ライフサイエンスコーパス: broadly applicable

1 of cells, indicating this approach could be broadly applicable.

2 ulations and ensure that genetic research is broadly applicable.

3 onate-containing N-heterocyclic carbene, are broadly applicable.

4 etic manipulation we describe here should be broadly applicable.

5 ging and therapy, which may prove to be more broadly applicable.

6 Our algorithm should thus be broadly applicable.

7 focused on minimizing alcohol intake may be broadly applicable.

8 nsive, enabling features that make CANs more broadly applicable.

9 easible transition interventions that can be broadly applicable.

10 target anti-cancer ILC2s and T cells may be broadly applicable.

11 age size and quality, and makes the software broadly applicable.

12 onjunction with existing Cre lines making it broadly applicable.

13 platform, these antibody-testing methods are broadly applicable.

14 super-resolution imaging protocols, and are broadly applicable across biology.

15 x of the dogs, resulting in a method that is broadly applicable across canid species' morphologies.

16 ed analysis and visualization techniques are broadly applicable across developmental and systems biol

17 ry events and population effects and is thus broadly applicable across eukaryotic species.

18 ting that the parameters determined here are broadly applicable across highly conserved cyclophilins

19 Our workflow is broadly applicable across imaging platforms and analysis

20 , suggesting that the microcosm findings are broadly applicable across marine habitats.

21 Our method is broadly applicable across microbial life, opening possib

22 rotein complex mapping studies and should be broadly applicable across organisms as more CF-MS datase

23 This analog-sensitive approach should be broadly applicable across the PARP family and has the po

24 rivers that emerge as the most important and broadly applicable across these key vegetation and distu

25 ctivation is chemically challenging, and few broadly applicable activation strategies for signaling e

26 ng drug response between patients to develop broadly applicable adherence criteria.

27 ultiple individuals is necessary to identify broadly applicable 'allelic elements'.

28 echanisms of inactivation and the absence of broadly applicable allosteric sites.

29 ne or more nitrogen-containing moieties, and broadly applicable and efficient catalytic transformatio

30 MARQUIS is a versatile method, broadly applicable and extendable to multiple mass spect

31 In this work, we present a broadly applicable and flexible tool: T-lex2.

32 of this unified representation (UniRep) are broadly applicable and generalize to unseen regions of s

33 Here, we present a broadly applicable and inexpensive biosensing technology

34 -2 in cancer cells could potentially lead to broadly applicable and innovative therapeutic avenues.

35 particular imaging targets, the approach is broadly applicable and is expected to improve resolution

36 reening and rational engineering approach is broadly applicable and suggests that greater potential o

37 We expect the model to be broadly applicable and useful in coarse-grained models o

38 lopment of more effective, safe, convenient, broadly applicable, and easy to manufacture vaccines for

39 al autonomy of coordinated neural systems is broadly applicable, and our findings provide evidence of

40 These approaches are becoming modular and broadly applicable, and show a strong potential for diss

41 ror estimation approaches described here are broadly applicable, and the provided tools work with oth

42 In summary, we present a novel, broadly applicable, and versatile therapeutic modality f

43 Therefore, our findings provide a broadly applicable approach for classifying functionally

44 y correlated oxide interfaces and lays out a broadly applicable approach for depth-resolving band hyb

45 ing of patients it may prove a versatile and broadly applicable approach for localizing neurological

46 ntrol over its function, we have developed a broadly applicable approach for the optical activation o

47 targets and verification by sequencing) is a broadly applicable approach for unbiased CRISPR-Cas off-

48 Our results illustrate a broadly applicable approach to design physiological prot

49 esulting complex, providing an efficient and broadly applicable approach to early fragment developmen

50 specific CD4(+) Th cells may be a useful and broadly applicable approach to generating improved vacci

51 rogenic nanoparticles represents a novel and broadly applicable approach to prevent the formation of

52 Here we present a broadly applicable approach to quantification and classi

53 These results describe a potentially broadly applicable approach to understanding the interac

54 lin aptamer-TAP siRNA conjugate represents a broadly-applicable approach to increase the antigenicity

55 erefore there is tremendous need for new and broadly applicable approaches to site-specific conjugati

56 action, microRNA-based therapeutics might be broadly applicable as a therapy for this type of deafnes

57 These nanoparticle-supported liposomes are broadly applicable as membrane antigen vehicles for indu

58 es and their usage as mechanistic tools in a broadly applicable assay platform.

