ライフサイエンスコーパス: calcification

1 solved inorganic carbon available to support calcification).

2 ogical processes to OA (e.g. respiration and calcification).

3 ng of carbon through both photosynthesis and calcification.

4 internal carotid artery without evidence of calcification.

5 onsequences for bone maintenance and ectopic calcification.

6 ved oxygen; creating conditions conducive to calcification.

7 sion model was used to estimate the risks of calcification.

8 ed the risk factors associated with residual calcification.

9 was 0.96 +/- 0.25 mm at the site of maximum calcification.

10 omen, could be predictive of coronary artery calcification.

11 0 (83.3%) had mild to severe breast arterial calcification.

12 s required for release of EVs, which promote calcification.

13 ed the increase in cytosolic Ca(2+) and VSMC calcification.

14 speciation of abnormal tubular deposits and calcification.

15 c pyrophosphate (PPi), a potent inhibitor of calcification.

16 e for thrombosis, endocarditis, or excessive calcification.

17 s attributed to an increased coronary artery calcification.

18 ify noncoronary atherosclerosis and coronary calcification.

19 ents associated with toxin-mediated arterial calcification.

20 icum (PXE), a disorder resulting in aberrant calcification.

21 ost with nutrients and energy for growth and calcification.

22 ate drugs that could be repurposed to target calcification.

23 proteins involved in prevention of vascular calcification.

24 CC, and defined risk factors associated with calcification.

25 partially caused by extensive cardiovascular calcification.

26 ts the nucleation and growth of pathological calcification.

27 r surrounded by basophilic cells and partial calcification.

28 lated with global plaque volume and coronary calcification.

29 y, different intracranial arterial beds, and calcification.

30 neurovascular unit is a key mechanism in CNS calcification.

31 re first detected on screening mammograms as calcifications.

32 ix proteins are present in vessel-associated calcifications.

33 sed by ex vivo and in vivo quantification of calcifications.

34 uding 31 masses (26 malignant), 20 groups of calcifications (12 malignant), 18 architectural distorti

35 Mediastinal sequelae included lymph node calcification (74%), fibrosing mediastinitis (1%), and p

36 e at 7 different wavelengths-540 and 560 nm (calcification), 920 nm (cholesteryl ester), 1040 nm (pho

37 Vascular calcification, a risk factor for cardiovascular disease,

38 In turn, viable EhVs impacted cellular calcification absent of lysis by inducing dramatic shift

39 in the top Lp(a) tertile had increased valve calcification activity compared with those in lower tert

40 Traditional cardiovascular risk factors and calcification activity in bone or remote atherosclerotic

41 Arterial medial calcification (AMC) involves an increased small extracel

42 lerosis, usually measured as coronary artery calcification, among athletes who are middle-aged and ol

43 In cases of primary familial brain calcification, an autosomally inherited neuropsychiatric

44 (7/7), and imaging findings (7/7), including calcification and abnormal signals in the white matter a

45 ll phenotype were increased ectopic myofiber calcification and altered macrophage infiltration patter

46 of phosphate-lowering medication on vascular calcification and arterial stiffness in CKD remain uncer

47 umental in vascular disease such as vascular calcification and atherosclerosis.

48 rates that the prevalence of coronary artery calcification and atherosclerotic plaques, which are str

49 ed novel mediators of ectopic cardiovascular calcification and biologically plausible candidate drugs

50 s a significant correlation between coronary calcification and breast artery calcification (p = 0.001

51 Breast arterial calcification and calcium scores were determined for eac

52 ity, including excessive Pi-related vascular calcification and chronic tissue injury.

53 patients with AS, Lp(a) and OxPL drive valve calcification and disease progression.

54 tectural distortion" lesions (referred to as calcification and distortion in the following) in mammog

55 )-4, which plays a key role in both vascular calcification and endothelial barrier damage observed in

56 n human aortic smooth muscle cells inhibited calcification and enhanced cell contractility.

