ライフサイエンスコーパス: calcium-ATPase

1 activation of SERCA (sarcoplasmic reticulum calcium ATPase).

2 mban, and sarcoplasmic/endoplasmic reticulum calcium ATPase).

3 ban in regulating the sarcoplasmic reticulum calcium ATPase.

4 um pump isoform 1 (PMCA1), a plasma membrane calcium ATPase.

5 (+)-ATPase, but failed to have any effect on calcium ATPase.

6 ole as a regulator of sarcoplasmic reticulum calcium ATPase.

7 e) and stimulation of sarcoplasmic reticulum calcium ATPase.

8 itor of the endoplasmic reticulum-associated calcium-ATPase.

9 ilin and the Ca(2+) ATPase secretory pathway calcium ATPase 1 (SPCA1) in the sorting of soluble secre

10 ATP-powered calcium pump (secretory pathway calcium ATPase 1 [SPCA1]) encoded by the ATP2C1 gene in

11 it co-localizes with PMCA1b (plasma membrane calcium ATPase 1b).

12 nsitivity to pain stimuli in plasma membrane calcium ATPase 2 (PMCA2) heterozygous mice: a possible m

13 Plasma membrane calcium ATPase 2 (PMCA2) is a calcium pump that plays im

14 elevated sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2a) expression, and faster lusitr

15 , whereas sarcoplasmic endoplasmic reticular calcium ATPase 2 abundance and sarcoplasmic reticulum Ca

16 gets both sarcoplasmic/endoplasmic reticulum calcium ATPase 2 and a novel Golgi inhibitor.

17 that is, sarcoplasmic/endoplasmic reticulum calcium ATPase 2 and the Na(+)/Ca(2+) exchanger.

18 ncreased SERCA2 (Sarco/Endoplasmic Reticulum Calcium ATPase 2) expression, which correlated with a le

19 p SERCA2 (sarcoplasmic/endoplasmic reticulum calcium ATPase 2).

20 e, as was sarcoplasmic endoplasmic reticular calcium ATPase 2/phospholamban protein ratio (45% reduce

21 MECs express the plasma membrane calcium-ATPase 2 (PMCA2), which transports calcium acros

22 he expression of sarco/endoplasmic reticulum calcium ATPase-2 (SERCA2), a protein that transports cal

23 izes with sarcoplasmic/endoplasmic reticulum calcium/ATPase-2 and calreticulin at membrane-bound cyto

24 ting the cardiac sarco/endoplasmic reticulum calcium ATPase 2a (SERCA2a) in the regulation of overall

25 m pump SERCA2a (sarco[endo]plasmic reticulum calcium ATPase 2a) within cardiomyocytes.

26 ptor 2, Ca(V)1.2, and sarcoplasmic reticulum calcium ATPase 2a, by attenuating transverse aortic cons

27 horylates sarcoplasmic/endoplasmic reticulum calcium-ATPase 2a (SERCA2a) and accelerates calcium re-u

28 creases in homogenate sarcoplasmic reticulum calcium ATPase-2a (SERCA2a) activity, protein density, a

29 fibrosis, normalized sarcoplasmic reticulum calcium ATPase-2a activity and expression of UCP-2 and U

30 nterstitial fibrosis, sarcoplasmic reticulum calcium ATPase-2a activity, expression of mitochondria u

31 s novel RyR2/PLN/sarco/endoplasmic reticulum calcium ATPase-2a complex was also identified in human a

32 oth RyR2 and PLN/sarco/endoplasmic reticulum calcium ATPase-2a macromolecular complexes.

33 eostasis through preserving sarcoplasmic/EnR calcium ATPase 2b (SERCA2b) function in AI-resistant cel

34 ium pump, sarcoplasmic-endoplasmic reticulum calcium ATPase-2b (SERCA2b).

