double-strand breaks.

16 ed, in which one or more disulfide bonds are broken.

17 instead the acetaldehyde crosslink itself is broken.

18 ive months old and had its neck purposefully broken.

19 cation across the cell required for symmetry breaking.

20 g and tension decay, which result in synapse breaking.

21 traction induced by solid-oil-water emulsion breaking.

22 iating this picture of a cascade of symmetry breaking.

23 lly important goal, the approach necessarily breaks a protective barrier, temporarily, which plays a

24 erspective of autocatalysis, chiral symmetry breaking, absolute asymmetric synthesis and its role in

25 Constraint-breaking adaptations are evolutionary tools that provide

26 Both Mojave species hold constraint-breaking adaptations in relation to their counterparts f

27 the twisting and substrate induced symmetry breaking allow an out of plane orbital magnetization to

28 bonate), is limited by its low elongation at break and high brittleness.

29 The elongation at break and the water vapor permeability (WVP) values of t

30 tive mechanistic paradigm decouples the bond-breaking and bond-forming steps of the catalytic cycle t

31 etal interfaces, owing to inversion symmetry breaking and spin-orbit coupling by a heavy metal such a

32 strate the persistence of inversion symmetry breaking and spontaneous, switchable polarization down t

33 of ODC1, UC cells undergo double-strand DNA breaks and apoptosis.

34 entry by Dox, promoting double-stranded DNA breaks and apoptosis.

35 rotecting against G4 induced double-stranded breaks and concomitant loss of cohesion, possibly at DNA

36 itates homologous recombination at two-ended breaks and contributes to repair within heterochromatic

37 recruited and activated by DNA double-strand breaks and functions as an important sensor of reactive

38 he loss of the endogenous centromere via DNA breaks and HP1-dependent epigenetic inactivation.

39 with greater occurrence of inferior retinal breaks and inferior retinal involvement in particular.

40 Bowman's layer featured breaks and irregularities.

41 nation encompasses high-fidelity chromosomal breaks and loss of specific genome sequences including a

42 , and increased markers of DNA double-strand breaks and proliferation were observed in the colonic mu

43 Delayed retinal breaks and RDs were found in 209 (2.6%) and 80 (1.0%) ey

44 n yeast Schizosaccharomyces japonicus, which breaks and reforms the NE during mitosis.

45 nous replication stress generated unrepaired breaks and SCEs at fragile sites.

46 ocarbon receptor, increase double-strand DNA breaks, and increase the expression of MMP-1, MMP-3, and

47 odulate antibiotic properties and ultimately break antimicrobial resistance.

48 sort into a distinct membrane network, while breaks appear in ER-like, pore-free regions.

49 are able to arrest the cell cycle until the breaks are repaired before entering mitosis.

50 These DNA breaks are repaired by homologous recombination, which f

51 udies of both the concept of chiral symmetry breaking as well as the subsequent chiral amplification

52 lay similar levels of alkylation-induced DNA breaks as wild type, PARP-1 activation is undetectable i

53 lazoparib led to increased DNA double strand breaks, as assessed by gamma-H2AX foci formation, as com

54 simplest paradigms in which angular symmetry-breaking assemblies of mechanical sensors are seen to de

55 Cas9 efficiently generates DNA double strand breaks at the target locus, followed by repair through e

56 These fundamental processes of symmetry breaking, axiation, patterning, and morphogenesis have b

57 onnections between sister chromatids must be broken before cells can divide, and eukaryotic cells hav

58 a finite velocity, resulting in a state that breaks both spatial and time-reversal symmetry, as well

59 6 and IL8, and markers of DNA double-strand breaks but reduced markers of DNA repair, indicating tha

60 To repair a DNA double-strand break by homologous recombination, 5'-terminated DNA str

61 on will impair the repair of single stranded breaks, causing synthetic lethality in tumors with loss

62 lly require harsh conditions to collectively break chemical bonds and overcome the stress caused to t

63 The healing of broken chromosomes by de novo telomere addition, while a

64 arance of dozens of robust recurrent genomic break clusters, termed RDCs, in cultured primary mouse n

65 Breaking continuous flash suppression (b.

66 s not reflect the abundance of double-strand breaks, detected by proxy as RAD51 foci at leptotene, bu

67 eV, and identify the main inversion symmetry breaking direction perpendicular to the MQW planes.

