ライフサイエンスコーパス: calcium uptake

1 s axon regrowth through axonal mitochondrial calcium uptake.

2 verse diffusion barriers and sites of active calcium uptake.

3 f environmental signals as well as nutritive calcium uptake.

4 d ADP plus oligomycin restored potential and calcium uptake.

5 ted ATPase activity and completely inhibited calcium uptake.

6 to 60 min significantly inhibited microsomal calcium uptake.

7 f sensitive target strains by blocking their calcium uptake.

8 ulation, calcium response, and extracellular calcium uptake.

9 creased depolarization-induced mitochondrial calcium uptake.

10 nd defective contact-dependent mitochondrial calcium uptake.

11 lls was highly correlated with mitochondrial calcium uptake.

12 antagonist properties on human P2X4-mediated calcium uptake.

13 inhibitor KT195, by preventing mitochondrial calcium uptake.

14 sis balances passive calcium leak and active calcium uptake.

15 rial membrane potential, ATP production, and calcium uptake.

16 erminant of MAMs that controls mitochondrial calcium uptake.

17 tors was silenced demonstrated a decrease in calcium uptake.

18 red function of aged hearts through improved calcium uptake.

19 onth-old mice did not change LV function and calcium uptake.

20 terocytes were tested for steroid-stimulated calcium uptake.

21 ins required for high-capacity mitochondrial calcium uptake.

22 , but did respond to forskolin with enhanced calcium uptake.

23 we have found that the PKA pathway mediates calcium uptake.

24 receptor failed to block 1,25D(3)-stimulated calcium uptake.

25 r CaMKII, namely, promotion of mitochondrial calcium uptake.

26 s in kidney cells show channel-mediated cell calcium uptake.

27 -ATPase (SERCA), thus modulating the rate of calcium uptake.

28 explained by reduced sarcoplasmic reticulum calcium uptake.

29 ining calcium-binding proteins mitochondrial calcium uptake 1 (MICU1) and MICU2 and the pore-forming

30 s controlled by its gatekeeper Mitochondrial Calcium Uptake 1 (MICU1).

31 CBARA1, that we call hereafter mitochondrial calcium uptake 1 (MICU1).

32 f mitochondrial Ca(2+) uptake, Mitochondrial Calcium Uptake 1 (MICU1/CBARA1) drives aerobic glycolysi

33 y decreases the association of mitochondrial calcium uptake 1 and 2 (MICU1/2) to alter channel gating

34 alcium uniporter (MCU) and the mitochondrial calcium uptake 1 protein (MICU1) with no change in level

35 niporter complex subunit MICU (mitochondrial calcium uptake) 1 limits mtCa(2+) uptake, preventing mtC

36 ndoplasmic reticulum Ca(2+) ATPase-dependent calcium uptake, activating calcium-signaling pathways kn

37 ociated with impaired sarcoplasmic reticulum calcium uptake activity.

38 d in a significant decrease in mitochondrial calcium uptake, an increase in reactive oxygen species p

39 stitution with phospholamban suppressed both calcium uptake and ATPase activities by approximately 50

40 cium waves are associated with mitochondrial calcium uptake and consequent depolarization.

41 Ai knockdown of MCU attenuated mitochondrial calcium uptake and dendritic/neuritic shortening elicite

42 ing a pivotal role of aberrant mitochondrial calcium uptake and dysfunctional calcium signalling casc

43 cur over a broad region of relatively slower calcium uptake and elevated diastolic calcium levels.

44 ptors (alpha7nAChR) on platelets to increase calcium uptake and enhance alpha granule release.

45 rease in SERCA2 protein leads to accelerated calcium uptake and enhanced Ca2+ loading.

46 use enterocytes paralleled that for enhanced calcium uptake and for LM females reached 250% of contro

47 rylated state, PLN binds SERCA, reducing the calcium uptake and generating muscle contraction.

48 ns promote skeletal development and modulate calcium uptake and gut microbial composition, supporting

49 f mammalian TRPV6, an important regulator of calcium uptake and homeostasis, is essential for channel

50 At the cellular level, AbetaP1-42 allows calcium uptake and induces neuritic abnormality in a dos

51 Here, capsaicin increases calcium uptake and induces vasoconstriction, an effect t

52 In 3T3-Trk cells, NGF increased both calcium uptake and intracellular calcium mobilization.

53 stimulated calcium uptake, the regulation of calcium uptake and intracellular mobilization by nerve g

54 AC6) expression in cardiac myocytes improves calcium uptake and left ventricular (LV) function in agi

55 myocyte shortening rate through increases in calcium uptake and more rapid lengthening.

56 e activation of Piezo1 induced mitochondrial calcium uptake and oxidative phosphorylation (OXPHOS).