59 f materials design, this approach provides a broadly applicable, automated tool to understand atomic

60 ity, robustness and economy of Flura-seq are broadly applicable beyond cancer research.

61 sting inhibition of autophagy as a potential broadly applicable cancer therapy.

62 A broadly applicable catalyst system consisting of water-s

63 fforts toward the creation of new useful and broadly applicable catalyst systems are ongoing.

64 Herein, we demonstrate a general and broadly applicable catalytic cross coupling of methylene

65 amenable to high throughput screens and as a broadly applicable cellular tool to interrogate the temp

66 Discovery of this broadly applicable, chemoselective, and solvent-versatil

67 tic objectives are defined, based on which a broadly applicable combination therapy is proposed to co

68 dy SCA10 RNA toxicity and potentially define broadly applicable compounds targeting RNA AU base pairs

69 uide to leukaemia cell line selection, and a broadly applicable computational approach for quantifyin

70 We believe that our synthesis provides a broadly applicable conceptual framework to understand an

71 The development of broadly-applicable, core microsatellite panels has the p

72 Here, we report an accurate and broadly applicable data-driven algorithm for dimensional

73 Thus, we demonstrate a broadly applicable device-based methodology to probe the

74 l development of an extremely simple and yet broadly applicable directing group for Pd(II) , Rh(III)

75 ghlight how data sharing efforts can provide broadly applicable discoveries.

76 The development of a broadly applicable dispersion quantification method will

77 These characteristics make aptamers broadly applicable (e.g., as an analytical, diagnostic,

78 This broadly applicable E2 delivery platform shows promise as

79 Here, we disclose a broadly applicable enantioselective [2 + 2]-cycloadditio

80 ell as sharing of such large-scale models, a broadly applicable, flexible, and high-performance data

81 This approach may be broadly applicable for designing effective and enduring

82 Our approach is broadly applicable for determining structures of undisco

83 mental and computational approaches that are broadly applicable for efficient elucidation of disease-

84 gp120 inner-outer domain interface and were broadly applicable for engineering Env from diverse stra

85 ational removal of ssDNA exonucleases may be broadly applicable for enhancing the efficacy and ease o

86 Our methodology should be broadly applicable for epigenomic comparisons and provid

87 This protocol is broadly applicable for filling structural gaps of many t

88 These methods are broadly applicable for high throughput single cell chemi

89 SAFIRe should be broadly applicable for imaging live cell dynamics with c

90 karyotic cells, we expect this assay will be broadly applicable for investigating mechanisms of MMR i

91 n contact for free-ranging hosts, and may be broadly applicable for investigations in wildlife diseas

92 Water activity measurements were broadly applicable for measuring deliquescence points wh

93 m all three germ layers and therefore may be broadly applicable for modeling of epithelia.

94 the Cre-switchable PET reporter mice will be broadly applicable for non-invasive long-term tracking o

95 This concept might be broadly applicable for protective antibody responses to

96 r)oxides makes this electrochemical approach broadly applicable for studying changes in iron oxide re

97 This assay should be broadly applicable for studying the mechanisms of AAA+ p

98 Overall, GxEMM is broadly applicable for testing and quantifying polygenic

99 or loop structures should make this approach broadly applicable for the atomic-level study of large R

100 Our method may be broadly applicable for the derivation of analogous stem

101 covery and validation that is accessible and broadly applicable for the progression of efforts toward

102 for a range of insects renders this strategy broadly applicable for the species-specific control of a

103 Cryoreduction-EPR is broadly applicable for the study of electron transfer in

104 bust, and easy-to-use tool is expected to be broadly applicable for the synthesis of challenging pept

105 nds were tested in vitro, making this method broadly applicable for tool compound development.

