ライフサイエンスコーパス: calcium signaling

1 e-analysis pipeline for decoding organ-level calcium signaling.

2 ells from patients with CF without impacting calcium signaling.

3 cover a role for SPV-1 as a key regulator of calcium signaling.

4 ith specific emphasis on cell-type-dependent calcium signaling.

5 ty in vivo using a zebrafish reporter of EEC calcium signaling.

6 ted calcium channel promoted the spontaneous calcium signaling.

7 tential canonical isoform 6 (TRPC6)-mediated calcium signaling.

8 phagocytic capacity and effects on neuronal calcium signaling.

9 hifts in neuronal activity through increased calcium signaling.

10 haft of neurons, triggering an inhibition of calcium signaling.

11 inflammatory processes, including increased calcium signaling.

12 s junctional integrity through modulation of calcium signaling.

13 rect response of CFTR to calmodulin-mediated calcium signaling.

14 d for understanding the stochastic nature of calcium signaling.

15 in astrocytes revealed a decrease in resting calcium signaling.

16 ymphatic sprouting, presumably by disturbing calcium signaling.

17 ding partners, suggesting a role of ABCD2 in calcium signaling.

18 glucose- or KCl-induced insulin release and calcium signaling.

19 es requires highly localized, or nanodomain, calcium signaling.

20 onds of ligand binding and preceding initial calcium signaling.

21 ntry is a central regulator of intracellular calcium signaling.

22 to the vascular architecture via collective calcium signaling.

23 ochondria membrane contacts are hotspots for calcium signaling.

24 fiber mGluR1-dependent synaptic currents and calcium signaling.

25 hanistic basis of the architecture-dependent calcium signaling.

26 in mitochondrial function, ATP release, and calcium signaling.

27 rs, Lrrtm1 and Lrrtm2, as targets of nuclear calcium signaling.

28 ellum that are accompanied by alterations in calcium signaling.

29 phosphorylation, mitochondrial function, and calcium signaling.

30 s GLP-1 stimulatory action of Hld occurs via calcium signaling.

31 ts of heterogeneous structural remodeling on calcium signaling.

32 dels and cell culture systems to investigate calcium signaling.

33 ppression of ryanodine receptor (RyR)-evoked calcium signaling.

34 a membrane junctions for STIM-ORAI-dependent calcium signaling.

35 ling of the junctions during store-dependent calcium signaling.

36 rmalities in endoplasmic reticulum-dependent calcium signaling.

37 olecular machinery for feedforward, cAMP-PKA-calcium signaling.

38 atically enhanced MAPK, NF-kappaB, PI3K, and calcium signaling.

39 a2B -AR increases the epinephrine-stimulated calcium signaling.

40 ding the importance of synaptic function and calcium signaling.

41 vation of protein kinase C and intracellular calcium signaling.

42 mbrane and cytoskeletal elements impacted by calcium signaling.

43 and is critically dependent on intracellular calcium signaling.

44 process extension and outgrowth with greater calcium signaling.

45 contraction rather than action potentials or calcium signaling.

46 ustering, polarization, lumen formation, and calcium signaling.

47 nd delivery by modulating activity-dependent calcium signaling.

48 ogen peroxide, which are known modulators of calcium signaling.

49 amily M member 8 (TRPM8) channels to prolong calcium signaling.

50 ctivation) also increased microglial process calcium signaling.

51 AR transport by modifying activity-dependent calcium signaling.

52 transcripts are involved in linking ROS with calcium signaling.

53 2 recapitulates many aspects of spv-1 mutant calcium signaling.

54 sms by which retinoids might affect synaptic calcium signaling.

55 neglected in the context of ER-mitochondrial calcium signaling.

56 ial and temporal complexity of virus-induced calcium signaling.

57 Integrated calcium signaling activity decreases with increasing tis

58 We found four qualitative classes of calcium signaling activity.

59 , channel, and protein binding that modulate calcium signaling, activity-dependent critical period de

60 's prooncogenic function, inhibiting PAR2-Gq-calcium signaling alone would not be sufficient to achie

61 Cortical astrocyte calcium signaling also altered the acute stimulatory and

62 which in turn enabled increased SE-activated calcium signaling and activation of peptidylarginine dei

63 anogaster embryos in a process that requires calcium signaling and actomyosin contractility.

