ライフサイエンスコーパス: by which

1 Here, we examine the mechanisms by which a cargo-bound inner coat layer recruits and is

2 th nutrient availability, but the mechanisms by which a cell responds to fluctuations in acetyl-CoA l

3 ere, we unravelled the full mechanistic path by which a climatic driver, the Atlantic trade winds, de

4 Here, we investigated the mechanisms by which a destabilizing HA mutation, Y17H (activation p

5 lar pathophysiology, and provide a mechanism by which a single receptor can exhibit a binary biochemi

6 Today, the mechanisms by which AA is reduced during roasting remain unclear.

7 However, the mechanisms by which Abeta affects sleep are unknown.

8 ng to neuronal damage, underlying mechanisms by which Abeta modulates Cx43 in astrocytes remain elusi

9 However, the molecular mechanisms by which activation of defence reduces growth are not ye

10 iry from neuronal to neuron-glial mechanisms by which activity and experience modulate circuit struct

11 drogenase A (LDHA), establishing a mechanism by which AHR regulates lactate and UMP production in MYC

12 These findings identify a novel mechanism by which alcohol induces TGFbeta1 in the lung.

13 he fusion kinase NPM1-ALK, but the mechanism by which ALK overactivity drives toxicity upon TKI withd

14 lial hemiplegic migraine, but the mechanisms by which alpha2-Na/K ATPase mutations lead to the migrai

15 of vesicular SOCS3 secretion as a mechanism by which AMs restrain allergic inflammatory responses in

16 microbiota in children with JIA; mechanisms by which an altered microbiota at birth and later on in

17 Our results uncover a mechanism by which an enteric pathogen subverts repair processes b

18 The exact mechanism by which an environmental stimulus to skin results in lo

19 These data provide direct mechanisms by which an MHC-II SE contributes to expression of the l

20 We describe a framework by which an understanding of the processes that promote

21 The molecular mechanisms by which animals integrate external stimuli with interna

22 Here, we describe the two-phase process by which antigen drives the generation of long-lived pla

23 latively less consideration of the processes by which anxious youth make avoidant decisions and how t

24 Finding and targeting the factors by which APOE and its variants influence Alzheimer's dis

25 One process by which astrocytes modulate homeostasis is the release

26 ively, our study uncovered a novel mechanism by which AtPRMT3 cooperates with RPS2B to facilitate the

27 The mechanism by which ATR signals that its cofactor cargo is ready (A

28 These findings define a novel mechanism by which autophagy regulates neuronal activity: control

29 The study results reveal a novel mechanism by which bacteria alter mood.

30 By understanding the mechanisms by which bacteria promote animal metamorphosis, we begin

31 advance our understanding of the mechanisms by which bacterial nucleic acids traffic extracellularly

32 This method provides a means by which bacterial redox systems can be exploited to gen

33 To begin to understand the mechanism by which beta-arr1 together with STAM1 activates FAK, we

34 ings also uncover a new pathogenic mechanism by which beta-catenin promotes podocyte injury and prote

35 Despite much work, the mechanisms by which bnAbs emerge remain uncertain.

36 ameter, interpretable as the "linking rate," by which bound TFs interact with Mediator components, en

37 ecent advances in elucidating the mechanisms by which BRCA1-BARD1 functions in DNA repair, replicatio

38 n together, these results reveal a mechanism by which BRD4 inhibition suppresses tumor growth, and su

39 In particular, the molecular basis by which Ca(2+) binding affects structure and enhances t

40 big data to elucidate the molecular networks by which cancer develops.

41 This supports a model by which Cav1 is a central regulatory hub for tumor-stro

42 Investigation of the mechanism by which CD82 promotes AML survival in response to chemo

43 The mechanism(s) by which cell-tethered mucins modulate infection by infl

44 However, there are many other ways by which cells can communicate with each other.

45 Mechanotransduction is the process by which cells convert physical forces into electrochemi

46 , apoptosis is an important innate mechanism by which cells counter viruses at local sites of infecti

47 Durotaxis, the process by which cells follow gradients of extracellular mechani

48 ation is a secondary developmental programme by which cells in the subapical stolon region divide and

49 ork describes a simple biophysical mechanism by which cellular proteostasis adapts to meet the needs

