ライフサイエンスコーパス: broad

1 nknown, schizophrenia involves networks with broad abnormalities.

2 ation cephalosporin, and 4971 (33%) received Broad-abx.

3 irect target of IL-4-activated STAT6, having broad action indispensable for 77% of the induced gene s

4 These drugs appear to have broad activity across tumors with activating RET alterat

5 There is broad agreement that religion is a social determinant of

6 Model p-ath773 has been designed to show broad agreement with published plant-scale properties su

7 We perform a broad analysis of the recorded data, compare different s

8 We also summarize the broad and exciting applications of SPRM to the analysis

9 Treatment of an upper UTI needs to be broad and last for 10 days, a lower UTI only needs to be

10 Granzymes have relatively broad and overlapping substrate specificities and may hy

11 Two mAbs displayed broad and potent capacity to inhibit IBV NA enzymatic ac

12 We found that C-subtypes displayed broad and potent in vitro antimicrobial activities compa

13 while maintaining sufficient ion numbers for broad and representative analysis of the tissue chemical

14 has recently been criticized as possibly too broad and unspecific.

15 control in grasses, and how this relates to broad- and fine-scale niche transitions within the famil

16 Field experiments revealed strong broad- and narrow-sense trait heritability (0.82 and 0.4

17 the beta-lactamase inhibitor relebactam has broad antibacterial activity, including against carbapen

18 The broad applicability of the cyclophellitol-derived activi

19 dological framework for drug repurposing has broad applicability to other diseases.

20 cyclization, a strategy that is amenable to broad application in pharmaceutical design.

21 ocytosis (SM) has greatly benefited from the broad application of precision medicine techniques to he

22 circuits that are of immense importance for broad applications in data communication, microwave phot

23 we present a BY4741 yeast strain created for broad applications in the yeast and synthetic biology co

24 itations have hampered rapid innovations and broad applications of conducting polymers.

25 equency FIR radiation has therefore become a broad area of research.

26 We consider a broad array of simulated and experimental datasets to de

27 lable R code and data, others can complete a broad assessment of the empirical false discovery rate a

28 The Profile is intended for use by a broad audience; applications can range from discovery sc

29 radiative cooling materials reported possess broad-band absorption/emission covering the whole mid-in

30 skite materials have demonstrated attractive broad-band white-light emission properties, they pose a

31 form are enabling for applications requiring broad bandwidth and high efficiency including energy har

32 nd relative to chemical fungicides, provides broad benefits to the environment, farmers and consumers

33 ally, high-mannose-binding lectins possess a broad capacity to neutralize and prevent infection with

34 The mechanisms were assigned to four broad categories-DNA damage response, intracellular sign

35 between diverse cellular RNAs allows for its broad cellular functions.

36 Thiopeptides are a broad class of macrocyclic, heavily modified peptide nat

37 e utilized to classify nanomotors into three broad classes: nanomotors driven by optical momentum tra

38 hniques we have at our disposal, I propose a broad classification of techniques into six complementar

39 We therefore sought to evaluate the broad clinical applicability of this approach for colist

40 These findings could have broad clinical implications for cancer patients.

41 RGS2, in particular, could have broad clinical importance.

42 ch should extend the generalizability to the broad, clinically heterogeneous ED population under cond

43 t evidence is sparse and often combined into broad CMC categories.

44 strong element-hydrogen bonds, which enables broad compatibility of carbon-heteroatom cross-coupling

45 imum attributes for a cure were debated, the broad consensus was that an acceptable cure need not be

46 y provides a key intermediary mechanism with broad consequences for sociality (e.g., group structure,

47 tinental margin is strikingly similar to the broad continental rifts in the North American Cordillera

48 African Americans (n = 97), which revealed a broad continuum of values.

49 wide association studies (meta-GWASs) of the broad depression phenotype with those from meta-GWASs of

50 used to estimate the genetic correlations of broad depression with self-reported MDD, recurrent MDD,

51 Study members with high scores across three broad diagnostic families of disorders (externalizing, i

52 However, broad differences in vertebral structures and morphogene

53 fter exposure demonstrates the importance of broad differential diagnostics in the context of liver a

54 , suggesting that connectome aging occurs on broad dimensions of variation in brain architecture.

