ライフサイエンスコーパス: build-up of

1 umulation of BRCA1 at DSBs, causing aberrant build-up of 53BP1, and allowing anti-resection activity

2 rsal tongue epithelium, which results in the build up of a plaque of cell debris that severely impair

3 This route allows the build-up of a carbon lattice by a chemistry free of hydr

4 al fields and a fast, reversible, and strong build-up of a charged dye-modified lipid in the directio

5 The model describes the progressive build-up of a HA concentration polarization layer at the

6 in tissue-resident macrophages, causing the build-up of a mevalonate metabolite and preventing prote

7 , two or more mutations participating in the build-up of a new complex function may be required to be

8 of the ATP concentration, indicative of the build-up of a pre-steady state intermediate.

9 kinase and absence of FraB deglycase causes build-up of a toxic metabolite: 6-phosphofructose-aspart

10 olvement of alternative electron routes, the build-up of a transmembrane pH gradient and membrane pot

11 ment learning (RL), which involves a gradual build-up of a value signal during learning.

12 The efficiency of the process relies on the building up of a CO(2) overpressure in the medium.

13 The building up of a prepotent response tendency was tested

14 ers, demonstrating his constant work and the building up of a research topic, which continued after h

15 on imaged at closest approach and led to the building up of a substantial and complex regolith consis

16 The capsid of herpes simplex virus is built up of a variety of proteins, and we scrutinized th

17 t is expected to considerably facilitate the built-up of a portable device for determination of analy

18 ity may be a promising approach to delay the build-up of AB deposits in the brain by enhancing the cl

19 d event detection, we demonstrate the subtle build-up of aberrant microdomain Ca(2+) transients in th

20 rotein, but not mRNA, levels, explaining the build-up of aberrant RNAs that characterizes DUX4-expres

21 ity may be a promising approach to delay the build-up of Abeta deposits in the brain by enhancing cle

22 the evidence for a central role of cerebral build-up of Abeta in the pathogenesis of Alzheimer's dis

23 rotein misfolding disease characterized by a build-up of Abeta peptide as senile plaques, neurodegene

24 d with markedly lowered vATPase activity and build-up of Abeta/APP-betaCTF selectively within enlarge

25 8 kinases, Hsp70 serves as a "sensor" of the build-up of abnormal proteins after heat shock and other

26 We conclude that the build-up of action plans in human motor cortical circuit

27 contrast to previous studies that observed a build-up of activity associated with the passage of time

28 First, we identify time-resolved build-up of activity in the EEG, akin to a process of ev

29 nsively analysed alterations in accumulation/build-up of AGEs and related metabolites in synaptic mit

30 nction and loss and may be associated with a build-up of aggregated proteins with altered physicochem

31 The backbone is built up of alpha-1,6-linked mannose residues and the si

32 ion of alpha-synuclein (alphaSyn), causing a build up of alphaSyn aggregates and post-translationally

33 mospheric NMHC mole fractions coincided with build-up of ambient 1-h ozone to levels exceeding 150 pp

34 riggers cortical polarization, including the build-up of an actin cap surrounded by a ring of activat

35 ndicating that it did not act by causing the build-up of an endogenous pathway signal.

36 ibution of both sexes, which foreshadows the build-up of an entire community, and subsequent dilution

37 d the charge density difference unravels the build-up of an inherent electric field at the interface,

38 thylamine oxidation suggest the pH-dependent build-up of an inhibitory intermediate, which was subseq

39 ow the H(+) into the vesicles to prevent the building up of an overwhelming electrical gradient acros

40 d perijunctional actin fibres leading to the building-up of anisotropic stress.

41 The first major build-up of Antarctic glaciation occurred in two consecu

42 In experiment 2 this protocol elicited a build-up of anticipatory head and gaze velocity, in oppo

43 ential of uterine macrophages resulting in a build up of apoptotic bodies at the uteroplacental inter

44 developed early in the Archaean to prevent a build-up of atmospheric oxygen before the Proterozoic.

45 rate and perceptual phase durations; and the build-up of auditory streaming.

46 ebrovascular pathology that results from the build-up of beta-amyloid in the vessel walls.