57 onal consequences of excessive mitochondrial calcium uptake and possible therapeutic strategies targe

58 suggest that HBx can increase mitochondrial calcium uptake and promote increased SOCE to sustain hig

59 compounds were able to reduce mitochondrial calcium uptake and protected cells against beta-amyloid-

60 The model predicts that perturbations of calcium uptake and release across the endoplasmic reticu

61 insight into the mechanisms of mitochondrial calcium uptake and release that are important in healthy

62 as increased in the absence of mitochondrial calcium uptake and slowed when MCU was overexpressed.

63 u can be inhibited by blocking mitochondrial calcium uptake and store-operated calcium entry (SOCE).

64 rexpression of CaBP stimulates both cellular calcium uptake and vectorial calcium transport activitie

65 n the presence of a blocker of mitochondrial calcium uptake and was mimicked by injection of ATP into

66 t neurons via sequestration of mitochondrial calcium uptake and we suggest that it can also be protec

67 between prognosis, changes in mitochondrial calcium uptake, and bioenergetic status in the heart dur

68 calcium transients showed a reduced rate of calcium uptake, and expression analysis showed reduced l

69 roblasts, along with increased mitochondrial calcium uptake, and in postmortem brains of sporadic PD/

70 r (Mcu), which is required for mitochondrial calcium uptake, and littermate controls.

71 Channel conductance, calcium uptake, and neurite degeneration are selectively

72 Respiration, oxidative phosphorylation, calcium uptake, and the mitochondrial membrane potential

73 Neurotrophin-stimulated presynaptic calcium uptake appears to play a key role in this proces

74 We identified mitochondrial calcium uptake as a key driver of EndMT; inhibiting mito

75 axonal development and identify insufficient calcium uptake as the pivotal mechanism.

76 calculation, mutagenesis, and mitochondrial calcium uptake assays to determine the functional role o

77 Moreover, mitochondrial calcium uptake at mitochondria-lysosome contact sites wa

78 was not a result of inhibited mitochondrial calcium uptake because robust calcium waves were still o

79 tion was increased independent of changes in calcium uptake because sarco(endo)plasmic reticulum Ca(2

80 acid release not by preventing mitochondrial calcium uptake but by inhibiting MPTP formation.

81 ablation of activity-dependent mitochondrial calcium uptake but had no effect on the rate or extent o

82 In 3T3-p75 cells, NGF increased calcium uptake but not intracellular calcium mobilizatio

83 ecrotic cell death by blocking mitochondrial calcium uptake but not the enzyme releasing fatty acids

84 kinase II on gene expression did not require calcium uptake but was synergistically enhanced by calci

85 xicity of glutamate depends on mitochondrial calcium uptake, but the toxicity to mitochondria also re

86 es mitochondrial transmembrane potential and calcium uptake by ca. 40 and 25% of the control level, r

87 25-Hydroxycholesterol stimulated calcium uptake by CHO-K1 cells within 2 min after additi

88 t C. communis leaves is increased apoplastic calcium uptake by guard cells.

89 0 microM); and (d) blockade of mitochondrial calcium uptake by microinjection of diaminopentane penta

90 lting in increased ER-mitochondria contacts, calcium uptake by mitochondria, and mitochondrial divisi

91 [(3)H]Resiniferatoxin (RTX) binding and calcium uptake by rat dorsal root ganglion (DRG) neurons

92 ECaC, have been postulated to mediate apical calcium uptake by rat intestine and rabbit kidney, respe

93 responses to JYL1421 and KJM429 differed for calcium uptake by rVR1 induced by heat or pH.

94 sted as a link for the mechanisms leading to calcium uptake by the colon and may thus reduce the risk

95 Regulation of mitochondrial calcium uptake by the mitochondrial calcium uniporter (m

96 Calcium uptake by the mitochondrial calcium uniporter co

97 Nifedipine blocked the increase in calcium uptake by these agents as well as their attenuat

98 Calcium uptake by TRPV5 was directly inhibited by magnes

99 apies against biofilm infections that target calcium uptake, calcium sensors, and calcium carbonate d

100 of CaBP expression had a negative effect on calcium uptake, calcium transport, and trophoblast diffe

101 ubes with knocked-down ANT1 exhibited higher calcium uptake capacity and voltage-thresholds of mPT op

102 we measured a slightly reduced mitochondrial calcium uptake capacity in the knockout mutant.

103 A possible function for the calcium uptake caused by albumin is to potentiate the pr

104 initiated to determine whether the decreased calcium uptake caused by ischemia was the result of inhi

105 hondria exhibit membrane potential-dependent calcium uptake compatible with uniporter activity, and a

106 myocytes, we hypothesized that mitochondrial calcium uptake contributes to HFD-induced mitochondrial

107 s demonstrated slower sarcoplasmic reticulum calcium uptake, decreased Ca(2+) release, and increased

108 ssion of DdMCU complements the mitochondrial calcium uptake defect in human cells lacking MCU or EMRE

109 ex III blockade, and decreased mitochondrial calcium uptake during neuronal activity.