68 ation of cells in agarose beads and labeling breaks directly and specifically with biotinylated linke

69 Repair of broken DNA by homologous recombination requires coordina

70 n units should be modified, as clear genetic breaks do not exist beyond the local population level.

71 In contrast, RAD51 loading at double-strand breaks does not require PrimPol.

72 The ability of a muscle to break down and reform fibers is vital for development; h

73 electrical and optical techniques typically break down at this scale due to inherent physical limita

74 Cyclic nucleotide phosphodiesterases (PDE) break down cyclic nucleotides such as cAMP and cGMP, red

75 iformity in cell contractility and stiffness break down in postconfluence confined multicellular syst

76 primitive version of metabolism to build and break down ketoacids, sugars, amino acids, and ribonucle

77 Herein we break down the process of how predation risk influences

78 ng repair mechanisms may cause the system to break down, under certain conditions, it should persist

79 he short-wavelength nondispersive TA phonons break down.

80 operation invites free-riding and can easily break down.

81 ies radiative transition; and, secondly, the breaking down of the dipole-selection rule for radiative

82 lipoprotein lipase (LPL) is responsible for breaking down triglycerides in the blood.

83 our capacity to actively control our memory breaks down and may have considerable implications for s

84 l redundancy for translation quality control breaks down during oxidative stress, wherein ThrRS is re

85 This process breaks down in hearing-impaired individuals and speech r

86 iency by illustrating how energy consumption breaks down into minimum energy of separation and the ir

87 It was found that FNA broke down a range of cell envelope molecules.

88 eneity of autism mechanisms in humans can be broken down by functional groups and translated to model

89 evelopment of structure inside a cell can be broken down into a number of basic processes.

90 (i.e. spatio-temporal locations (x, y, t)), broken down into three stages: pre-processing, post-proc

91 in a high rate Li-air battery, and iv) high break-down current density for interconnect applications

92 Shot loss leads to double-strand break (DSB) DNA damage, and the apoptotic response is ex

93 ent cells also exhibit reduced double-strand break (DSB) formation and increased survival upon replic

94 he minimal requirement for DNA double-strand break (DSB) formation is as low as even one AID deaminat

95 n BLM-deficient cells involved double-strand break (DSB) formation, in this case by the SLX4/SLX1 nuc

96 induction of an enzyme-linked double-strand break (DSB) in one DNA molecule and passage of another i

97 air outcomes of a Cas9-induced double-strand break (DSB) introduced on the paternal chromosome at the

98 To determine whether double-strand break (DSB) mobility enhances the physical search for an

99 on assay that identified the double-stranded break (DSB) repair and Fanconi anemia (FA) factors activ

100 ly, XRN2 was implicated in DNA double strand break (DSB) repair and in resolving replication stress.

101 The early steps of DNA double-strand break (DSB) repair in human cells involve the MRE11-RAD5

102 Tracking DNA double strand break (DSB) repair is paramount for the understanding an

103 factor to master regulator of double-strand break (DSB) repair pathway choice.

104 perspective will highlight DNA double-strand break (DSB) repair pathways in human cells, how DNA repa

105 ture of editing outcomes after double strand break (DSB) repair.

106 ce between the Cas9-mediated double-stranded break (DSB) to the mutation site, rather than DSB effici

107 k (SSB) yields for plasmid and Double Strand Break (DSB) yields for plasmid/human cell.

108 DNA double-strand breaks (DSB) are the most deleterious type of DNA damage

109 ore telomeric and subtelomeric double-strand breaks (DSBs) and increase VSG switching rate.

110 ll as at intergenic areas when double-strand breaks (DSBs) are induced.