57 e addition of nitrate, genes associated with calcification and genes unique to the diploid life stage

58 here that contractile VSMCs are resistant to calcification and identify Nox5 as a key regulator of VS

59 be a suitable predictor for coronary artery calcification and is a valid method for predicting cardi

60 ts with XDR-TB tend to have more parenchymal calcification and left-sided plural effusion.

61 nce that ambient seawater density influences calcification and may account for the observed planktoni

62 There was no difference in aortic valve calcification and mitral annular calcification between p

63 exuberant growth and dilation of the aorta, calcification and ossification of the aortic wall, and i

64 ic phenotypes likely to contribute to plaque calcification and plaque destabilization.

65 a significant relationship between coronary calcification and postmenopausal calcification (p < 0.00

66 in human aortic smooth muscle cells promoted calcification and reduced contractility, while inhibitio

67 Secondary outcomes included abdominal aortic calcification and serum and urine markers of mineral met

68 r, and only in 4.4% of the participants were calcification and tear at the same location on the same

69 accumulate in uterine fluid during eggshell calcification and that they contain high levels of calci

70 ooth muscle cell mineralization and vascular calcification and the possible mechanisms involved.

71 SMC phenotypic switching influences vascular calcification and the possible role of the uniquely calc

72 ant relationship between the localisation of calcification and the rotator cuff tear, and only in 4.4

73 Results A total of 74 DCIS calcifications and 148 benign calcifications were includ

74 urological disorder leukoencephalopathy with calcifications and cysts (LCC) is poorly understood.

75 s the universal reporting of breast arterial calcifications and personalized patient-provider discuss

76 come, neuropathologies, such as intracranial calcifications and polymicrogyria, can occur in the abse

77 scans is highly recommended to detect these calcifications and refer patients for further medical ev

78 suggest a decreased abundance of "centers of calcification" and nitrogen-fixation in GAs.

79 ibroblast growth factor 23 (FGF23), arterial calcification, and cardiovascular mortality.

80 esulted in a strong induction of chondrocyte calcification, and gene expression data suggested that t

81 gment, specifically the degree and extent of calcification, and maybe even be superior to angiography

82 lyzed for the presence of AMCC, aortic valve calcification, and mitral annular calcification as well

83 rom adjacent ecosystems rather than by local calcification, and that Blue Carbon ecosystems are sites

84 lmonary vessels, focal cardiac fibrosis with calcifications, and focal renal injury.

85 (22%), with 40.9% of these patients showing calcifications, and one patient with chronic chylous ple

86 fication detected by computed tomography [CT calcification], and interferon gamma release assay for t

87 Some factors associated to calcification are modifiable and may be approached to de

88 Intracranial large and small arterial calcifications are a common incidental finding on comput

89 We found that intracranial calcifications are a frequent finding in all arterial be

90 rtic valve calcification, and mitral annular calcification as well as quantified AMCC and aortic valv

91 ry artery smooth muscle cells in an in vitro calcification assay.

92 ponents were examined in vitro using diverse calcification assays, ex vivo by using the murine aortic

93 Calcifications associated with DCIS were larger than tho

94 e of 0.538 cm(3) distinguished patients with calcification-associated VT from patients without calcif

95 fication-associated VT from patients without calcification-associated VTs (area under the curve, 0.87

96 These observations exclude extracellular calcification assumed in selected foraminiferal clades,

97 P1GAP, were associated with abdominal aortic calcification at a genome-wide level (P < 5.0 x 10(-8)).

98 was 10.8 m/s, and 81.3% had abdominal aortic calcification at baseline.

99 tiparasitic treatment ended up in a residual calcification at one year.

100 Predictors for calcification at the cyst level were cysts larger than 1

101 mited and allocate energy towards growth and calcification at the expense of decoration behavior.

102 No SNPs were associated with thoracic aortic calcification at the genome-wide threshold.

103 ttle is known about the disease pathology or calcification behavior.

