ライフサイエンスコーパス: c-myc gene

1 in activating expression of the translocated c-myc gene.

2 far upstream element (FUSE) upstream of the c-myc gene.

3 yrimidine sequence in the P2 promoter of the c-myc gene.

4 C-rich strand from the promoter of the human c-MYC gene.

5 or more sites within 2.4 kb upstream of the c-myc gene.

6 ult in the transcriptional activation of the c-MYC gene.

7 ation at the first exon/intron border of the c-myc gene.

8 exes induced by the top2(S740W) in the human c-myc gene.

9 to restriction fragments from the germ-line c-myc gene.

10 om gain of chromosome 15, which contains the c-myc gene.

11 is a transcriptional repressor of the human c-myc gene.

12 ion factors for optimal transcription of the c-Myc gene.

13 single strand of DNA in the 5' region of the c-myc gene.

14 lies upstream of the key P1 promoter of the c-Myc gene.

15 lled at promoter-proximal pause sites of the c-myc gene.

16 approximately 820-bp promoter region of the c-myc gene.

17 nces within approximately 1,400 bp 5' to the c-myc gene.

18 istic increase in ERalpha recruitment to the c-Myc gene.

19 , with the promoter region of the endogenous c-myc gene.

20 fold greater than that of a known MAR in the c-myc gene.

21 epress the transcriptional elongation of the c-myc gene.

22 lastoma gene product and upregulation of the c-myc gene.

23 al stage-specific activation of translocated c-myc genes.

24 ctivating the transcription of cyclin D1 and c-Myc genes.

25 nce and in the promoter regions of bcl-2 and c-myc genes.

26 vealed common insertions in either notch1 or c-myc genes.

27 the E-responsive promoter regions of pS2 and c-myc genes.

28 roliferation via repression of cyclin D1 and c-myc genes.

29 (hnRNP) K is a transcription factor for the c- myc gene, a proto-oncogene critical for the regulatio

30 ental translocation region by insertion of a c-myc gene about 50 kb from the IgH intron enhancer in a

31 Herein, aspects of c-myc gene activation and the function of the c-Myc prot

32 d expression of c-Myc mRNA, caused either by c-myc gene amplification or by enhanced signaling via ST

33 um to induce transcription of the endogenous c-myc gene and cell entry into S phase.

34 e structural characterization of the chicken c-myc gene and have begun to investigate c-myc transcrip

35 an regulate the expression of the endogenous c-myc gene and is a potent activator of the c-myc promot

36 ew outlines the nature and regulation of the c-myc gene and of c-Myc and presents the systems and con

37 nce chromosomal translocations involving the c-myc gene and one of the Ig loci.

38 conserved enhancer cluster downstream of the c-Myc gene and super-enhancers flanking both Jun and Fos

39 forks diverge from an origin 5' to the human c-myc gene and that a 2.4-kb core fragment of the origin

40 mplex that binds to the MIF-1 element in the c-myc gene and the major histocompatibility complex clas

41 found to co-localize at the promoters of the c-myc gene and the RPPH1 sRNA in vivo.

42 ymphoma (BL) cell lines carry a translocated c-myc gene and, in 60-80% of cases, exhibit mutations in

43 ate a transcriptional block on the Cox-2 and c-myc genes and that this block may be a potential targe

44 g region of the progesterone-regulated avian c-myc gene, and nuclear matrix-like attachment sites fla

45 ing defects, lower levels of REF1/Aly at the c-myc gene, and nuclear retention of bulk HeLa poly(A)+

46 an chromosome 8q24), the map location of the c-Myc gene, and six of the tumors exhibited copy number

47 trains after proviral integration within the c-myc gene, and subsequent expansion of Myc-overexpressi

48 ickens after proviral integration within the c-Myc gene, and subsequent expansion of Myc-overexpressi

49 pt the regulation or expression level of the c-myc gene are among the most common found in human and

50 nslocations of the coding exons of the human c-myc gene are consistent features of human Burkitt lymp

51 stic morphology and overexpress the cellular c-MYC gene are highly aggressive and carry a very poor p

52 and tamoxifen at ER alpha-regulated pS2 and c-myc genes are in part mediated by HER-2/neu.

53 egulation of B-cell survival and confirm the c-myc gene as one of the downstream targets of A-myb in

54 thelial regression through the repression of c-myc gene at the chromatin level.