35 oach, we discovered that the plasma membrane calcium ATPase 4 (PMCA4) is required for TNF-induced cel

36 form of the Ca(2+)-extruding plasma membrane calcium ATPase 4 (PMCA4) pump in Jurkat T cells unexpect

37 aracrine mechanism involving plasma membrane calcium ATPase 4 (PMCA4).

38 explored the role played by plasma membrane calcium ATPase-4 (PMCA4) and its alternative splice vari

39 e NADPH oxidase RBOHD, ABC-transporter PEN3, calcium-ATPase ACA8, noncanonical Galpha protein XLG2 an

40 We discovered that autoinhibitory calcium ATPases (ACAs) redundantly contribute to the ste

41 activity is elevated, and Na+-K+-ATPase and calcium ATPase activities are subnormal.

42 RS and the decrease of Na(+)-K(+)-ATPase and calcium ATPase activities in retinas of diabetic animals

43 The myosin high-salt EDTA and calcium ATPase activities of the isolated modified S1 we

44 -induced decreases of both Na+-K+-ATPase and calcium ATPase activities.

45 e calcium channel/sarcoendoplasmic reticulum calcium-ATPase activity and cardiac tissue fibrosis.

46 sitivity of the myofibers, cooperativity, or calcium-ATPase activity in the myofibers.

47 +) channels, N-methyl-d-aspartate receptors, calcium ATPase, adenomatous polyposis coli, and PTEN tum

48 ochondrial lipids and sarcoplasmic reticulum calcium ATPase after reperfusion.

49 SERCA2a (sarcoplasmic-endoplasmic reticulum calcium ATPase), along with an increased BNIP3 expressio

50 76, and PLCgamma2 as well as plasma membrane calcium ATPase and focal adhesion kinase.

51 of an intracellular calcium gradient by the calcium ATPase and processing within the Golgi compartme

52 e to mitochondria and sarcoplasmic reticulum calcium ATPase and restored mitochondrial and cardiac fu

53 inhibitors of the sarcoendoplasmic reticulum calcium ATPase and ryanodine receptor.

54 e to mitochondria and sarcoplasmic reticulum calcium ATPase and to impaired functional recovery.

55 tectable abundance of sarcoplasmic reticulum calcium-ATPase and sodium calcium exchanger were greater

56 ion of SERCA1a [sarco(endo)plasmic reticulum calcium ATPase] and SERCA2a calcium pump isoforms by pho

57 Interestingly, we identified calcium ATPases as ABCD2-binding partners, suggesting a

58 estrated by the preferential localization of calcium ATPases at one cell pole, in a ring pattern, fac

59 SERCA, a sarco-endoplasmic reticulum calcium ATPase, being the main agent for calcium uptake

60 nce ryanodine and sarcoendoplasmic reticulum calcium-ATPase blockers altered the time course and magn

61 and cardiac muscle, where it inhibits SERCA (calcium ATPase) by lowering its apparent Ca2+ affinity i

62 tained both a sodium/calcium exchanger and a calcium ATPase (Ca-ATPase).

63 pholamban-sarcoplasmic/endoplasmic reticulum calcium ATPase complex.

64 of the sarcoplasmic or endoplasmic reticulum calcium ATPase family that pumps Ca(2+) into the ER, res

65 In vivo both of these calcium ATPases function to maintain millimolar levels o

66 ) vector carrying the sarcoplasmic reticulum calcium ATPase gene (AAV1/SERCA2a) in patients with adva

67 The sodium-calcium exchanger and sarcolemmal calcium ATPase had a lower activity and the exchanger wa

68 idue integral membrane protein that inhibits calcium ATPase in the cardiac sarcoplasmic reticulum.

69 etes-induced reductions in Na+-K+-ATPase and calcium ATPase in the retina are mediated in large part

70 oding beta1- and beta2-adrenergic receptors, calcium ATPase in the sarcoplasmic reticulum, and alpha-

71 e further insights into the critical role of calcium ATPases in maintaining epidermal integrity.