104 ortic valve calcification and mitral annular calcification between patients with and without PPMI (al

105 ncluded augmentation index, abdominal aortic calcification, BP, physical function, and blood markers

106 ore and other measurements of cardiovascular calcification by computed tomography scan during 52 week

107 th spironolactone allowed for replacement of calcification by hyalinosis.

108 ker for atherosclerosis, and coronary artery calcification (CAC) progression according to the baselin

109 Preeclampsia, coronary artery calcification (CAC), and atherosclerotic plaque are risk

110 to determine the severity of coronary artery calcification (CAC), and its effect on mortality rates i

111 as >=1 of the following: any coronary artery calcification (CAC), elevated carotid intima-media thick

112 otid plaque (CP) burden, and coronary artery calcification (CAC).

113 Breast artery calcification can be a suitable predictor for coronary a

114 The lower Omega(cf) at the site of calcification can explain a large proportion of the decr

115 iously reported human primary familial brain calcification cases, we describe high interindividual va

116 significantly increased in rats with medial calcification compared with controls.

117 did not affect arterial stiffness or aortic calcification compared with placebo.

118 ptake demonstrated more rapid progression of calcification compared with those without uptake (change

119 The calcifications correspond to areas of unexcitability and

120 Calcifications correspond to effective ablation sites in

121 risk profile, so that the risk for coronary calcifications could be considered similar between migra

122 Cardiovascular calcification (CVC) contributes to morbidity and mortali

123 Net calcification declined more severely than in previous st

124 We find shell calcification decreased towards high latitude, with muss

125 s directed against pkd1 manifest severe bone calcification defects and a curly tail phenotype.

126 dentified calcified raphe and excess leaflet calcification (defined as more than median calcium volum

127 e, hemoglobin, weight loss, low-grade fever, calcification detected by computed tomography [CT calcif

128 te-onset PXE extends the spectrum of ectopic calcification disorders caused by mutations in ABCC6 and

129 The diagnosis is based on pancreatic calcifications, ductal dilatation, and atrophy visualize

130 In addition, arterial calcification due to CD73 deficiency (ACDC) occurs late

131 We created a human calcification endophenotype module (ie, the "calcificaso

132 Our analyses revealed an association between calcification events, acute-phase response signaling, an

133 tions, including accelerated coronary artery calcification, exercise-induced cardiac biomarker releas

134 and show that cells around vessel-associated calcifications express markers for osteoblasts, osteocla

135 g 2 biomarkers related to mineral metabolism/calcification (fibroblast growth factor-23 and OPG [oste

136 MGP is a well-established inhibitor of calcification gene, highly expressed in arteries' smooth

137 ie, the "calcificasome") by mapping vascular calcification genes (proteins) to the human vascular smo

138 AV morphology including the number of raphe, calcification grade in raphe, and leaflet calcium volume

139 -effects models estimated the association of calcification growth rates with patholo findings.

140 Ectopic calcification had the same temporal pattern of presentat

141 Breast arterial calcification has emerged as a potential risk stratifica

142 role of these toxins in CKD-related vascular calcification has not been reported.

143 Coronary calcification hinders stent delivery and expansion and i

144 Intracranial carotid artery calcifications (ICACs) are one type of calcification tha

145 nificant association between the presence of calcifications, ill-defined borders and overall observer

146 The presence of calcifications, ill-defined borders and the overall impr

147 the key role that SIRT1 plays in preventing calcification in a diabetic environment, through the inh

148 h are associated with primary familial brain calcification in a subset of patients.

149 an also be an effective approach to reducing calcification in Abcc6(-/-) mice.

150 may be responsible for perpetuating vascular calcification in diabetes.

151 throcyte membranes dose-dependently enhanced calcification in murine aortic rings, and extravasated C

152 is study assessed the proportion of residual calcification in parenchymal NCC, and defined risk facto

153 -fluoride uptake and progression of coronary calcification in patients with clinically stable coronar

154 of coronary artery calcium and aortic valve calcification in patients with end-stage kidney disease

155 by patients with CKD significantly increased calcification in the aorta and peripheral arteries.

