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4 ctivation was examined using photolysis of a caged agonist, carboxynitrobenzyl-tyrosine-[Leu(5)]-enke
5 Chemical tools for optopharmacology include caged agonists and antagonists and reversibly photoswitc
6 gh activation kinetics can be assessed using caged agonists, deactivation kinetics are obscured by sl
9 Carboxynitroveratryl-naloxone (CNV-NLX), a caged analog of the competitive opioid antagonist NLX, w
11 Opening of the coadded hairpin releases the caged analyte sequence, resulting in the dendritic RCA-i
12 of WNS in two simultaneous experiments with caged and free-flying Myotis lucifugus bats at a mine in
14 Ru(II) center, the nitriles of complex 2 are caged, and 2 does not act as a potent enzyme inhibitor.
18 to load both hydrophobic phenylboronic ester-caged anticancer prodrugs (e.g., camptothecin or paclita
21 nm, optically selective uncaging of DEAC450-caged biomolecules at 900 nm may allow facile two-color
28 n analogue containing a thioether group was "caged" by coordination of its thioether group to a photo
32 duced by flash-induced Ca(2+) release from a caged Ca(2+) buffer), which we had reported previously.
33 l Ca(2+) signals, by flash photolysis of the caged Ca(2+) chelator diazo-2-acetoxymethyl ester, arres
35 otropic glutamate receptors or photolysis of caged Ca(2+) produced dilation of penetrating arterioles
36 ificial elevation of intracellular Ca(2+) by caged Ca(2+) release agents sensitizes hair cells to the
37 Accordingly, we applied flash photolysis of caged Ca(2+) to activate BK channels and determine their
38 uorometry and UV photolysis of intracellular caged Ca(2+), we optically resolved VSD activation promp
40 es of release, evoked by flash-photolysis of caged Ca(2+): exocytotic capacitance changes from indivi
41 ne capacitance together with photorelease of caged-Ca2+ and membrane depolarization to study exocytos
42 alized calcium transients with photolysis of caged calcium induced rapid outgrowth of axonal processe
43 d during activation in situ by photolysis of caged calcium using bifunctional fluorescent probes in t
45 used this chromophore to synthesize DEAC450-caged cAMP and found this probe was very stable toward a
50 S release kinetics from a series of isomeric caged-carbonyl sulfide (COS) compounds, including thioca
53 ntracellular Ca(2+) elevation through either caged chelators or pharmacological inhibitors of Ca(2+)
55 kinetics of opioid signaling we developed a caged competitive antagonist that can be quickly photore
56 of the pair of radicals forming the solvent-caged complex is caused by the reduced stability (high r
61 have recently utilized a new ruthenium-based caged compound, ruthenium-bipyridine-triphenylphosphine-
62 photolysis of many widely used nitroaromatic caged compounds (e.g., 4-carboxymethoxy-5,7-dinitroindol
63 mit UV light locally, for photoactivation of caged compounds and, in particular, used for photo-contr
68 not need a standard and can be used for any caged compounds that present different emission properti
69 ed to striatal cholinergic interneurons, the caged compounds were photolyzed in an chromatically orth
75 ylenedisulfotetramine (TETS) is a so-called "caged" convulsant that is responsible for thousands of a
77 oxymethyl ester); (ii) locally photolyzing a caged coumarin in one cell of a coupled cell pair to rel
78 s and photochemical properties of a coumarin-caged cyclic RGD peptide and demonstrate that uncaging c
79 ion, a conjugate between the dicyanocoumarin-caged cyclic RGD peptide and ruthenocene, which was sele
81 different approaches: (i) incorporation of a caged cysteine into the active site for controlling cata
82 rand, respectively) and a substrate with the caged cytotoxic (monomethyl auristatin E: MMAE; a high-a
83 N-protected p-hydroxyphenacyl (pHP) ammonium caged derivatives at 313 nm releases primary and seconda
84 is- (photo-DIBOD, 1) and mono-cyclopropenone-caged dibenzocyclooctadiynes (MC-DIBOD, 5) allows for se
85 mple diffusion, continuous-time random walk, caged diffusion, obstructed diffusion, two-state diffusi
86 verage number of cooperative duplexes, these caged dimers constitute the first example of cooperative
87 ly route to a variety of discrete cyclic and caged disulfide structures, which can then be kineticall
89 ntisense agents through the preparation of a caged DNA phosphoramidite and its site-specific incorpor
92 tion in vivo, we developed a bioconjugate of caged dye, named dextran-CANPE-HCC, for imaging cell cou
101 ximately 60-79%, no toxicity was observed in caged fish, and there were marked decreases in concentra
104 n their absorption regime (365-630 nm), thio-caged fluorophores can be efficiently desulfurized to th
105 The effective photoactivation makes thio-caged fluorophores promising candidates for super-resolu
106 s tetrazine reactivity to unmask vinyl ether caged fluorophores spanning the visible spectrum, includ
107 espread used indicator of live bacteria is a caged form of carboxyfluorescein in which 3' and 6' hydr
109 izontal lineNOR' are of interest as prodrug (caged) forms of the bioeffectors nitric oxide (NO) and n
111 d application of a practically useful doubly caged GABA analog, termed bis-alpha-carboxy-2-nitrobenzy
113 neurological disorders, numerous versions of caged GABA and, more recently, photoswitchable ligands h
114 njugation of a large, neutral dendrimer to a caged GABA probe we introduce a "cloaking" technology th
115 ght penetration from an LED and diffusion of caged GABA to quickly terminate intense focal seizures.
