ライフサイエンスコーパス: calcium-sensing receptor

1 ships (metabotropic glutamate receptor 5 and calcium-sensing receptor).

2 cytes, which is identical to the parathyroid calcium-sensing receptor.

3 o utilize a unique signaling mechanism via a calcium-sensing receptor.

4 blast-like cells involves a G-protein-linked calcium-sensing receptor.

5 cellular calcium and mediated in part by the calcium-sensing receptor.

6 d magnesium and are tightly regulated by the calcium-sensing receptor.

7 ce, consistent with the existence of another calcium-sensing receptor.

8 eptor (CASR) is the prototypic extracellular calcium-sensing receptor.

9 channels; ions, protons and amino acids; the calcium-sensing receptor (a G protein-coupled receptor)

10 is due to loss-of-function mutations of the calcium-sensing receptor, a guanine nucleotide-binding p

11 Calcium-sensing receptor activation was assessed in colo

12 calcimimetic compound NPS R-467, a selective calcium-sensing receptor activator, augmented the calciu

13 of studies have demonstrated a role for the calcium-sensing receptor along the entire gastrointestin

14 An antagonist to the calcium-sensing receptor and an activin receptor fusion

15 TC-1, and to evaluate the involvement of the calcium-sensing receptor and G-protein coupled receptor-

16 Calcimimetics target the calcium-sensing receptor and lower parathyroid hormone l

17 thways for pharmacological intervention, the calcium-sensing receptor and the receptor activator of n

18 ng its pathogenesis focus on the key role of calcium-sensing receptors and TRPV5 channels in the modu

19 Calcium sensing receptors are part of a growing G protei

20 heterocycles and their effects on the human calcium-sensing receptor are discussed.

21 V2 vasopressin receptor, ACTH receptor, and calcium-sensing receptor are responsible for retinitis p

22 Calcium-sensing receptors are present in membranes as di

23 t correlated in vivo with production of anti-calcium-sensing receptor autoantibodies, which are typic

24 This is the exact size of the calcium sensing receptor (Ca-SR).

25 n keratinocytes express both the full-length calcium sensing receptor (CaR) and an alternatively spli

26 ion(s) of the carboxyl terminus of the human calcium sensing receptor (CaR) by assessing extracellula

27 Activation of the calcium sensing receptor (CaR) by small increments in ex

28 e have recently reported the presence of the calcium sensing receptor (CaR) in keratinocytes and sugg

29 The calcium sensing receptor (CaR) is essential for mediatin

30 been previously shown that the extracellular-calcium sensing receptor (CaR) is expressed in intact ra

31 We previously reported that the calcium sensing receptor (CaR) is required for mediating

32 The aminoglycoside antibiotics (AGAs) are calcium-sensing receptor (CaR) agonists that are toxic t

33 ocytes express the full-length extracellular calcium-sensing receptor (CaR) and an alternatively spli

34 rat striatum revealed that the extracellular calcium-sensing receptor (CaR) could be involved in sens

35 The extracellular calcium-sensing receptor (CaR) forms a disulfide-linked

36 ed that the G protein-coupled, extracellular calcium-sensing receptor (CaR) forms disulfide-linked di

37 The calcium-sensing receptor (CaR) has an essential role in

38 r Ca(2+) (Ca(2+)(o)) functioning through the calcium-sensing receptor (CaR) induces E-cadherin-mediat

39 The calcium-sensing receptor (CaR) is a G protein-coupled re

40 The calcium-sensing receptor (CaR) is a G protein-coupled, s

41 The calcium-sensing receptor (CaR) is a G-protein-coupled re

42 The calcium-sensing receptor (CaR) is a G-protein-coupled re

43 The calcium-sensing receptor (CaR) is activated by small cha

44 The calcium-sensing receptor (CaR) is activated by small cha

45 The calcium-sensing receptor (CaR) is an allosteric protein

46 The calcium-sensing receptor (CaR) is the major sensor and r

47 The calcium-sensing receptor (CaR) modulates renal calcium r

48 functional significance of the extracellular calcium-sensing receptor (CaR) on human pancreatic beta-

49 , perhaps acting via the seven-transmembrane calcium-sensing receptor (CaR) on mature monocytes/macro

50 The calcium-sensing receptor (CaR) recently has been shown t

51 The G protein-coupled, extracellular calcium-sensing receptor (CaR) regulates parathyroid hor

52 te in the coding region of the extracellular calcium-sensing receptor (CaR) that are associated with

53 ncreasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium.

54 Just a decade after the the calcium-sensing receptor (CaR) was identified, pharmacol

55 The calcium-sensing receptor (CaR), a member of G protein-co

56 ored by the G-protein coupled, extracellular calcium-sensing receptor (CaR), but neither its ontogeny

57 aste receptors (T1Rs), and the extracellular calcium-sensing receptor (CaR), represent a distinct gro

58 express the G protein-coupled, extracellular calcium-sensing receptor (CaR), showed that activation o

59 Recently, a calcium-sensing receptor (CaR), similar to the G protein

60 ons through the seven-transmembrane-spanning calcium-sensing receptor (CaR), which we identified as b

61 by extracellular calcium acting through the calcium-sensing receptor (CaR).