111 DNA double-stranded breaks (DSBs) are strongly associated with active transc

112 DNA double-strand breaks (DSBs) are toxic to mammalian cells.

113 arts with the formation of DNA double-strand breaks (DSBs) at specific genomic locations that corresp

114 ally, BGL3 is recruited to DNA double-strand breaks (DSBs) by PARP1 at an early time point, which req

115 to A3B-mediated mutations and double-strand breaks (DSBs) by perturbing canonical base excision repa

116 Repair of double strand DNA breaks (DSBs) can result in gene disruption or gene modi

117 ication stress markers and DNA double-strand breaks (DSBs) in cells depleted for Topoisomerase I (Top

118 In many vertebrates, double-strand breaks (DSBs) initiate recombination within hotspots whe

119 c sequences subjected to double-stranded DNA breaks (DSBs) made by programmable nucleases (e.g. CRISP

120 Efficient repair of DNA double-strand breaks (DSBs) requires a coordinated DNA Damage Response

121 were randomly distributed, the double-strand breaks (DSBs) that initiate recombination are not locate

122 ctrum of DNA damage, including double strand breaks (DSBs) that interfere with replication.

123 scalable method for analyzing double-strand breaks (DSBs) that we apply in parallel to eight Cas9 va

124 l stress in DNA by introducing double-strand breaks (DSBs) via a transient, covalently linked TOP2 DN

125 recognizing and repairing double-strand DNA breaks (DSBs) via non-homologous end joining.

126 AR), in which the formation of double-strand breaks (DSBs), pairing and crossing over must occur for

127 nts, which lack endogenous DNA double-strand breaks (DSBs), to induce a single DSB by Mos1 transposon

128 oralen-ICLs without generating double-strand breaks (DSBs), unlike the FA/BRCA pathway.

129 virulent Mtb strain, Rv caused double strand breaks (DSBs), whereas the non-virulent Ra strain trigge

130 us types of DNA damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepai

131 ion (dnTA) is regulated at DNA double-strand breaks (DSBs).

132 omology-directed repair of DNA double-strand breaks (DSBs).

133 combination (HR) repair of DNA double strand breaks (DSBs).

134 sites originating from meiotic double-strand breaks (DSBs).

135 es cellular sensitivity to DNA double-strand breaks (DSBs).

136 e-strand breaks (SSBs) and DNA double-strand breaks (DSBs); lesions that can trigger neurodegeneratio

137 ologous DNA end joining (NHEJ), bringing two broken dsDNA ends into proximity is an essential prerequ

138 mplies a high potential for restructuring or breaking during transport.

139 ication, low temperature-mediated floral bud break, early blooming in winter, and strong cold toleran

140 ification and extraction induced by emulsion breaking (EIEB).

141 arent state with massless Dirac fermions and broken electronic flavor symmetry; superconductivity and

142 repair these cytotoxic lesions by rejoining broken ends, among them the nonhomologous end-joining me

143 This "chain-breaking" epistasis creates sinkholes in SD fitness land

144 Significant variation in break-even costs are observed across different technolog

145 We also develop a new method to calculate break-even costs, which indicate the capital costs at wh

146 ually preceded by and influenced by symmetry breaking events and cell polarization.

147 rotein domains pack more closely and have to break extensive contacts before rearrangement, correspon

148 rvation offers insights into charge-symmetry-breaking forces acting in atomic nuclei.

149 DNA breaks generated by topoisomerases are short-lived becau

150 The cranium from Broken Hill (Kabwe) was recovered from cave deposits in

151 ors with loss of high-fidelity double-strand break homologous recombination.

152 ed on assumptions (e.g., the weak ergodicity breaking hypothesis) which have never been put under a s

153 een of interest since Anderson's 1973 ground-breaking idea.

154 This structure shows the distinct break in TM6.

155 al networks and automatically completing the breaks in ancient Akkadian texts from Achaemenid period

156 he impaired Tyr68Ala mutant displays similar breaks in Arrhenius plots of both kinetic and HDX proper

157 muli that break the balanced state and these breaks in balance push the network into a "semi-balanced

158 DNA double-strand breaks in cells of radionuclide-treated patients are qua

159 Breaks in DNA strands recruit the protein PARP1 and its

160 ic maps of site-specific endonuclease strand-breaks in purified DNA from Eschericia coli, phosphoroth

161 t from DNA replication or aberrant repair of breaks in sequence-specific contexts.