55 Our results revealed broad dissemination and high levels of somatic hypermuta

56 ion of dedicated sepsis guidelines and their broad dissemination over the past 2 decades have contrib

57 with this weakened portfolio, maintaining a broad distribution in migration traits still increased a

58 By demonstrating that a broad diversity of chemoorganotrophic and culturable spa

59 -directed assembly has been shown to yield a broad diversity of highly ordered mesostructures(1,2), w

60 The soil environment contains a broad diversity of organic acids, so it is not surprisin

61 learning approach, we predict personality at broad domain ([Formula: see text] = 0.37) and narrow fac

62 eases the binding affinity for the repressor Broad, driving differential allele-specific nutcracker e

63 for testing a greater number of sites with a broad dynamic range and modified to study other RNA modi

64 substrate Leu-FC empowered sensor displayed broad dynamic range with admirable detection limits.

65 ome studies in atopic dermatitis (AD) showed broad dysregulation as well as "improvement" under thera

66 These findings suggest that cdnf has broad effects on regulating neurogenesis and maturation

67 ule kinase inhibitors have the potential for broad efficacy, convenience and tissue penetrance, and t

68 Remarkably, a broad emission can be demonstrated with quick formation

69 (0.6 ns) of a small spectral side band, the broad emission line shape is constant to 100 ns.

70 f human and model organism datasets and find broad evidence of context-specific genetic effects, incl

71 crop rating data naturally encapsulates the broad expert knowledge of many individual surveyors spre

72 The broad expression of homologues of floral ABCE genes in N

73 e nematode Caenorhabditis elegans produces a broad family of pheromones, known as the ascarosides, th

74 ial part of this strategy is expression of a broad family of salivary proteins, called Evasins, to ne

75 ine where individual neurons sit within this broad FR distribution are not understood.

76 However, BDNF's broad functionality has manifested a heterogeneous liter

77 EGR2 as a downstream regulator of STAT6 with broad functionality that further induces many transcript

78 The broad generality and functional group tolerance of this

79 Given such variation among species, broad generalizations about the vulnerability of tropica

80 inical characteristics, which converged with broad genetic profiles.

81 s from >8200 tumor-normal pairs, we discover broad genic repression domains (BGRD) on chromatin as an

82 a represents a group of plant pathogens with broad global distribution.

83 The framework has four broad goals: understanding the obstacles to changes in t

84 ) and short tandem repeats (STRs) comprise a broad group of diverse DNA variants which vastly differ

85 rotype Typhimurium (S. Typhimurium) boasts a broad host range and can be transmitted between livestoc

86 In sum, these results show the broad impact of PDK4 deficiency and reveal mechanistic p

87 SCLC and other advanced tumors, could have a broad impact on its treatment.

88 Most notably, telomeres have a broad impact on pluripotency and differentiation.

89 Thus, broad impairment of antigenic responses, including autoa

90 Our work has broad implications for anti-Alzheimer's research and dru

91 ane proteins for lysosomal degradation, with broad implications for biochemical research and for ther

92 CD8(+) memory T cell pool, with potentially broad implications for the development of immunotherapie

93 zed tuning of an oscillatory circuit and has broad implications for the spatiotemporal regulation of

94 the function of terminal web myosin and hold broad implications for understanding apical morphogenesi

95 ity was demonstrated in mice with potent and broad induction of FSP-specific CD8 and CD4 T-cell respo

96 The extremely broad infrared spectrum of water in the OH stretching re

97 finally, to classify fossil individuals into broad ingesta related hardness categories using a suppor

98 compounds that we previously showed to have broad inhibitory activity across multiple Clostridioides

99 es the results from several tools to provide broad insights into overall metabolic function.

100 chanically guided, 3D assembly has attracted broad interests, owing to its compatibility with planar

101 tification of these residues will enable the broad interrogation of the kinome and its inhibitors.

102 oresees a potential use of this pigment as a broad kind of industries on lipo-soluble formulations.