118 trifluoromethylated p-hydroxyphenacyl (pHP)-caged gamma-aminobutyric acid (GABA) and glutamate (Glu)
119 Here, multisubstance indicators based on caged gammarid bioaccumulated contamination data are pro
120 also used laser scanning photostimulation of caged glutamate and whole cell recordings to map excitat
121 o acid carrier 1) through photo-release from caged glutamate generated a transient inward current, as
122 ed laser scanning photostimulation (LSPS) of caged glutamate in conjunction with whole-cell patch-cla
123 the preBotC using holographic photolysis of caged glutamate in medullary slices from neonatal mice.
124 nation with minimal and maximal stimulation, caged glutamate photolysis, and single axon tracing.
126 we used laser-scanning photostimulation with caged glutamate to characterize the spatial distribution
127 d), which, when combined with an appropriate caged glutamate, allows bimodal control of neuronal memb
128 -photon calcium imaging, flash photolysis of caged glutamate, and patch-clamp electrophysiology in co
129 Here, using fast 3D two-photon imaging and a caged glutamate, we challenge this classical view by dem
132 recordings, and scanning photostimulation of caged glutamate, we report first that principal neurons
137 ental results demonstrated that neither DECM-caged glycine nor its byproduct inhibits or activates hu
141 PgammaS) in solution, and caged GTPgammaS or caged GTP loaded on the RhoA.RhoGDI complex to show that
142 iotriphosphate) (GTPgammaS) in solution, and caged GTPgammaS or caged GTP loaded on the RhoA.RhoGDI c
143 We used photolysis of caged phenylephrine, caged guanosine 5'-O-(thiotriphosphate) (GTPgammaS) in s
145 ate a fluorescence response and also release caged H2S, thus addressing challenges of analyte homeost
147 ional alterations of eight selected genes in caged honey bees exposed to different concentrations of
148 n (Kcat and kcat/Km), DFP decay, and protein-caged hydrated ferric oxide accumulation decreased in fe
149 drug discovery, and entertains the classical caged hydrocarbon systems potentially missing from the c
152 ion of fathead minnows (Pimephales promelas) caged in four Nebraska, USA watersheds - the Niobrara an
153 osphotriesterase (a bioremediation catalyst) caged in GSBs and isolate a 20-fold faster mutant in les
154 tem consists of the analyte-sequence that is caged in the stem region and a single-stranded loop doma
155 benzyl trimethylammonium hydroxide (PVBTAH) caged in ZIF-8 is synthesized in steps of chloro-monomer
156 NAzyme) linked to a G-rich domain, which is "caged" in the complex structure, is assembled on Au-coat
158 d one-fourth of the HRP-mimicking DNAzyme in caged, inactive configurations are used as functional el
159 racellular calcium oscillations, while other caged inositol pyrophosphates (3,5-(PP)(2)-InsP(4), 5-PP
163 ormer describes the organic synthesis of the caged IP(3), which requires 12 d, and the latter an appl
168 isphosphate (IP3) receptors by photolysis of caged IP3 The rate of Ca(2+) removal from the cytosol wa
169 PIP2 was inhibited by the addition of single-caged IP3, suggesting that single-caged IP3 is an antago
172 Here, a new lanthanide-chelating NMR probe, Caged Lanthanide NMR Probe-7 (CLaNP-7), is presented.
173 signaling, and they highlight the utility of caged, light-activated kinases for dissecting stress-act
178 , and in vivo imaging applications of Copper-Caged Luciferin-1 (CCL-1), a bioluminescent reporter for
179 t the synthesis and characterization of iron-caged luciferin-1 (ICL-1), a bioluminescent probe that e
180 ynthesis, and in vivo applications of Peroxy Caged Luciferin-1 (PCL-1), a chemoselective bioluminesce
181 lish this approach, we have developed Peroxy Caged Luciferin-2 (PCL-2), a H(2)O(2)-responsive boronic
182 sualizing cellular networks, we developed a "caged" luciferin that produces light only when cells are
184 ing a kinase with activating mutations and a caged lysine blocking the active site, we can rapidly sw
185 talytic activity and (ii) incorporation of a caged lysine into the kinase interaction motif for contr
189 Here we describe a strategy for the use of a caged metabolic precursor that is activated for cellular
190 HC products loaded with conditional ligands (caged MHC molecules) provides a fast and straightforward
191 ational change that locks the substrate in a caged Michaelis complex that provides optimal stabilizat
192 ianion activation by stabilization of active caged Michaelis complexes may be generalized to the many
193 ds to fast and efficient release of a set of caged model species, conjugated via various linkages.