156 mice exhibited a reduced potency to promote calcification in the aortic ring assay and after injecti

157 targets to modulate vascular remodeling and calcification in the context of mineral imbalance.

158 ensional vascular ultrasound and/or coronary calcification in the PESA (Progression of Early Subclini

159 elease inhibitor decreased sEV secretion and calcification in these cells.

160 EDTA chelation therapy successfully reversed calcification in this adenine rat model of CKD.

161 in subjects with T1DM in the Coronary Artery Calcification in Type 1 Diabetes (CACTI) study.

162 ticipants of the prospective Coronary Artery Calcification in Type 1 Diabetes study with normal TG le

163 To prevent extraosseous calcification in vivo, the serum protein fetuin-A stabil

164 cterize the cellular environment surrounding calcifications in Pdgfbret/ret animals and show that cel

165 solved intravascular thrombosis and included calcifications in pulmonary vessels, focal cardiac fibro

166 ic disorder, the presence of bilateral brain calcifications in the absence of secondary causes of bra

167 nclude the rapid progression of fibrosis and calcifications in the diaphragm and progressive fibrosis

168 thelial-mesenchymal transitions and vascular calcification, including bone morphogenetic protein (BMP

169 e CO(2) vent population for genes central to calcification, including genes for calcium management (c

170 In the absence of a calcification-inducing stimulus, SMCs assume a synthetic

171 ned the pharmacodynamic effects of SNF472, a calcification inhibitor, on plasma calcium phosphate cry

172 egulated in calcified regions and acted as a calcification inhibitor.

173 predictive tool to evaluate the activity of calcification inhibitors.

174 in the absence of secondary causes of brain calcification is a diagnostic criterion.

175 Ectopic cardiovascular calcification is a highly prevalent pathology for which

176 Aortic calcification is an important independent predictor of f

177 Vascular calcification is associated with significant morbidity a

178 Coronary calcification is seen as an aetiopathological event in t

179 The pathophysiology of myocardial calcifications is variable and may have potentially fata

180 nsist of more complex visual structures than calcification lesions [23-26].

181 ining is necessary for VPL of distortion and calcification lesions to be retained for 6 months.

182 e describe high interindividual variation in calcification load in Pdgfbret/ret animals, as assessed

183 ar n-3 PUFA content, exhibited reduced valve calcification, lower aortic valve leaflet area, increase

184 Medial arterial calcification (MAC) is a common outcome in diabetes and

185 Mitral annular calcification (MAC) is associated with cardiovascular ev

186 annuloplasty rings or native mitral annular calcification (MAC).

187 mammography, measurement of breast arterial calcification may offer a personalized, noninvasive appr

188 -7 supplementation tended to increase active calcification measured with 18F-NaF PET activity compare

189 We assessed subsequent coronary artery calcification (measured once during years 7-9 in the pos

190 ementation on vascular stiffness or vascular calcification measures.

191 ardial structure/function, fitness, vascular calcification), mechanisms, and outcomes over 2 decades.

192 and alanine concentrations combined with the calcification media pH (a likely indicator of the dissol

193 ays, ex vivo by using the murine aortic ring calcification model, and in vivo after murine erythrocyt

194 us, hyperechoic hepatic mass with or without calcification (n = 20), or heterogeneous mass with solid

195 Role of NGF-TrkA signaling in calcification of articular chondrocytes.

196 issues producing reduced vision /cataract or calcification of basal ganglia.

197 idemark indicating they may be formed during calcification of cartilage matrix.

198 Generalized arterial calcification of infancy (GACI) is a rare genetic diseas

199 ther conditions include generalized arterial calcification of infancy (GACI), characterized by severe

200 ma elasticum and type 2 generalized arterial calcification of infancy, heritable ectopic mineralizati

201 The demonstrable secondary calcification of lens cuticle that was initially chitino

202 d reduced pH led to a drastic decline in net calcification of living corals to no net growth, and acc

203 Calcification of scar tissue has been described, but the

204 This was associated with increased calcification of synthetic cells in response to high ext

205 tic valve as a consequence of thickening and calcification of the aortic valve leaflets.

