ライフサイエンスコーパス: calcitonin receptor

1 in receptor), 87.5% of which coexpressed the calcitonin receptor.

2 ielded cDNAs that encode two isoforms of the calcitonin receptor.

3 ronal expression of Calcr, which encodes the calcitonin receptor.

4 siological function of amylin binding to the calcitonin receptor.

5 s occurred at the concentration of the Kd of calcitonin receptor.

6 .9 nm) and was able to efficiently label the calcitonin receptor.

7 vasoactive intestinal polypeptide type 1 and calcitonin receptors.

8 um stability and specific affinity for human calcitonin receptors.

9 ant peptide sequence homology with the human calcitonin receptor, a member of the G-protein-coupled r

10 ls in the mPFC, supporting the idea that VTA calcitonin receptor activation decreases dopamine releas

11 To first establish that VTA amylin receptor (calcitonin receptor) activation can modulate mPFC activi

12 gest that the deltae13 variant of the rabbit calcitonin receptor acts to regulate the surface express

13 s, is cagrilintide, a long-acting amylin and calcitonin receptor agonist.

14 Dual amylin and calcitonin receptor agonists (DACRAs) show promise as ef

15 385, as well as nonselective dual amylin and calcitonin receptor agonists (DACRAs), with San45 being

16 Small molecule calcitonin receptor agonists are of potential utility in

17 Only chimeric constructs including the calcitonin receptor amino terminus exhibited responses t

18 ocalcitonin was shown to signal through both calcitonin receptor and calcitonin gene-related peptide

19 ssed mRNA for the noninserted isoform of the calcitonin receptor and excavated characteristic resorpt

20 The OCL that form express calcitonin receptors and contract in response to calcito

21 te-resistant acid phosphatase), cathepsin K, calcitonin receptor, and RANK (receptor activator of nuc

22 ated from the gene for the G protein-coupled calcitonin receptor, and some of the splice variants sho

23 ressions of vitronectin receptors, c-src and calcitonin receptors, and bone resorption.

24 cells that stably express the cloned rabbit calcitonin receptor, as in many other cells that express

25 Activation of calcitonin-calcitonin receptor autocrine loop in prostate cancer ce

26 In addition, the activation of calcitonin-calcitonin receptor axis induced epithelial-mesenchymal

27 he first time identify actions of calcitonin-calcitonin receptor axis on prostate cancer cells that l

28 re potent stimulants of cAMP accumulation in calcitonin receptor-bearing human embryonic kidney 293 c

29 /or alanine replacement of the region of the calcitonin receptor between residues 150 and 153 resulte

30 lated all phases of angiogenesis through the calcitonin receptor, but its effect on tube morphogenesi

31 fail to multinucleate and do not up-regulate calcitonin receptor, but they express tartrate-resistant

32 inizing hormone receptor by 97% and from the calcitonin receptor by 100%.

33 3 cell line that stably expresses the rabbit calcitonin receptor C1a isoform.

34 ne that overexpresses the C1a isoform of the calcitonin receptor (C1a-HEK), calcitonin induces the ty

35 The presence of calcitonin receptor, calcitonin receptor-like receptor,

36 ession and that amylin functions through the calcitonin receptor (CalcR) and receptor activity modify

37 f DEX with D3 or PTH increased gene encoding calcitonin receptor (Calcr), acid phosphatase 5, tartrat

38 Calcitonin receptor (Calcr)-expressing neurons of the nu

39 his latter function after its binding to the calcitonin receptor (CALCR).

40 Since the calcitonin receptor can couple to all three of these G p

41 Thus, the calcitonin receptor can couple to Gi, but the inhibition

42 The CAL-RAMP1 selectively activates the calcitonin receptor (CR), whereas, the CGRP-RAMP1 activa

43 in receptors (AMY(1)R, AMY(2)R, AMY(3)R) and calcitonin receptor (CTR) and compare cagrilintide inter

44 mylin receptors (AMYRs), heterodimers of the calcitonin receptor (CTR) and one of three receptor acti

45 selectivity of the class B G protein-coupled calcitonin receptor (CTR) and the CTR-like receptor (CLR

46 The calcitonin receptor (CTR) family is particularly challen

47 The calcitonin-like receptor (CLR) and the calcitonin receptor (CTR) interact with receptor activit

48 he class B G protein-coupled receptor (GPCR) calcitonin receptor (CTR) is a drug target for osteoporo

49 e calcitonin receptor-like receptor (CLR) or calcitonin receptor (CTR) together with one of three acc

50 We found that the G protein-coupled calcitonin receptor (CTR) undergoes tonic internalizatio

51 mRNA for the calcitonin receptor (CTR) was localized to these MNCs in

52 d AMY(3)R are heterodimers consisting of the calcitonin receptor (CTR), a G protein-coupled receptor,

53 ugh fusion of luciferase to either the human calcitonin receptor (CTR), human receptor activity-modif

54 how that the core component of the AmyR, the calcitonin receptor (CTR), is expressed on VTA dopamine

55 , the core component of the amylin receptor, calcitonin receptor (CTR), was depleted from POMC neuron

56 Recent studies show that activation of calcitonin receptors (CTRs) is sufficient to reduce the

57 The crystal structure of the human calcitonin receptor ectodomain (CTR ECD) in complex with

58 Silencing of calcitonin receptor expression in HMEC-1 cells abolished

59 Although calcitonin receptor expression is irrelevant for disease

60 Surprisingly, calcitonin receptor expression was not found on VTA-to-m

61 region of the amino terminus of the Family B calcitonin receptor for agonist drug action.