47 inflammation drives a time-of-day-dependent build-up of bioactive lipid species driven by rhythmic i

48 n leads to the removal of oxidised DOM and a build-up of both reduced photodegradable formulae and ae

49 isease (AD) both exhibit sleep disturbances, build-up of brain metabolic wastes and amyloid-beta (Abe

50 rtone bulk acoustic resonances(18), resonant build-up of bulk acoustic energy allows a 14-fold reduct

51 ation of these channels results in a gradual build-up of calcium, which is amplified by calcium- and

52 A build-up of carbon in the deep ocean has been shown to h

53 questration of Abeta1-42 was followed by the build-up of carboxyterminal fragments of the endogenous

54 xon sustains the requirements for such rapid build-up of cellular constituents has remained elusive.

55 ation of coordinated water molecules and the build-up of charge on the metal ion in its DPP complex b

56 ments of their composition can constrain the build-up of chemical elements in galaxies during the ear

57 Furthermore, the build up of cholesterol in NP-C lysosomes was not a phys

58 articular, DNA replication correlates with a build-up of compartments and a reduction in TAD insulati

59 The build-up of complexity in communities is theoretically d

60 s decomposition of metabolites can lead to a build-up of compounds that compete with natural enzyme s

61 cs simulations, which indicate a progressive build-up of conformational strain upon RCS with destabil

62 not thought to have a major influence on the build-up of continental diversity.

63 isrupted magnetosome chain, and an anomalous build-up of cytoskeletal filaments between magnetosomes.

64 tions in somatic maintenance, resulting in a build-up of damage.

65 tion of mmpL10 or chp2 leads to an important build-up of DAT inside the cells and to the formation of

66 A build-up of degradative organellar by-products and decre

67 ed reduced levels of genomic diversity and a build-up of deleterious mutations compared to mainland d

68 pans have evolved mechanisms to mitigate the build-up of deleterious somatic variants.

69 The neurodegenerative processes driving the build-up of disability in progressive multiple sclerosis

70 We find that the build up of diversity from a single founding strain is e

71 A build-up of eggs in the uterus of the nematode C. elegan

72 hibitors, which might be expected to lead to build-up of endogenous fatty acids, also activate native

73 ynthesizing AHCBs is how do we cope with the build-up of energy in the highly strained structures dur

74 This compound is a new lignan built up of epiphyllic acid and two isocitryl esters in

75 op in accuracy can be partly attributed to a build-up of error and ambiguity as more sequences are al

76 Build-up of excitation to reticulospinal neurons is the

77 This build-up of excitation to threshold is the key decision-

78 We hypothesize that the build-up of extracellular adenosine during theta activit

79 n by inhibitory interneurons via the initial build-up of extracellular K(+) due to intense interneuro

80 A build-up of extracellular K(+) in the internode and pers

81 ions in eukaryotes with implications for the build-up of extracellular matrices, retroviral infection

82 otective effect occurs despite the continued build-up of extraneuronal PrP(Sc) and continued replicat

83 a new framework to explicitly understand the building up of FC through neuronal dynamics underpinned

84 amine ferulate is a sink for the anticipated build-up of feruloyl-SCoA, and may be up-regulated in re

85 Our results show the build-up of food-web complexity in natural productivity

86 es the utilization of PCNA by inhibiting the build-up of free PCNA on DNA in the absence of polymeras

87 anic electronic device phenomena such as the build-up of functional deeply trapped charge layers in p

88 In this disease, abnormal build up of G(M1)-ganglioside in the endoplasmic reticul

89 permassive black-hole growth may precede the build-up of galaxy spheroids.

90 f the relative importance of islands for the build-up of global diversity.

91 ative phosphorylation enzymes meant that the build-up of glucose intermediates was less severe in the

92 pendent FMRFa signaling is essential for the build-up of glycogen stores in the jump muscle which exp

93 been proposed as a method of mitigating the build-up of greenhouse gases in the atmosphere.

94 In Expt 1, the build-up of hand and eye responses was examined for targ

95 version of parvalbumin (PV.NLS-mC) led to a build-up of HDAC4 and HDAC5 in the cell nucleus, which i

96 Importantly, reversing the build-up of histone deacetylase 2 by short-hairpin-RNA-m

97 nt on such transport pathways to prevent the build-up of hydrostatic pressure that otherwise offsets

98 The build-up of ice on aircraft, bridges, oil rigs, wind tur

99 bsence of human perturbations no substantial build-up of ice sheets would occur within the next sever

100 e clinical course of MS, suggesting that the build-up of immune cell aggregates in the meninges repre

101 Understanding the build-up of immunity with successive severe acute respir

102 ere we report the observation of spontaneous build-up of in-phase ('zero-state') and antiphase ('pi-s

103 different: Ca2CdSb2 has a layered structure built up of infinite layers of CdSb4 tetrahedra connecte

104 fraction of its theoretical value due to the build-up of insulating lithium peroxide (Li(2)O(2)), the

105 strain in the incoming band, preventing the build-up of interfacial stresses.