106 This framework is broadly applicable for understanding the mechanisms of s

107 on regulates cell signalling, which might be broadly applicable for understanding the signalling func

108 Taxon-BRI provides a broadly applicable framework for standardization and err

109 ogether, this presents CellTag Indexing as a broadly applicable genetic multiplexing tool that is com

110 enhanced ascorbate peroxidase 2 (APEX2) as a broadly applicable genetic tag that generates EM contras

111 Our findings may be broadly applicable given that transcription on topologic

112 There remains a need for a broadly applicable, hernia-specific tool that incorporat

113 This work demonstrates LAMIMS as a broadly applicable high-throughput operando screening me

114 for such materials and paving the way for a broadly applicable high-throughput-discovery and materia

115 The method is broadly applicable, highly regio-, chemo-, and enantiose

116 that our process represents an important and broadly applicable improvement to the state of the art f

117 anoPOTS top-down proteomics platform will be broadly applicable in biomedical research, particularly

118 aches for cholinergic modulation that may be broadly applicable in dystonia.

119 Consequently, information on BCO2 becomes broadly applicable in human biology with important impli

120 ination of HDX stability fingerprints may be broadly applicable in many applications for understandin

121 In conclusion, this versatile method is broadly applicable in screening and characterisation of

122 We expect the method to be broadly applicable in the chemical sciences, and to comp

123 h ratios (UVVR) suggesting these metrics are broadly applicable indicators of microtidal marsh vulner

124 nvestigated whether these molecules are more broadly applicable inhibitors of beta2m amyloid formatio

125 ing widely studied classes of MOFs, provides broadly applicable insight into the rigidity and compres

126 validity of this assumption, or consider how broadly applicable it may be to all genes that are in th

127 technique can provide this information in a broadly applicable manner and thus structural studies of

128 ts has not been studied in a prospective and broadly applicable manner.

129 s and nanostructured minerals provide a new, broadly applicable mechanism to stabilize proteins in th

130 This study demonstrates a broadly applicable mechanistic principle for how cells a

131 Temporal variance is a simple and broadly applicable method for analyzing bacterial swarmi

132 Here, we present dStruct which is the first broadly applicable method for differential analysis acco

133 Overall, we provide a broadly applicable method for evaluating the selectivity

134 Here, we describe a broadly applicable method for labeling and imaging pili

135 Herein, we report a mild and broadly applicable method for the construction of comple

136 se insights exemplify spliceosome iCLIP as a broadly applicable method for transcriptomic studies of

137 ration sequencing has generated a need for a broadly applicable method to remove unwanted high-abunda

138 ng requires the development of efficient and broadly applicable methods for delivering programmable n

139 A set of broadly applicable methods for efficient catalytic addit

140 extensive research, but highly effective and broadly applicable methods remain elusive.

141 in looping is key to gene regulation, yet no broadly applicable methods to selectively modify chromat

142 p of the cancer-immunity cycle and propose a broadly applicable 'minimal combination' of therapies de

143 The MRF-MGL represents an effective, broadly applicable model for the storage, analysis, and

144 shown promise in the field, but accurate and broadly applicable models are still lacking.

145 warrants further studies that may lead to a broadly applicable molecular imaging tool to examine abn

146 This work highlights a broadly applicable nanoscale structure-refinement method

147 brain functional network strength provides a broadly applicable neuromarker of sustained attention.

148 are provided open access; they constitute a broadly applicable neuroscience toolbox resource for res

149 Herein, we report the rational design of a broadly applicable Pd-catalyzed method to prepare phenol

150 Taken together, this work provides a broadly applicable platform for high-throughput function

151 A broadly applicable, practical, scalable, efficient and h

152 tion process that should serve as useful and broadly applicable principles for future design of more

153 A set of two broadly applicable procedures for the N-arylation of hyd

154 In this article, we describe a broadly applicable process for identifying degrader hits

155 omparisons with a potential for establishing broadly applicable quantitative BKV DNA load cutoffs for

156 The MGRB provides a broadly applicable reference cohort for clinical genetic

157 elucidate carcinogenic mechanisms and inform broadly applicable risk assessment efforts.

