ライフサイエンスコーパス: by use of

1 This latter outcome can be avoided by use of a 5' nicked DNA donor.

2 By use of a adenoviral eIF5A shRNA, we have achieved an

3 A Mediterranean diet score was created by use of a baseline-validated food-frequency questionna

4 paclitaxel 175 mg/m(2) given intravenously), by use of a biased coin minimisation procedure with stra

5 in which full-length AnxA1 was overexpressed by use of a cardiotropic adeno-associated virus.

6 e, pimeloyl-ACP methyl ester to pimeloyl-ACP by use of a catalytic triad, each member of which was es

7 selective strategy to access these alkaloids by use of a challenging palladium-catalyzed asymmetric a

8 composed of HA and clay minerals was studied by use of a coated-wall flow reactor and cavity-enhanced

9 drug use (IDU) to HBV and HCV disease burden by use of a cohort method that recalibrated individuals'

10 eneic stem cell transplantation twice weekly by use of a commercial GM enzyme-linked immunosorbent as

11 mulative incidence of relapse was calculated by use of a competing risk model.

12 By use of a computer-based algorithm, men were randomly

13 re randomly assigned to a pembrolizumab dose by use of a computer-generated randomisation schedule at

14 with the alternative diastereoisomer formed by use of a deuterium blocking group.

15 ries, patients were randomly assigned (1:1), by use of a dynamic hierarchical randomisation scheme, t

16 rated with an in-plane charge current simply by use of a FM/NM bilayer with magnetization collinear t

17 sal nerve analysis by 2 masked observers and by use of a fully automated method; wide-field mosaics o

18 reducing depression at the population level by use of a fully automatised system with the potential

19 tial identification of the bacterial species by use of a kmer-based approach.

20 t week 5 of each medication period, analysed by use of a linear mixed-effect regression model.

21 By use of a macrocyclic phosphinite pincer ligand and bu

22 d traffic-related injuries for 166 countries by use of a macroeconomic model that accounts for the ef

23 UBD was identified by use of a MAPPIT (mammalian protein-protein interactio

24 e quantify the likelihood of this phenomenon by use of a mathematical model parametrised with combina

25 al carcinoma in situ were randomly assigned, by use of a minimisation algorithm, to tumour bed boost

26 on a modified intention-to-treat population by use of a mixed-effect model for repeated measures.

27 ents were classified as core or supplemental by use of a modified Delphi process.

28 In another set of experiments, in this case by use of a modified Synapt G2-S QTOF mass spectrometer

29 By use of a more clinically relevant protocol, 0.3 or 1

30 aracteristics of the tumour microenvironment by use of a NanoString RNA assay, which might provide pr

31 By use of a narrative analysis that combined approaches

32 We explain these observations by use of a new self consistent kinetic Monte Carlo mode

33 itrate intake from vegetables was calculated by use of a newly developed comprehensive database.

34 By use of a noncovalent double mutant (T790M/L858R and T

35 By use of a novel human repetitive nasal allergen challe

36 Data were collected by use of a patient questionnaire and primary care and h

37 we demonstrate native LESA mass spectrometry by use of a Q Exactive UHMR Hybrid Quadrupole-Orbitrap (

38 lus education or education-only intervention by use of a random number generator from a fixed seed.

39 Allocation concealment was achieved by use of a randomisation schedule that required scratch

40 r actual weight (if known) or saline placebo by use of a real-time, dynamic, internet-based, stratifi

41 By use of a reliable enzymatic assay together with X-ray

42 ries, we estimated LBW prevalence and trends by use of a restricted maximum likelihood approach with

43 standard ACLS treatment on hospital arrival by use of a secure schedule generated with permuted bloc

44 Participants were allocated in a 1:1 ratio by use of a secure web-based computer-generated randomis

45 modulate cytokine receptor signaling output by use of a series of designed C2-symmetric cytokine mim

46 uncertainty, which is not readily explained by use of a simple prior favouring peripheral locations.