162 ential to this process and can occur despite breaks in the continuity of neighboring features.

163 Similarly, double-strand breaks in the LPCAT3 and CD4 genes induced an LPCAT3-CD4

164 nd triggers DNA degradation at double-strand breaks in the target DNA.

165 When this symmetry is broken in anisotropic materials a wide array of novel ph

166 y measurements indicating that double-strand breaks induced by antibiotics strongly stimulate pol IV

167 mage, including age-related DNA lesions, DNA breaks induced by several agents (bleomycin, doxorubicin

168 gene conversion, crossover recombination and break-induced replication (BIR), only after DDC activati

169 ng protein barriers may be beneficial during break-induced replication where barriers are expected to

170 The weighting tool generally assigned breaks intentionally placed in simulated data (i.e., tru

171 insulin proximal to the PM and preventing or breaking interactions between the PM and the remaining n

172 enerating interfacial DMI at mirror symmetry-breaking interfaces.

173 n addition of MMP-2, these filaments rapidly break into fragments prior to reassembling into spherica

174 plane of the stars, the disk should warp and break into precessing rings, a phenomenon known as disk

175 sition metal dichalcogenide multilayers with broken inversion symmetry and substantially enhanced non

176 we show that the nucleolar response to rDNA breaks is dependent on both ATM and ATR activity.

177 corresponding to chemically-driven symmetry breaking, is observed.

178 nator where the nonreciprocity is induced by breaking its time-invariance, we report, in full agreeme

179 ics in a scanning tunneling microscope-based break junction (STM-BJ) device.

180 studied by the scanning tunneling microscopy break-junction method.

181 detection method: immobilized direct in situ breaks labeling, enrichment on streptavidin and next-gen

182 vity and traps PARP1 on DNA at single-strand breaks, leading to replication-induced DNA damage that r

183 A Broken line model was used to identify the periods of th

184 romosomes plays a major role in evolution by breaking linkage between advantageous and deleterious al

185 Reasons for non-compliance were broken/lost spectacles, forgetfulness, and parental disa

186 rrhage was a risk factor for earlier retinal breaks (<=6 weeks vs. >6 weeks; odds ratio, 3.58; P < 0.

187 ne 3 lysine 9 (H3K9) at loci surrounding DNA breaks, masking a local H3K9 trimethylation signal that

188 DNA hairpins and accumulation of chromosomal breaks may reduce the proliferation and viability of pre

189 and/or jaw pain), teeth problems (toothache; broken/missing fillings or teeth; loose, crooked, or sta

190 The most frequently broken motif was REST (p value = 0.0028), which has been

191 imensional (3D) hierarchical film structures broke new ground toward high device performance and good

192 vior of a tissue cell polarity protein BASL (BREAKING OF ASYMMETRY IN THE STOMATAL LINEAGE) in the si

193 of superconducting qubits is affected by the breaking of Cooper pairs of electrons(4-6).

194 weak antilocalization signatures as well as breaking of fourfold spin-valley symmetry, consistent wi

195 e two main responsible IgG receptors for the breaking of immune tolerance of microglia.

196 multiferroics induced by inversion-symmetry-breaking of spin order.

197 morphological changes are caused by symmetry breaking of the irreducible building blocks, with the fo

198 tice scattering are intertwined resulting in breaking of the Matthiessen's rule with increasing EES.

199 owing to their unusual lattice geometry and breaking of time-reversal symmetry(14,15).

200 lease Cas9, we induced two DNA double-strand breaks, one each in the GAPDH and CD4 genes, that caused

201 e ice shell can undergo hemispheric symmetry breaking only if the mean shell thickness is around 10 t

202 ile there appears to be no sequence-specific break or rejoining points for the generation of copyback

203 the DNA damage response without causing DNA breaks or allowing cellular dormancy.

204 target sites without requiring double-strand breaks or donor templates.