62 Although calcitonin was able to activate the calcitonin receptor fully with the first 58 residues abs

63 or activity-modifying protein-1 (RAMP-1) and calcitonin receptor gene (CT-R) expression in striatum [

64 Human calcitonin receptor (hCTR) subtypes contain three or fou

65 affinities of these analogues for the human calcitonin receptor, hCTR(I1)(-), and for rat-brain memb

66 identical to two previously described human calcitonin receptors (hCTR1 and hCTR2).

67 d sequencing of labeled wild type and mutant calcitonin receptors identified the sites of labeling fo

68 oclast marker genes NFATc1, cathepsin K, and calcitonin receptor in a RANKL-dependent manner, and con

69 They covalently labeled the calcitonin receptor in a saturable and specific manner.

70 tor assays showed the presence of functional calcitonin receptor in HMEC-1 cells.

71 duals with normal heart rhythm, with loss of calcitonin receptors in the fibroblast membrane.

72 cture of a full-length class B receptor, the calcitonin receptor, in complex with peptide ligand and

73 lls, that stably express a myc-tagged rabbit calcitonin receptor, induced the formation of complexes

74 dependent protein kinase plays a key role in calcitonin receptor-induced destabilization of cell-cell

75 Our results suggest that the calcitonin receptor induces Shc phosphorylation and Erk1

76 or and Galphai subunits, confirming that the calcitonin receptor interacts with Gi.

77 consisting of 32 amino acid residues and the calcitonin receptor is a Class B G protein-coupled recep

78 The calcitonin receptor is a member of the class B family of

79 The calcitonin receptor is a member of the class B family of

80 The Family B G protein-coupled calcitonin receptor is an important drug target.

81 Thus, in C1a-HEK cells, the calcitonin receptor is coupled to the tyrosine phosphory

82 at the deltae13 splice variant of the rabbit calcitonin receptor is expressed together with the more

83 The calcitonin receptor is known to couple to Gs and Gq, act

84 Calcitonin receptor like-receptor is a family B G-protei

85 enomedullin (AM) and its receptor complexes, calcitonin receptor-like receptor (Calcrl) and receptor

86 get CGRP receptor, produced in part from the calcitonin receptor-like receptor (Calcrl) gene, has bee

87 activity modifying protein 1 (RAMP1) and the calcitonin receptor-like receptor (CALCRL) to promote eg

88 activity modifying protein 1 (RAMP1) and the calcitonin receptor-like receptor (CALCRL) to promote eg

89 ator that transduces its effects through the calcitonin receptor-like receptor (calcrl) when the rece

90 , whereas, the CGRP-RAMP1 activates both the calcitonin receptor-like receptor (CLR) and CR.

91 It forms a complex with the calcitonin receptor-like receptor (CLR) and is required

92 Rs) is formed through the association of the calcitonin receptor-like receptor (CLR) and one of three

93 pression and define cellular localization of calcitonin receptor-like receptor (CLR) and receptor act

94 resence of CGRP and its receptor components, calcitonin receptor-like receptor (CLR) and receptor act

95 r is a heterodimer of two membrane proteins: calcitonin receptor-like receptor (CLR) and receptor act

96 Calcitonin receptor-like receptor (CLR) and receptor act

97 Calcitonin receptor-like receptor (CLR) and the receptor

98 Calcitonin receptor-like receptor (CLR) and the receptor

99 AM and its putative receptor calcitonin receptor-like receptor (CLR) are implicated i

100 ) with the G protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) enables selectiv

101 The G protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) mediates essenti

102 mers comprising two distinct components: the calcitonin receptor-like receptor (CLR) or calcitonin re

103 e contribution of endosomal signaling of the calcitonin receptor-like receptor (CLR) to pain transmis

104 ization of a G protein-coupled receptor, the calcitonin receptor-like receptor (CLR), and receptor ac

105 -related peptide (CGRP) co-internalizes with calcitonin receptor-like receptor (CLR), receptor activi

106 t identified through an interaction with the calcitonin receptor-like receptor (CLR), these single tr

107 ide mediates neurogenic inflammation via the calcitonin receptor-like receptor (CLR).