55 itt lymphomas (BL) and murine plasmacytomas, c-myc genes become juxtaposed to immunoglobulin heavy-ch

56 The c-myc gene becomes transcriptionally activated as a cons

57 nt, located in the 5'-flanking region of the c-myc gene, between nucleotides -1406 and -1387 (relativ

58 oma cell lines that do not have an amplified c-myc gene but differ in their p53 status, high c-myc le

59 f prostate tumors have amplifications of the c-Myc gene, but the precise role of c-Myc in prostate ca

60 Aid gene itself as well as in the bcl-6 and c-myc genes, but not in the p53 gene, consistent with ab

61 ossible mechanism for transactivation of the c-myc gene by mutant p53 is proposed.

62 king c-Myc activity due to disruption of the c-myc gene by targeted homologous recombination are defe

63 is involves direct promoter targeting of the c-myc gene by the complexes.

64 It is well established that Ha-ras and c-myc genes collaborate in promoting transformation, tum

65 Moreover, inappropriate expression of c-myc genes contributes to the development of many types

66 of the chromosomal translocation leading to c-myc gene deregulation, remains unclear.

67 on, we showed that T3 directly activated the c-Myc gene during metamorphosis in the intestine via bin

68 recruitment of androgen receptor (AR) to the c-Myc gene enhancer and induced H3K9 demethylation, incr

69 e found to produce dose-dependent changes in c-Myc gene expression after delivery into HEK293 cells e

70 ta 1 treatment of B cell lymphomas decreases c-myc gene expression and induces apoptosis.

71 cription, mediated by a rapid suppression of c-myc gene expression and its binding to KOR promoters,

72 Both anaplasia and increased c-myc gene expression have been shown to be negative pro

73 nstrate that the suppressive effect of OM on c-myc gene expression in H3922 cells occurs at the trans

74 ity of TFOs designed to act as repressors of c-myc gene expression in human leukemia and lymphoma cel

75 cific molecules and discuss their effects on c-MYC gene expression in vitro and in vivo.

76 Deregulated c-myc gene expression is associated with many human and

77 C-myc gene expression is greater in the undamaged caroti

78 NOTCH2 and c-MYC gene expression positively correlated with AR expr

79 2, which alters immunoglobulin mu (Igmu) and c-myc gene expression, RTA did not affect Igmu and c-myc

80 tions in endothelin-induced c-fos, c-jun, or c-myc gene expression, suggesting either that the inhibi

81 ctivity and the effect of these compounds on c-MYC gene expression, we have demonstrated, using a cel

82 repression of beta-interferon (IFN-beta) and c-myc gene expression.

83 the H4R3me2a mark, and the complex promotes c-MYC gene expression.

84 ibited IGF-I-dependent changes of GAP-43 and c-myc gene expression.

85 ncreased L-myc gene expression and decreased c-myc gene expression.

86 indicative of transcriptional repression of c-MYC gene expression.

87 tes multiple biosynthetic routes and induces c-MYC gene expression.

88 gene, mediated by a rapid downregulation of c-myc gene expression.

89 ate to bind to NF-kappaB elements and induce c-myc gene expression.

90 The targeted knockout of the c-myc gene from rat fibroblasts leads to a stable defect

91 The c-myc gene has been implicated in multiple cellular proc

92 e region of mutant p53 responsiveness in the c-myc gene has been mapped to the 3' end of exon 1; (iii

93 In certain types of Burkitt's lymphoma, the c-myc gene has undergone translocation to the S regions

94 role in the deregulation of the translocated c-myc gene in Burkitt's lymphoma and suggest that interf

95 The deregulation of expression of the c-myc gene in Burkitt's lymphoma results from the transl

96 of the frequent mutations that occur in the c-myc gene in Burkitt's lymphomas.

97 uggest aberrant translational control of the c-myc gene in cell lines derived from patients with MM,

98 The origin of replication of the c-myc gene in HeLa cells was previously identified at lo

99 ticancer drugs within a 683-bp region of the c-myc gene in human CEM leukemia cells.

100 further reinforces the important role of the c-Myc gene in KSHV lytic replication and latency.

101 the differentiation program shutting off the c-Myc gene in large pre-B cells.

102 ly, we demonstrated an essential role of the c-myc gene in promoting cell survival of WEHI 231 cells

103 h the promoter and downstream regions of the c-myc gene in response to estrogen.

104 orks, which moved through this region of the c-myc gene in the 5' to 3' direction, were specifically

105 nitiation of DNA replication upstream of the c-MYC gene in the HeLa cell cycle.