103 erbicide that is widely used for controlling broad leaf weeds.

104 alternative diagnostic methods and showed a broad linear range between 10(3) and 10(9) cells L(-1) w

105 e use genomic profiling to reveal strong and broad loss of neural APA in elav/fne double mutant CNS,

106 raits, their combined utility for predicting broad measures of health, such as mortality, remains poo

107 its performance and interoperability between broad modeling capabilities.

108 t GTPase signaling dynamics can generate the broad morphological characteristics observed in many mig

109 llagen-coated glass coverslips, however, had broad morphologies, formed abundant stress fibers, exhib

110 gle-arm study to determine the impact of the broad mTOR inhibitor, everolimus, on residual HIV burden

111 that they have high optical absorbance in a broad near-infrared region spectral range (wavelength, 7

112 exhibit different developmental paths toward broad neutralization activity.

113 s were not produced in sufficient levels for broad neutralization of diverse HCV isolates.

114 sured, and the sera of all animals displayed broad neutralizing activity.

115 pecies are vital pieces of information for a broad number of applications such as material developmen

116 These results present a broad opportunity to tailor intriguing ferromagnetism or

117 Though still only in broad outline, these data suggest how distributed brain

118 This review provides a broad overview of the mechanistic pathways through which

119 rains lacking both pilins are resistant to a broad panel of SSVs as well as a panel of unrelated S. i

120 ve behaviours have similar correlations with broad personality domains(3).

121 To enable further understanding of the broad phenotype characteristic of pan-BET inhibition, th

122 A broad phenotypic spectrum has been described, with poten

123 SR), while decreasing at higher doses over a broad physiological range, AID and Blimp1 expression, CS

124 ause most focus on responses to stimuli from broad "pleasant" and "unpleasant" categories and ignore

125 Broad preoperative screening led to 1 positive COVID-19

126 efore offering great potential for rapid and broad protection against influenza reinfection.

127 Broad proteomic analysis of recalcitrant cancers has the

128 sform Infrared (FTIR) spectroscopy in a very broad range (from near- via mid- to far-IR).

129 ffective response to DNA concentrations in a broad range from 10 aM to 100 pM and a limit of detectio

130 suggest associations between marijuana and a broad range of adverse cardiovascular risks.

131 The method provides access to a broad range of aliphatic fluorides, including primary, s

132 A broad range of anti-HAV Ig plasma titers was observed am

133 platform for automated fluid handling with a broad range of applications in medical diagnostics and a

134 ular cages with novel topologies targeting a broad range of applications.

135 nol catalysts have been used to facilitate a broad range of asymmetric transformations, including ald

136 he cytoskeletal architecture, which impact a broad range of biological processes in malignant cells i

137 been implicated in critical roles covering a broad range of biological processes in the Apicomplexa.

138 panying visualization schemes available to a broad range of biologists.

139 and a user-friendly data portal, enabling a broad range of biomedical investigations.

140 s CTLA-4 and PD(L)1 are efficacious across a broad range of cancers, resulting in reductions in tumor

141 at the plasma membrane (PM) is crucial to a broad range of cellular functions, including cell motili

142 m prevention, diagnosis, and treatment for a broad range of CF carrier-related conditions.

143 tween ADHD polygenic risk scores (PRS) and a broad range of childhood psychiatric symptoms, and to qu

144 Fifty T. cruzi peptides predicted to bind a broad range of class I and II HLA molecules were selecte

145 of DNA damage is of great significance for a broad range of clinical and research applications.

146 d length distributions of the species over a broad range of concentrations and mixing ratios of a-BTA

147 al fiber technologies which now allows for a broad range of cost-effective fabrication protocols.

148 We demonstrate soft devices relevant to a broad range of disciplines: models that simulate the geo

149 through RNAi has been used successfully in a broad range of diseases, and, more recently, this techni

150 rful treatment strategy across a potentially broad range of diseases.