108 G-protein-coupled receptor (GPCR) called the calcitonin receptor-like receptor (CLR).

109 eric CGRP receptor requires co-expression of calcitonin receptor-like receptor (CRLR) and an accessor

110 eatment of 293T cells expressing recombinant calcitonin receptor-like receptor (CRLR) and one of the

111 A candidate CGRP receptor named calcitonin receptor-like receptor (CRLR) has been identi

112 Calcitonin receptor-like receptor (CRLR) is a seven-tran

113 eteromer formation is the interaction of the calcitonin receptor-like receptor (CRLR) with different

114 ide (CGRP) receptor requires dimerization of calcitonin receptor-like receptor (CRLR) with receptor a

115 cently the G-protein coupled receptor (GPCR) calcitonin receptor-like receptor (CRLR), and receptor a

116 2 or RAMP3 (AM1R and AM2R, respectively) and calcitonin receptor-like receptor (CRLR), while a CRLR h

117 o act through the G protein-coupled receptor calcitonin receptor-like receptor (CRLR), with specifici

118 eceptors, adrenomedullin receptor (ADMR) and calcitonin receptor-like receptor (CRLR).

119 lin (AM), is comprised of RAMP2 or RAMP3 and calcitonin receptor-like receptor (CRLR).

120 tonin gene-related peptide receptor subunits calcitonin receptor-like receptor and receptor activity

121 Adrenomedullin (AM) signals through calcitonin receptor-like receptor and receptor activity-

122 alcitonin gene-related peptide receptor, the calcitonin receptor-like receptor and the receptor activ

123 the CGRP-binding protein referred to as the calcitonin receptor-like receptor is highly concentrated

124 ion competing for RAMP3 association with the calcitonin receptor-like receptor to yield a functional

125 e encouraging the exploration of the AM-CLR (calcitonin receptor-like receptor) signaling pathway as

126 tance of the most likely candidate receptor, calcitonin receptor-like receptor, a gene-targeted knock

127 ented lysosomal trafficking and recycling of calcitonin receptor-like receptor, a non-ubiquitinated r

128 Knockdown of ADM, calcitonin receptor-like receptor, and receptor activity

129 The presence of calcitonin receptor, calcitonin receptor-like receptor, and receptor activity

130 ts, including the complement receptor C3AR1, calcitonin receptor-like receptor, or decorin.

131 duce arterial differentiation in ECs via the calcitonin receptor-like receptor, thus revealing a surp

132 s and endothelial cells are known to express calcitonin receptor-like receptor, we examined the poten

133 We also identify a population of calcitonin receptor-like receptor-positive (Calcrl(+)) s

134 gene-related peptide (CGRP) or its receptor (calcitonin receptor-like receptor/receptor activity modi

135 ceptor with seven transmembrane domains, the calcitonin-receptor-like receptor (CRLR), can function a

136 Expression of RANK, TRAP, cathepsin K, calcitonin receptor, matrix metalloproteinase 9, NFATc1,

137 The gene encoding the murine calcitonin receptor (mCTR) was isolated, and the exon/in

138 Furthermore, calcitonin receptor-mediated signal transduction in cell

139 The abundance of calcitonin and calcitonin receptor mRNA displays positive correlation w

140 13 accounting for less than 15% of the total calcitonin receptor mRNA in osteoclasts, kidney, and bra

141 action to estimate the relative abundance of calcitonin receptor mRNA, a 25-fold accumulation of the

142 mediate in the synthesis of pyrazolopyridine calcitonin receptor partial agonists 2a-f.

143 The activated calcitonin receptor phosphorylated glycogen synthase kin

144 n-polymerase chain reaction amplification of calcitonin receptor sequences from rabbit osteoclast RNA

145 eceptor, as in many other cells that express calcitonin receptors, shows little pertussis toxin sensi

146 Global disruption of calcitonin receptor signalling in mice causes atrial fib

147 e examined whether heterodimerization of the calcitonin receptor splice variants occurs and, if so, w

148 ated following stimulation of the rabbit C1a calcitonin receptor stably expressed in HEK-293 cells.

149 ta are two proximal signal effectors for the calcitonin receptor, the more distal signaling pathways

150 d sequencing of labeled wild-type and mutant calcitonin receptors, the site of attachment was identif

151 lpha(s) mutant blocks all signaling from the calcitonin receptor to G(q).

152 entrations of the G(s) protein-coupled human calcitonin receptor type 2 (hCTR2) cDNA produced suffici

153 The cDNA that encodes the rabbit calcitonin receptor was cloned by screening a rabbit ost

154 Expression of mRNA for calcitonin receptor was confirmed in all cases by revers

155 In addition, Calcr (calcitonin receptor), which regulates osteoclast surviva

156 Both probes specifically bound to the human calcitonin receptor with high affinity and were potent s

157 All compounds were full agonists at the calcitonin receptor with no activity at the secretin rec

158 thin the extracellular amino terminus of the calcitonin receptor, with the former adjacent to the fir