ライフサイエンスコーパス: breakage

1 s (free volume collapse and endothermic bond breakage).

2 ient to protect microtubules from mechanical breakage.

3 ant increase in the frequency of microtubule breakage.

4 guingly limits recombination induced by fork breakage.

5 hyphae in both fungi with serious folds and breakage.

6 rs may predispose certain genomic regions to breakage.

7 n constraining recombination induced by fork breakage.

8 at speeds up to 5 mum/s without the risk of breakage.

9 the enzyme's star activity or to random DNA breakage.

10 g membrane availability and necessitating NE breakage.

11 on, as tissue failure still occurred by cell breakage.

12 romoting survival following replication fork breakage.

13 tence length and increased susceptibility to breakage.

14 he elongated mitotic spindle as the cause of breakage.

15 d breaks (DSBs) result from replication-fork breakage.

16 yosin forces are required for initial bridge breakage.

17 h one another in the apparent absence of DNA breakage.

18 reakage as the archetypical mode of symmetry breakage.

19 ncreases S phase progression and chromosomal breakage.

20 stence of cohesin on chromosomes cause their breakage.

21 n, which generates an abasic site for strand breakage.

22 suppressing APE1 endonuclease-mediated ssDNA breakage.

23 catalysis does not involve bond formation or breakage.

24 ts associated with cellular responses to DNA breakage.

25 actin filaments, causing their buckling and breakage.

26 ated in a clinically relevant manner without breakage.

27 action, nanopore-collapse, and chemical bond-breakage.

28 rearrangement initiated by DNA double-strand breakage.

29 mensional chromatin topology at sites of DNA breakage.

30 integrity at loci that are disrupted by DNA breakage.

31 d pronounced susceptibility to single-strand breakage.

32 chanical strength and are prone to permanent breakage.

33 t can form a new cap and resume growth after breakage.

34 , local infiltration (3.0%), leakage (1.5%), breakage (1.4%), phlebitis (1.2%), and thrombosis (0.5%)

35 Complications such as intraoperative device breakage (7%) and postoperative extrusions (12.5%) were

36 he transmembrane region, indicating symmetry breakage across the channel.

37 glycan/peptide modifications including bond breakages, adducts, repeat structures, ambiguous identif

38 eplication fork reversal protects forks from breakage after poisoning of Topoisomerase 1.

39 In wishboning, symphyseal breakage always occurs at the midline in taxa with unfus

40 We hypothesize that even though there are breakages among neighboring capsomers, RNA-capsid protei

41 ect of 2.44 +/- 0.22 for the C-H vs C-D bond breakage and a secondary isotope effect corresponding to

42 isms in cultured cells and causes DNA strand breakage and an increased lesion burden in cecal enteroc

43 y the depletion of Mcm10 leads to chromosome breakage and cell cycle checkpoint activation.

44 at Fcy1-mediated deamination is one cause of breakage and contractions in the presence of R-loops.

45 Oncogene-induced DNA breakage and DDR activation instead occurred upon persis

46 n function of Mrc1 is key for preventing DNA breakage and death of cells containing expanded CAG trac

47 that CIN in terms of ICL-induced chromosomal breakage and defective chromatid cohesion is frequently

48 t stalled forks, CMG removal results in fork breakage and end joining events involving deletions and

49 In plants and animals, chromosomal breakage and fusion events based on conserved syntenic g

50 d label-free manner without any need of cell breakage and has great potential for both diagnostic and

51 psis-like pattern generated after chromosome breakage and illegitimate rejoining.

52 ty in the Malassezia species complex through breakage and inactivation.

53 cally to the transposon ends and carries out breakage and joining at the 3' ends, and TnsA, which car

54 recognizes the transposon ends and mediates breakage and joining is heteromeric.

55 lated nuclease, markedly limited chromosomal breakage and led to further accumulation of reversed for

56 cation making DNA more susceptible to strand breakage and mutations.

57 DNA strand breakage and perturbation of cell-cycle progression cont

58 riptional responses, leading to elevated DNA breakage and poly(ADP-ribose) induction that cannot be r

59 amage and ameliorated spontaneous chromosome breakage and radials in human FA patient-derived cells.