106 revealed bottlenecks in substrate flow, with build-up of intermediate metabolites consistent with oxi

107 take place by a distributive mechanism, with build-up of intermediates observed in electrospray mass

108 toxicity disorder characterized by dramatic build-up of intracellular hepatic copper with subsequent

109 urchins held in air: 231.58 and 245.16) and build-up of its degradation products, mainly inosine (co

110 ng of action potentials, a process driven by build-up of K(+) in small invaginations of muscle membra

111 call self-driven jamming, that promotes the build-up of large mechanical pressures in microbial popu

112 results suggest that self-driven jamming and build-up of large mechanical pressures is a natural tend

113 t a property-based level of hierarchy in the build-up of larger protein structures and suggest that t

114 Feeding a fat-free diet suppressed the build-up of LDs in DARS2-deficient enterocytes, which sh

115 ective immunity could result from a retarded build-up of leukocytes around migrating lung worms and/o

116 in both asymmetric catalysis and convenient build-up of libraries of molecules with novel three-dime

117 s for both QTL, a finding which supports the build-up of linkage disequilibrium due to selection.

118 ed cell death that is triggered by the toxic build-up of lipid peroxides on cellular membranes.

119 We found greater build-up of lobsters within MPAs relative to unprotected

120 which the small number of neighbours causes build-up of local correlations between the state of adja

121 l, formed by enhanced meltwater from initial build-up of local glaciers, is also shown.

122 nce, this pCO(2) drop favoured the potential build-up of local polar ice.

123 A similar lack of wyosine base and build-up of m(1)G(37) is seen in certain mammalian tumor

124 ificant positive effect on larval population build-up of M. separata.

125 dual functions of the Ir layer allows future build-up of magnetoresistive stacks for memory and logic

126 countered with the lean case facilitates the build up of many pocket-type and tunnel-type interaction

127 th critical components for understanding the build-up of mass in the Universe(7).

128 Here we show that the parallel build-up of mating incompatibilities between stickleback

129 lar homeostatic balance leading to excessive build-up of matrix in kidney.

130 s and planets is accompanied not only by the build-up of matter, namely accretion, but also by its ex

131 ouse oesophagus is guided by the progressive build-up of mechanical strain at the organ level.

132 The latter finding allows for the building up of mesoscale domains with spontaneous polari

133 ffusion by mechanism (1) were limited by the build-up of metabolites, while mechanisms (2) and (3) yi

134 However, biofouling, the build-up of microbes and their polymeric matrix, clogs t

135 ype of senile dementia, is associated to the build-up of misfolded amyloid-beta (Abeta) in the brain.

136 ubiquitin-proteasome system (UPS) to avoid a build-up of misfolded protein aggregates.

137 We propose that a delayed build-up of mitosis-dependent genomic DNA damage or a lo

138 rare genetic disease is characterized by the build-up of MLCL resulting from inactivating mutations i

139 and cyclopropane derivatives allows a rapid build-up of molecular complexity.

140 red acquisition of genes and the progressive build-up of molecular mechanisms that increase virulence

141 This delayed build-up of morphological and behavioral effects offers

142 junction (NMJ) denervation and pre-synaptic build-up of mutant GlyRS.

143 lines selected for molecular analysis; (iii) build-up of mutation load was prevented by screening Mu-

144 ng of conduction velocity in C-fibres by the build-up of Na(+) channel inactivation.

145 e accumulation within plaques, contribute to build-up of necrotic pools, and explain in part the reti

146 nts can sufficiently stabilize the resulting build-up of negative charge during Meisenheimer complex

147 2 acts as both a Lewis acid (stabilizing the build-up of negative charge upon hydride transfer from F

148 er strands to entwine, or produces extensive build-up of negative supercoils in the newly synthesized

149 exhibiting progressive adaptation during the build-up of network excitability before an IED and reduc

150 e temporal dynamics, characterized by a slow build-up of neural activity prior to the reported onset

151 ling of large diameter sensory neurons and a build-up of neurofilaments in the cell bodies and proxim

152 model, we assessed whether the intracellular build-up of neuromelanin that occurs with age can be slo

153 surface segregation of defects leads to the building-up of new surface structures that are responsib

154 ects to sugar beet proteinase inhibitors and build up of non-sensitive midgut proteases.

