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3 modulation of p75(NTR) signaling inhibits a broad spectrum of Abeta-triggered, tau-related molecular
5 Depending on the packaged cargo, EVs have a broad spectrum of action and are involved in pathogenesi
7 impeded proliferation of tumors harboring a broad spectrum of activated RTKs as the oncogenic driver
8 ce time, absorption and bioavailability of a broad spectrum of active compounds upon mucosal administ
10 ed in the 1940s, these antibiotics offered a broad spectrum of activity against multiple types of pat
11 of novel anti-influenza therapeutics with a broad spectrum of activity against various subtypes is n
13 ystemic treatment and training modules for a broad spectrum of adolescents with problem behaviours.
17 alyst system for the rapid construction of a broad spectrum of alkylated scaffolds from alkyl zinc re
21 in yeast, OsLHT1 supported cell growth on a broad spectrum of amino acids, and effectively transport
22 ithin a conformational ensemble occur over a broad spectrum of amplitude and time scales, and are oft
31 (RDV) is an investigational compound with a broad spectrum of antiviral activities against RNA virus
33 e design of MFCs that enable their use for a broad spectrum of applications ranging from scaled-up po
34 ps of 1D metal nanostructures have enabled a broad spectrum of applications, including sensing, imagi
42 of STIM1/STIM2 in Treg cells, mice develop a broad spectrum of autoantibodies and fatal multiorgan in
43 of drugs, potentially useful for treating a broad spectrum of autoimmune conditions in a disease-spe
44 placebo groups could be attributable to the broad spectrum of azithromycin activity and the study se
45 class of cationic lipids characterized by a broad spectrum of bactericidal activity resulting from a
47 Metallo-beta-lactamases (MBLs) degrade a broad spectrum of beta-lactam antibiotics, and are a maj
48 lly disordered proteins (IDPs) can display a broad spectrum of binding modes and highly variable bind
50 hough Michael acceptors display a potent and broad spectrum of bioactivity, they have largely been ig
52 odiscs provide a new and powerful tool for a broad spectrum of biochemical and biophysical studies of
56 ate predictive models of CRISPR-Cas across a broad spectrum of biological conditions as well as provi
59 scopy to examine the hydrodynamic radii of a broad spectrum of biologically important RNAs, ranging f
62 ration, migration and invasion in vitro in a broad spectrum of cancer types and has therapeutic effic
65 th antimalarial drugs for the treatment of a broad spectrum of cancers, many of which will likely ben
66 These properties of HSF1 are exploited by a broad spectrum of cancers, which exhibit high levels of
69 tems are needed for directing treatment in a broad spectrum of cardiovascular diseases and coagulopat
72 and identified the molecular signatures of a broad spectrum of cell states, from stem cells to termin
73 e viral immunomodulatory protein targeting a broad spectrum of cell surface molecules involved in the
74 s interaction rewiring across a surprisingly broad spectrum of cellular pathways in the antiviral res
75 s to VPA in budding yeast, and highlight the broad spectrum of cellular pathways influenced by this c
76 number of these loci, we demonstrate that a broad spectrum of cellular processes contribute to hydro
78 an cytomegalovirus (HCMV) infection causes a broad spectrum of central and peripheral nervous system
79 effects of alertness were uniform across the broad spectrum of CG axonal conduction times.SIGNIFICANC
81 RAG1 and RAG2 represent the prototype of the broad spectrum of clinical and immunological phenotypes
83 ; increased chromosome missegregation; and a broad spectrum of clinical features, including various c
84 is an inflammatory myeloid neoplasia with a broad spectrum of clinical manifestations and outcomes i
86 infection typically results in meningitis, a broad spectrum of CNS involvement and severity is emergi
87 vascular disease, and cognitive disorders, a broad spectrum of collateral oral disease may be encount
88 , the increasing resistance of bacteria to a broad spectrum of commonly used antibiotics has become a
89 water, they catalyze peroxide oxidation of a broad spectrum of compounds, many of which are micropoll
90 The technology, with its ability to remove a broad spectrum of contaminants and produce high-quality
91 relaxation of myometrium precontracted by a broad spectrum of contractile agonists, and that targeti
93 onizing STAT3 could lead to suppression of a broad spectrum of cytokines and growth factors to allow
97 ponse (DDR) is essential for prevention of a broad spectrum of different human neurologic diseases.