158 supports the potential of this antibody as a broadly applicable scaffold for the development of selec

159 ealing recognition principles and of raising broadly applicable strategies, including functional assa

160 These data reveal a broadly applicable strategy across tumor types for repro

161 P is a powerful, experimentally concise, and broadly applicable strategy for directly visualizing RNA

162 Here we introduce a broadly applicable strategy for robustly controlling pro

163 However, development of a broadly applicable strategy for stable and functional va

164 This broadly applicable strategy may lead to decreased pestic

165 ene capping is introduced as a practical and broadly applicable strategy that can expand the scope of

166 of targeted therapy and Quisinostat may be a broadly applicable strategy to induce a prolonged respon

167 Here, we describe a broadly applicable strategy, based on llama-derived sing

168 surface processes, sulfidation represents a broadly applicable surface modification approach to modu

169 We have realized a reliable and broadly applicable surface modification strategy that re

170 Here we describe a broadly applicable technique called 'Ligation in situ Hy

171 We introduce a new, broadly applicable technique for the precisely controlle

172 CANE is a broadly applicable technology for dissecting causality a

173 tes that IDLV-mediated HDR is a powerful and broadly applicable technology to carry out site-specific

174 PIC-seq provides a direct and broadly applicable technology to characterize intercellu

175 ible and customizable and are therefore more broadly applicable than the examples presented.

176 In this review, we discuss general and broadly applicable themes that have emerged from this co

177 Broadly applicable, these predictive models can use stan

178 of BK virus (BKV) DNA precludes establishing broadly applicable thresholds for the management of BKV

179 cation-based band gap tuning we describe are broadly applicable to 3D metal halide perovskites and wi

180 s (lower capital and operating costs) and is broadly applicable to a host of electronically conductiv

181 tform for solid-state protein studies and is broadly applicable to a variety of systems and experimen

182 aining in communication skills that would be broadly applicable to a wide clinical audience.

183 me indicates that the correction strategy is broadly applicable to a wide range of microduplication l

184 Our modeling assumptions are broadly applicable to adherent, monolayer cell cultures,

185 ods validated here are general and should be broadly applicable to allow the direct and rapid detecti

186 Beyond chemokines our approach is broadly applicable to alternative systems of chemo- and

187 imaging pathophysiology research system), is broadly applicable to analyses of other respiratory path

188 nd show that the optimized masking domain is broadly applicable to antibodies of interest.

189 We expect this technique to be broadly applicable to any assembly where very short scal

190 the study of mammalian cells, but it can be broadly applicable to any cell or tissue of interest, gi

191 surfactants in multiple environments and are broadly applicable to any discipline where finite volume

192 The strategies described herein are broadly applicable to any full-length IgG or Fc-based AD

193 introduces a novel analysis method, which is broadly applicable to any LPTV networks, and validates i

194 oach for connecting genotype to phenotype is broadly applicable to any sample that is phenotypically

195 As a computational methodology, WIF is broadly applicable to any SMLM dataset, imaging system,

196 ich to study human in situ adaptive immunity broadly applicable to autoimmunity, infection, and cance

197 annotate novel sphingolipid species make LDA broadly applicable to automated sphingolipid analysis, e

198 anisotropy and hence biofilm morphology, are broadly applicable to bacterial biofilms with similar mo

199 integrative analysis, which we expect to be broadly applicable to bacterial epigenomic studies.

200 EM data sets from the same specimen area, is broadly applicable to biological and environmental sampl

201 lymer systems, suggesting that the method is broadly applicable to block copolymer materials assemble

202 y immunogenic antigens in principle could be broadly applicable to cancers and other diseases.