62 The extracellular calcium-sensing receptor (CaR; alternate gene names, CaR

63 g pathways in rat fibroblasts and implicates calcium-sensing receptors (CaR) as mediators of this res

64 Calcium-sensing receptors (CaR) contribute to regulation

65 Calcium-sensing receptors (CaR) regulate cell proliferat

66 The calcium-sensing receptor (CaS) is the principal controll

67 ER, and CBS) expressed the human parathyroid calcium sensing receptor (CaSR) and that a function of e

68 SOCE) amplitude, cationic channel TRPC6, and calcium sensing receptor (CaSR) expression.

69 The Calcium Sensing Receptor (CaSR) has been designated as t

70 cent studies show that the human parathyroid calcium sensing receptor (CaSR) is expressed in human co

71 The calcium sensing receptor (CaSR) plays an important role

72 d SVR sequences, clustered within a group of calcium sensing receptor (CaSR) sequences.

73 reases in [Ca](o) activate the extracellular calcium sensing receptor (CaSR) which in turn inhibits n

74 protein kinase (ERK1/2) by the AA-sensitive calcium sensing receptor (CaSR).

75 ied the glycosylated extracellular domain of calcium-sensing receptor (CaSR) (ECD) (residues 20-612),

76 Here we map the activation of the calcium-sensing receptor (CaSR) - a dimeric class C G pr

77 Here we show that the murine calcium-sensing receptor (CASR) activates the NLRP3 infl

78 Extracellular calcium-sensing receptor (CaSR) and ovarian cancer gene

79 or (PAM) drugs enhance the activation of the calcium-sensing receptor (CaSR) and suppress parathyroid

80 through high-throughput screening as a novel calcium-sensing receptor (CaSR) antagonist.

81 A calcium-sensing receptor (Casr) belonging to the metabot

82 ed normally to activation of the parathyroid calcium-sensing receptor (Casr) by both hypercalcemia an

83 activation and by another [Ca2+]o activates Calcium-sensing receptor (CaSR) closing the sodium-leak

84 The parathyroid calcium-sensing receptor (CaSR) controls the release of

85 The human calcium-sensing receptor (CaSR) detects fluctuations in

86 The calcium-sensing receptor (CaSR) drives essential calcium

87 ed by gain-of-function (GoF) variants in the calcium-sensing receptor (CaSR) encoded by CASR.

88 Loss of calcium-sensing receptor (CaSR) expression in vascular s

89 ed in the coding region of the extracellular calcium-sensing receptor (CASR) gene and cause human aut

90 Rare loss-of-function mutations in the calcium-sensing receptor (Casr) gene lead to decreased u

91 diabetes and to evaluate the association of calcium-sensing receptor (CaSR) gene single nucleotide p

92 deduced by the cloning of the extracellular calcium-sensing receptor (CaSR) in 1993 in the laborator

93 The calcium-sensing receptor (CaSR) in the distal convoluted

94 To understand the role of the calcium-sensing receptor (CasR) in the skeleton, we used

95 real-time internalization assay to show that calcium-sensing receptor (CaSR) internalization is beta-

96 The calcium-sensing receptor (CaSR) is a family C G-protein-

97 The calcium-sensing receptor (CaSR) is a G-protein-coupled r

98 The calcium-sensing receptor (CaSR) is critical for skeletal

99 The calcium-sensing receptor (CaSR) is important in the skin

100 The extracellular calcium-sensing receptor (CaSR) is the first identified

101 The calcium-sensing receptor (CaSR) is the main controller o

102 ino acid and extracellular cations, of which calcium-sensing receptor (CASR) is the prototypic extrac

103 The extracellular calcium-sensing receptor (CaSR) monitors the systemic, e

104 not have mutations in the gene encoding the calcium-sensing receptor (CASR) or AP2S1.

105 The calcium-sensing receptor (CASR) plays a pivotal role in

106 The calcium-sensing receptor (CaSR) provides a fundamental m

107 The calcium-sensing receptor (CaSR) regulates PTH secretion

108 The calcium-sensing receptor (CaSR) regulates serum calcium

109 Gain-of-function mutations of the calcium-sensing receptor (CaSR) result in autosomal domi

110 , GPIC1, and BCR, are predicted to influence calcium-sensing receptor (CaSR) signaling.