72 gargin, a sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor that induces ER stress, underwe

73 IP3), the sarcoplasmic-endoplasmic reticulum calcium ATPase inhibitor, thapsigargin, and the calcium

74 s were induced to undergo apoptosis with the calcium ATPase inhibitor, thapsigargin, or the glucocort

75 with the sarcoplasmic-endoplasmic reticulum calcium ATPase inhibitor, thapsigargin, was completely b

76 channel release activator (caffeine) and SR calcium-ATPase inhibitor (cyclopiazonic acid), consisten

77 th the kinase inhibitor staurosporine or the calcium-ATPase inhibitor thapsigargin.

78 SERCA [sarco(endo)plasmic reticulum calcium ATPase] is regulated by oxidative posttranslatio

79 a decrease in the levels of plasma membrane calcium ATPase isoform 2 (PMCA2), a major pump extruding

80 l as an activation of sarcoplasmic reticulum calcium ATPase isoform 2 and citrate synthase, was evide

81 ntified the calcium exporter plasma membrane calcium ATPase isoform 4 (PMCA4) as the interaction part

82 gin-resistant activity was a plasma membrane calcium ATPase isoform in transit to the plasma membrane

83 ump was a sarcoplasmic/endoplasmic reticulum calcium ATPase isoform.

84 Plasma membrane calcium ATPase isoforms (PMCAs) are expressed in a wide

85 Inhibition of sarco-endoplasmic reticulum calcium ATPase led to store depletion and dramatic redis

86 ession of sarcoplasmic/endoplasmic reticular calcium ATPase, less stored calcium, smaller calcium tra

87 ionophore, and thapsigargin, an inhibitor of calcium ATPase, mimicked the ET-1-stimulated PGHS-2 mRNA

88 se had an increase in sarcoplasmic-reticulum calcium ATPase mRNA and alpha-myosin heavy chain mRNA an

89 timulated decrease in sarcoplasmic reticulum calcium ATPase mRNA.

90 malarial exerts its activity by inhibiting a calcium ATPase (PfATP6) that is most similar to sarcopla

91 ntly described by our group, plasma membrane calcium ATPase (PMCA) activity can be regulated by the a

92 The plasma membrane calcium ATPase (PMCA) extrudes calcium from the cytosol

93 H+ uptake by the ubiquitous plasma membrane calcium ATPase (PMCA) has not been measured in any neuro

94 on is internalization of the plasma membrane calcium ATPase (PMCA).

95 Inhibition of plasma membrane calcium-ATPase (PMCA) attenuated these effects, as did d

96 The plasma membrane calcium-ATPase (PMCA) helps to control cytosolic calcium

97 lar calcium ([Ca2+](i)), the plasma-membrane calcium-ATPase (PMCA) may actively contribute to the gen

98 hibition of isoform 4 of the plasma membrane calcium ATPase (PMCA4) prevents chronic remodelling and

99 Plasma membrane calcium ATPases (PMCAs) actively extrude Ca(2+) from the

100 ) extrusion by high-affinity plasma membrane calcium ATPases (PMCAs) is a principal mechanism for the

101 Plasma membrane calcium ATPases (PMCAs), responsible for high-affinity C

102 ily of Ca(2+) pumps includes plasma membrane calcium ATPases (PMCAs).

103 oads due to the abundance of plasma membrane calcium ATPases (PMCAs).

104 The plasma membrane calcium ATPase pump (PMCA) is one of two major mechanism

105 inhibitor of the Sarco/Endoplasmic Reticulum Calcium ATPase pump (SERCA), but unlike thapsigargin, ar

106 2 trial targeting the sarcoplasmic reticulum calcium ATPase pump (SERCA2a), along with the start of m

107 Treatment of DM with a calcium ATPase pump inhibitor substantially recapitulate

108 bling the sarcoplasmic/endoplasmic reticulum calcium ATPase pump-leak system and suggest that it is i

109 te to the sarcoplasmic/endoplasmic reticulum calcium ATPase pump.