155 umulation of iridescent species, whereas the build-up of non-iridescent species in the tropics was dr

156 erse matrix-related effect caused by gradual build-up of nonvolatile matrix components in the GC syst

157 an become stagnant and nonpotable due to the build-up of nutrients that promote algal growth.

158 Atherosclerosis, the build-up of occlusive, lipid-rich plaques in arterial wa

159 late aminotransferase (AGT1), resulting in a build-up of oxalate.

160 tains neutral lipid integrity to prevent the build-up of oxidized lipids and induction of ferroptosis

161 ssion of antioxidant defense responses, abet build-up of ozone-derived ROS and ultimately lead to oxi

162 The build-up of p21(CIP1/WAF1) and especially p27(KIP1) comm

163 Peat soils are formed by the build-up of partially decomposed organic matter under wa

164 eural networks with delays by preventing the build up of pathological synchrony without overwhelming

165 biosynthesis of valine and further revealed build-up of pathway intermediate 2,3-dihydroxy-3-isovale

166 l that Pd oxide formation is preceded by the build-up of Pd regions caused by oxygen-driven segregati

167 that it relies purely on a fast feed-forward build-up of perceptual activity.

168 male mice was associated with a progressive build-up of perineuronal nets (PNNs) in the contralatera

169 ncluding DNA damage repair, ciliogenesis and build-up of perineuronal nets.

170 vestments in leaf chloroplast biogenesis and build-up of photosynthetic capacity.

171 To avoid a massive build-up of plastic in the environment, coordinated glob

172 ly fits the data and accurately predicts the build-up of plasticity during random firing.

173 osphatidylinositol-4-phosphate rather than a build-up of polyphosphoinositides or changes in the acti

174 To avoid the build-up of potentially toxic intracellular protein aggr

175 ng agent dithiothreitol, which prevented the build up of Pr-SSGs in the cell, also blocked the accumu

176 he ends of each segment were overcome by the build-up of pressure in the dyke end; then a new segment

177 interacting destabilisation mechanisms: The build-up of pressures, strategic responses by central sy

178 The linear build up of primary sequence (1 degrees ) also enabled a

179 rarchical complexity, and revealed a gradual build up of protein repertoires associated with metaboli

180 The build up of quantum correlations during the dynamics is

181 biotic resistance mechanisms, as well as the build-up of rapid tolerance/resistance.

182 phagy may potentially help to counteract the build-up of reactive oxygen species in cells undergoing

183 se and distant effects are attributed to the build-up of refractoriness in representations with share

184 for the rapid assembly of oligosaccharides, built up of repetitive elements.

185 al selection in speciation is to connect the build-up of reproductive isolation between populations t

186 ments (POSs) and contributed to a persistent build-up of rhodopsin.

187 es recombination-dependent DNA synthesis and build-up of RPA-bound single-stranded DNA in the G2 phas

188 nt the radionuclide impurity of (177m)Lu and build-up of secondary (177)Lu from the (177m)Lu decay.

189 pression control by Ldb2a enables an initial build-up of signalling via a fully active positive feedb

190 ap temperature by q=0 magnetic order and the build-up of significant dynamic antiferromagnetic correl

191 This was associated with a faster build-up of sleep pressure, as reflected in higher EEG s

192 associated with reduced performance and the build-up of sleep pressure.

193 velop cognitive deficits associated with the build-up of soluble TDP-25.

194 due complementarity, redundancy, incremental build-up of specificity and conformational side chain pl

195 h pronounced charge anomalies, arises from a build-up of spin correlations, in agreement with recent

196 , in the absence of external visual input, a build-up of spontaneous fluctuations in early visual cor

197 of Abeta1-42WT and Abeta1-42A2V peptides in building up of stable intermolecular interaction.

198 ffness and lower afferent density affect the build-up of stimulus information and the response of SA1

199 ging changes are not primarily a result of a build-up of stochastic damage but are rather a product o

200 ying of nanoparticle suspensions release the build-up of strain through a variety of different mechan

201 chemical shift analysis, which describes the build-up of structure at the level of individual residue

202 e star-formation events and the hierarchical build-up of structure(2,3).