50 The mineralization mechanism by which cellulosic, keratinous, and silk tissues fossil

51 The mechanisms by which certain ART agents differentially contribute to

52 It also points to a mechanism by which changes in flowering phenology can affect plant

53 The mechanism by which changes in O(2) tension modulate ion channels h

54 mental data, reveal processes and mechanisms by which chemical species (cations, peptides, lipids, li

55 Elucidating the mechanisms by which CHIKV subverts antiviral immunity to establish

56 identified a potential allosteric mechanism by which cholesterol binding regulates the conformation

57 d liver of cachectic, suggesting a mechanism by which chronic IL-1R signaling could be leading to cac

58 Understanding the mechanisms by which cis-regulatory element turnover generate emerge

59 nd analysis to demonstrate a novel mechanism by which cocaine potency is determined in vivo These stu

60 ecedented insight into some of the processes by which cognition evolves.

61 n and chromosome organization, the mechanism by which cohesin rings are loaded onto DNA is still unkn

62 tions and summarize the molecular mechanisms by which commensal microbes act on hosts and arboviruses

63 Equipped with a mechanism by which complex information can be rapidly relayed thro

64 Characterizing the mechanisms by which coronavirus infection dictates pathogenesis or

65 Here we elucidate the mechanism by which CXCR4 inhibition affects the tumor immune micro

66 Our results demonstrate a novel mechanism by which cystic epithelial cells stimulate myofibroblast

67 an evolutionarily conserved cellular process by which cytoplasmic contents are targeted for lysosomal

68 The findings delineate mechanisms by which decreased hepatocyte autophagy promotes IL-1bet

69 We further aim to explore the mechanisms by which disease perturbations could cause changes in sp

70 isease pathogenesis; however, the mechanisms by which disrupted NCT causes neurodegeneration remain u

71 hanges in mGlu5 signaling may be a mechanism by which disruptions in negative-outcome updating emerge

72 s presents a relatively unexplored mechanism by which diversity could emerge.

73 her subnetworks represented separate streams by which DMN couples with other canonical large-scale ne

74 eport a previously uncharacterized mechanism by which DNMT3A loss confers increased fitness to HSCs b

75 echanism of chemotherapy-mediated metastasis by which drug-induced upregulation of sEV secretion and

76 molecule analyses, we examined the mechanism by which E449K activates Int for gp3-independent attL x

77 To better understand the mechanism by which each complex distinctly modulates Hippo kinase

78 The channels by which early state capacity leads to greater social ca

79 Here, we investigated the mechanism by which ECT2 engages UBF1 on rDNA promoters.

80 Here we sought to characterize the mechanism by which EHD1 couples with SNX17 to regulate recycling o

81 However, the mechanism by which EHD1 is coupled to various receptors and regula

82 xis is a novel and conserved paracrine means by which EMT cells enhance metastasis, and provides pote

83 isparate habitats is a fundamental mechanism by which energy, nutrients, and biomass are transported

84 ging in mice to assess the temporal dynamics by which ensembles of vCA1 neurons mediate encoding and

85 However, the underlying mechanism by which ethanol causes toxicity in muscle is poorly und

86 spite the fact that this reveals a mechanism by which evolution could drive a pathogen to colonize ne

87 However, the processes by which evolution repurposes or re-engineers host and p

88 e is limited understanding of the mechanisms by which experience drives circuit reorganization to est

89 s an excellent model to study the mechanisms by which extracellular matrix macromolecules control col

90 Probing the neural mechanisms by which features become bound into meaningful episodes

91 However, the mechanism by which FlrC regulates transcription is not fully eluci

92 To investigate the mechanism by which FOP-ACVR1 enhances pSmad1/5 activation, we used

93 We describe an alternative view by which forebrain signaling in cortex driving cognition

94 In this study, we investigate the mechanism by which formin-2 (FMN2) orchestrates the initial moveme

95 The mechanisms by which G-quadruplexes transition from one folded confo

96 This study provides a mechanism by which GRK4, via regulation of renal ETBR function, pa

97 ses various HA receptor subtypes, mechanisms by which HA modulates NAc circuit dynamics are undefined

98 Elucidating the mechanisms by which HCMV stimulates monocyte survival is an importa

99 s residues that play roles in the mechanisms by which heat, mechanical stretch, and pharmacological m

100 However, the mechanism by which HFD/obesity induces chondrocyte apoptosis is no

101 ooth eruption is a unique biological process by which highly mineralized tissues emerge into the oute

102 Next, we discuss mechanisms by which histone variants influence chromatin properties

103 activation in metabolic control and a model by which hnRNPs can impact health and disease states.