110 We have used thapsigargin (TG), an ER calcium-ATPase pump inhibitor that induces calcium relea

111 7-nAChRs are associated with plasma membrane calcium-ATPase pump isoform 2 (PMCA2).

112 hapsigargin, an inhibitor of the endoplasmic calcium-ATPase pump.

113 /l of the SERCA (sarco/endoplasmic reticulum calcium ATPase) pump inhibitor thapsigargin and reduced

114 ceptors, and calcium reuptake and efflux via calcium-ATPase pumps and sodium-calcium exchangers.

115 ytoplasm, where it repletes the ER store via calcium-ATPases pumps.

116 tions of regulatory membrane proteins of the calcium ATPase SERCA, namely sarcolipin and phospholamba

117 gargin, a sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) (Ca2+ pump) blocker.

118 ion of CLNX with sarco endoplasmic reticulum calcium ATPase (SERCA) 2b results in inhibition of intra

119 sequence of sarco endoplasmic reticulum (ER) calcium ATPase (SERCA) 2b to inhibit Ca2+ oscillations.

120 tightly regulated, and the sarco-endoplasmic calcium ATPase (SERCA) actively pumps calcium from the c

121 he inhibition of sarco/endoplasmic reticulum calcium ATPase (SERCA) activity and ER stress.

122 ver, high sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) activity can also decrease local

123 used by impaired sarco/endoplasmic reticulum calcium ATPase (SERCA) activity due to altered phospholi

124 s modulation of sarco(endo)plasmic reticulum calcium ATPase (SERCA) activity.

125 The sarco(endo)plasmic reticulum calcium ATPase (SERCA) and its regulatory partner phosph

126 plasmic reticulum (ER) Ca(2+) pump sarco-/ER calcium ATPase (SERCA) and the single transmembrane-solu

127 structure, and sarco(endo)plasmic reticulum calcium ATPase (SERCA) binding were quantified by fluore

128 Sarco/endoplasmic reticulum calcium ATPase (SERCA) channels emerged at the intersect

129 The cardiac sarco/endoplasmic reticulum calcium ATPase (SERCA) establishes the intracellular cal

130 hat a decline in sarco/endoplasmic reticulum calcium ATPase (SERCA) function occurs with advancing ag

131 ose, a blocker of sarcoendoplasmic reticulum calcium ATPase (SERCA) had little effect on OCR despite

132 activity of the sarco(endo)plasmic reticulum calcium ATPase (SERCA) in cardiac myocytes is modulated

133 The sarco/endoplasmic reticulum calcium ATPase (SERCA) is essential for the control of i

134 The sarco(endo)plasmic reticulum calcium ATPase (SERCA) is regulated in a tissue-dependen

135 The sarcoplasmic reticulum calcium ATPase (SERCA) plays a central role in regulatin

136 The sarcoendoplasmic reticulum calcium ATPase (SERCA) plays a key role in cardiac calci

137 ncreasing sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) pump activity enhances sarcoplasm

138 te a role for the sarcoendoplasmic reticulum calcium ATPase (SERCA) pump in the regulation of endopla

139 highly abundant sarco/endoplasmic reticulum calcium ATPase (SERCA) pump.

140 sP(3)R)], sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) pumps, bradykinin receptors, and

141 Ca2+ channels and sarcoendoplasmic reticulum calcium ATPase (SERCA) pumps.

142 ibitor of sarcoplasmic endoplasmic reticulum calcium ATPase (SERCA)) while 1-EBIO (300 microM, an IKC

143 uding the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA), calreticulin, and calsequestrin,

144 onists of sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA), cyclopiazonic acid, and thapsiga

145 nanomolar inhibitor of the endo/sarcoplasmic calcium ATPase (SERCA), is presented.