60 transposase of these elements catalyzes DNA breakage and rejoining reactions required for transposit

61 e elastic-fluid model to the kinetics of DNA breakage and repair by assuming that the local volume fr

62 Coordination of DNA breakage and repair during the cell cycle is critical to

63 hat ultrasonication was responsible for cell breakage and subsequent lycopene release in a highly vis

64 some overduplication, aneuploidy, chromosome breakage and the formation of micronuclei by targeting c

65 ed replication forks are sites of chromosome breakage and the formation of toxic recombination interm

66 t protects bacteria from double-stranded DNA breakage and TLD.

67 ions predispose genome regions to chromosome breakage and translocations.

68 modifications as facilitators of chromosome breakage and translocations.

69 d: macromolecular deformation, chemical bond breakage, and biomineral crystal imperfections at the at

70 le sites (CFSs) are hot spots of chromosomal breakage, and CFS breakage models involve perturbations

71 gns of growth failure, increased chromosomal breakage, and NK cell deficiency.

72 upporting replicative models for spontaneous breakage, and providing the first true breakage rates.

73 suggesting that incomplete replication, fork breakage, and repair occur widely in polytene cells.

74 Expanded CAG repeats are prone to breakage, and repair of the breaks can cause repeat cont

75 coupled microvoid nucleation and early fiber breakage, and that small fragments of fibers can play an

76 at replication forks independently of their breakage, and to be antagonized by poly (ADP-ribose) pol

77 ng mechanisms that repair these forms of DNA breakage are largely unknown.

78 is best compatible with flow-based symmetry breakage as the archetypical mode of symmetry breakage.

79 , redox-neutral and photoreductive Fe-N bond breakage as well as photooxidative N-N bond breakage occ

80 transport renders the spindle susceptible to breakage, as observed in cells with a variety of defects

81 nt to PCNA or in helicase-deficient mutants, breakage at a CAG/CTG repeat increases.

82 hyde, associated with widespread chromosomal breakage at a concentration not producing breaks in pare

83 ) is crucial to prevent excessive DNA strand breakage at activation-induced cytidine deaminase off-ta

84 These findings provide evidence that breakage at expanded CAG repeats occurs due to R-loop fo

85 DNA breakage at fragile sites is associated with regions tha

86 logical RNR activity and reduced chromosomal breakage at fragile sites.

87 tion via a mec1 mutation leads to chromosome breakage at replication forks initiated from virtually a

88 Such breakage at single-strand interruptions results in artif

89 ecise plant genome editing by catalyzing DNA-breakage at specific targets to stimulate targeted mutag

90 cally, while MEC1 cells exhibited chromosome breakage at stress-response transcription factors, mec1

91 at the 3' ends, and TnsA, which carries out breakage at the 5' ends of Tn7.

92 chromosomal translocation typically involves breakage at the bcl-2 major breakpoint region (MBR) to c

93 mec1 cells predominantly suffered chromosome breakage at transporter genes, many of which are the sub

94 Thus, in addition to governing SPO11 breakage, ATM and PRDM9 are critical local regulators of

95 plication stress induce distinct patterns of breakage: ATR inhibition induces more breaks at early re

96 culate that telomeric aggregates and ongoing breakage-bridge-fusion cycles lead to disturbed cytokine

97 rm anaphase bridges, resulting in chromosome breakage by an unknown mechanism.

98 f histone marks sensitizes genome regions to breakage by endonuclease challenge or irradiation and pr

99 y to examine their gemifloxacin-mediated DNA breakage by Streptococcus pneumoniae topo IV and gyrase.

100 ollectively, these data implicate chromosome breakage by TOP2 as an endogenous threat to gene transcr

101 n of water on the occurrence of checking and breakage (C&B) in biscuits, considering a round and thic

102 lternative DNA structure formation and a DNA breakage cell assay were used to validate the computatio

103 we recorded no evidence of healing and when breakage characteristics were typical of fresh bone.

104 We show that gene breakage commonly inactivates the tumour suppressors RB1

105 breaks are abundant forms of endogenous DNA breakage, contributing to hereditary ataxia and underlyi

106 rated that BRCA1 recruitment to areas of DNA breakage depended on RAP80 and the RNF8/RNF168 E3 ubiqui

107 me maintenance are linked to rare chromosome breakage disorders.

108 nically distinct, chromosome instability (or breakage) disorders.