203 s with high impact for further study, and is broadly applicable to complex human diseases.

204 Our approach is broadly applicable to complex multimetallic systems and

205 The system may be broadly applicable to controlling invasive fishes and re

206 This method for TI into AAVS1 may be broadly applicable to correction of other monogenic dise

207 ransferable, the method should be robust and broadly applicable to counting colocalized molecules in

208 lization and communication in science and is broadly applicable to courses of any size and sub-discip

209 This report describes chemistry that is broadly applicable to cysteine-rich peptides and the inf

210 tection of protein S-acylation levels and is broadly applicable to different classes of S-palmitoylat

211 abled selection of CID (COMBINES-CID) method broadly applicable to different ligands.

212 ic cross-link design is highly versatile and broadly applicable to different polymer architectures as

213 tigation of essential gene functions in vivo broadly applicable to diverse microorganisms and amenabl

214 Furthermore, our technique is broadly applicable to earlier image-based detection of m

215 Our approach is broadly applicable to elucidating pathogen-host interact

216 tiochelin system; therefore, our results are broadly applicable to emerging clinical isolates of S. m

217 roteins regulate NK cell function and may be broadly applicable to Fcgamma-receptor-bearing cells.

218 This approach can be broadly applicable to functional imaging of other brain

219 Our approach can be broadly applicable to functional imaging of other core b

220 roach and mechanism of action that should be broadly applicable to functional RNA targeting.

221 Our allele balance framework is broadly applicable to genotype analysis of any variant t

222 he computational approaches applied here are broadly applicable to global optimization problems.

223 of omics-driven predictive modelling that is broadly applicable to guide biological discovery.

224 T cell, suggesting that this approach may be broadly applicable to heterogeneous and resistant tumor

225 D-PSR method is broadly applicable to holographic microscopy application

226 microbe-phenotype triangulation may be more broadly applicable to human microbiome studies.

227 The implications of this work are broadly applicable to hydrogenation and dehydrogenation

228 Rapid conductance measurements will be broadly applicable to IC-based sensors that undergo anal

229 tor functions, while our network approach is broadly applicable to identifying regulators in other in

230 tinase inhibitors and may be a strategy more broadly applicable to inhibiting proteins that require u

231 from vertebrates, although the concepts are broadly applicable to invertebrates.

232 genetic variants in native context, which is broadly applicable to investigate and improve protein fu

233 targeting was not required, the approach is broadly applicable to LABC with different phenotypes.

234 The method should be broadly applicable to many bosonic and fermionic species

235 tanding of tombusvirus-host interactions are broadly applicable to many other viruses, which also usu

236 This new insight is broadly applicable to many types of molecular threading

237 The resulting potential is broadly applicable to materials science, biology, and ch

238 It is broadly applicable to mechanistic studies of chromatin i

239 We expect that the method will be broadly applicable to modeling and predicting paired mac

240 resent an oligonucleotide MS method which is broadly applicable to monitor in vitro RNA (de-)modifica

241 lts suggest that the underlying chemistry is broadly applicable to nucleic acid sensing.

242 als, this mRNA delivery technology should be broadly applicable to numerous research and therapeutic

243 ligands, and a small-molecule agonist may be broadly applicable to other aGPCR family members.

244 Our strategy is broadly applicable to other aptamers, enabling the devel

245 This methodology can be broadly applicable to other bioconjugated systems, biose

246 etween monomers and dimers is expected to be broadly applicable to other biogenic and anthropogenic S

247 te structure and catalytic activity could be broadly applicable to other CCD members and provide insi

248 ent loading in the Mississippi Basin and are broadly applicable to other coupled human-natural system

249 ticles or semiconductors, are believed to be broadly applicable to other heterostructures with novel

250 W-type materials, which may prove to be more broadly applicable to other layered zeolites.

251 e cryptic inhibitor envelope approach may be broadly applicable to other lead optimization campaigns

252 the SSZ-13 growth mechanism may prove to be broadly applicable to other materials.