146 The sarco/endoplasmic reticulum calcium ATPase (SERCA), which plays a key role in the ma

147 ylation activates the sarcoplasmic reticulum calcium ATPase (SERCA), which reduces cytoplasmic Ca(2+)

148 raction with the sarco-endoplasmic reticulum calcium ATPase (SERCA).

149 efilling via the sarco/endoplasmic reticulum calcium ATPase (SERCA).

150 hospholamban) and Sarcoendoplasmic Reticulum Calcium ATPase (SERCA).

151 cium pump sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA).

152 tags to PLB and sarco/endoplasmic reticulum calcium ATPase (SERCA).

153 thapsigargin in sarco/endoplasmic reticulum calcium ATPase (SERCA).

154 r by transfecting sarcoendoplasmic reticulum calcium ATPase (SERCA).

155 Reduced expression of sarcoplasmic reticulum calcium ATPase (SERCA)2 and other genes in the adult car

156 hibitors of sarco- and endoplasmic reticulum calcium-ATPase (SERCA) have important therapeutic value

157 symmetric distributions of RyRs and sarco/ER calcium-ATPase (SERCA) pumps that we predict using a com

158 ed mild ER stress and inhibition of sarco/ER calcium-ATPase (SERCA) without significant increase in s

159 ng regulation of sarco/endoplasmic reticulum calcium-ATPase (SERCA).

160 The calcium ATPase SERCA1 was coexpressed with the potassium

161 skeletal muscle sarco(endo)plasmic reticulum calcium ATPase (SERCA1) gene is transactivated as early

162 asmic reticulum (ER) calcium pump, sacro-/ER calcium ATPase (SERCA1).

163 The stimulation of sarcoplasmic reticulum calcium ATPase SERCA2a emerged as a novel therapeutic st

164 own-regulation of the sarcoplasmic reticulum calcium ATPase (SERCA2a) by GSK-3beta, acting at the lev

165 ession of the cardiac sarcoplasmic reticulum calcium ATPase (SERCA2a), a critical pump regulating cal

166 The sarcoplasmic reticulum calcium ATPase SERCA2b is an alternate isoform encoded b

167 3)Rs) and sarcoplasmic/endoplasmic reticulum calcium ATPases (SERCAs).

168 imilar to sarcoplasmic endoplasmic reticulum calcium ATPases (SERCAs).

169 or actin and P-type ATPase secretory pathway calcium ATPase (SPCA)-dependent sorting of secretory pro

170 ltiazem), ryanodine and inhibitors of the SR calcium ATPase (thapsigargin, cyclopiazonic acid) were w

171 f IRS-1 and the sarco(endo)plasmic reticulum calcium ATPase, the calcium pump of the endoplasmic reti

172 ine changes in expression of plasma membrane calcium ATPase type 2 (PMCA2), a high-affinity calcium e

173 hich encodes the sarco-endoplasmic reticulum calcium ATPase type 2 (SERCA2).

174 revealed that PDE3A associates with both SR calcium ATPase type 2a and phospholamban in a complex th

175 ns containing macromolecular complexes of SR calcium ATPase type 2a-phospholamban-PDE3A.

176 and upregulated sarco(endo)plasmic reticulum calcium-ATPase type 2 (SERCA2).

177 calcium channel, sarco/endoplasmic reticulum calcium-ATPase type 2a, Kv1.4, and Kv4.3 were downregula

178 Cav1 and the localization of plasma membrane calcium ATPase was disrupted.

179 The change in sarcoplasmic-reticulum calcium ATPase was not present in the patients in the pl

180 nto contact with the PLB binding site on the calcium ATPase, while the presence of twisting motions a

181 s similar to that for phosphorylation of the calcium ATPase with and without initial incubation with

182 nhibiting sarcoplasmic/endoplasmic reticulum calcium ATPase with cyclopiazonic acid or thapsigargin),