110 lations, only reduced sarcoplasmic reticulum calcium uptake explained our results, causing calcium os

111 )/Ca(2+) ATPase activity or an uncoupling of calcium uptake from ATP hydrolysis.

112 ryonic development, our results suggest that calcium uptake from the environment via TRPM channels is

113 Mitochondrial calcium uptake has a central role in cell physiology by

114 The biophysical properties of mitochondrial calcium uptake have been studied in detail, but the unde

115 trast to its antagonism of vanilloid-induced calcium uptake, IBTU (30 microM) inhibited [3H]resinifer

116 upon their suppression of capsaicin-induced calcium uptake in a mouse dorsal root ganglion primary c

117 These channels allow calcium uptake in amyloid precursor protein-deficient ce

118 JM429 had little or no effect on ATP-induced calcium uptake in CHO cells lacking rVR1, unlike capsaze

119 ations increased dendritic and mitochondrial calcium uptake in cortical neurons and familial PD patie

120 r 6 (TRPV6) channels play a critical role in calcium uptake in epithelial tissues.

121 male LM mice with 1,25D(3) elicited enhanced calcium uptake in females and males within 5 min.

122 Stc1a inhibits calcium uptake in fish by repressing trpv6 expression an

123 strate that there is increased mitochondrial calcium uptake in HBx-expressing cells.

124 ven, supported both alpha-latrotoxin-induced calcium uptake in HEK293 cells and alpha-latrotoxin-stim

125 ral importance to steroid hormone-stimulated calcium uptake in mammalian intestinal cells.

126 how that these mutants reduced mitochondrial calcium uptake in MEF cells.

127 The role of mitochondrial calcium uptake in modulating SV recycling has been debat

128 brain-derived neurotrophic factor stimulates calcium uptake in p75(NGFR) cells but not in p140(trk) c

129 rophenone blocked MCU-mediated mitochondrial calcium uptake in permeabilized fibroblasts but not in i

130 Pyrophosphate was able to drive calcium uptake in permeabilized T. cruzi.

131 OX(R) showed no enhanced calcium uptake in response to 25-hydroxycholesterol.

132 s did not increase during culture in A23187, calcium uptake in the lens may be responsible for CPE ac

133 pholamban, a key player in the regulation of calcium uptake in the sarcoplasmic reticulum, and by pro

134 a high-throughput screening assay, measuring calcium uptake in TRPV1-expressing cells, we identified

135 lcium signalling, particularly mitochondrial calcium uptake, in ALS pathogenesis.

136 sed of genes previously linked to intestinal calcium uptake, including S100g, Trpv6, Atp2b1, and Cldn

137 composition, interfering with mitochondrial calcium uptake independently of cytosolic calcium and mi

138 the other hand, did not affect the level of calcium uptake induced by glutamate but rather the durat

139 The channel mediated calcium uptake induces neurite degeneration in human cor

140 Nerve growth factor stimulates calcium uptake into both transfectants but not into untr

141 t the later stages of the secretory pathway, calcium uptake into CTL SGF1 and CHX SGF1 was examined.

142 All calcium uptake into CTL SGF1 was dependent on a thapsiga

143 atio of rate of calcium extrusion to rate of calcium uptake into internal stores increased, indicatin

144 eased by approximately 100 microM s-1 due to calcium uptake into internal stores.

145 Inhibition of calcium uptake into mitochondria by ruthenium red induce

146 Calcium uptake into mitochondria occurs via a recently i

147 Calcium uptake into mitochondria was sometimes evident w

148 Finally, manipulating calcium uptake into or release from intracellular stores

149 lum calcium ATPase, being the main agent for calcium uptake into the ER, plays a central role in this

150 lta) modulate this process via regulation of calcium uptake into the sarcoplasmic reticulum through t

151 actions of cAMP are distinct from increasing calcium uptake into the sarcoplasmic reticulum.