104 inspired researchers to rethink the process by which horses were first domesticated and then diversi

105 , highlighting a novel "bottom-up" mechanism by which host diet can impact both pathogen and host fit

106 n some gliomas(1-5); however, the mechanisms by which hypermutation develops and whether it predicts

107 For example, the mechanisms by which i) nanoscale materials can improve targeting an

108 These results demonstrate mechanisms by which IDL improves skin hydration and epidermal barri

109 These findings demonstrate a novel mechanism by which IFN-I regulate immunological memory and provide

110 -driven effects, but the molecular mechanism by which IL-17A regulates IkappaBzeta expression is not

111 anding the molecular and cellular mechanisms by which increased pressure promotes GBM invasiveness ma

112 ve begun to uncover the molecular mechanisms by which inflammation - driven by Toll-like receptor 4-r

113 e inflammatory mediators, and the mechanisms by which inflammation may inhibit immunity.

114 mergence of hypertension, yet the mechanisms by which inflammatory mediators contribute to this dysfu

115 reasingly apparent, and the insidious manner by which interbacterial toxins disarm their targets emph

116 e discovered a novel osmosensitive mechanism by which intron 1 positively mediates glutamine syntheta

117 in lung injury resolution and the mechanisms by which it regulates angiogenesis remain unclear.

118 The mechanisms by which LLTS affect the central neural circuits within

119 ic for proinsulin, we studied the mechanisms by which LNSC regulate low-avidity autoreactive cells in

120 However, the mechanism by which m-Tyr damages cells is unclear.

121 However, the mechanisms by which major histocompatibility complex-associated gen

122 ciliary clearance, the physiological process by which mammalian conducting airways expel pathogens an

123 ith domestication via the commensal pathway, by which many common examples of animal domestication ar

124 Spin Hall effect (SHE), a mechanism by which materials convert a charge current into a spin

125 The mechanism by which maternal obesity influences fetal brain develop

126 tes nuclear mechanotransduction, the process by which mechanical signals and forces are transmitted a

127 Our study elucidates the mechanism by which meiotic cells modulate their kinetochore compos

128 ation is emerging as the universal mechanism by which membraneless cellular granules form.

129 These results highlight the mechanisms by which memories are used to prepare for upcoming atten

130 n the form of NADH as an important mechanism by which metabolic activity modulates inflammatory signa

131 Yet, the molecular mechanisms by which METH causes neurodevelopmental defects have rem

132 However, the mechanism by which METTL2 identifies specific tRNA arginine specie

133 t and clinical course of IBD, and strategies by which microbiome-based therapies can be used to preve

134 The mechanisms by which microbiomes impact on cancers can yield new dia

135 excreted metabolites represents a mechanism by which microbiomes with beneficial effects on host gro

136 The means by which microhomologies are identified is thus a critic

137 le of mitochondria in cancer, the mechanisms by which mitochondrial Ca(2+) (mtCa(2+)) regulates tumor

138 Our findings provide a mechanism by which mnemonic prediction errors may drive memory upd

139 ence of signal 4 and the specific mechanisms by which MoAPC-Trm interactions affect the long-term mai

140 r MALT1 monoubiquitination and the mechanism by which monoubiquitination activates MALT1 had remained

141 The mechanisms by which morphogens spread through a tissue to establish

142 However, the molecular mechanisms by which mucus affords this protection are unclear.

143 The mechanisms by which mutant huntingtin (mHTT) leads to neuronal cell

144 altered splicing might be a common mechanism by which mutations cause disease.

