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1 delta/notch-like EGF repeat containing; and calcitonin.
2 ure peptide as compared to undigested salmon calcitonin.
3 Alzheimer's amyloid-beta, human amylin, and calcitonin.
7 eful work-up, including measurement of serum calcitonin and carcinoembryonic antigen (and their doubl
8 al based on such prognostic factors as serum calcitonin and carcinoembryonic antigen (CEA) doubling t
10 come of (18)F-FDG PET or (18)F-DOPA PET with calcitonin and CEA doubling times in 47 MTC patients.
12 separation, detection, and quantification of calcitonin and each of its precursors in human cancer ce
13 overy and characterization of O-glycosylated calcitonin and its analogous biosynthetic precursors.
14 he sequence from Asp(15) to Phe(19) of human calcitonin and reported as the minimal amyloidogenic mod
17 es and clinical observations (eg, oestrogen, calcitonin, and teriparatide) or opportunistic repurposi
18 The expression of Samd9L was upregulated by calcitonin, and this was preceded by a significant incre
19 or 4, heart-type fatty acid binding protein, calcitonin, and tumor necrosis factor-related apoptosis-
20 ses, and persistently elevated postoperative calcitonin; and argue for the aggressive management of e
21 ata strongly suggest antiparallel beta-sheet calcitonin assembly, whereas modeling studies on the sho
23 we present two crystal structures of salmon calcitonin-bound, GlcNAc-bearing CTR ECD at 1.78 and 2.8
24 complex with a truncated analogue of salmon calcitonin ([BrPhe(22)]sCT(8-32)) has been determined to
25 tion show sixfold lower levels of myocardial calcitonin compared to control individuals with normal h
27 or (CTR) and the CTR-like receptor (CLR) for calcitonin (CT), amylin (Amy), calcitonin gene-related p
28 LDTg amylin receptors by the agonist salmon calcitonin dose-dependently reduces body weight, food in
30 amino-acid peptide hormone belonging to the calcitonin family, is an intrinsically disordered protei
33 teral parabrachial nucleus (PBel) containing calcitonin gene related peptide (PBel(CGRP) neurons) are
34 arch into the therapeutic potential of alpha-calcitonin gene-related peptide (alpha-CGRP) has been li
35 of exon 5 of Calca, which encodes the alpha-calcitonin gene-related peptide (alpha-CGRP), in intesti
36 s, increased hippocampal expression of alpha calcitonin gene-related peptide (alphaCGRP) transcripts,
39 ing site of the homologous receptors for the calcitonin gene-related peptide (CGRP) and adrenomedulin
40 nables selective recognition of the peptides calcitonin gene-related peptide (CGRP) and adrenomedulli
41 ed receptors involved in energy homeostasis: calcitonin gene-related peptide (CGRP) and amylin recept
42 rleukin (IL)-5, together with Calca-encoding calcitonin gene-related peptide (CGRP) and its cognate r
43 w that ILC2s expressed both the neuropeptide calcitonin gene-related peptide (CGRP) and its receptor.
44 s for the treatment of acute migraine target calcitonin gene-related peptide (CGRP) and serotonin (5-
45 irst evidence that antisera directed against calcitonin gene-related peptide (CGRP) and substance P c
46 expression of the potent vasoactive agents' calcitonin gene-related peptide (CGRP) and vascular endo
51 pain, inhibited release of the neuropeptide calcitonin gene-related peptide (CGRP) from dorsal root
52 CIM0216 elicited the release of the peptides calcitonin gene-related peptide (CGRP) from sensory nerv
53 ovided strong evidence that the neuropeptide calcitonin gene-related peptide (CGRP) has a key role in
54 emale-biased disorder.SIGNIFICANCE STATEMENT Calcitonin gene-related peptide (CGRP) has long been imp
55 usion of neural factors, norepinephrine, and calcitonin gene-related peptide (CGRP) in denervated kid
56 y of evidence supports an important role for calcitonin gene-related peptide (CGRP) in migraine patho
60 SIGNIFICANCE STATEMENT: The neuropeptide calcitonin gene-related peptide (CGRP) is a central play
71 inase and estrogen receptor (CreER) into the calcitonin gene-related peptide (CGRP) locus that encode
72 very migraine patient.SIGNIFICANCE STATEMENT Calcitonin gene-related peptide (CGRP) monoclonal antibo
73 the contribution to cancer anorexia made by calcitonin gene-related peptide (CGRP) neurons in the pa