106 in the PNNs and tumors, and amplification of C-MYC gene in the tumors were confirmed by Southern blot

107 equence (CCCTCCCCA; CT-element) of the human c-myc gene in vitro.

108 beta-cat promotes H3K4 trimethylation at the c-Myc gene in vivo.

109 e site was detected in the first exon of the c-myc gene in VM-26-treated cells.

110 Deletion of both c-Myc genes in B cells led to severely impaired prolifer

111 pattern of deregulated expression of linked c-myc genes in BL and plasmacytoma cell lines.

112 increase in histone acetylation along linked c-myc genes in Raji BL cells.

113 e melting of specific cis elements of active c-myc genes in vivo suggested that transcriptionally ass

114 oit the activity of a cellular oncogene, the c-MYC gene, in addition to inactivation of the tumor sup

115 ormal human fibroblasts with one copy of the c-myc gene inactivated by targeted homologous recombinat

116 define numerous biological activities of the c-myc gene, including transformation, immortalization, b

117 ed Ba/F3 cell proliferation, suggesting that c-Myc gene induction is required for IFN-gamma-mediated

118 s bursal lymphoma in chickens after proviral c-myc gene integration, while the HB-1 retrovirus carrie

119 a target gene of c-Myb and activation of the c-myc gene is a necessary event in Myb-mediated transfor

120 is not clear if activation of the endogenous c-myc gene is an apoptotic signal after toxicant exposur

121 of differential functional expression of the c-myc gene is discussed.

122 The c-myc gene is frequently deregulated and overexpressed i

123 Expression of the c-myc gene is frequently dysregulated in malignant tumor

124 Although the c-myc gene is overexpressed in approximately 70% of huma

125 rthermore, we and others have shown that the c-myc gene is potently transactivated by A-Myb in severa

126 Transcription of the c-myc gene is repressed by Blimp-1 during B-cell differe

127 ng sequence and expression of the endogenous c-myc gene is the same in resistant and susceptible bird

128 The c-myc gene is translocated to one of the immunoglobulin

129 The MYCC (c-MYC) gene is amplified in 30-60% of human ovarian canc

130 F binding site, conserved in mouse and human c-myc genes, is found immediately downstream of the majo

131 Furthermore, c-myc gene knockout fibroblasts are refractory to transf

132 A cis element of the human c-myc gene, known to be melted in vivo, and its associat

133 lasmid containing the promoter region of the c-myc gene linked to a reporter gene.

134 ot methodology, we have established that the c-myc gene, located at 8q21, exhibited amplification of

135 th HN2, and only detectable in the amplified c-myc gene of the Colo320HSR cell line.

136 osslinks were not detectable in the N-ras or c-myc genes of LS174T, J6 or U937 cells treated with HN2

137 q, suggesting that the amplification for the c-myc gene on 8q was relatively specific, and this was c

138 During the translocation, c-MYC gene on chromosome 8 gets juxtaposed to the Ig swi

139 ing array of biological activities makes the c-myc gene one of the most intriguing oncogenes and pres

140 lar in tumors harboring either the wild-type c-Myc gene or the NCR allele.

141 lls may block Myc function by repressing the c-myc gene P2 promoter, as well as by antagonizing Myc-d

142 These data indicate that c-Myc gene plays an important role in mediating CD437-in

143 ngle-stranded far upstream element of active c-myc genes, possesses potent transcription activation a

144 Segments of the human c-myc gene possessing non-B structure in vivo located wi

145 f v-abl and frequently harbored a rearranged c-myc gene, probably as a result of chromosome transloca

146 The c-myc gene produces an oncogenic transcription factor th

147 istone deacetylase 1 and 2 to the endogenous c-myc gene promoter and the subsequent deacetylation of

148 ein can bind to the cis-element of the human c-myc gene promoter and to the gene promoter of STZ/ZAT1

149 odulates the transcriptional activity of the c-myc gene promoter by dissociating the active form of N

150 Both TIP30 and CIA are recruited to the c-myc gene promoter by liganded ERalpha in the second tr

151 with high affinity a specific region at the c-MYC gene promoter characterized by parallel G-quadrupl

152 or the identification of the first dual BCL2/c-MYC gene promoter G-quadruplex ligand.