151 Ti(3) C(2) T(x) MXene assembled films over a broad range of film thicknesses, monolayer by monolayer.

152 ntly from ancestral C(3) photosynthesis in a broad range of flowering land plant families and in both

153 he decarbonylative coupling is tolerant of a broad range of functional groups and demonstrates little

154 th aromatic and aliphatic substituents and a broad range of functional groups, providing a variety of

155 ecent research highlights the complexity and broad range of functions that these alarmones control.

156 s and glycoconjugates will find utility in a broad range of fundamental and applied clinical studies,

157 s of specificity, potentially facilitating a broad range of future decisions.

158 cal loops of the major capsid protein VP1, a broad range of GAG oligosaccharides bind to recessed reg

159 hiostrepton is a potent antibiotic against a broad range of Gram-positive bacteria, but its medical a

160 roadly neutralizing human antibody against a broad range of H3N2 with high potency.

161 The critical role of blood lipids in a broad range of health and disease states is well recogni

162 We observed a broad range of heteroplasmy across all cell types but al

163 on high-quality epitope datasets covering a broad range of HLA alleles.

164 ptical access to the sensing interfaces at a broad range of incident angles, which is a significant a

165 The RMTg receives a broad range of inputs and produces diverse outputs, whic

166 on increases Ca(2+) transient duration for a broad range of IP(3)R properties, but the effect of IP(3

167 Over the past decade, a broad range of laboratory and experimental studies have

168 ) for comparison of bond distances between a broad range of metal atoms of different sizes.

169 se the likelihood of spectral matching for a broad range of microplastics because our libraries inclu

170 n of O(2) with a diffusion model generates a broad range of microsite concentrations of O(2) , which

171 Apparently, a broad range of neurodevelopmental pathologic mechanisms

172 diverse drugs and biologics, could enable a broad range of non-cutaneous and cutaneous drug delivery

173 Since ATI showed a broad range of optimal thresholds, exact thresholds rega

174 ryl boronic acids provides ready access to a broad range of ortho-substituted benzamides.

175 n with a specific topology likely found in a broad range of other inverse autotransporters.

176 There is a broad range of patient travel distances to reach a lung

177 ge Seahorse was able to infect the host in a broad range of pH and temperatures, and it had a relativ

178 AAs are allosteric modulators and exhibit a broad range of pharmacological properties, altering both

179 (TTA-UC) is an exciting research area for a broad range of photonic applications due to its tunable

180 These marker genes are associated with a broad range of phototrophic and chemotrophic genera.

181 LOD = 0.023 g/L, LOQ = 0.075 g/L) and over a broad range of physiologically relevant concentrations.

182 where it supports efficient encoding over a broad range of possible percepts.

183 A broad range of primary and secondary amines may be inser

184 airments, we derive lesion-deficit maps of a broad range of psychological subdomains underlying affec

185 nts, but its course is heterogeneous, with a broad range of rates of cognitive decline(1).

186 s method has a general scope for detecting a broad range of redox active and nonredox active species

187 n to being a simple and effective route to a broad range of rotaxanes, the strategy enables 1:1 inter

188 onsuming experiments causes bottlenecks in a broad range of scientific and engineering disciplines(1,

189 for detection applications by quantifying a broad range of single analytes such as small molecules,

190 under simulated 1 sun conditions employing a broad range of solar fluxes.

191 The method can be adapted for a broad range of species and evolve as a new omics tool in

192 Mechanical cues regulate the function of a broad range of stem cells in culture and in tissue.

193 rapidly, cheaply, and simply hyperpolarize a broad range of substrates (e.g. metabolites with carboxy

194 tunable synthetic platform applicable for a broad range of substrates with variable deprotonation su

195 e metalloprotease ADAM10 on the surface of a broad range of target cells and tissues(2,5,6).

196 rovide scalable routes to 3D surfaces with a broad range of targeted shapes.

197 portable, low-cost, and rapid detection of a broad range of targets, but it has proven challenging to

198 bility of the Hsp70 machinery to recognize a broad range of Tau aggregates.

199 rocess could provide a route to synthesize a broad range of TMD/graphene van der Waals heterostructur

200 SARS-CoV-2 are unimodally distributed over a broad range, with symptom severity correlating directly

201 Broad-ranging alterations to the DNA methylome were obse

202 ed pluripotent stem cells (iPSCs) would have broad reaching implications for regenerative medicine.