145 ata suggest a possible disassembly mechanism by which N-terminal ubiquitination and the proteasome ma

146 represents a potentially important mechanism by which nanoparticles induce biological effects, as the

147 The mechanism by which netropsin binds to hairpin DNA remains controve

148 ltogether, these data reveal an unusual mode by which neuroligin splicing controls synapse developmen

149 The regulatory mechanisms by which neurons coordinate their physiology and connect

150 Until now, the mechanism by which NIS transports different anion substrates with

151 k provides novel insight into the mechanisms by which nitric oxide, which is produced in hepatocytes

152 However, the molecular mechanisms by which NLRP6 function is inhibited to prevent excessiv

153 on have been studied, the complete mechanism by which NS1 antagonizes RIG-I signaling remains unclear

154 However, the mechanisms by which NUCKS1 positively impacts these processes had r

155 In order to unravel the mechanisms by which nucleosomes can influence, or be altered by, DN

156 The mechanisms by which obesity and hypertension may synergistically in

157 eption may be an important circuit mechanism by which octopamine modulates behavior.

158 The molecular mechanisms by which one ancestral rDNA set is selected for silencin

159 SPSTF recommendations and proposes a process by which others may be considered for primary care preve

160 ctively, this work defines a novel mechanism by which p190A and E-cadherin cooperate in modulating Hi

161 ctively, our study reveals a novel mechanism by which PCH1 and PCHL regulate diverse light responses

162 However the mechanisms by which periodontal pathogens influence the development

163 findings provide insight into the mechanisms by which PGE(2) promotes tumor development and progressi

164 netic accommodation, an evolutionary process by which phenotypic flexibility in response to environme

165 The mechanisms by which phlebotomy promotes the mobilization of hepatic

166 spite its apparent importance, the principle by which plant stems respond to vertical loading forces

167 The mechanisms by which plants coordinately respond to distinct levels

168 The molecular mechanism by which plants defend against plant root-knot nematodes

169 hat sensing of iron depletion is a mechanism by which plants recognize a pathogen threat.

170 However, the mechanisms by which plants sense temperature are not well understoo

171 have limited understanding of the mechanisms by which Plasmodium parasites induce CM.

172 Our study revealed a new mechanism by which platelets promote the metastasis of colon and b

173 s the complexity of the molecular mechanisms by which polymorphisms affect diseases.

174 etween 2-5 Hz and 5-9 Hz theta oscillations, by which power increases in 2-5 Hz oscillations were uni

175 se findings provide evidence for a mechanism by which PPARalpha attenuates hepatic inflammasome activ

176 Nonetheless, the mechanism by which PRC2 engages with native-like chromatin remains

177 cted to play a direct role in the mechanisms by which proteins target and interact with LDs.

178 However, the molecular mechanism by which proteoglycans regulate signal transduction is l

179 se of this study was to elucidate mechanisms by which PXN affects cancer growth and progression, whic

180 However, the mechanisms by which Rab27 contributes to airway inflammation and cy

181 The underlying ionic mechanisms by which reduced Na(v) availability in Fhf2 knockout (Fh

182 dings point to a dedifferentiation mechanism by which reprogramming transcription factors Oct4 and So

183 ew information has emerged on the mechanisms by which RGS proteins modulate the efficacy of opioid an

184 responsible for RIT removal, and the pathway by which RITs reach these cells, we studied SS1P, a 63-k

185 action but failed to fully explain the means by which s(2)C(32) restricts I(34) wobbling.

186 ork with SARS-CoV-2 yet study the mechanisms by which SARS-CoV-2 enters and exits human cells.

187 up to the task of deciphering the mechanisms by which SARS-CoV-2 induces the multisystem and multiorg

188 Our results reveal a mechanism by which satellite repeats regulate global gene expressi

189 lamic neurons, providing a circuit substrate by which SCN(VIP) neurons may regulate LMA rhythms.

190 The mechanisms by which SCN8A variants lead to epilepsy are poorly unde

191 We sought to determine the extent by which selecting only one fit limits the biological fe

192 in semaphorin biology, providing a mechanism by which Sema6s may balance cis and trans functionalitie

193 roduce the parameter of dissipation capacity by which several sizes of liposome and DNA structures we

194 during mitosis and illuminates the mechanism by which signaling enzymes regulate this process at a di

195 al populations act as pacemakers, and if so, by which signalling mechanisms, and finally the nature o

196 Our findings revealed a novel mechanism by which SLB1 targets BS1 for degradation to regulate M.

197 Our findings demonstrate a mechanism by which smaller copy number variations, not including t

198 ge tracing mouse to understand the mechanism by which SMC phenotypic transitions affect lesion pathog

199 efore lack a consolidation of the mechanisms by which sociality impacts reproduction.