153 x binding site (acceptor site) for PR in the c-myc gene promoter is composed of RBF dimers bound to a

154 The TDRD3-TOP3B complex is recruited to the c-MYC gene promoter primarily by the H4R3me2a mark, and

155 -associated region (MAR) of the Pg-regulated c-myc gene promoter.

156 es the expression of c-myc by binding to the c-myc gene promoter.

157 bited Burkitt or Burkitt-like morphology and c-myc gene rearrangements and, therefore, appeared to be

158 emonstrated in 3 other cases (19%), although c-myc gene rearrangements were not seen by Southern blot

159 ll lymphoma, and all 12 cases studied lacked c-myc gene rearrangements.

160 ed recruitment of beta-catenin and AR on the c-Myc gene regulatory locus in the tumor tissues express

161 nding to the specific promoter region of the c-Myc gene, resulting in drastic suppression of c-Myc ex

162 The c-myc gene's regulatory sequences were normal in those c

163 ing that dispersion and amplification of the c-MYC gene sequences occurred after and was most likely

164 only patients whose tumors have an amplified c-myc gene show improved disease-free and overall surviv

165 very closely related to the structure of the c-myc gene single-strand binding proteins (MSSPs).

166 sites in the promoters of both the c-myb and c-myc genes, suggesting that c-myb and c-myc may be amon

167 2-kilobase pair region upstream of the human c-myc gene that contains 86 CpGs.

168 ectivity and suppresses promoter activity of c-MYC gene that contains G-quadruplex DNA forming sequen

169 IL-3 and IFN-gamma induce expression of the c-Myc gene that is not dependent on the Stat1 activity.

170 ematopoietic tumor cell lines having altered c-myc genes, the c-Myc S proteins are constitutively exp

171 pyrimidine-rich DNA sequence upstream of the c -myc gene to activate its expression.

172 oma is characterized by translocation of the c-MYC gene to an immunoglobulin enhancer region, resulti

173 hodiester TFOs directed to four sites in the c-myc gene to inhibit gene expression and proliferation

174 acting homopyrimidine tract upstream of the c-myc gene to which the well-characterized transcription

175 ressive histone mark, on promoters of AR and c-Myc genes to increase their transcription.

176 a novel cAMP-dependent increase in renin and c-myc gene transcription by binding as a monomer to a un

177 nhibitor p27 which was an indirect effect of c-myc gene transcription control by Ada3.

178 odium nitroprusside (SNP), rapidly represses c-myc gene transcription in a protein synthesis-independ

179 appaB and AhR resulting in the activation of c-myc gene transcription in breast cancer cells.

180 fied as a DNA-binding protein that regulates c-Myc gene transcription through binding to the far upst

181 factor activity, which regulates the rate of c-myc gene transcription, to determine whether the incre

182 as a cAMP-responsive regulator of renin and c-myc gene transcriptions by the interaction with a spec

183 hese results implicate H-DNA-induced DSBs in c-myc gene translocations in diseases such as Burkitt's

184 genesis in a transgenic model expressing the c-myc gene under the MMTV-LTR promoter.

185 SHC/Grb2/MAPK and STAT6 pathways and through c-myc gene up-regulation.

186 In vitro binding to the c-myc gene was abolished after deletion of the N-termina

187 in a 280-base pair region in intron 1 of the c-myc gene was explored.

188 Whereas overexpression of the c-myc gene was found to promote apoptosis in fibroblasts

189 sing fluorescence in situ hybridization, the c-myc gene was localized to hamster chromosome 6qb.

190 lysis showed that the induction of egr-1 and c-myc genes was associated with a transient recruitment

191 ted to suppress polymerase elongation on the c-myc gene, we employed the chromatin immunoprecipitatio

192 mutations of the 5' noncoding region of the c-myc gene were demonstrated in 3 other cases (19%), alt

193 TBLV insertions near the c-myc gene were detectable in 2 of 30 tumors tested, whe

194 hylated E2F sites derived from the c-myb and c-myc genes whereas both E2F1 and E2F3 fail to transacti

195 c-IRF4) directly regulates expression of the c-Myc gene, which is not only associated with various B

196 a-catenin/TCF4-mediated transcription of the c-myc gene, which was caused by GLIPR1-mediated redistri

197 Histone hyperacetylation of control c-myc genes, which was induced by the deacetylase inhibi

198 esults in the decreased levels of GATA-1 and c-myc genes, with an accompanying induction of apoptosis

199 Active and inactive c-myc genes yielded different patterns of S1 nuclease an