205 es are as likely to die standing as they are broken or uprooted-modes of death with different ecologi

206 rature orders and the parent flavor symmetry-breaking orders.

207 e rare and counterintuitive inverse-symmetry-breaking phenomenon(3).

208 The spatial resolution of HDX below a break point of 15-20 degrees C indicates changes in flex

209 The increase in response before the break point of age 7 years is significant only for SMA I

210 ficant at low light (including above the Kok break point) and increased with decreasing irradiance be

211 es are identified as polytract hinges, i.e., break-points of tandem polytracts.

212 of these contributions to the bond formation/breaking process.

213 nciple of spontaneous translational symmetry breaking, providing a general route towards designing ve

214 ility and 53BP1 recruitment at double-strand breaks, providing yet another mechanism of 53BP1 regulat

215 theoretical constructions which necessarily break reciprocity, by pairing nodal knots with their mir

216 High absolute and record-breaking relative flight characteristics suggest that th

217 ts MSI-associated cancers from double-strand breaks remains unclear.

218 whereas KAT5 depletion rewires double strand break repair by promoting 53BP1 binding to double-strand

219 Efficient double-strand break repair in eukaryotes requires manipulation of chro

220 meiotic hotspots, impaired DNA double-strand-break repair, and reduced crossover number.

221 elity through diverse roles in double-strand break repair, replication stress, and meiosis.

222 tivation and also hindered DNA double-strand break repair, which both led to improved radiosensitivit

223 pair, mismatch repair, and DNA double-strand break repair.

224 EXO5) gene in androgen-induced double strand breaks repair via homology-directed repair pathway and p

225 ctional retinal detachment, folds, dragging, breaks, rhegmatogenous detachment, or worsening traction

226 rred locations for extratropical Rossby wave breaking (RWB).

227 structured region of DNA corresponds to the break site for a large (3,895 bp) deletion observed in m

228 The missing sequence at the terminal break site was restored in the recircularized plasmid in

229 egulating GTP-tubulin incorporation into the break site.

230 esulted from the recruitment of 53BP1 to DNA break sites and inhibition of DNA end resection.

231 By breaking spatial inversion symmetry, the stator defines

232 PR/Cas9 strategy to induce DNA double strand breaks specifically in the telomeres, ChIP, telomere imm

233 experimental data in terms of Single Strand Break (SSB) yields for plasmid and Double Strand Break (

234 ated in the repair of both DNA single-strand breaks (SSBs) and DNA double-strand breaks (DSBs); lesio

235 DNA single-strand breaks (SSBs), or "nicks," are the most common form of D

236 chnique can be generalized to study symmetry-broken states and low energy magneto-optical properties

237 signaling modules and actin cytoskeleton to break symmetry and achieve a stable polarized state.

238 trated an inherent ability of this system to break symmetry and evolve directional spindle motion.

239 The energy required for breaking symmetry with chiral bias is compared for this

240 ation density, manifested as a spontaneously broken symmetry in distinct domains of opposite polar or

241 Topological defects are a consequence of broken symmetry in ordered systems and are important for

242 ranches are resolved that display an unusual broken symmetry.

243 y and chiral charge transport as a result of broken symmetry.

244 behavior for this simple model, featuring a broken-symmetry striped phase that is disrupted at both

245 We conclude that strong ergodicity breaking takes place in mean-field spin glasses aging dy

246 de resolution, allows detection of ultrarare breaks, takes 5 d to complete, and can be applied to sam

247 degrees C) and a combination of the emulsion-breaking techniques was required for efficient oil relea

248 In the grassland, record-breaking temperatures in the winter of 2015/2016 led to

249 inner (-19%) cookies characterized by easier breaking texture (fracture strengths of 41-157 vs. 48-22

250 ced network architecture admits stimuli that break the balanced state and these breaks in balance pus

251 structural perturbations can be employed to break the energetic degeneracy and provide selective tra

252 st striking finding is that age demographics break the expected self-similarity underlying the urban

253 the emerging therapeutic strategies that may break the inexorable link between antithrombotic therapy