47 types allows the testing of T-cell responses by use of a simple, approachable technique and points to

48 pK52 cells but made the reactivation of KSHV by use of a small amount of the reactivator (doxycycline

49 the effect of hospital competition (measured by use of a spatial competition index [SCI], with a scor

50 e levels of and trends in neonatal mortality by use of a statistical model that can be used to assess

51 on for >/=24 h) were randomly assigned (1:1) by use of a stratified block randomisation via restricte

52 By use of a structure-based computational method for ide

53 By use of a suitably synthesized 3D point spread functio

54 Women were actively followed up by use of a telephone call once every 3 months, and a mo

55 structured interviews were conducted, guided by use of a topic guide developed with input from patien

56 togenerated oxygen was measured in real-time by use of a two-electrode cell design.

57 and back-extraction procedures are optimized by use of a two-step multivariate optimization strategy.

58 Random assignment was done by use of a web-based automated randomisation system, st

59 Patients were randomly assigned (1:1) by use of a web-based randomisation service to receive e

60 andomisation was done by local investigators by use of a web-based software with random blocks accord

61 Randomisation was done by use of a web-based system and was stratified (block s

62 complexes across the periods of TM elements, by use of ab initio valence-bond theory.

63 This risk is neither mitigated nor inflated by use of acetaminophen.

64 racted from aged oil sands-influenced waters by use of acid precipitation, and the mixture was fracti

65 g well-shielded special nuclear materials is by use of active interrogation using an external radiati

66 acquisition and infections were not impacted by use of active surveillance and Contact Precautions in

67 esity, socioeconomic status, and time period by use of age-period-cohort modelling.

68 r may have a bigger benefit than that gained by use of an active compound vs a placebo.

69 pulses can be reconstructed in a single shot by use of an angle-multiplexed spatial-spectral interfer

70 field mosaics of subbasal nerve architecture by use of an automated method; and ocular surface touch

71 ed 1:1 to undergo PCI or a placebo procedure by use of an automated online randomisation tool.

72 risks of rotavirus vaccination were modelled by use of an Excel-based static cohort model with a fine

73 By use of an excess amount of ketene, a distinct reactio

74 By use of an in vivo expression technology (IVET)-based

75 acial BSA were randomly assigned (1:1:1:1:1) by use of an interactive response technology system to r

76 By use of an interactive response technology using fixed

77 , and anatomic site (pleural vs peritoneal), by use of an interactive voice or web system, to receive

78 igned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response

79 Randomisation (1:1) was done by use of an interactive voice-response system and was s

80 n 50 years to groups (1:1) in blocks of four by use of an interactive web portal; these groups were a

81 Patients were randomly assigned (1:1) by use of an interactive web response system to subcutan

82 Participants were randomly assigned (1:1) by use of an interactive web-response system, stratified

83 Participants were randomly assigned (1:1) by use of an interactive web-response system, with strat

84 s to quantitative measurements was evaluated by use of an iodine clock reaction to quantify ascorbic

85 ere diagnosed with a major motility disorder by use of an STM than with SWS in the development set (3

86 nces in chemical exchange rates are measured by use of an unstructured reporter peptide, YPI.

87 nt for ophthalmologists was primarily driven by use of anti-vascular endothelial growth factor (anti-

88 tion perovskite thin films are normally made by use of antisolvent protocols.

89 country-reported trends in birthweight data by use of B-spline regression.

90 changes in the autophagic flux (as assessed by use of bafilomycin A1) occurred either when TPC1 or T

91 ly 31, 2017, 3615 child deaths were recorded by use of biannual house-to-house censuses, and verbal a

92 ted from Cox models and internally validated by use of bootstrap and cross-validation.

93 tigated the trafficking properties of GPRC6A by use of both a classical antibody feeding internalizat

94 Analysis of the IRES region in vitro by use of both the TCV gRNA and reporter constructs did

95 n all plants) is alleviated in some lineages by use of carbon-concentrating-mechanisms, such as the C

96 high prevalence among PLHIV) by age and sex by use of case-finding algorithms.

97 hts into mechanisms of disease brought about by use of catalytic DNA in vitro and in vivo, including

98 oxicities, compared to materials synthesized by use of chemical methods.