98 frared spectrometer with a photorheometer, a broad spectrum of different photopolymerizable formulati
101 We studied 20 genotyped ARVC patients with a broad spectrum of disease using electrocardiographic ima
102 ography provides important insights into the broad spectrum of disease which comprise the inflammator
103 rial dysfunction underlies the etiology of a broad spectrum of diseases including heart disease, canc
109 ndividual consideration, thereby revealing a broad spectrum of diversity as well as identifying extre
110 ropose that Pseudomonas jumbo phages evade a broad spectrum of DNA-targeting nucleases through the as
111 hput platform for nontargeted screening of a broad spectrum of DoA and their metabolites based on mul
112 of insulin and GLP-1 analogs highlights the broad spectrum of drug delivery strategies that have bee
115 can be optimized by directed evolution for a broad spectrum of enantioselective C(sp(3))-H amination
116 approach to efficient cell replacement for a broad spectrum of endocrine disorders and other organ dy
118 s host membranes could potentially inhibit a broad-spectrum of enveloped viruses, but currently such
119 tituent conveys excellent activity against a broad spectrum of ESKAPE pathogens and other Gram-negati
120 is an attractive antiviral host target for a broad spectrum of established and emerging viral infecti
122 dy repertoires are shaped by an unexpectedly broad spectrum of evolutionary processes and shows how s
128 lfonylated indazole derivatives containing a broad spectrum of functional groups were synthesized in
129 adipocyte-derived hormone adiponectin has a broad spectrum of functions beyond metabolic control.
130 le, reproducible, and readily adaptable to a broad spectrum of fundamental questions in biology.
131 ere support the view that CDC belongs to the broad spectrum of fungal-associated immune reconstitutio
133 onism of Fzd5 and/or Fzd8 receptors, while a broad spectrum of Fzd receptors can induce liver zonatio
134 mor and germline WES revealed mutations in a broad spectrum of genes previously implicated in both ad
135 nct, reproducible signature phenotypes for a broad spectrum of genes that are involved in cell fate s
136 ic landscape of glioma in the CSF included a broad spectrum of genetic alterations and closely resemb
141 alleles and demonstrate the coexistence of a broad spectrum of genome configurations in a cell popula
143 or binding has changed from recognition of a broad spectrum of glycan receptors to a narrower spectru
144 preferentially, the HA190 mutant bound to a broad spectrum of glycans with alpha2,6/8/9-linked siali
145 for the detection and characterization of a broad spectrum of GMOs in routine analysis of food/feed
151 mit the intramolecular cyclopropanation of a broad spectrum of homoallylic diazoacetate substrates in
152 rum, causes white mold disease and infects a broad spectrum of host plants (> 500), including soybean
153 a devastating agricultural insect pest with broad spectrum of host range, causing million dollars cr
154 phylococcus aureus is capable of infecting a broad spectrum of host tissues, in part due to flexibili
156 NA m(6)A reader YTHDF2 is overexpressed in a broad spectrum of human AML and is required for disease
160 models to recapitulate the pathobiology of a broad spectrum of human maladies, including infectious d
161 asive window for diagnosing and monitoring a broad spectrum of human pathologies as well as providing
163 cian awareness, which is necessary given the broad spectrum of ICI toxicities often experienced by pa
164 its suboptimal activity is associated with a broad spectrum of immune manifestations, such as late-on
165 rial genetics explains how Shigella evades a broad spectrum of immune surveillance systems by coopera
168 polymorphic AIPL1 gene are associated with a broad spectrum of inherited retinal diseases ranging fro
170 wever, TSLP, IL-33, and IL-25 all regulate a broad spectrum of innate immune cell populations and are
171 d coordinate complementary activities from a broad spectrum of innovative researchers clearly benefit
174 how that the SCOE can be utilized to study a broad spectrum of issues involving the function of skin
178 l tyrosine kinase inhibitor active against a broad spectrum of KIT and PDGFRA mutations, with placebo
179 of generating protective immunity against a broad spectrum of lethal pathogen challenges, including
180 opt the design to diverse GPCRs that sense a broad spectrum of ligands, including synthetic compounds
182 ategy may open a very promising avenue for a broad spectrum of light-energy-conversion technologies.
185 ies have the potential to markedly enhance a broad spectrum of medical and public health practices.
189 Samples of all colors were analyzed with a broad spectrum of methods to assess their physico-chemic
191 hotspots were novel and appeared to affect a broad spectrum of molecular function, including hotspots
192 Our study characterized for the first time a broad spectrum of molecular signatures in AIM and CAEBV.
193 ng of cancer genetic variants, including the broad spectrum of mutation classes and the wide range of
194 active synthetic approach grants access to a broad spectrum of N-benzoylguanidines under mild conditi
199 red to as STXBP1 encephalopathy, encompass a broad spectrum of neurologic and psychiatric features, b
201 een linked to suicide, but the risk across a broad spectrum of neurological disorders remains to be a
202 iated with a new syndrome characterized by a broad spectrum of neurological phenotypes and developmen
203 ne (DA) signaling has been associated with a broad spectrum of neuropsychiatric disorders, prompting
208 d studies and clinical trials that include a broad spectrum of older patients representative of those
209 nificantly shorten the synthetic period of a broad spectrum of open organic materials presents an ent
210 restore exon 7 inclusion in SMN1 carrying a broad spectrum of pathogenic mutations at both the 3'ss
212 ety of dietary products that it absorbs, the broad spectrum of pathogens that it encounters, and the
213 alphaHDPs) contributes to immunity against a broad spectrum of pathogens via multiple functions.