64 nding the interplay between Sph homeostasis, calcium signaling and autophagy will be crucial in devel

65 ed with Abeta treatment were associated with calcium signaling and axonal vesicle transport (includin

66 ellular PAR4 C-terminal motif that regulates calcium signaling and beta-arrestin interactions.

67 ession in cholangiocytes, leading to reduced calcium signaling and bile duct secretion.

68 Loss of TrkB.T1 in these cells impairs calcium signaling and causes cardiomyopathy.

69 enomes (KEGG) pathways included networks for calcium signaling and cell adhesion molecules, among oth

70 rangement of endothelial cells in collective calcium signaling and cell contractility.

71 y of genes associated with GTPase signaling, calcium signaling and cell death.

72 that neuronal CALHM1 controls intracellular calcium signaling and cell excitability, two mechanisms

73 ITPR2-knockout cells exhibited less nuclear calcium signaling and cell proliferation than control ce

74 increased, explaining the decoupling between calcium signaling and contractility.

75 that P2X7 plays a critical role in mediating calcium signaling and coordinating cytoskeletal rearrang

76 nted in MDD, providing initial evidence that calcium signaling and dendrite regulation may be involve

77 ling plays an important role in the aberrant calcium signaling and depressed contractile and beta-adr

78 ensitized MSCs to mechanical-loading-induced calcium signaling and differentiated marker expression.

79 e 1 (PKD1L1), a gene associated with ciliary calcium signaling and embryonic laterality determination

80 rall activity, accelerates the refinement of calcium signaling and excitatory inputs without affectin

81 vigating zebrafish motor neurons, regulating calcium signaling and filopodial formation.

82 This effect is mediated by voltage-gated calcium signaling and gap-junctional communication.

83 eteromerization of AT1-B2 led to exaggerated calcium signaling and high vascular smooth muscle mechan

84 o rat spinal astrocytes in culture initiates calcium signaling and induces secretion of ATP that with

85 of the probe for these two species triggered calcium signaling and intracellular protein translocatio

86 d in transgenic mice with impaired astrocyte calcium signaling and is decreased by pharmacogenetic st

87 eregulation of IP(3)Rs leads to pathological calcium signaling and is implicated in many common disea

88 whereas a peptide that is able to stimulate calcium signaling and is more potent for beta-arrestin r

89 s has changed our understanding of astrocyte calcium signaling and its consequences for neuronal func

90 y analysis also implicated genes involved in calcium signaling and long-term potentiation.

91 vant targets, including proteins involved in calcium signaling and members of the MEF2 family of tran

92 ducing NAD-derived metabolites that regulate calcium signaling and migration of inflammatory cells.

93 of inter-organelle communication, regulating calcium signaling and mitochondrial activities.

94 ying MYBPC3 PTC mutations displayed aberrant calcium signaling and molecular dysregulations in the ab

95 mal regions, where it stabilizes the mRNA of calcium signaling and neural associated genes by interac

96 le of nociceptor mu-opioid receptor-mediated calcium signaling and peripheral protein translation in

97 ence for the role of nociceptor MOR-mediated calcium signaling and peripheral protein translation, in

98 -adrenergic receptors couple to Gq proteins, calcium signaling and protein kinase C activation; subse

99 responding cells, the temporal dependence of calcium signaling and provides global and individual cal

100 This pathway thereby links sodium to calcium signaling and represents a new mechanism for the

101 mutation inhibited the magnitude of initial calcium signaling and severely blunted persistent calciu

102 fetal ECM-enriched cultures was confirmed by calcium signaling and spectral/cluster analysis.

103 i2 as a potential intermediary between early calcium signaling and subsequent tissue regeneration.

104 amics of CaMKII establishes the link between calcium signaling and the morphological plasticity of de

105 elegantly resolve an apparent discrepancy in calcium signaling and the pathogenesis of pancreatitis i

106 one hand, specific Ship1 inhibition enhanced calcium signaling and thereby abrogated an anergic respo

107 The eutopic expression of CCR5 activates calcium signaling and thereby augments regulatory T cell

108 ic pathways, regulation of extracellular pH, calcium signaling, and apoptosis.