254 s enable gel electrocatalysts to potentially break the limitations of current materials, enhancing th

255 also describe how fluctuations spontaneously break the time-translation symmetry of a driven oscillat

256 while ensuring stable OER performances, thus breaking the activity/stability tradeoff normally encoun

257 the electron rich Ni cathode surface without breaking the aromaticity of the neighboring phenyl ring,

258 port at low temperatures is made possible by breaking the conventional horizontal alignment of the tw

259 Upon breaking the inversion symmetry, a spin splitting ('Rash

260 T11, PLT11_T1, TMT3, and TMT4 contributed to breaking the limitations of the storage sink.

261 Here, we investigated the effect of breaking the neurotoxic neuroinflammatory loop at 1-mont

262 atomic chains are in amorphous state without breaking the orientational and periodic translation symm

263 This breaks the dogma that beta-lactams enter Gram-negative b

264 Our results provide an approach that breaks the long-standing trade-off between low energy co

265 4SS channel, causing a torsional stress that breaks the mature F-pilus at the cell surface.

266 Solvent-driven localization breaks the symmetry and traps the exciton in one branch.

267 he quasiparticles form a chiral field, which breaks the time-reversal symmetry on a nanometre spatial

268 nsitive to DNA damage, such as single strand breaks, the most frequently-occurring lesions that uniqu

269 ce of spin-orbit coupling and magnetic field breaks these symmetries and can lead to a finite supercu

270 Unless these symmetries are broken, they can give rise to novel phenomena, such as t

271 of an organism; the presence of a tumor can break this equilibrium.

272 To break this fundamental tradeoff between acquisition time

273 rved bacteria encountering new resources can break this trade-off by evolving phenotypic heterogeneit

274 lly triggered displacement of the carotenoid breaks this balance, allowing the complex to dissociate.

275 Here, a novel strategy is demonstrated to break through the resolution limit of micro-supercapacit

276 symmetry of such flow is then spontaneously broken through actomyosin-membrane interactions, leading

277 The magnetic order breaks time reversal symmetry, but preserves inversion s

278 sional (2D) topological band insulators with broken time-reversal symmetry.

279 Cancer cells break tissue barriers by use of small actin-rich membran

280 s the error-free repair of DNA double-strand breaks to maintain genomic stability.

281 bonds with the heteroepitaxial substrate are broken to create a freestanding film.

282 ryonic lethality, yet how tissue symmetry is broken to specify trabecular cardiomyocytes is unknown.

283 e parity-time ([Formula: see text]) symmetry breaking transition in the underlying non-Hermitian quan

284 formation of spherical hollow crystals with broken translational symmetry in crystalline molecular b

285 nsgenic zebrafish strains made with the gene-break transposon (GBT) protein trap to simultaneously re

286 rminated by ferromagnetic iron clusters that break TRS.

287 rimental electronic instability, and display broken type-III gap, thus offering optimal carrier densi

288 g platelets showed an enhanced resistance to breaking under strain compared to their spherical and cy

289 ither died out in whole-pack death events or broke up when their founders died, irrespective of pack

290 We show that earlier ice break-up conditions created a "resource-rich" littoral-b

291 ceptual model that expresses how earlier ice break-up dates influence within lake habitat production,

292 Our data show that changes to ice break-up drive multi-directional results for resource pr

293 stability was assessed by measuring the tear break-up time (TBUT) and the tear volume was determined

294 -Disease-Index (OSDI), Schirmer test 2, tear break-up time (TBUT), fluorescein staining, Lissamine-gr

295 ght, noninvasive first and average tear film break-up time, and Schirmer test results were also recor

296 ace Disease Index questionnaire (OSDI), tear break-up time, evaluation of corneal and conjunctival st

297 rface Disease Index questionnaire, Tear film break-up time, Ocular Protection Index, Ocular Surface S

298 ionally placed in simulated data (i.e., true breaks) with weights averaging >0.8 and those due to sam

299 those due to sampling error (i.e., erroneous breaks) with weights averaging <0.2.

300 DR factors, is substantially impaired at DNA breaks, with reduced end resection and diminished recrui