81 t is an orally administered, small-molecule, calcitonin gene-related peptide (CGRP) receptor antagoni
82 sign enabled the discovery of 8, HTL22562, a calcitonin gene-related peptide (CGRP) receptor antagoni
83 eover NO increased neuronal excitability and calcitonin gene-related peptide (CGRP) release and these
84 PA1-selective agonist, mustard oil (MO), for calcitonin gene-related peptide (CGRP) release from rat
85 rmacologic inhibition of substance P (SP) or calcitonin gene-related peptide (CGRP) signaling in Vglu
86 pharmacological inhibition of substance P or calcitonin gene-related peptide (CGRP) signaling in Vglu
87 had no effect on acanthosis; restoration of calcitonin gene-related peptide (CGRP) signaling reverse
88 DCN A and C fibers and their relationship to calcitonin gene-related peptide (CGRP) staining in the d
90 s depend, in part, on its ability to release calcitonin gene-related peptide (CGRP) through an uniden
91 els of migraine, we show that application of calcitonin gene-related peptide (CGRP) to the rat dura m
92 sal root ganglia (DRG), some neurons express calcitonin gene-related peptide (CGRP) without substance
93 y trigeminal nerve fibers immunoreactive for calcitonin gene-related peptide (CGRP), a marker for pol
94 that reacted with a labeled antibody against calcitonin gene-related peptide (CGRP), a marker of noci
95 ceptors directly respond to STm by releasing calcitonin gene-related peptide (CGRP), a neuropeptide t
97 tor (CLR) for calcitonin (CT), amylin (Amy), calcitonin gene-related peptide (CGRP), and adrenomedull
98 rves induced production of the neuropeptide, calcitonin gene-related peptide (CGRP), and CGRP treatme
99 ron somata, especially those also expressing calcitonin gene-related peptide (CGRP), and in central p
100 The relative numbers of neurons containing calcitonin gene-related peptide (CGRP), cocaine- and amp
101 ed transcript (cart), cholecystokinin (cck), calcitonin gene-related peptide (cgrp), galanin, hypocre
102 b, a humanized monoclonal antibody targeting calcitonin gene-related peptide (CGRP), is being investi
103 reactive (IR) for neurofilament 200 (N52) or calcitonin gene-related peptide (CGRP), or labeled by is
104 characterized by using six neuronal markers: calcitonin gene-related peptide (CGRP), substance P (SP)
106 n exists between migraine and release of the calcitonin gene-related peptide (CGRP), the possibility
107 the PBel neurons that respond to CO2 express calcitonin gene-related peptide (CGRP), we hypothesized
108 ological states, we injected the vasodilator calcitonin gene-related peptide (CGRP), which induces he
109 nerve fibers innervating taste buds contain calcitonin gene-related peptide (CGRP), which may be as
113 afferent neurons are almost exclusively non-calcitonin gene-related peptide (CGRP)-immunoreactive (-
114 as to identify the location, morphology, and calcitonin gene-related peptide (CGRP)-immunoreactivity
122 and a population of cisplatin-activated lPBN calcitonin gene-related peptide (CGRP, a marker for glut
124 ochemistry analysis using antibodies against calcitonin gene-related peptide (CGRP; sensory nerve fib
125 Here, we used stimulated immunoreactive Calcitonin Gene-Related Peptide (iCGRP) release as a mea
126 d that pIII glutamatergic neurons expressing calcitonin gene-related peptide alpha (CALCA) are NREM-s
128 d and thin myelinated afferents labeled with calcitonin gene-related peptide and isolectin B4, and in
130 peptidergic nociceptive fibers (positive for calcitonin gene-related peptide and substance P) and mye
131 subset of sensory neurons that colabel with calcitonin gene-related peptide and TRPV1 suggestive of
132 assess the safety and efficacy of monoclonal calcitonin gene-related peptide antibodies for the preve
134 ADA reduces blood levels of the neuropeptide calcitonin gene-related peptide but increases the neurop
135 in trigeminal sensory afferents, increasing calcitonin gene-related peptide expression and basal tri
136 een confirmed, and the subsequent release of calcitonin gene-related peptide from a mouse heart has b
138 ated release of the neuropeptide transmitter calcitonin gene-related peptide in mouse DRG neurons.