99 of this concept when considering risks posed by uses of chemicals, and provide examples of how functi

100 the global temperature perturbation induced by use of coal to generate an equivalent amount of elect

101 chanism for overcoming neutralization escape by use of cocktails of cross-neutralizing monoclonal ant

102 uhoun, Burkina Faso, were randomly allocated by use of computer generated pseudo-random numbers, and

103 nd cognitive deficits were randomly assigned by use of computer-based allocation to receive 6 weeks o

104 ere randomly assigned (2:1), with allocation by use of computer-generated random permuted blocks of s

105 method; and ocular surface touch sensitivity by use of contact esthesiometry.

106 Mass spectrometry imaging by use of continuous-flow liquid microjunction sampling

107 ed projections were made at the county level by use of current levels of and trends in neonatal morta

108 e assessed changes in rotavirus epidemiology by use of data from eight active surveillance hospitals.

109 , comparative interrupted time-series design by use of data on RTAs and alcohol consumption in Scotla

110 By use of data-dependent product ion scans, multiple dru

111 By use of density functional theory calculations and mol

112 ys in which the OEEF effects can be mimicked by use of (designed) local-electric fields (LEFs), i.e.,

113 and increase sensitivity of detection mainly by using of different assay formats, immobilization stra

114 min(-1) in a N2 atmosphere and characterized by use of differential scanning calorimetry (DSC) and th

115 ong MSM relative to adult men was calculated by use of direct age-stratification.

116 eous setting can be facilitated tremendously by use of DNP-enhanced solid-state NMR spectroscopy.

117 fforts to intensify pharmacological blockade by use of dual inhibitors that interfere with the renin-

118 vities of daily living) or death up to 2025, by use of evidence-based age-specific, sex-specific, and

119 By use of exoglycosidase sequencing, in conjunction with

120 The neural networks are trained by use of experimental IC50 values collected in the CATN

121 pecific dropout rates and amplification bias by use of external RNA spike-ins.

122 By use of fast-scan cyclic voltammetry, CNT-coated niobi

123 hat n-3 polyunsaturated fatty acids (PUFAs), by use of fat-1 transgenic mice and oral administration

124 utcome was 3-year overall survival, analysed by use of flexible proportional mortality models, and we

125 rated into proteins for tracking and imaging by use of fluorogenic tetrazines that become strongly fl

126 istic regime in a single crystal of PdCoO(2) by use of focused ion beam (FIB) micro-machining, defini

127 Findings were tabulated or combined by use of forest plots (random-effects meta-analysis).

128 antibody assay using human complement (hSBA) by use of four meningococcal serogroup B test strains ex

129 es of the purified compounds were elucidated by use of FTMS and NMR.

130 RhoA, Rheb, and N-Ras, and can identify GEFs by use of GDP-bound forms.

131 We identified diagnostic events by use of general practitioners' records, hospital disch

132 hypofractionated whole breast radiotherapy, by use of generalised estimating equation models.

133 Diabetes was defined by use of glucose concentrations, self-report, or medica

134 trocatalytic oxygen evolution reaction (OER) by use of heterogeneous catalysts is highly desirable to

135 By use of Hg isotope tracers added in situ to the mesoco

136 the opposite transformation is also possible by use of high-power lasers.

137 This was achieved by use of high-resolution (c. 5 mum) synchrotron radiati

138 induce humoral and cellular immune responses by use of highly attenuated and safe vaccine backbones.

139 By use of HIV-negative patients as reference, the aOR of

140 constructed a molecular transmission network by use of HIV-TRAnsmission Cluster Engine (with a pairwi

141 By use of human and rat neuronal cell lines (SK-N-SH and

142 her deprotection of these isolated compounds by use of hydrochloric acid (12 N) in methanol afforded

143 from cardiac arrest to discharge, stratified by use of hydrocortisone, using a Japanese health-insura

144 By use of hydrogen/deuterium exchange and biochemical an

145 atment allocations, and masking was achieved by use of identical opaque capsules.

146 from phosphoproteins is commonly facilitated by use of immobilized anti-pY antibodies prior to phosph

147 wo groups (a milder and a more severe group) by use of impulse oscillometry and spirometry, which are

148 In this study, by use of in vivo imaging, we identified hydrogen peroxi

149 The strong link to a task paradigm provided by use of independent component analysis is a potential

150 rkers identified from the discovery analysis by use of independent immunoassays for each biomarker.