253 strategy to prevent synapse loss that may be broadly applicable to other neurodegenerative diseases.

254 The conceptual framework we describe is broadly applicable to other novel disease systems.

255 We expect that the methods developed are broadly applicable to other obligates, particularly to r

256 s for N- and O-glycosylation that are likely broadly applicable to other plant cell-wall-degrading en

257 ds of RNA-seq described in this protocol are broadly applicable to other sample types beyond whole or

258 vity are shown, but the PIE-FLIM approach is broadly applicable to other signaling pathways.

259 hibit improved voltage sensitivity should be broadly applicable to other types of PeT-based voltage-s

260 t this five-dimensional imaging method to be broadly applicable to problems in energy, materials, env

261 emonstrated that the present approach may be broadly applicable to proteins undergoing relatively sma

262 We anticipate that sci-fate will be broadly applicable to quantitatively characterize transc

263 ral agents and diagnostic tests that are not broadly applicable to resource limited settings, includi

264 icacious and safe CRISPR/Cas9 antimicrobial, broadly applicable to Staphylococcus aureus.

265 Our APE-based method is easily computed and broadly applicable to statistically similar models found

266 analytical approaches demonstrated here are broadly applicable to studies of dynamic biological syst

267 Our approach is broadly applicable to study human immunity and can help

268 This analytical method is broadly applicable to study membrane protein interaction

269 autodE is broadly applicable to study organic and organometallic r

270 The SunTag should be broadly applicable to study translational regulation in

271 dynamics and the approach presented here is broadly applicable to studying order in macromolecular s

272 -molecule fluorescence imaging and should be broadly applicable to studying protein-DNA interactions.

273 paired with sample flexibility, makes HOTMAQ broadly applicable to targeted peptidomics, proteomics,

274 We also demonstrate how MEIRLOP is broadly applicable to the analysis of numerous types of

275 ma transcriptomic subtype classifier will be broadly applicable to the cancer research and clinical c

276 se as a surprising approach that is possibly broadly applicable to the challenge of designing biased

277 iple binding of the Et4N(+) guest, but it is broadly applicable to the deconvolution of other intrica

278 The IsoTaG platform is broadly applicable to the discovery of PTM sites that ar

279 s employed in this study are likely to prove broadly applicable to the fine analysis of folding mecha

280 The approach may be broadly applicable to the kinetic stabilization and char

281 catalytic system is practical, scalable, and broadly applicable to the reductive coupling of a wide r

282 ChIP-nexus will be broadly applicable to the study of in vivo transcription

283 he NADH photo-activation coupled with EPR is broadly applicable to trap reactive intermediates at low

284 The approach is broadly applicable to type II fatty acid synthase system

285 This technology platform is broadly applicable to various diseases with well-known b

286 e projects by presenting guidelines that are broadly applicable (to any species), sustainable over ti

287 CiBER-seq profiling provides a powerful and broadly applicable tool for dissecting genetic networks.

288 private databases as a specific in-house but broadly applicable tool for optimizing exome analysis.

289 troduced by Hofer, Wysocki, and Zehnder as a broadly applicable tool for regularizing moduli spaces o

290 ate parameters using FRAP recovery data is a broadly applicable tool for systems where intracellular

291 MALDI-HiTES is a broadly applicable tool for the discovery of cryptic pep

292 ed using dynamic pathway regulation, but few broadly applicable tools are available to achieve this.

293 iction to lose its PHL capacity, and provide broadly applicable tools for other jurisdictions to enha

294 Broadly applicable tools for the efficient delivery of m

295 advantages for the development of robust and broadly applicable tools.

296 mpounds are central to modern chemistry, and broadly applicable transformations that generate them ef

297 ionary origins may thus present powerful and broadly applicable treatment strategies for cancer.

298 echnology may therefore provide a practical, broadly applicable treatment that can generate anti-tumo

299 thod represents the first, to our knowledge, broadly applicable use of unactivated alcohols as latent

300 ropose a chemotactic precision index that is broadly applicable, valid, and allows for a straightforw