109 ns with neutral molecules may result in bond breakage, dissociation, or fragmentation of the molecula

110 ask that often results in untimely electrode breakage due to crashing against a substrate.

111 often occur at genomic sites susceptible to breakage during DNA replication, including regions with

112 e-induced mortality, and were protected from breakage during Hugo but not Maria.

113 us and DNA damage-induced nicks are prone to breakage during PFGE.

114 We show that self-targeting and genome breakage events that are induced by self-targeting, such

115 e of seeding, nucleation, growth, and fibril breakage events.

116 pseudocapillary networks because of numerous breakage events.

117 e-chromosome ancestral state: (a) chromosome breakage followed by loss of centromere DNA and (b) cent

118 sts a sequence-independent mechanism for DNA breakage followed by telomere healing, with the formatio

119 pi systems, which assist phosphate-C1' bond breakage following FMN reduction, leading to formation o

120 HM) for antibody affinity maturation and DNA breakage for antibody class switch recombination (CSR) v

121 reduced susceptibility to DNA double-strand breakage for IR makes double-strand breaks (DSBs) in bde

122 The LC-MS analysis reveals that the breakage, formation, and exchange of the disulfide bonds

123 chaperone protein, catalyzes disulfide bond breakage, formation, and rearrangement.

124 e in logistic regression models) and of aCFS breakage frequencies (explaining approximately 45% of th

125 We also analyzed aCFS breakage frequencies as a function of their genomic land

126 ents show that this damage is not due to DNA breakage from mechanical stress on chromatin in the defo

127 trisomy, and evidence of chromothripsis and breakage-fusion bridge cycling.

128 The chromosome breakage-fusion-bridge (BFB) cycle is a mutational proce

129 Breakage-fusion-bridge (BFB) cycle is a series of chromo

130 mation of double minute (DM) chromosomes and breakage-fusion-bridge (BFB) cycles, have been repeatedl

131 te, which subsequently undergoes a series of breakage-fusion-bridge (BFB) cycles.

132 Breakage-fusion-bridge (BFB) is a mechanism of genomic i

133 inute chromosome formation (MYC and MDM2) or breakage-fusion-bridge (KRAS, MDM2 and RFC3).

134 reveal the complex architecture of ecDNA, a breakage-fusion-bridge and other complex rearrangements.

135 plex chromosomal rearrangements initiated by breakage-fusion-bridge cycles and completed by simultane

136 ic complexity, together with the presence of breakage-fusion-bridge cycles and high DNA methylation c

137 induced by telomere crisis primarily involve breakage-fusion-bridge cycles and simple genome rearrang

138 Breakage-fusion-bridge cycles and translocations activat

139 In sporadic iAMP21, breakage-fusion-bridge cycles are typically the initiati

140 Breakage-fusion-bridge cycles followed by chromothripsis

141 15;21)c to be constitutionally dicentric and breakage-fusion-bridge cycles generate dicentric chromos

142 Perpetuation of breakage-fusion-bridge cycles in CML progenitors was med

143 via a dicentric chromosome intermediate and breakage-fusion-bridge cycles that are repaired using mu

144 result in fusions which initiate chromosomal breakage-fusion-bridge cycles, causing genomic instabili

145 ow-level drug selection underwent continuing breakage-fusion-bridge cycles, generating amplicons more

146 omatic retrotranspositions can also initiate breakage-fusion-bridge cycles, leading to high-level amp

147 rearranged, and corroded through hundreds of breakage-fusion-bridge cycles.

148 they generate new DSBs downstream of IgH via breakage-fusion-bridge cycles.

149 epeatedly generates palindromic DNA, such as Breakage-Fusion-Bridge cycles.

150 of telomeric fusions indicative of multiple breakage-fusion-bridge cycles.

151 ases of amplifications are compatible with a breakage-fusion-bridge mechanism.

152 ic chromosomes and c-myc amplification via a breakage-fusion-bridge mechanism.

153 omosome damage, repair, and damage through a breakage-fusion-bridge mechanism.

154 duplication such as tandem duplications and breakage/fusion/bridge (B/F/B) cycles.

155 We observed ICL-induced chromosomal breakage in 9 of 17 (53%) HNSCC cell lines derived from

156 tes stalled fork degradation and chromosomal breakage in BRCA2-defective cells.