203 The experiments reveal a transient build-up of surface intermediates (OH(-) and Ce(3+)) and

204 articular interest because it allows for the building-up of surface covalent organic frameworks.

205 ance both of control strategies that address build-up of susceptible individuals and efforts to mitig

206 Skin wetness occurring secondary to the build-up of sweat on the skin provokes thermal discomfor

207 ealed that these changes resulted in a lower build-up of task-relevant stimulus information.

208 anges, disruption of autophagy function, and build-up of tau and P-tau-S396.

209 activity resulted in opposite outcomes, with build-up of Tau oligomers in enlarged auto-lysosomes.

210 with increasing chain length faster than the build-up of tertiary interactions, indicating that alpha

211 This results in a build up of the intermediate phosphatidylmonomethylethan

212 ivities in these patients concomitant with a build-up of the abiogenic 7-isomer (7BH(4)), leading to

213 Build-up of the biosensor was carefully optimized with a

214 ive amounts of urea that is consumed for the build-up of the carbogenic cores, the molecular fluoroph

215 wild type and took place without detectable build-up of the heme Fe(III)NO immediate product.

216 vivax transmission model to demonstrate the build-up of the hypnozoite reservoir following new infec

217 There is no gradual build-up of the large conformational change known to acc

218 cytoplasmic side of the plasma membrane by a build-up of the linker disaccharide [rhamnosyl (Rha) - N

219 that the observed saturation is linked to a build-up of the magnetic pressure, which decelerates and

220 on the rate at which cells became melanized, build-up of the melanin pigment layer resulted in a conc

221 directly influence how drugs diffuse and the build-up of the osmotic pressure in areas with high drug

222 t chain in both cell types, causing dramatic build-up of the p8 product of Cathepsin S and interferin

223 Such feedback leads to build-up of the pathway intermediate uridine monophospha

224 hesis, which posits that AD results from the build-up of the peptide beta-amyloid.

225 ontinues with the establishment and then the build-up of the plastid genetic machinery.

226 hanced kinase activity is facilitated by the build-up of the reduced and acetylated forms of the lipo

227 Fmoc-Nle(epsilon-N3)-OH during the stepwise build-up of the resin-bound peptide 1b.

228 ouse models of inflammation due to the toxic build-up of the substrate 6-phosphofructose-aspartate (6

229 Lysosomal build-up of the substrate glucocerebroside occurs in cel

230 utative pathways controlling the progressive build-up of the SV40 capsid.

231 nic events such as those associated with the build-up of the Tharsis rise.

232 However, the initial build-up of the thermal distribution proved difficult to

233 ompounds, like other double perovskites, are built up of the alternating sequence of corner-sharing (

234 It is built up of the linear tetrasaccharide repeating unit [3

235 us to conclude that the O-polysaccharide is built up of the tetrasaccharide repeating sequence: -->6

236 the capillary, which is responsible for the built-up of the potential at the tip, and the electrospr

237 physiological terms as a need to reduce the build-up of thermolabile metabolic intermediates that wo

238 As the build-up of this critical activity requires a certain pe

239 -apoptotic form of cell death induced by the build-up of toxic lipid peroxides.

240 Here we report a build-up of trace gases over the south pole approximatel

241 oan TATA promoters, the precisely structured building up of transcription factor (TF) IID-based PICs

242 in striking contrast to the slow and gradual build-up of transgenic copies during plastid transformat

243 interact with RNA, and preceded the gradual build-up of translation.

244 y acid oxidation (FAO) and prevent the toxic build-up of triacylglycerols.

245 However, this build-up of triglyceride-rich chylomicrons/very low dens

246 r a formal representation of the progressive build-up of trust in the model.

247 and small-angle X-ray scattering, reveal the build-up of two partially folded intermediate conformati

248 n lipid degradation would likely result in a build up of undigested material in RPE that could contri

249 sponse, where cells react to the stress of a build-up of unfolded proteins in their endoplasmic retic

250 lations of 2(Y) and 2(Gd) reveal significant build-up of unpaired spin on the tin atoms, with magneti

251 are uncharacteristically susceptible to the build-up of urate because we no longer have a functional

252 This intracellular build-up of VOCs lowers their biosynthesis by feedback d

253 The build-up of waste products coincided with an altered CCV

254 The data suggest an irregular cellular build-up of WUSCHEL expression in the primordium and new

255 vates the CARD8 inflammasome by inducing the build-up of Xaa-Pro peptides.