206 fied coronary plaque, potentially reflecting calcification of the noncalcified plaque component.

207 d to investigate the possible causal role of calcification on clinical outcomes.

208 ataxia, extrapyramidal signs, and extensive calcifications on brain imaging.

209 ports on prevalence of intracranial arterial calcifications on computed tomography imaging and histop

210 Small vessel caliber, significant calcification or atheroma, and severe tortuosity may pla

211 ), fibrocalcific (fibrous tissue followed by calcification), or other.

212 others, such as subsurface nanoglistenings, calcifications, or discolorations, may require IOL excha

213 en coronary calcification and postmenopausal calcification (p < 0.001).

214 een coronary calcification and breast artery calcification (p = 0.001), and there was also a signific

215 0.001), histopathologically detected severe calcifications (P = 0.001) and severe fibrosis (P < 0.00

216 A nonconfluent calcification pattern was associated with VT target site

217 Primary familial brain calcification (PFBC) is a rare neurodegenerative disorde

218 h are associated with primary familial brain calcification (PFBC), a genetic disease characterized by

219 alignancy ultrasonographic features, such as calcification, poorly defined margin, and a markedly hyp

220 in the coronary arteries, moderate-to-severe calcification portends lower procedural success rates, i

221 e and may be approached to decrease or avoid calcification, potentially decreasing the risk for seizu

222 Arterial calcification predicts accelerated restenosis after angi

223 ty NGF receptor) pathway plays a role in the calcification process of human articular chondrocytes (h

224 Our findings show that dystrophic calcification processes could explain structural differe

225 In this Review, we discuss ectopic calcification processes in the cardiovascular system, wi

226 Longitudinal studies on calcification progression and intervention studies are w

227 presents a possible intervention to mitigate calcification progression in pseudoxanthoma elasticum, t

228 herosclerosis-relevant phenotypes related to calcification, proliferation, and migration in VSMCs iso

229 We demonstrated significant variations in calcification, proliferation, and migration.

230 ents with more rapid progression of coronary calcification, providing important insights into disease

231 0.008), and the presence of brachial artery calcification (r = -0.178, p = 0.036).

232 Here, we report high heritability of calcification rate among the eight most dominant Hawaiia

233 e proportion of the decreasing P. astreoides calcification rates at low Omega(sw).

234 Almost all variance in calcification rates between corals can be explained by c

235 ut had lower grazing, gonad development, and calcification rates than those in ambient conditions.

236 biomolecules may contribute to reduced coral calcification rates under ocean acidification.

237 th was reduced under all hypoxia treatments, calcification rates under variable hypoxia were intermed

238 Broad sense heritability of calcification rates was high among all eight species, ra

239 ogic characteristics, with model A mandating calcification result and model B recording cyst formatio

240 ile these trends ultimately affect ecosystem calcification, scaling experimental analyses of the resp

241 by a combined metric of the coronary artery calcification score and 2-dimensional vascular ultrasoun

242 s to be considered, that the coronary artery calcification score does not indicate the total risk of

243 as well as quantified AMCC and aortic valve calcification score using the Agatston method.

244 tery (p=0.002) and thoracic aortic (p<0.001) calcification scores.

245 nt of athletes with elevated coronary artery calcification scores.

246 tly between groups, nor did abdominal aortic calcification, serum phosphate, parathyroid hormone, FGF

247 Arterial calcification severity was assessed by computed tomograp

248 edicted target in the network, and decreased calcification significantly (P < 0.009).

249 These mineralization processes comprise calcification, silicification, and iron mineralization.

250 oncentrations inferred to occur at the coral calcification site.

251 d targeting to vascular degraded elastin and calcification sites within 24 hours.