157 -called "mustard oil bomb," in which vacuole breakage in cells harboring myrosinase and glucosinolate

158 The data illuminate spontaneous DNA breakage in E. coli and human cells and illustrate the v

159 nvestigated fork progression and chromosomal breakage in human cells in response to a panel of sublet

160 The ability to catalyze covalent bond breakage in isolated small molecules using compressive f

161 e failure during ripening was mainly by cell breakage in Kanzi apples and, in contrast, by cell separ

162 s in chromatin changes induced by chromosome breakage in mammalian cells and their implications for g

163 Although our understanding of dormancy breakage in mature seeds is well advanced, relatively li

164 Dicentric chromosomes undergo breakage in mitosis, resulting in chromosome deletions,

165 ion of FANCM was responsible for chromosomal breakage in one cell line, whereas in two other cell lin

166 are reported to be especially vulnerable to breakage in sir2Delta mutants.

167 endonuclease 1, introducing a single-strand breakage in the hairpin loop.

168 elta kip3Delta cells, we detected chromosome breakage in the meiosis II cells.

169 omolecular features are often accompanied by breakages in the glucan chains.

170 (SET to a sigma* orbital concerted with C-Cl breakage) in alkanes compared to stepwise OS-SET (SET to

171 ary amines as indicator for protein backbone breakage increased in early stages of oxidation in high

172 tion of helix disruption, in which the helix breakage increases from 26% at pH 7.5 to 53% at pH 5.5.

173 is thus provided for further analysis of the breakage-independent recognition of homology that underl

174 oxidation and supercoiled plasmid DNA strand breakage inhibition induced by both peroxyl and hydroxyl

175 sition owing to the similarity of sigma-bond breakage into a delocalized pi-system.

176 maintenance of chromatin structure after DNA breakage involves basic mechanisms that shape three-dime

177 , over the studied speed range, the junction breakage is caused purely by the growth of the gap betwe

178 use genetic models indicate that chromosomal breakage is common at sites of transcriptional turbulenc

179 uce radiation damage levels to hydrogen bond breakage is demonstrated.

180 We explore how chromosome breakage is integrated with meiotic progression and how

181 Under quiescent conditions where fibril breakage is minimal, faster growing fibrils have a selec

182 ontrast, the role of Tof1 in preventing fork breakage is specific to long CAG tracts of 85 or more re

183 e DNA secondary structures can result in DNA breakage leading to cancer and other diseases.

184 Yet the breakage mechanism is not well understood, and the exper

185 e hot spots of chromosomal breakage, and CFS breakage models involve perturbations of DNA replication

186 omputationally that water cage formation and breakage near the hydrophobic groups control the fusion

187 se, are neither associated with chromosomal breakage nor with significant DDR activation.

188 breakage as well as photooxidative N-N bond breakage occur on a time scale well below a few hundred

189 ed bone and molar fragments, indicating that breakage occured while fresh.

190 of bone, molar and stone refits suggest that breakage occurred at the site of burial.

191 tinum(0), a complete silicon-phosphorus bond breakage occurs, yielding the unprecedented dinuclear pl

192 his issue for gradual deterioration via beam breakage of 2-dimensional (2D) disordered lattices, whic

193 o IDDS system in three other cases including breakage of a catheter, pump malfunction and arachnoid a

194 on are remotely coupled to the formation and breakage of a disulfide bond over a distance of >14 A.

195 -mercaptopropanehydrazide cargo by formation/breakage of a disulfide bond, while dynamic hydrazone ch

196 ng the activation pathway accompanied by the breakage of a number of key interactions stabilizing the

197 contribution that roughly corresponds to the breakage of a single hydrogen bond.

198 bilin chromophore and, in certain cases, the breakage of a thioether linkage to a conserved cysteine

199 n small amounts of fluoride are added during breakage of Al flocs, there can be significant improveme

200 ased gene conversion and/or repair after the breakage of ancestral gene clusters.

201 nificantly lower than barriers involving the breakage of Au-S bonds (2.5 eV).

202 ergo an energy dissipation mechanism through breakage of bonds when strain is applied, while retainin

203 Raman analysis indicates reversible breakage of C S and S S bonds upon potassiation to 0.01

204 nd mineral nutrient uptake, compensating for breakage of Casparian strips.