109 nstruct the refinement of excitatory inputs, calcium signaling, and biophysical properties is unknown

110 c mitochondrial quality control, cell death, calcium signaling, and cardiac development.

111 omeostasis, cell growth and differentiation, calcium signaling, and DMP1 transcription.

112 lation of proteins involved in intracellular calcium signaling, and down-regulation of neurofilament

113 This hyperactivated ERK, calcium signaling, and ER stress, autonomously stimulati

114 processes, such as neurotransmitter release, calcium signaling, and gene expression changes.

115 carinic 1 receptor activation, intracellular calcium signaling, and GluR2-lacking AMPAR insertion.

116 rgy metabolism, oxidative stress, apoptosis, calcium signaling, and growth of the nervous system.

117 Here, we examine phenotypic changes, calcium signaling, and intrathymic migration in a synchr

118 d causative dysfunctions of ion homeostasis, calcium signaling, and neurotransmitter clearance, as we

119 P) is a critical cofactor during metabolism, calcium signaling, and oxidative defense, yet how animal

120 orchestrated by endocannabinoids, astrocytic calcium signaling, and presynaptic N-methyl-D-aspartate

121 oproxyfan were all markedly biased away from calcium signaling, and principal component analysis of t

122 Cav2.3 impacts cellular excitability and calcium signaling, and the alterations in channel transl

123 discover relationships between the speed of calcium signaling, and the amplitude of PKA signaling, u

124 s as varied as blood clotting, intracellular calcium signaling, and tissue inflammation are all heavi

125 olume regulation by integrating osmosensing, calcium signaling, and water transport and, when overact

126 apting in response to stress to modulate the calcium signaling apparatus.

127 function studies, abrogation of the PAR2-Gq-calcium signaling arm failed to suppress TGF-beta1-induc

128 nd shortens the period of activity-dependent calcium signaling around hearing onset.

129 d stretch induced ATP release and purinergic calcium signaling as a central mediator of this chromati

130 This was confirmed by differential calcium signaling as well as effects on neurite growth a

131 P+ cells and glucose-responsive synchronized calcium signaling as well as expression of the transcrip

132 importance in light of their involvement in calcium signaling, association of proteins with cellular

133 signal transduction events, or disruption of calcium signaling attenuated the response to acute mecha

134 tial molecular therapeutics including axonal calcium signaling, axoglial energy metabolism and cell a

135 s that are poor activators of PAR4-dependent calcium signaling but were fully competent in recruiting

136 hat Ly6h reduces cell-surface expression and calcium signaling by alpha7 nAChRs.

137 phosphorylation at the C terminus regulates calcium signaling by tuning the content of CaV1.2 at sig

138 Upon glucagon-induced calcium signaling, calcium/calmodulin-dependent kinase I

139 Excessive levels of cAMP-calcium signaling can have a number of detrimental effec

140 the cell surface and activation of a complex calcium signaling cascade.

141 Loss of TRPV1 inactivates a calcium-signaling cascade that ends in the nuclear exclu

142 ls and examine their potential function as a calcium signaling compartment.

143 suggest that one mechanism by which nuclear calcium signaling controls neuronal network function is

144 Calcium signaling controls the function of these cells,

145 As such, selectively regulating calcium signaling could be an alternative approach for a

146 that were unable to stimulate PAR4-dependent calcium signaling could not trigger MAPK activation.

147 In the absence of nuclear calcium signaling, cytosolic calcium activating nuclear

148 ects of a high dose, while reduced astrocyte calcium signaling diminished sensitivity to the hypnotic

149 membrane and the size of channel-associated calcium signaling domains, and for understanding the sto

150 r T cell activation is promoted by sustained calcium signaling downstream of the TCR.

151 Furthermore, retinoids can interact with calcium signaling during homeostatic plasticity.

152 levels, and disrupted spatial regulation of calcium signaling during spermathecal contraction.