203 )Cl(2)](2) complex (3 mol %) and exhibited a broad reaction scope with different alcohols, allowing p

204 el Ca(2+) nanodomains with great accuracy in broad regions of parameter space.

205 g a novel robust analysis pipeline, we found broad regions with elevated probability of uracil occurr

206 These data suggest a broad regulation of motor behavior by DA neurons within

207 emistry, they were selected because of their broad relevance to other areas.

208 Methodology included 4 broad research activities: 1) a series of descriptive an

209 glutathione S-transferase (GST) and confers broad resistance to Fusarium species by detoxifying tric

210 Our data serve as a broad resource on the dynamics occurring in metabolome a

211 This broad resource will hopefully enable the community to id

212 Our broad-scale analysis highlights the overall evolutionary

213 Broad-scale assessments of vegetation responses to droug

214 The results of this study highlight that broad-scale comparisons in combination with long time se

215 by anthropogenic land use, it is clear that broad-scale systems of nature reserves connected by corr

216 nds have been constructed efficiently with a broad scope and high functional group tolerance.

217 tivity, scalability to the gram scale, and a broad scope for both aromatics and halogens.

218 A broad scope with all six-carbon-substituted arene motifs

219 operational simplicity, mild conditions and broad scope, and allows for the synthesis of highly func

220 te under mild reaction conditions, display a broad scope, and show excellent functional group toleran

221 The reaction has a broad scope, as demonstrated by the synthesis of 35 diff

222 ack of definitional clarity and their overly broad scope.

223 development of site-selective catalysts with broad scope.

224 A broad-scoped review of kiwifruit guides further innovati

225 skeletons from methylenecyclopropanes and a broad selection of alpha,beta-unsaturated aldehydes.

226 , we show that, in addition, mecA provides a broad selective advantage across diverse chemical enviro

227 However, the genetic aetiology of broad sense (non-suicidal and suicidal) self-harm has no

228 sults were supported by the observation that broad-sense heritability in hybrids was substantially hi

229 selectively encode small decrements, and (c) broad sensitivity OFF-RGCs that respond to a wide range

230 traits (average N = 320K), conditioning on a broad set of coding, conserved and regulatory annotation

231 anding coevolution may require investigating broad sets of populations sampled across the range of th

232 se, while limiting their side effects, is of broad significance.

233 olution, down to the attosecond regime, with broad spectral coverage; we introduce two-dimensional sp

234 s, thermophotovoltaic cells must utilize the broad spectrum of a radiative thermal source.

235 ce time, absorption and bioavailability of a broad spectrum of active compounds upon mucosal administ

236 art failure and improved symptoms across the broad spectrum of age studied in DAPA-HF.

237 Nuclear receptors have a broad spectrum of biological functions in normal physiol

238 esponses to more than 200 drugs inhibiting a broad spectrum of cancer-relevant targets.

239 Cancer therapies can lead to a broad spectrum of cardiovascular complications.

240 inally differentiated cells contributes to a broad spectrum of disorders.

241 polymorphic AIPL1 gene are associated with a broad spectrum of inherited retinal diseases ranging fro

242 us, opening up the possibility of studying a broad spectrum of neurological conditions in vivo.

243 showed significant changes in the level of a broad spectrum of plasma proteins including serine prote

244 Fibers are the building blocks of a broad spectrum of products from textiles to composites,

245 GATA2 deficiency is associated with a broad spectrum of rheumatological disease manifestations

246 Here, we review a broad spectrum of single-molecule tools and techniques s

247 Matrix metalloproteinases have a broad spectrum of substrates ranging from extracellular

248 hod relies on measurements of the width of a broad spectrum, and does not require any information abo

249 l polymerase activity that possesses unusual broad-spectrum activity against diverse paramyxoviruses

250 haride binding lectin that has shown in vivo broad-spectrum activity against viruses, including sever

251 antibiotic prescription rates, especially of broad-spectrum agents, have decreased in recent years.