139 evention and provide support for the role of calcitonin gene-related peptide in the pathogenesis of m
140 vascular activation, including expression of calcitonin gene-related peptide in the trigeminal gangli
142 E11.5, followed by neurofilament-M neurons, calcitonin gene-related peptide neurons (peak cell cycle
143 ibers were predominant (tyrosine hydroxylase/calcitonin gene-related peptide ratio 25.1 +/- 33.4; p <
144 ric synthesis of the major metabolite of the calcitonin gene-related peptide recepotor antagonist BMS
146 Treatment of a migraine attack with the oral calcitonin gene-related peptide receptor antagonist rime
148 t is an orally administered, small-molecule, calcitonin gene-related peptide receptor antagonist that
151 : 5-HT1F receptor agonists, and the gepants: calcitonin gene-related peptide receptor antagonists, in
153 ore used to migraine, such as naproxen and a calcitonin gene-related peptide receptor inhibitor, olce
154 human monoclonal antibody that inhibits the calcitonin gene-related peptide receptor, for the preven
155 ain G-protein-coupled receptors, such as the calcitonin gene-related peptide receptor, to the plasma
156 tch-clamp electrophysiology, Ca(2+) imaging, calcitonin gene-related peptide release assay from tissu
157 icin-evoked nocifensive responses, increased calcitonin gene-related peptide release from hindpaw ski
159 ch, in return, allowed endoneurally released calcitonin gene-related peptide to pass through the nerv
160 As for sensory axons (immunostained for calcitonin gene-related peptide) in the urinary bladders
161 ng factor, thyrotropin-releasing hormone and calcitonin gene-related peptide) involved in the mediati
163 1, TRPA1, and neuropeptides (substance P and calcitonin gene-related peptide) using genetic and pharm
165 axons (peripherin-positive axons containing calcitonin gene-related peptide), without changes in sym
167 omatostatin, gastric inhibitory polypeptide, calcitonin gene-related peptide, and adrenomedullin.
168 apsaicin measured by (Ca(2+))(i), release of calcitonin gene-related peptide, and inward currents.
169 e fly homolog of the vertebrate neuropeptide calcitonin gene-related peptide, as a circadian wake-pro
170 ide, but was induced by aristolochic acid I, calcitonin gene-related peptide, endothelin-1, gentamici
171 42, a fully humanised monoclonal antibody to calcitonin gene-related peptide, for migraine prevention
172 and efficacy of galcanezumab, an antibody to calcitonin gene-related peptide, in patients with migrai
173 anezumab, a humanized monoclonal antibody to calcitonin gene-related peptide, may be a preventive tre
174 nt differences were observed in substance P, calcitonin gene-related peptide, or neuropeptide Y prote
176 modicum of investment, new targets, such as calcitonin gene-related peptide-based mechanisms, and en
178 dult mice, MET was restricted to a subset of calcitonin gene-related peptide-immunoreactive (IR) myen
180 y, accompanied by increased axonal growth of calcitonin gene-related peptide-labeled fibers in the do
181 ased the density of PGP9.5-positive, but not calcitonin gene-related peptide-positive, free nerve end
188 staltic transmitters 5-hydroxytryptamine and calcitonin gene-related peptide; antagonists of these tr
189 fibers containing the sensory neuropeptides, calcitonin gene-related polypeptide, and substance P, oc
190 mpanied by substantial increases of neuronal calcitonin gene-related polypeptide-alpha (CGRP) in both
191 l circuit for appetite suppression involving calcitonin gene-related protein (CGRP)-expressing PBN (C
192 hydroxylase (sympathetic neuron marker; TH), calcitonin gene-related protein (peptidergic nociceptor
195 the lateral parabrachial nucleus (lPBN) and calcitonin-gene related peptide (CGRP) projections from
196 des vasoactive intestinal polypeptide (VIP), calcitonin-gene related peptide (CGRP), substance P (SP)
197 ensory axons expressing Phox2b, substance P, calcitonin-gene related peptide, and the serotonin recep
198 knowledge, between the internal dynamics of calcitonin-gene-related peptide (CGRP) and amylin (islet
199 express both IL-33 and the receptor for the calcitonin-gene-related peptide (CGRP); and demonstrate
201 and cOv are characterized with expression of calcitonin-gene-related peptide and cholecystokinin.
203 vation by icilin blocked capsaicin-triggered calcitonin-gene-related peptide release from colon tissu
204 onic levels of the inflammatory neuropeptide calcitonin-gene-related peptide, although inflammatory i
205 f rat spinal sensory afferents identified by Calcitonin-Gene-Related-Peptide (CGRP) for peptidergic t
207 etrogradely labeled neurons from the DP were calcitonin-gene-related-peptide-positive (peptide-expres
210 rosis and Paget's disease for decades, human calcitonin (hCT) forms fibrils in aqueous solution that
211 nteractions leading to fibrillation of human calcitonin (hCT), a peptide hormone important in calcium
212 0 in its extracellular domain (ECD) enhances calcitonin hormone affinity with the proximal GlcNAc res
213 o degradative release of encapsulated salmon calcitonin in gastric conditions while yielding rapid an
214 igin of thyroid C cells, the major source of calcitonin in mammals and ancestors to neuroendocrine th
220 e relationship between the incremental serum calcitonin level before reoperation and the number of ly