151 al in patients with hepatocellular carcinoma by use of individualised, preoperatively assessed charac

152 all interfering RNA transfection in vitro or by use of inhibitor of Wnt production in vivo led to an

153 er were enrolled and randomly assigned (1:1) by use of interactive responsive technology to intraveno

154 Incident AF was ascertained by use of International Classification of Diseases, Nint

155 dentified from the electronic medical record by use of International Classification of Diseases-9 bil

156 has greatly advanced, with rapid reperfusion by use of intravenous thrombolysis and endovascular thro

157 l and 5-year overall survival were estimated by use of Kaplan-Meier methods, and the 5-year cumulativ

158 d accurately identified to the species level by use of kmer comparisons and MLST.

159 Here we mitigate this problem by use of laser-induced post-ionization (MALDI-2) and by

160 erve density and subbasal nerve architecture by use of laser-scanning in vivo confocal microscopy; su

161 We developed a six-SNP-based classifier by use of LASSO Cox regression, based on the association

162 es built through geometry mismatch generated by use of ligand bend angles, twisted functional groups,

163 Then, by use of linear and logistic regression, we assessed co

164 In the past, unspecific elimination of ROS by use of low molecular mass antioxidant compounds was n

165 By use of MALDI-MS imaging (MSI) in combination with PNG

166 ease in risk of these adverse fetal outcomes by use of Mantel-Haenszel methods.

167 Sequence data are analysed by use of measurements of population diversity and diver

168 In summary, targeting PKR, including by use of metformin, is a promising therapeutic approach

169 enerated, permuted-block schedule stratified by use of methotrexate at baseline (0, >0 to <12.5 mg/we

170 or whom the presence of ND-CNVs was excluded by use of microarray results and also medical records wh

171 alised treatment pathways could be developed by use of miR-122, HMGB1, and full-length K18 at hospita

172 mokers was compared to that of never-smokers by use of mixed models adjusted for sociodemographic and

173 pendent suboptimal mutation incorporation or by use of mixed repair templates.

174 By use of moderate electrodeposition conditions such as

175 effects, and interactions were characterised by use of modified Poisson models and compared with and

176 tween Indigenous and non-Indigenous children by use of modified Poisson regression.

177 esults produced are practically inaccessible by use of multiple conventional isothermal irradiations.

178 By use of multivariate analysis, shift work (odds ratio

179 variables of interest with overall survival by use of multivariate Cox regression: MELD-sodium (MELD

180 ed and predictors of decline were identified by use of multivariate models.

181 The approach is introduced by use of myoglobin from four meats: beef, pork, horse a

182 f obesity prevalence by socioeconomic status by use of national health surveys done between 1998 and

183 We identified mortality by use of national Swedish registers.

184 dried blood spots and thin tissue sections, by use of native-like extraction/ionization solvents.

185 either heme, zinc, nor ethoxzolamide) simply by use of native-like LESA solvents.

186 mated the effect of the intervention on RTAs by use of negative binomial panel regression and on alco

187 Heartland (121-fold increase), likely driven by use of neonicotinoid seed treatments in corn and soyb

188 he treatment of generalised anxiety disorder by use of network analysis.

189 e assessed intrinsic tumour genomic features by use of next-generation DNA sequencing and characteris

190 tegies and population subgroups was compared by use of nonparametric tests.

191 Here, by use of novel and highly selective JNK inhibitors, we

192 Lightweighting of automobiles by use of novel low-cost, high strength-to-weight ratio

193 t loss can be maintained in some individuals by use of novel written material with occasional brief n

194 or guardians) were randomly assigned (1:1), by use of numbered sealed envelopes containing a randomi

195 ts and the study team were masked throughout by use of oat flour that was similar in look and feel to

196 es of four, six, and eight) with concealment by use of opaque, sequentially numbered, sealed envelope

197 46) collected stool samples and were grouped by use of opioid agonists (heroin, prescription opioids)

198 Randomisation was stratified by use of opioids for prostate cancer-related pain at sc

199 incident gastric cancer could be identified by use of our newly developed polygenic risk score.