252 resistance patterns and avoid the overuse of broad-spectrum agents.

253 ding of the detrimental effects conferred by broad-spectrum antibiotic use on the health of the benef

254 of antibiotics are rare, structurally novel broad-spectrum antibiotics exceptionally so.

255 ystem exploits the toxicity of commonly used broad-spectrum antibiotics geneticin and puromycin to ki

256 patients with septic shock warrant emergent broad-spectrum antibiotics.

257 ainst gram-positive pathogens, verine showed broad-spectrum antimicrobial activity.

258 thways, providing the possibility to develop broad-spectrum antiviral agents targeting host factors.

259 ace that govern recognition specificity by a broad-spectrum antiviral aptamer, and they open new poss

260 work defines the mammalian SKI complex as a broad-spectrum antiviral drug target and identifies lead

261 strategy in developing highly selective and broad-spectrum antiviral molecules active against emergi

262 uation of HSD17B12 inhibition as a promising broad-spectrum antiviral strategy for the treatment of F

263 Few broad-spectrum BLs inhibitors were identified; among the

264 an endogenous stress metabolite that induces broad-spectrum disease resistance in plants.

265 Four compounds showed broad-spectrum EV and RV activity and inhibited contempo

266 ased design led to AA139, an antibiotic with broad-spectrum in vitro activity against multidrug-resis

267 oronaviruses fostering the identification of broad-spectrum inhibitors.

268 VICE 3: When infected necrosis is suspected, broad-spectrum intravenous antibiotics with ability to p

269 article (NP) that functions as an effective, broad-spectrum metalloproteinase inhibitor.

270 2008, Victoria lineage), demonstrating their broad-spectrum prophylactic and therapeutic activity aga

271 , we have reported the identification of the broad-spectrum resistance-Digu 1 (bsr-d1) allele from ri

272 tigated the interface between HIV-1 RT and a broad-spectrum UCAA-family aptamer.

273 The process shows broad substrate scope and delivers complex, chiral homop

274 This method features a broad substrate scope and good functional group toleranc

275 The enzyme has a broad substrate specificity and includes mammalian cores

276 l-chemical properties and is a basis for its broad successful application in pharmaceutical research,

277 at religious practices are correlated with a broad swath of health outcomes.

278 A broad T(h)1/T(h)2/T(h)17 inflammatory signature is detec

279 dual steps, and DMN adding representation of broad task context.SIGNIFICANCE STATEMENT Achieving one'

280 been tested on a large sample size and at a broad taxonomic scale in mammals.

281 while the intensity is constant over a very broad temperature range (145-415 K) with a photoluminesc

282 nd during the immune response, we discuss in broad terms developmental stage and context-dependent fu

283 The discussion is framed around two broad themes: i) the biology of the virus itself; ii) th

284 Broad third-party participation is maintained throughout

285 The IL-17A signal transduction triggers two broad, TRAF6- and TRAF5-dependent, intracellular signali

286 is study provides new insights into YAP as a broad transcriptional repressor of key regulators of the

287 A broad treatment perspective is needed, including carer s

288 a promising vector for gene therapy, but its broad tropism can be detrimental if the transgene being

289 opulations but from a single population with broad tuning characteristics.

290 assessed with sufficient scrutiny to warrant broad, universal application, but encouraging limited da

291 high selectivity, thereby demonstrating its broad utility and functional group tolerance.

292 We expect that barRNA-seq will have broad utility for investigating and understanding how co

293 This study sought to investigate the broad utility of orlistat (tetrahydrolipstatin) in reduc

294 visible light 3D printing, demonstrating the broad utility of these catalysts in additive manufacturi

295 and pyrrole functional groups highlight the broad utility of this method for target molecule synthes

296 The broad utility of this reaction-driven approach facilitat

297 The broad utility of this transformation has been demonstrat

298 , and an attractive therapeutic target for a broad variety of disease conditions.

299 of the method for exploring the evolution of broad versus narrow use of cellular receptors among phag

300 tic upregulation of many ISGs, which confers broad viral infection resistance.