216 pproach necessary to diagnose and manage the broad spectrum of patients presenting with syncope.
217 ir and sofosbuvir are highly effective for a broad spectrum of patients with HCV genotype 1 infection
218 tion protocol is safe and effective across a broad spectrum of patients, irrespective of the type of
219 These observations are consistent across a broad spectrum of patients, risk factors, and concomitan
222 1 have been reported to be associated with a broad spectrum of phenotypes but all affected individual
224 hertz: ones that prefer to emit a relatively broad spectrum of photon pairs, potentially allowing for
225 of commercial products worldwide due to its broad spectrum of physical properties and low production
226 hat affects various cellular events during a broad spectrum of physiological and pathological conditi
227 ane proteins involved in the regulation of a broad spectrum of physiological processes and are a majo
228 negative bacteria suggests the presence of a broad spectrum of phytochemicals with antibiotic activit
229 active components, especially because of the broad spectrum of phytochemicals with potential health b
230 showed significant changes in the level of a broad spectrum of plasma proteins including serine prote
233 s would require studies that both evaluate a broad spectrum of posttraumatic sequelae (to overcome fr
234 unctionalization of the BASHY platform for a broad spectrum of potential applications, ranging from b
235 WCNT species are calculated, which reveals a broad spectrum of potentially achievable colors of SWCNT
236 monstrate that cobalamin riboswitches have a broad spectrum of preference for the two biological form
237 prevention of the sepsis-induced surge of a broad spectrum of pro-inflammatory cytokines, including
239 nockdown resulted in impaired induction of a broad spectrum of proinflammatory cytokines, including I
243 to stressors can precipitate the onset of a broad spectrum of psychiatric disorders and addiction in
244 not a unitary disease entity, encompassing a broad spectrum of psychopathology arising from distinct
245 e (SAM) and a [4Fe-4S] cluster to initiate a broad spectrum of radical transformations throughout all
248 y offer an alternative and is relevant for a broad spectrum of readers because of its clear translati
251 in many eukaryotic lineages, resulting in a broad spectrum of reduced and modified mitochondrion-rel
255 expression levels of Wip1 and PTEN exhibit a broad spectrum of responses to DNA damage: from a fast t
257 many studies in kidney transplantation and a broad spectrum of risk factors has been identified, the
259 d polymorphism of F-box genes well support a broad spectrum of SCF functions, experimental evidence i
260 These SFE values may find applications in a broad spectrum of scientific disciplines including the s
261 e approach to fabricate nanographenes with a broad spectrum of semiconducting properties and high cha
262 manifestations of SLE are diverse and have a broad spectrum of severity and prognostic implications.
263 sed awareness has led to identification of a broad spectrum of severity of illness in patients who we
264 e expression of psychotic phenomena across a broad spectrum of severity, extending from the subclinic
265 nded this analysis to 679 diseases to test a broad spectrum of side effects associated with hypotheti
268 global sustainability challenges, there is a broad spectrum of societal needs where the development o
270 microearthquakes and geochemical data over a broad spectrum of spreading rates, but such data have no
274 ing and acid-catalysed reactions, spanning a broad spectrum of substrates including sugars and platfo
277 ceae in diverse ecological niches across the broad spectrum of symbiotic associations, from free-livi
281 ting a novel role for BACH1 in controlling a broad spectrum of the repair response genes in macrophag
283 , but also provides a general approach for a broad spectrum of therapeutic proteins for in vivo appli
284 review articles have extensively examined a broad spectrum of these SSEs using evaluation factors su
285 bnormally high extracellular Pi results in a broad spectrum of toxicity by rewiring complicated signa
286 This model system has implications toward a broad spectrum of translational studies, regarding the v
289 rategies include engineering OVs to target a broad spectrum of tumor cells while evading the immune s
291 gulation of Id proteins is associated with a broad spectrum of tumors, recent studies have identified
293 -scale features with special shapes impart a broad spectrum of unique properties to the surface of in
295 ith IC(100) as low as 0.04 mug/mL, showing a broad spectrum of variable (V) genes and low levels of s
296 errant formation of blood vessels precedes a broad spectrum of vascular complications; however, the c
297 These are very heterogeneous, resulting in a broad spectrum of vesicular release probabilities within
298 nstrated potent antiviral activity against a broad spectrum of viruses in multiple in vivo disease mo
300 eloped using a large VF dataset containing a broad spectrum of visual deficit types, has the potentia