222 artment, and for an MTC with increased basal calcitonin level of 20-200 pg/ml (ipsilateral dissection
223 led to long-term remission (ie, undetectable calcitonin level) in 15 (83%) of 18 individuals (2 patie
224 means of 5.3 vs 17.6 years) and having lower calcitonin levels (means of 115 vs 25,519 pg/mL), smalle
225 ary thyroid cancer (MTC) stratified by basal calcitonin levels before reoperation and the number of l
227 ective CND based on preoperative basal serum calcitonin levels is an effective and safe alternative t
228 olvement, and in MTC with preoperative basal calcitonin levels more than 200 pg/ml (normal limit <10
234 Their actions are mediated by the class B calcitonin-like G protein-coupled receptor (CLR), which
235 ate crosslinker, a small polypeptide (salmon calcitonin) loads and releases up to 45 mug/mg hydrogel
236 impact on DT (>/=100% increase of pre-pRAIT calcitonin or CEA DT or prolonged decrease of the biomar
237 nitiation of treatment with bisphosphonates, calcitonin, or raloxifene were treated as competing risk
240 n, whereas atrial-specific overexpression of calcitonin prevents both atrial fibrosis and fibrillatio
242 y in the atria, atrial-specific knockdown of calcitonin promotes atrial fibrosis and increases and pr
243 asts reveals little change after exposure to calcitonin, proteomic analysis shows extensive alteratio
244 non-vertebral fracture (for alendronate and calcitonin), psychiatric hospitalization rate (for sertr
245 ession and that amylin functions through the calcitonin receptor (CalcR) and receptor activity modify
246 f DEX with D3 or PTH increased gene encoding calcitonin receptor (Calcr), acid phosphatase 5, tartrat
247 selectivity of the class B G protein-coupled calcitonin receptor (CTR) and the CTR-like receptor (CLR
248 he class B G protein-coupled receptor (GPCR) calcitonin receptor (CTR) is a drug target for osteoporo
249 how that the core component of the AmyR, the calcitonin receptor (CTR), is expressed on VTA dopamine
250 , the core component of the amylin receptor, calcitonin receptor (CTR), was depleted from POMC neuron
252 or activity-modifying protein-1 (RAMP-1) and calcitonin receptor gene (CT-R) expression in striatum [
253 consisting of 32 amino acid residues and the calcitonin receptor is a Class B G protein-coupled recep
256 cture of a full-length class B receptor, the calcitonin receptor, in complex with peptide ligand and
258 enomedullin (AM) and its receptor complexes, calcitonin receptor-like receptor (Calcrl) and receptor
259 activity modifying protein 1 (RAMP1) and the calcitonin receptor-like receptor (CALCRL) to promote eg
260 Rs) is formed through the association of the calcitonin receptor-like receptor (CLR) and one of three
261 pression and define cellular localization of calcitonin receptor-like receptor (CLR) and receptor act
262 resence of CGRP and its receptor components, calcitonin receptor-like receptor (CLR) and receptor act
265 ) with the G protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) enables selectiv
266 e contribution of endosomal signaling of the calcitonin receptor-like receptor (CLR) to pain transmis
267 ization of a G protein-coupled receptor, the calcitonin receptor-like receptor (CLR), and receptor ac
271 duce arterial differentiation in ECs via the calcitonin receptor-like receptor, thus revealing a surp
274 ndary visceral nucleus, which also expressed calcitonin-related polypeptide alpha (calca), a marker o
275 II afferents of two genes found in C-fibers: calcitonin-related polypeptide alpha (Calca/Cgrpalpha),
276 rs for fast motor neurons (Chondrolectin and calcitonin-related polypeptide alpha [Calca]), we analyz
277 that substantially change the proportions of calcitonin-related species released into the culture med
278 hermore, the amylin and GLP-1 analogs salmon calcitonin (sCT) and liraglutide produce synergistic-lik
279 insertion into the disulfide bond of salmon calcitonin (sCT) demonstrates the utility for fluorescen
282 onjugation to the therapeutic peptide salmon calcitonin (sCT) via bridging of the Cys(1)-Cys(7) disul
283 sidues of both leucine enkephalin and salmon calcitonin (sCT) were targeted using appropriate diazoni
285 ion of acylation of octreotide (Oct), salmon calcitonin (sCT), and human parathyroid hormone (hPTH) w
289 a neuroendocrine cancer that originates from calcitonin-secreting parafollicular cells, or C cells.
291 a broad localization within the brain, while calcitonin, SIFamide, vasotocin, RGWamide, DLamide, FLam
292 a significant physiological impact of amylin/calcitonin signaling in CTR-POMC neurons on energy metab
293 Strategies to restore disrupted myocardial calcitonin signalling thus may offer therapeutic avenues
294 ork, we first predict the structure of human calcitonin through two complementary molecular dynamics
295 e tested in vitro with model proteins salmon calcitonin, urokinase, and rituximab to determine the ef
296 int disruption afforded by dexamethasone and calcitonin was established in comparison to the melanoco
298 ype II turn is the preferred conformation of calcitonin, whereas a type I turn is the preferred confo
299 al performance for the small peptide, salmon calcitonin, whereas lower crosslinking density of 1 mol%
300 ly investigated with a small protein, salmon calcitonin, which could be analyzed both without and wit