205 rystals in pumices, whereas there is limited breakage of crystals in lavas.

206 egions of unreplicated DNA can result in the breakage of DNA during mitosis, which in turn can give r

207 for nucleotide excision repair suggest that breakage of DNA strands triggers reorganization of the n

208 An imbalance of the normal microbial flora, breakage of epithelial barriers or dysfunction of the im

209 derivatized polyether track by the formation/breakage of ester linkages.

210 he conserved carboxy tail of FtsZ leading to breakage of FtsZ filaments.

211 It is proposed that the formation and breakage of GaAs-O-Si bonding bridges are responsible fo

212 s in the region 1175-1157cm(-1), linked with breakage of glycosidic bonds, were the most useful for d

213 The breakage of GroES symmetry requires the stochastic hydro

214 of the following conformational changes: the breakage of H-bond interactions between the backbone nit

215 ydrogen-bond scalar couplings, it seems that breakage of hydrogen bonds in the ion pairs occurs on a

216 s system (CNS) mainly in young adults, and a breakage of immune tolerance to CNS self-antigens has be

217 The earliest breakage of left-right symmetry occurs as the result of

218 We discuss how breakage of nicked DNA may be mechanistically linked to

219 Although breakage of nicked subchromosomal fragments is field str

220 ns, the stochastic hydrolysis of ATP and the breakage of nucleotide symmetry also occur within the en

221 res the stochastic hydrolysis of ATP and the breakage of nucleotide symmetry.

222 through the formation of C5'=O5' ketone and breakage of P-O5' bond.

223 Additionally, the two step action ((i) breakage of polymer-water hydrogen bonding and (ii) poly

224 of peptide desorption and/or water-mediated breakage of pore connections.

225 With respect to the breakage of symmetry, it is induced by asynchronous expa

226 In contrast to Ras . GAP catalysis, the bond breakage of the beta-gamma-phosphate but not the Pi rele

227 in and GAF domain dynamically transition via breakage of the C10/Cys-494 thioether bond, opposite rot

228 hyde, and the aldehydes corresponding to the breakage of the carboncarbon double bonds: propanal, hex

229 The late breakage of the compensatory mechanism at work in the wa

230 The movement of H6 is associated with breakage of the E247-R135 and R135-E134 salt bridges and

231 Importantly, we showed that breakage of the gut barrier integrity in BDC2.5XNOD mice

232 ture, and position of its atoms, governs the breakage of the molecule and, as a result, determines th

233 erol:PUFA ratio of the sperm membrane caused breakage of the neck and acrosome region and immotility

234 use of Y385F COX-2, it was observed that the breakage of the pentapeptide has probably been taken pla

235 attack on the phosphorous atom that leads to breakage of the phosphodiester bond.

236 Interestingly, breakage of the phosphodiester bonds at the AID-initiate

237 ll contact to a surface triggers the initial breakage of the symmetry of an apolar neutrophil and is

238 pumping in the system, which results in the breakage of the time-reversal symmetry.

239 rittle oxide glasses due to the preferential breakage of the weak coordinative bonds (Zn-N).

240 The breakage of this strained bond upon Zn(2+) dissociation

241 n, class switching, increased cell turnover, breakage of tolerance, and a loss of the capacity to gen

242 ic class switching, increased cell turnover, breakage of tolerance, increased immature/transitional B

243 an spontaneously regenerate, their temporary breakage offers a limited time window when hair cells ar

244 into molecular vibrational modes, leading to breakage or formation of individual bonds.

245 nome instability that may lead to chromosome breakage or nondisjunction during mitosis.

246 There was no prosthesis loosening, breakage, or infection leading to removal after a mean f

247 lements of the theory, we found that the MBR breakage process is indeed highly dependent on DNA methy

248 hondrial samples is often considered to be a breakage product of the F(1)F(O) ATP synthase during sam

249 e strongly nonlinear dependence of crosslink breakage rate on crosslink elongation.

250 Breakage rates were calculated by analyzing the capsular

251 neous breakage, and providing the first true breakage rates.

252 Analysis of the chromosomal breakage regions suggests a sequence-independent mechani

253 regulating the number of rotations during a breakage-religation cycle.