200 in spacer adaptation and reveal a mechanism by which spacer orientation is defined in E. coli.

201 A and cortical dynein, the precise mechanism by which spindles detect and align with the long cell ax

202 ve affective states; however, the mechanisms by which stress increases amygdala-dmPFC synaptic streng

203 Identifying mechanisms by which stress regulates attention may guide the develo

204 ata included age of the subject, and the age by which subjects initiated brushing habits, and the typ

205 The mechanisms by which such elements work are largely unknown.

206 eurotransmitter switching provides the basis by which sustained running benefits motor skill learning

207 high-resolution constraints on the processes by which swarms initiate, grow, and arrest.

208 nt conditions to delineate a novel mechanism by which Synaptotagmin-1 and Complexin act synergistical

209 ology in LF pathogenesis, but the mechanisms by which T cells influence disease severity and outcome

210 results demonstrate a wholly novel mechanism by which T-helper (T(H) ) polarization is governed and p

211 ics and facilitate to uncover the mechanisms by which TARPs modulate the receptor.

212 However, the exact mechanisms by which TBC1D23 regulates cargo transport are poorly un

213 The molecular mechanism by which TCF21 regulates SMC phenotype is not known.

214 nd KIT and the widespread copy number events by which TGCT is characterised.

215 er migration and invasion, but the mechanism by which TGF-beta signaling converts into cell motility

216 However, the mechanisms by which the activation of SARM1 is stringently controll

217 We then consider mechanisms by which the activity of multiple niche cell types may b

218 However, the mechanism by which the adiponectin signaling pathway attenuates co

219 Here, we describe a mechanism by which the ARF tumor suppressor binds PPM1G to negativ

220 is well established; however, the mechanisms by which the background interacts with Mendelian loci re

221 licated findings illuminate the computations by which the brain decides to imitate or emulate others.

222 s identify a frontostriatal neural mechanism by which the brain may untangle the 'curse of dimensiona

223 ur results help to understand the mechanisms by which the brain merges auditory and visual speech int

224 r shape and human pathologies, the mechanism by which the cancer nucleus becomes misshapen is not ful

225 er a previously unknown regulatory mechanism by which the catalytic activity of OTUD3 is tightly cont

226 The mechanisms by which the cerebellum impacts seizures, however, are u

227 tion, with a specific focus on the mechanism by which the cytosolic C terminus of the synaptic cell a

228 cell-intrinsic epigenetic feedback mechanism by which the duration of the transcriptional response to

229 advance our understanding of the mechanisms by which the early synergism between antibody-mediated t

230 These findings suggest mechanisms by which the enigmatic cytokine IL-17F contributes to ho

231 The mechanisms by which the environment, including high-altitude, heat,

232 Altogether, we identified a mechanism by which the host scales immune responses according to f

233 Here, we uncover a novel mechanism by which the human papillomavirus (HPV) inhibits the act

234 These data suggest a mechanism by which the hydroxylase is tuned for converting hispidi

235 Here, we discuss potential mechanisms by which the immune system affects the central nervous s

236 repair have been identified, the mechanisms by which the injured liver maintains vital functions pri

237 Here, we describe a mechanism by which the innate immune system allows rapid quality c

238 tein engineering, we explicate the mechanism by which the intrinsically unstructured N-terminal trans

239 he central nervous system, but the mechanism by which the membrane-bound Nogo-A is presented intercel

240 Furthermore, we delineate the mechanism by which the mitochondria, through MUL1 ligase, can inhi

241 wake mice, pointing to a potential mechanism by which the olfactory cortex can actively and dynamical

242 However, the molecular mechanism by which the OX40 cosignaling regulates the T-cell respo

243 y-dependent enhancement (ADE) is a mechanism by which the pathogenesis of certain viral infections is

244 vivo These studies identify a novel process by which the pharmacodynamics of cocaine are derived in

245 Image-based profiling is a maturing strategy by which the rich information present in biological imag

246 ressure substantially, providing a mechanism by which the RVLM could contribute chronically to cardio

247 These findings define a mechanism by which the same signaling pathway promotes both autono

248 The reaction mechanism by which the shelterin protein POT1 (Protection of Telom

249 ):water pretreatment and provide a mechanism by which the solvent components drive efficient biomass

250 outsourcing of malonyl-CoA may be a strategy by which the soma communicates nutritional status to the

251 However, the mechanism by which the UBQLN2 mutations cause disease remains uncl

252 We investigated the mechanisms by which the Western diet promotes tumor recurrence, inc

253 -producing bacteria; however, the mechanisms by which these cells evade the deleterious effects of CD

254 ospholipid bilayers; however, the mechanisms by which these changes happen are still largely unknown.