200 , with the association at 0-14 days modified by use of P-gp inhibitors or substrates (interaction p-v

201 By use of PALICC PARDS definition, severity of PARDS at

202 By use of Parkinson's disease as a model condition, we s

203 By use of pdcd5 mutants, we here demonstrate that these

204 ients were randomly assigned (1:1) centrally by use of permuted blocks to receive induction therapy w

205 otocontrol over proteins of mammalian origin by use of photoswitches, visible light (typically), and

206 By use of physiologically-based pharmacokinetic modeling

207 ssociation with more-severe disease, defined by use of positive pressure ventilation (PPV), in infant

208 overdose crisis precipitated and exacerbated by use of prescription opioid medicines.

209 ectrum disorder were randomly assigned (1:1) by use of probabilistic minimisation, controlling for tr

210 Outcomes were compared by use of propensity score adjustment to account for bas

211 three users of other glucose-lowering drugs by use of propensity scores.

212 ChAdOx1 nCoV-19 group and many were reduced by use of prophylactic paracetamol, including pain, feel

213 the risk of subsequent disability worsening by use of proportional hazards models that included OCT

214 ltation on infection acquisition and outcome by use of proportionate morbidity ratios.

215 ee type-B ARR DNA-binding motifs, determined by use of protein-binding microarrays, were enriched at

216 By use of protocols that preserve proximal retinal neuro

217 class discrimination, was 100% as determined by use of quadratic discriminant analysis (QDA).

218 olyphosphate quantification can be shortened by use of Raman microscopy from days to hours and, addit

219 Trials Unit telephone randomisation service by use of random number generators.

220 ive pressure exerted on parasite populations by use of RDTs for diagnosis of symptomatic cases.

221 Detection was dramatically improved by use of real-time immuno-polymerase chain reaction (PC

222 urated phospholipids (PL) in tissue sections by use of refined matrix-assisted laser desorption ioniz

223 By use of regression analyses adjusted for demographics,

224 y our algorithm can subsequently be analyzed by use of relevant specialized software.

225 itive fluid balance, however, was attenuated by use of renal replacement therapy.

226 We recruited the study population by use of respondent-driven sampling and did the baselin

227 After stratifying by use of RGP lenses for orthokeratology, storing lenses

228 dicate that recurrence risk was not affected by use of rhTSH.

229 oRNAs, sensing of changes in the environment by use of riboswitches (RNAs that change shape in respon

230 neumonia case estimates prepared by WHO/MCEE by use of risk factor prevalence data from India.

231 itate single cell cultures that are achieved by use of ROCK (Rho kinase) inhibitors.

232 By use of routinely collected laboratory data from South

233 each 1 km(2) of the region from 2006 to 2012 by use of satellite data, land-use predictors, and meteo

234 Allocation concealment was implemented by use of sealed envelopes.

235 gression and on alcohol consumption outcomes by use of seasonal autoregressive integrated moving aver

236 indicators of quality (e.g., dietary fiber) by use of self-report or objective biomarkers of intake.

237 and researchers before assignments were made by use of sequentially numbered opaque envelopes.

238 s were followed up for a median of 22 months by use of serial systemic, ophthalmic, and imaging exami

239 Cancer cells break tissue barriers by use of small actin-rich membrane protrusions called i

240 study data were linked with Medicare claims by use of Social Security numbers.

241 e to compensate for any drift between images by use of software.

242 This instability may be controlled by use of solid/gas synthetic techniques that enable the

243 HICs, MICs, and LICs across five continents by use of standardised approaches.

244 assessed as prespecified secondary outcomes by use of standardised tests at baseline and months 6, 1

245 n-like components can be desorbed and eluted by use of stepwise elution as progressively greater pH v

246 By use of stillbirths as cases and a sample of matched l

247 mber of GPCR drugs that have been discovered by use of structural information that are in clinical de

248 this decomposition pathway can be inhibited by use of substrates in which the olefin bears a beta-me

249 By use of survey data from Australians aged 14 years and

250 By use of survival models, the estimated risk of repeat

251 facts, validated for tetranucleotide repeats by use of synthetic constructs of fixed, known length.