195 ) that bear tetrazines (TZ@SWCNTs) and a TCO-caged molecule was used to deliver active effector molec
197 rthogonal approach to rescue the activity of caged molecules, such as proteins and cytotoxic drugs, u
198 manipulations, as exemplified by the use of caged morpholino (cMO) oligonucleotides to inactivate ge
201 d antagonist, carboxynitroveratryl-naloxone (caged naloxone), blocked the current induced by a series
204 rast to non-cloaked BIST compounds, the BIST-caged neurotransmitter can be safely delivered onto neur
207 Thus, the synthesis of dinitroindolinyl-caged neurotransmitters is within the scope of a modestl
208 ray of strategies, including photorelease of caged neurotransmitters, engineered light-gated receptor
212 ng two-photon activation of an intracellular caged NMDA receptor antagonist (tc-MK801), we found that
213 oscopy and laser-triggered NO release from a caged NO compound, we found that both free hemoglobin an
217 ructural model, with one Ca position and the caged O on a 24d special position, being preferred.
219 present investigation used photolysis of two caged opioid ligands to examine the kinetics of MOR-indu
220 ble) protecting groups (PPGs), also known as caged or photocaged compounds, are used to enable non-in
222 f using silicone rubber passive samplers and caged organisms (Ruditapes philippinarum), simultaneousl
224 lculations, grows rapidly with the number of caged p-H(2) molecules and is a significant fraction of
226 five-step total synthesis of arborisidine, a caged pentacyclic monoterpene indole alkaloid, has been
227 n can be efficiently performed both with the caged peptide and with its ruthenocenoyl bioconjugate re
228 farnesyltransferase; irradiation of the NDBF-caged peptide in the presence of the enzyme resulted in
230 onjugate reveals great potential for DEAdcCE-caged peptide sequences as selective drug carriers in th
233 c force decay upon release of phosphate from caged phosphate was previously interpreted as a signatur
236 7-(diethylamino)coumarin-4-yl]methyl (DEACM)-caged phosphorylated serine, threonine, and tyrosine bui
237 ing 'click' chemistry to couple biotin to a 'caged' photocleavable (PC) guanosine monophosphate (GMP)
241 of firefly luciferin from two complementary caged precursors that can be unmasked by different bioch
243 describe the synthesis and application of a caged proline system that can initiate organocatalysis u
245 porates a transcription factor, a LOV domain-caged protease cleavage site, and a calcium-activated TE
246 e been extended to allow the introduction of caged proteins into cells by permeabilization or microin
247 ver, the chemical or genetic construction of caged proteins is nontrivial, with subsequent laborious
251 o muscle contraction and that the release of caged protons is sufficient to induce muscle contraction
252 c and protein-based photoactivatable probes, caged QDs can confer increased spatial and temporal reso
253 ovel optical properties, we have synthesized caged quantum dots, which are nonluminescent under typic
255 O proceed through the same [Fe(IV)=O *NO(2)] caged radical intermediate and lead to similar outcomes.
258 e in solution, while 3 generates short-lived caged radicals that rapidly form product C-OH bonds, so
259 II directly or through photo-release of the caged Rho kinase inhibitor also reduced the rate of VE-c
260 st bioadhesion, were internally labeled with caged rhodamine to make the particles photoactivatable.
262 ferent approaches were investigated with the caged RNA molecules: the light-regulation of catalytic R
265 d a synthetic approach to the preparation of caged secondary amines by acid-catalyzed rearrangement o
266 transmission model, in which guinea pigs are caged separately, the oseltamivir-resistant viruses tran
267 ed the method with 2P active ruthenium-based caged serotonin and compared the obtained value with a s
270 us elevation of intracellular Sph levels via caged Sph leads to a significant and transient calcium r
272 tic disconnections, which indicated that the caged structure could arise from a simpler fused ring sy
273 line-earth complexes prefer a highly compact caged structure with both phenyl rings providing cation-
278 exemplify the utility of this amino acid, we caged the nuclear localization sequences (NLSs) of nucle
279 orpholino-based antisense reagents have been caged through oligonucleotide cyclization, enabling phot
280 ncaging properties displayed by two coumarin-caged thymidine compounds, each conjugated with (2) or w
281 e was developed through the incorporation of caged thymidine nucleotides into a DNA-based logic gate.
286 w (Pimephales promelas), a small-bodied fish caged upstream and downstream of a local wastewater trea
288 ovarian carcinoma (SKOV3) cells with an NDBF-caged version of a farnesylated peptide followed by UV i
290 ter male mosquitoes can efficiently suppress caged wild-type mosquito populations, providing the foun
291 ter male mosquitoes can efficiently suppress caged wild-type populations, providing a powerful tool f
293 /6J female mice were randomly assigned to be caged with an unlocked (U) or locked (L) running wheel b
298 of alcohols, phenols, and carboxylic acids "caged" with the (3-hydroxy-2-naphthalenyl)methyl group r