255 The mechanism by which these different groups are added to the ascaros

256 ivity(3-5); however, the molecular mechanism by which these fibroblasts differentiate and expand is u

257 The mechanisms by which these immune cells converge on target tissues,

258 Here we determine the pathway by which these metabolites disrupt DNA repair.

259 However, the mechanism by which these small RNAs inhibit translation has yet to

260 The population genetic processes by which these traits evolve are complex, in part due to

261 S effects across subjects supporting a model by which theta oscillations are excitatory to neural act

262 model solution to understand the mechanisms by which they are involved in haze formation.

263 ave been extensively studied, the mechanisms by which they damage the central immune organs have rare

264 the specific pathways and downstream targets by which they exert their tumorigenic effects remain elu

265 ejection fraction (HFrEF), but the mechanism by which they improve outcomes remains unclear.

266 physical interactions, molecular mechanisms by which they interact are not clear.

267 na is assembled, and the distinct mechanisms by which they regulate dendritic growth to generate thei

268 d CEnC death, and to elucidate the mechanism by which this cytoprotection occurs.

269 ovide evidence of an informational mechanism by which this early investment in infrastructural capaci

270 daily anthropogenic life, and the processes by which this fixation occurs have been a longstanding a

271 g features of a stimulus, yet the mechanisms by which this integration occurs are not fully understoo

272 Mechanisms by which this is accomplished include AR amplification a

273 We also focus on the processes by which this microbiota-immune-stress matrix may influe

274 findings that have revealed a new mechanism by which this molecule influences dynein-mediated transp

275 ing their account to illuminate the dynamics by which this occurs, and in particular, to shed light o

276 ion-but little is known about the mechanisms by which this occurs.

277 duced inhibition of contraction, a mechanism by which those channels in smooth muscle are thought to

278 lexes, and provide insight into the pathways by which those complexes assemble.

279 orce of infection increased through age 3 y, by which time 65% (95% CI: 53%, 75%) of children were SE

280 Together, our results support a model by which Tip60 protects against neurological impairments

281 ients and in mouse models, but the mechanism by which TLR signaling to self-ligands is regulated rema

282 nd neural plasticity; however, the mechanism by which TNFalpha signaling contributes to the developme

283 afish is the lack of a cost-effective method by which to identify mutants.

284 Here we explored the molecular mechanisms by which Trial 2 achieves the essential prolonged gene e

285 ikely identify novel proteins and mechanisms by which TRIM9 and TRIM67 regulate neuronal form and fun

286 acquire chromosomal alterations, a mechanism by which tumor cells evolve, adapt, and resist therapeut

287 epresents a previously unappreciated pathway by which type 3 immunity is modulated and immune-mediate

288 However, the neural mechanisms by which unattended, but future-relevant, information is

289 , although the detailed molecular mechanisms by which uncontrolled NRF2 activation promotes cancer pr

290 f response subspace and suggests a mechanism by which value-related signals are prevented from premat

291 l types/states, target genes, and mechanisms by which variants can cause diseases or alter phenotypic

292 characterization of the precise mechanism(s) by which various CI regulators modulate CI assembly.

293 They further provide a potential mechanism by which vascular interactions facilitate microglial col

294 Our goal was to identify effectors by which VEGF and anti-VEGF control the endothelial cell

295 Yet the mechanisms by which viable interneurons are produced from progenito

296 However, the mechanism by which virulence is regulated by PE synthesis is only

297 uires a detailed understanding of mechanisms by which viruses coopt vesicular trafficking.

298 these results provide a potential mechanism by which widely reported individual differences in forag

299 However, the mechanism by which WRN protects MSI-associated cancers from double

300 The exact signals by which YAP is activated are still not fully understood