254 In all cases, dicentric breakage requires anaphase exit, ruling out stretching b

255 Instead, breakage requires cytokinesis.

256 of cell cycle activity and DNA double-strand breakage, respectively, associated with neuron death.

257 When DNA breakage results in a 3'-PO4 terminus, the end is consid

258 MIC are highly consistent with the chromatin breakage sequence (CBS) sites, suggesting that each TAD-

259 fragmentation occurs at conserved chromosome breakage sequences, generating macronuclear chromosomes.

260 This breakage should allow TALEs to access superhelically-bro

261 nts for -4G, -2A and -1T bases preceding the breakage site (between -1 and +1) and enzyme-unique or d

262 c modifications can be introduced around the breakage site during its repair by two major DNA damage

263 nrestrained fork progression and chromosomal breakage, suggesting fork remodeling as a global fork sl

264 The irreversible nature of floc breakage suggests that some form of specific, chemical i

265 (FA), ataxia telangiectasia (A-T), Nijmegen breakage syndrome (NBS) and Bloom syndrome (BS) are clin

266 Warsaw Breakage Syndrome (WABS) is a rare disorder related to c

267 Warsaw breakage syndrome (WABS) is caused by defective DDX11, a

268 Nijmegen breakage syndrome 1 (NBS1) is a component of the MRE11 c

269 ing directly to DNA breaks requires Nijmegen breakage syndrome 1 (NBS1).

270 11 (Mre11)/DNA repair protein Rad50/Nijmegen breakage syndrome 1 proteins] to sites of DNA damage whe

271 Here, we have identified a chromosome breakage syndrome associated with severe lung disease in

272 th a unique genetic disorder known as Warsaw breakage syndrome characterized by cellular defects in g

273 th a unique genetic disorder known as Warsaw breakage syndrome characterized by cellular defects in s

274 other hand, the mutant protein from a Warsaw breakage syndrome patient failed to unwind these triplex

275 SMCE3 with an autosomal recessive chromosome breakage syndrome that leads to defective T and B cell f

276 oderma pigmentosum/Cockayne syndrome, Warsaw breakage syndrome, and dyskeratosis congenita, respectiv

277 ed activation of the repair protein Nijmegen Breakage Syndrome-1 but not p53.

278 the chromosomal instability disorder Warsaw breakage syndrome.

279 h SCID, XLA, ataxia-telangiectasia, Nijmegen-breakage-syndrome, common variable immunodeficiency, imm

280 ions in these regions may lead to chromosome breakage syndromes in humans.

281 ficiencies or ataxia telangiectasia/Nijmegen breakage syndromes.

282 e loss, micronuclei formation and chromosome breakage that are further elevated by replication stress

283 e genomic alterations defined as chromosomal breakages that generate chromosomal gains or losses of g

284 llenic hydroarylation/N1-C4 beta-lactam bond breakage to afford dihydro-oxepino[4,5-b]indole-4-carbox

285 R.PabI from a hyperthermophile, ascribed the breakage to high temperature while another showed its we

286 tases and specifically functions in C-S bond breakage to reduce ubiquitous and appreciable volatile o

287 DNA double strand breakage triggers the DNA damage response network and tw

288 to increased OS rigidity and thus increased breakage, ultimately contributing to retinal degeneratio

289 fork degradation, but increases chromosomal breakage, uncoupling fork protection, and chromosome sta

290 gions of the genome that exhibit chromosomal breakage under conditions of mild replication stress, ar

291 le sites (CFSs) are genomic regions prone to breakage under replication stress conditions recurrently

292 Chemical bond formation and breakage underlie the lives of cells, but as this specia

293 phosphorylation is essential to prevent DNA breakage upon replication stress and cells harboring SIR

294 city; blocks resection; and demonstrates DNA breakage via APOBEC3A cytosine deaminase.

295 DNA breakage was further indicated by reciprocal subchromoso

296 The activation energy of double bond breakage was relatively low ( approximately 25 kJ/mol) a

297 mice showed hypersensitivity and chromosomal breakage when treated with mitomycin C, a DNA interstran

298 increased cell spreading and increasing bond breakage, which leads to decreased spreading.

299 uits yields checking (cracks) and eventually breakage, which originated mainly from heterogeneity in

300 omerase (topo) IV inducing site-specific DNA breakage within a bent DNA gate engaged in DNA transport