153 In vivo calcium signaling dynamics depend on both receptor tyros

154 ine, we extracted spatiotemporal features of calcium signaling dynamics during the development of the

155 Together, these findings define how calcium signaling dynamics integrate upstream inputs to

156 nputs specifying cell and organ development, calcium signaling dynamics, and final organ morphology a

157 Calcium signaling encodes a significant portion of the c

158 ery that RV increases [Ca(2+)]cyt by dynamic calcium signaling, establishes a new, paradigm-shifting

159 we found that a peptide that cannot activate calcium signaling fails to cause platelet aggregation, w

160 s, consistent with an abnormality of nuclear calcium signaling feedback control.

161 transfected NSC-34 motor neurons and altered calcium-signaling following glutamate stimulation.

162 les in ATP production, metabolic regulation, calcium signaling, generation of reactive oxygen species

163 Astrocyte identity and synaptic calcium signaling genes were enriched in alcohol-associa

164 Calcium signaling has been the primary mechanism in euka

165 Research on calcium signaling has centered on STIM1, ORAI1, and a fe

166 ism; immune response and inflammation; MAPK; calcium signaling) highly associated with longevity (P <

167 Although a role for calcium signaling in AMPAR transport has been described,

168 ng a new pathway for the generation of local calcium signaling in astrocyte processes.

169 sical model of glutamate-based intracellular calcium signaling in astrocytes, we suggest that the ste

170 her organisms, investigations of voltage and calcium signaling in bacteria have lagged due to their s

171 defects in spontaneous neuronal activity and calcium signaling in both organoid- and 2D-derived corti

172 Finally, we found that calcium signaling in both primary innate and adaptive im

173 Insufficient nuclear calcium signaling in CA1 hippocampal neurons and, conseq

174 IL-1beta inhibited the spontaneous calcium signaling in chondrocytes, a fundamental signali

175 ting granule localization and/or priming and calcium signaling in concert.

176 The role of calcium signaling in cytokinesis has long remained ambig

177 s for noninvasive detection of intracellular calcium signaling in deep tissue and intact organisms re

178 ey molecular determinant of subtype-specific calcium signaling in IP(3)Rs.

179 pendent Protein Kinases are key effectors of calcium signaling in malaria parasite.

180 um entry, a major mechanism of physiological calcium signaling in mammalian cells.

181 calmodulin and calcium implicates a role for calcium signaling in mitochondrial protein ubiquitylatio

182 emotaxis of human neutrophils and diminished calcium signaling in monocytic cell line U937 transfecte

183 hydropyridine site, and potent modulation of calcium signaling in muscle cells and vascular tissue.

184 protein 57 (ERp57) as it pertains to altered calcium signaling in myeloproliferative neoplasms (MPNs)

185 The spatial and temporal regulation of calcium signaling in neuronal growth cones is essential

186 ative stress reduced expression of ITPR3 and calcium signaling in NHC cells; quercetin also reduced s

187 ITPR3 activity was determined by measuring calcium signaling in normal human cholangiocyte cells an

188 Alterations in calcium signaling in pancreatic acinar cells can result

189 To determine the precise role of calcium signaling in polar body formation, we used live-

190 receptor activation is accompanied by local calcium signaling in processes of neocortical astrocytes

191 properties of GoC dendrites and the role of calcium signaling in regulating GoC spontaneous activity

192 st a possible role for the strength of early calcium signaling in selective coordination of subsequen

193 Whether excitation and calcium signaling in the MSO are similarly affected by t

194 opic agents exert their effect by modulating calcium signaling in the myocardium.

195 Inhibition of calcium signaling in the steroidogenic prothoracic gland

196 ough phospholipase C (PLC) and intracellular calcium signaling in vivo.

197 We report that (1) calcium signaling increases with the application of ultr

198 arly in pancreatic injury through pathologic calcium signaling independent of trypsinogen activation.

199 n of MEF2C was associated with intracellular calcium signaling induced by beta-catenin.

200 at inorganic polyphosphate is able to reduce calcium signaling induced by physiological or high conce

201 The ability of NF279 to abrogate cellular calcium signaling induced by the respective chemokines s

202 , that translates neuronal-activity-mediated calcium signaling into gene expression in a light-depend

203 isms in males and females include kinase and calcium signaling involved in synaptic potentiation, dem

204 To reveal whether Gq-calcium signaling is a prerequisite for PAR2 to enhance

205 To test the hypothesis that GPCR-induced calcium signaling is also involved in the behavioral eff

206 Calcium signaling is an essential function during neural

207 PC3-dependent mechanisms, by which activated calcium signaling is coupled to lipid metabolism and the

208 Calcium signaling is critical for lymphocyte function, a

209 beled vesicles in the gland is observed when calcium signaling is disrupted, and these vesicles conta

210 tage-gated calcium (Cav1) channels in T-cell calcium signaling is emerging.