152 itochondrial pathology, especially when that calcium uptake is accompanied by another stressor, in pa

153 Mitochondrial calcium uptake is an important regulator of bioenergetic

154 Mitochondrial calcium uptake is crucial to the regulation of eukaryoti

155 SR calcium uptake is mediated by a Ca(2+)-ATPase (SERCA2),

156 Mitochondrial calcium uptake is present in nearly all vertebrate tissu

157 f 875 miRNAs tested, miR-25 potently delayed calcium uptake kinetics in cardiomyocytes in vitro and w

158 pus oocytes, microinjected Calx cRNA induces calcium uptake like that of its homolog, the 3Na+-1Ca2+

159 her energetic demand decreased mitochondrial calcium uptake may constitute an adaptive cellular respo

160 Calcium-dependent calcium uptake measurements showed that the maximal velo

161 ischemia significantly inhibited microsomal calcium uptake mediated by Mg(2+)/Ca(2+) ATPase, the maj

162 Hasan et al. demonstrated that mitochondrial calcium uptake (MICU)1 and MICU2, regulatory subunits of

163 This is ensured by the mitochondrial calcium uptake (MICU)1/2 proteins that gate the pore of

164 l stimulation to the optic nerve can enhance calcium uptake more than a double pulse stimulation of t

165 1a production to allow the inaugural wave of calcium uptake necessary to initiate bone mineralization

166 can account for both the ligand binding and calcium uptake observed in rat DRG neurons.

167 Calcium uptake occurs through a channel called the unipo

168 erapeutic strategies targeting mitochondrial calcium uptake or the mitochondrial calcium uniporter, t

169 = 0.01), velocity of sarcoplasmic reticulum calcium uptake (p < 0.0001), and sarcoplasmic reticulum

170 calcium, and the high opacity mitochondrial calcium uptake pathway provides a mechanism that couples

171 molecular characterization of mitochondrial calcium uptake pathways, and offers genetic strategies f

172 The calcium uptake potentiates the efficacy of low concentra

173 Thus, reduction of the mitochondrial calcium uptake protects neurons and astrocytes against b

174 tion of an inhibitory subunit, mitochondrial calcium uptake protein 1, is central to PAH's pathogenes

175 Mitochondrial dynamics, mitophagy and calcium uptake proteins were abundant during early postn

176 nger RNA encoding the sarcoplasmic reticulum calcium uptake pump SERCA2a (also known as ATP2A2).

177 nd that both proteins associated with the ER calcium uptake pump SERCA2B, and TMTC2 also bound to the

178 sed SERCA2a protein expression and decreased calcium uptake rate by muscle homogenates.

179 , could account for most of the increases in calcium uptake rate observed in homogenates of muscles f

180 rowth of the target fungal cells by blocking calcium uptake rather than forming channels, as had been

181 resolve the submitochondrial localization of calcium uptake regulatory protein MICU1.

182 Mitochondrial calcium uptake stimulates bioenergetics and drives energ

183 Calcium uptake studies revealed that, in the atria, abla

184 hough concurrent inhibition of mitochondrial calcium uptake substantially enhanced this cytoplasmic c

185 ns sufficient to promote local mitochondrial calcium uptake, suggesting a tight coupling of calcium s

186 ivities are low concomitant with a defective calcium uptake, suggesting an extracellular accumulation

187 ll morphology with a concomitant increase in calcium uptake that is dependent on the MID1 and CCH1 ge

188 and the mechanism of neurotrophin-stimulated calcium uptake, the regulation of calcium uptake and int

189 Nifedipine, an inhibitor of calcium uptake through L-type calcium channels, inhibite

190 Mitochondrial bioenergetics is regulated by calcium uptake through the mitochondrial calcium uniport

191 This calcium uptake, through a mitochondrial calcium uniporte

192 Comparing calcium uptake to ATP hydrolysis as ischemia increased f

193 vators rapidly stimulated uniporter-mediated calcium uptake to open mitochondrial permeability transi

194 antigen-induced degranulation, extracellular calcium uptake, tyrosine phosphorylation of several key

195 from heterozygous mice showed an attenuated calcium uptake upon agonist stimulation.

196 PEF parameters necessary to cause observable calcium uptake, using cells preloaded with calcium green

197 UVA-evoked signaling led to mitochondrial calcium uptake via mitochondrial calcium uniporter to pr

198 tions of enhanced calcium entry, the rate of calcium uptake was faster compared with control conditio

199 ed that the effect of ischemia on microsomal calcium uptake was mediated by an uncoupling of calcium

200 at CL is essential for optimal mitochondrial calcium uptake, we measured the levels of other biologic

201 ater, LV function and sarcoplasmic reticulum calcium uptake were assessed.

202 ifferences in H(2)O(2) production or maximal calcium uptake were detected in the Ts16 mitochondria, t

203 ulum (SR) Ca(2+) ATPase (SERCA2)-mediated SR calcium uptake which was balanced by enhanced trans-sarc

204 CaT2 mediated saturable calcium uptake with a Michaelis constant (K(m)) of 0.66

205 +/- 6.5 nM and antagonized capsaicin-induced calcium uptake with an EC(50) of 9.2 +/- 1.6 nM, reflect

206 fibroblasts were depolarized and had reduced calcium uptake with impaired ATP production by oxidative

207 F reduced the magnitude of glutamate-induced calcium uptake with no apparent regulation thereafter.

208 Monitoring calcium uptake with the fluorescent dye calcein shows th