252 quantified metabolic rates, grazing, growth, calcification, spine regeneration, and gonad production

253 analysed (composition, echogenicity, margin, calcification status, the presence of halo and overall o

254 i-allelic variants are associated with brain calcification, suggesting that defective cell-to-cell ad

255 CAC and thoracic aorta calcification (TAC) were quantified using a convolutiona

256 rtery calcifications (ICACs) are one type of calcification that may be detected as incidental finding

257 anges, sex differences, and the intracranial calcifications that develop in the brains of susceptible

258 ll cases of DCIS (n = 404) were reviewed for calcifications that were visible on mammograms taken at

259 Vascular calcification, the formation of calcium phosphate crysta

260 Lysed erythrocyte membranes enhanced calcification to a similar extent as the NO donor diethy

261 on, highlighting the susceptibility of coral calcification to future changes in ocean conditions.

262 ly, in Klotho(-/-) mice with marked vascular calcification, treatment with spironolactone allowed for

263 ency included left ventricular outflow tract calcifications under the left coronary cusp (odds ratio,

264 e presence of left ventricular outflow tract calcifications under the left coronary cusp, but not mem

265 further calcified in vitro to simulate graft calcifications upon implantation was characterized nonde

266 ed as probable cause of accelerated vascular calcification (VC) in patients on hemodialysis.

267 a natural product known to inhibit vascular calcification (VC), but with limited potency and low pla

268 D, both IS and PCS directly promote vascular calcification via activation of inflammation and coagula

269 -in-ring (MViR), and valve-in-mitral annular calcification (ViMAC) outcomes has not been performed.

270 sociated with VT target sites independent of calcification volume ( P=0.01).

271 A calcification volume of 0.538 cm(3) distinguished patien

272 RUNX2 and OPN expression, respectively) and calcification (von Kossa staining) in our scaffolds.

273 The overall proportion of calcification was 38% (188/497 cysts, from 147 patients)

274 Conclusion CT-based abdominal aortic calcification was a strong predictor of future cardiovas

275 Reduced cellular calcification was associated with increased infection an

276 The efficacy of these agents in limiting calcification was confirmed experimentally by treating h

277 Calcification was detected from the stable plaque (540 a

278 Intracranial calcification was detected in three individuals.

279 pathways, whereas escape from toxin-induced calcification was linked with liver X receptors and farn

280 Parenchymal calcification was more common in the XDR group than in t

281 In 37 (61.7%) cases, mild to severe coronary calcification was observed, and 50 (83.3%) had mild to s

282 Coronary calcification was quantified by measuring calcium score,

283 Calcified raphe and excess leaflet calcification were associated with increased risk of pro

284 Both calcified raphe plus excess leaflet calcification were found in 269 patients (26.0%), and th

285 Calcifications were associated with VT when compared wit

286 Myocardial calcifications were identified in 39 of 56 patients (70%

287 tal of 74 DCIS calcifications and 148 benign calcifications were included for final analysis.

288 Calcifications were the most common biopsy target for bo

289 ild-type animals did not develop significant calcifications when exposed to vitamin D.

290 hat partial feedback is necessary for VPL of calcifications, whereas detailed feedback is required fo

291 ascular tissue affect vascular stiffness and calcification, which is associated with cardiovascular d

292 Studies have shown that breast artery calcification, which is routinely found in mammography o

293 ic conditions in vitro demonstrated enhanced calcification, which was positively associated with the

294 contractile marker expression and decreased calcification, while overexpression of Nox5 decreased co

295 annuloplasty rings or severe mitral annular calcification who are poor surgical candidates.

296 l valve replacement in severe mitral annular calcification with a dedicated prosthesis is feasible an

297 SIRT1 in vascular smooth muscle cell (vSMC) calcification within the diabetic environment.

298 mals presented with multiple foci of ectopic calcification within the walls of the great vessels.

299 been described, but the relationship between calcifications within endocardial scar and VTs is unclea

300 id wall with multiple small rounded punctate calcifications within it, and no other visceral involvem