252 By use of synthetic oligomannoside model compounds, we d

253 By use of the 2018 definition, 96 (76%) of 126 cases of

254 734), on cognitive function at 24 mo of age by use of the Bayley scales of infant and toddler develo

255 action was achieved directly on the filament by use of the carburized filaments.

256 By use of the CLK family as a model, structural and bioc

257 tinine clearance of 30-69 mL/min (calculated by use of the Cockcroft-Gault equation) or Cumulative Il

258 By use of the cumulative incidence, we estimated 5- and

259 Generation of PK profiles by use of the device was initially performed with fluore

260 nation with switching at <=2.6 V is achieved by use of the extraordinary 2.1 eV conduction band offse

261 The more generalized concept is demonstrated by use of the Fc(0/+) (Fc = ferrocene) reversible proces

262 ata are reported as pooled odds ratios (ORs) by use of the generic inverse variance method with the u

263 st per test result returned was approximated by use of the Global Fund's total cost of ownership esti

264 nsistent with empirical potencies determined by use of the H4IIE-luc transactivation bioassay.

265 mical exchange correction factor, determined by use of the HX data from the reporter peptide, is then

266 isolate (WPI) and zein in healthy volunteers by use of the naso-ileal intubation method, which allows

267 or COVID-19 diagnosis and hospital admission by use of the NRTIs tenofovir disoproxil fumarate (TDF)/

268 nd, the modulation of endocannabinoid levels by use of the phytocannabinoid cannabidiol and selective

269 of precise dental restoration is achievable by use of the proposed method.

270 ominal and femoral ATBF were studied in vivo by use of the radioactive xenon washout technique after

271 red to that of reference broth microdilution by use of the revised breakpoints.

272 s of ASCVD before enrollment in the registry by use of the SAFEHEART risk equation, the modified Fram

273 7 mutants in this codon range were evaluated by use of the same recombinant phenotyping system and ex

274 This notion is further supported by use of the same treatments-cognitive behavioral thera

275 By use of the six factors regarding surgical technique a

276 (123)I-ABC577 binding was quantified by use of the standardized uptake value ratio, which was

277 ting in 82 cases, including positive results by use of the STTTA, PCR, or culture or positive results

278 t least one of the tiers and 6 were positive by use of the STTTA.

279 ks per week over the past 30 days at week 24 by use of the timeline followback method, assessed in th

280 placebo (ETD -1.1%, -1.2 to -0.9; p<0.0001) by use of the treatment policy estimand.

281 By use of the trial product estimand, oral semaglutide h

282 By use of the trial product estimand, weight loss at wee

283 Furthermore, by use of the triple-color total internal reflection flu

284 By use of the tryptophan (Trp) analog probe 2,7-diaza-tr

285 ng new class of near-infrared devices where, by use of the unusual band structure properties of GaAsB

286 partial, or complete response, were assessed by use of the urticaria activity score, physician and pa

287 kage for depression with usual care enhanced by use of the WHO Mental Health Gap Action Programme int

288 -80 (human intestinal) cells were determined by use of the xCELLigence real time cell analyzer.

289 bimetallic nanoparticles (BNPs), synthesized by use of this "green" method, were evaluated for cytoto

290 ul scope, is demonstrated for the first time by use of this catalyst, and is competitive with the mos

291 By use of this information, the structure-activity relat

292 siological) and six clusters of risk factors by use of three inputs: risk factor exposure, relative r

293 By use of trio sequence data, we identified diagnostic g

294 dnexal masses have been classified as benign by use of ultrasonography.

295 ement of adnexal masses classified as benign by use of ultrasound.

296 ean OR door opening frequencies and SSI risk by use of uni- and multivariable Cox regression models.

297 icient protocols discussed herein are marked by use of UVA LEDs (365 nm), which have reduced the reac

298 us among harbor seals of northwestern Europe by use of various samples collected during the outbreak.

299 t, we increased SIRT1 levels directly in NAc by use of viral-mediated gene transfer and observed an i

300 By use of WES of the fetuses and parents (parent-fetus t