211 eticulum IP3 and ryanodine receptor-mediated calcium signaling is present in the induction of hyperal

212 unknown how the potassium channel-repressed calcium signaling is translated into the induction of th

213 hree of these four pathways (MAPK; immunity; calcium signaling) is supported by findings in other hum

214 Calcium signaling leads to a promotion of complex format

215 Impaired calcium signaling leads to decreased beta cell mass and

216 led that these shared genes were enriched in calcium signaling, long-term potentiation and neuroactiv

217 Aberrant calcium signaling may contribute to arrhythmias and adve

218 nsient mechanical stimuli through a two-part calcium signaling mechanism.

219 iding further evidence for the complexity of calcium signaling mechanisms in CNS astroglia.

220 ese data provide important insights into the calcium signaling mechanisms involved in early developme

221 ifferent cell types and processes, including calcium signaling, migration, adhesion, proliferation, a

222 These "resets" are induced by calcium signaling, modulation of actomyosin contractilit

223 ory region of CFTR and calmodulin, the major calcium signaling molecule, and report protein kinase A

224 cilia may potentially function as a crucial calcium-signaling nexus in hASCs during EFS.

225 ude of field action potential, and cytosolic calcium signaling of cardiomyocytes.

226 Spontaneous calcium signaling of cartilage cells: from spatiotempora

227 This feature is used to study the calcium signaling of endothelial cells under successive

228 of this system for studying the drug-induced calcium signaling of human monocytes under dynamic therm

229 rapid detection of E. coli O157:H7 by using calcium signaling of the B cell upon cellular membrane a

230 nged exendin-4-induced activation (live cell calcium signaling) of NTS astrocytes and neurons; these

231 tion) triggered increased microglial process calcium signaling, often concomitant with process extens

232 tigations have described indirect effects of calcium signaling on CFTR or other calcium-activated chl

233 or knockout mice to show distinct effects of calcium signaling on D2S and D2L autoreceptor function.

234 ons or other genetic aberrations that impair calcium signaling or disrupt the survival of young hippo

235 otably, not all CAR T cell contacts elicited calcium signaling or killing while interacting with tumo

236 te or mutations disrupting sensory activity, calcium signaling, or genes that restrict outgrowth duri

237 The ER-mitochondrial interface is central to calcium signaling, organellar dynamics, and lipid biosyn

238 thways; axon-guidance, adherens-junction and calcium-signaling, particularly at later timepoints of m

239 The calcium signaling pathway (hsa04020) was the only pathwa

240 promising anti-cancer activity by mediating calcium signaling pathway and inducing apoptosis as well

241 ified in this TMEM16A-dependent EGFR-induced calcium signaling pathway form a gene set that makes it

242 These studies unveil a calcium signaling pathway in which a Piezo1-induced TRPV

243 lasses of wing phenotypes that resulted from calcium signaling pathway perturbations, including defec

244 The calcium signaling pathway was the top gene set enriched

245 ficant enrichment for genes constituting the calcium signaling pathway, especially those related to t

246 ignaling pathway, cAMP signaling pathway and calcium signaling pathway, were significantly enriched w

247 al remodeling (LAD, LVA) and AF type via the calcium signaling pathway.

248 sceptibility gene, CACNA1C, belonging to the calcium signaling pathway.

249 tored activation of the Galpha(q/11)-coupled calcium-signaling pathway, beta-arrestin recruitment, an

250 In this review, we discuss how calcium signaling pathways in endothelial cells play an

251 at SPV-1 works through both the Rho-ROCK and calcium signaling pathways to coordinate cellular contra

252 n triggers osteoclastogenesis via ITAM-based calcium signaling pathways, skewing osteoclast metabolis

253 -1beta attack with a focus on cell cycle and calcium signaling pathways.

254 al stretch, including integrins, Notch1, and calcium signaling pathways.

255 uconeogenesis, and MAPK, PI3K-AKT, HIPPO and calcium signaling pathways.

256 Rho-ROCK (Rho-associated protein kinase) and calcium signaling pathways.

257 ATPase-dependent calcium uptake, activating calcium-signaling pathways known to improve insulin sens

258 The process relies on intracellular calcium signaling, PDZ [postsynaptic density-95 (PSD-95)

259 rly participants, this study identified that calcium signaling plays a central role in hippocampus-de

260 Notably, calcium signaling promotes the polymerization of linear

261 populations distinguished by their dendritic calcium signaling, rebound excitation, and physiological

262 The expression of 24 genes from 6 calcium-signaling related pathways were changed by IL-1b

263 roliferation, and preventing the increase of calcium signaling rescues the cell-cell junctional defec

264 ted to microglia, we assessed how microglial calcium signaling responds to alterations in neuronal ac

265 y attenuate the alpha7 nAChR-induced Galphaq calcium signaling response as evidenced by a decrease in

266 calcium in DIS3L2-deficient cells activates calcium signaling response genes and perturbs ESC differ

267 a7 nAChRs to G proteins enables a downstream calcium signaling response that can persist beyond the e

268 We further demonstrate that calcium signaling suppresses the transcription of PD-1 l

269 in-dependent protein kinases and the nuclear calcium signaling target CREB-binding protein.

270 in and suggest that it serves as a potential calcium signaling target within stress granules and othe

271 mitochondria resulted in drastically altered calcium signaling that could disrupt neurovascular coupl

272 In both cell types, intracellular calcium signaling that links membrane depolarization to

273 Perturbation of calcium signaling that occurs during cell injury and dis

274 Two pathways of calcium signaling that regulated D2 autoreceptor-depende

275 Calcium signaling through calcineurin and its major tran

276 een NMDA-receptor-mediated sodium influx and calcium signaling through the reversal of sodium/calcium

277 y-encoded calcium indicators to characterize calcium signaling throughout RV infection by time-lapse

278 osphorylation pathway that directly connects calcium signaling to the MAPK machinery.

279 mmune evasion, increased stemness, increased calcium signaling, transformation, and novel E-cadherin-

280 pathways including neuroendocrine signaling, calcium signaling, triggering receptor expressed on myel

281 Microglial calcium signaling underlies a number of key physiologica

282 podocytes become sensitized to AngII-induced calcium signaling upon injury might explain results from

283 f NFAT, a downstream target of intracellular calcium signaling using a reporter in live cardiac fibro

284 dynamics using the Grx1-roGFP2 biosensor and calcium signaling using the GcAMP6s biosensor.

285 dy indicate a role for endoplasmic reticulum calcium signaling via calreticulin in the differentiatio

286 Soluble klotho regulates TRPC6 calcium signaling via lipid rafts, independent of the FG

287 (3)) signaling appeared to be unaffected, as calcium signaling via protease-activated receptor 2 rema

288 However, the calcium signaling was not dramatically changed in the pe

289 t to be substrate-stiffness dependent, early calcium signaling was unaffected by substrate rigidity,

290 sed and SiglecG, a molecule shown to inhibit Calcium signaling, was downregulated in the absence of D

291 Because LR depends on calcium signaling, we examined the effects of NAFLD on e

292 ly responses to low strain were dependent on calcium signaling, whereas actin inhibition abrogated al

293 increased CO2) evokes increases in astrocyte calcium signaling, which in turn stimulates COX-1 activi

294 lly, glucose triggers KATP channel-dependent calcium signaling, which promotes HDAC5 phosphorylation

295 m stores and loss of ATP- and KCl-stimulated calcium signaling while uninfected cells in the populati

296 In contrast, reducing calcium signaling with an astrocyte-specific calcium ext

297 Detecting intracellular calcium signaling with fluorescent calcium indicator dye

298 nction, including long-term potentiation and calcium signaling with higher levels of postnatal expres

299 roles in proliferation and differentiation, calcium signaling within the brain, and neurotrophic and

300 cessive elevation or prolonged activation of calcium signaling would lead to cell death.