111 amino acid-containing peptide agonist of the calcium-sensing receptor (CaSR) that is being evaluated

112 lopment of the resistance of the parathyroid calcium-sensing receptor (CaSR) to circulating calcium t

113 otein alpha-11 (Galpha11), which couples the calcium-sensing receptor (CaSR) to intracellular calcium

114 The thick ascending limb (TAL) calcium-sensing receptor (CaSR) was critical for control

115 y cytokines by up-regulating the parathyroid calcium-sensing receptor (CaSR) with consequent developm

116 sis patients, subjects with GG at rs7627468 (calcium-sensing receptor (CASR)) have lower pH level in

117 The calcium-sensing receptor (CaSR), a cell-surface sensor f

118 The calcium-sensing receptor (CaSR), a family C GPCR, regula

119 rafficking of membrane proteins, such as the calcium-sensing receptor (CaSR), a G-protein coupled rec

120 Activation of the calcium-sensing receptor (CaSR), a G-protein-coupled rec

121 en embryos of both sexes, our data show that calcium-sensing receptor (CaSR), a G-protein-coupled rec

122 was associated with higher expression of the calcium-sensing receptor (CaSR), a heterotrimeric G-prot

123 dium phosphate co-transporter (SLC34A1), the calcium-sensing receptor (CASR), and fibroblast growth f

124 oduce parathyroid hormone (PTH), express the calcium-sensing receptor (CASR), and mobilize intracellu

125 ride channel CLCNKB, barttin (BSND), and the calcium-sensing receptor (CASR), each of which is import

126 o class C GPCRs, including the extracellular calcium-sensing receptor (CaSR).

127 calcium [eCa(2+)] via the G-protein coupled calcium-sensing receptor (CaSR).

128 that ophthalmate binds to and activates the calcium-sensing receptor (CaSR).

129 of plasma membrane constituents such as the calcium-sensing receptor (CaSR).

130 the NLRP3 inflammasome in monocytes through calcium-sensing receptor (CaSR).

131 e regulator (CFTR), chymotrypsin (CTR)C, and calcium-sensing receptor (CASR).

132 ulator (CFTR), chymotrypsinogen C (CTRC) and calcium-sensing receptor (CASR).

133 id hormone receptor (PTH1R; type B), and the calcium-sensing receptor (CaSR; type C) using fluorescen

134 GLUT2, could act as a glucose sensor and the calcium-sensing receptor, CasR, could detect amino acids

135 his hypercalcaemia acts on the extracellular calcium-sensing receptor, CaSR, to promote fluid-driven

136 eport a central role in this process for the calcium-sensing receptor, CaSR, which enables cellular r

137 report of ER Ca(2+) oscillations mediated by calcium sensing receptors (CaSRs), and revealed ER Ca(2+

138 Extracellular calcium-sensing receptors (CaSRs) are required for whole

139 ctivity were attributable to the activity of calcium-sensing receptors (CaSRs), which appear to be fu

140 disulfide bond-mediated dimerization of the calcium-sensing receptor contributes to stabilization of

141 Despite the homodimeric calcium-sensing receptor coupling to only one G protein

142 ial role for the G protein-coupled receptor, calcium-sensing receptor (CSR), in the regulation of Ca(

143 t (AP2S1) mutations, which result in altered calcium-sensing receptor endocytosis.

144 sphate response of cloned human keratinocyte calcium-sensing receptor expressed in human embryonic ki

145 hese results support the hypothesis that the calcium-sensing receptor expressed in keratinocytes medi

146 tide receptor, P2Y2 purinergic receptor, and calcium-sensing receptor) expressed in murine dendritic

147 The genetic mutations in the calcium-sensing receptor from patients with autosomal do

148 in of function, like the mutations effecting calcium-sensing receptor gain of function that cause aut

149 ty of a parathyroid-specific enhancer of the Calcium Sensing Receptor gene, which contains a risk all

150 10(-22), minor allele frequency 14%) in the calcium-sensing receptor gene (CASR).

151 Identification of mutations of calcium-sensing receptor has improved our understanding

152 A homology model for the human calcium sensing receptor (hCaR) transmembrane domain uti

153 found that cells expressing wild-type human calcium-sensing receptor (hCaSR-wt) and its gain of func

154 In order to define the role of the calcium-sensing receptor in calcium induced epidermal di

155 vious studies demonstrated the presence of a calcium-sensing receptor in human keratinocytes, which i

156 ctly inhibit PTH secretion by activating the calcium-sensing receptor in the parathyroid glands, but

157 pport a role for the luminal and basolateral calcium-sensing receptors in mediating some of the effec

158 Our discovery that the calcium-sensing receptor is a keratinocyte-selective MVP

159 asts to extracellular calcium and imply that calcium-sensing receptors may play a role in regulating

160 The benefit of R-568 alone suggests calcium-sensing receptor modulation may have additional

161 um calcium is mediated by G-protein coupled, calcium-sensing receptors on parathyroid cells, whereas

162 stry of calcium equilibrium results from the calcium-sensing receptors on the parathyroid glands, whi

163 Acute activation of the calcium-sensing receptor or feeding a zero phosphate die

164 The recently cloned extracellular calcium-sensing receptor plays a central role in this pr

165 rotein, the phosphate cotransporter Pit-1, a calcium-sensing receptor related factor, osteoprotegerin

166 g gastric acid secretion through the stomach calcium-sensing receptor (SCAR) located on the basolater

167 mutations on Galpha11 protein structure and calcium-sensing receptor signaling in human embryonic ki

168 s of function, since Galpha11 is involved in calcium-sensing receptor signaling, and its gene (GNA11)

169 All studies were carried out on the human calcium-sensing receptor tagged at the carboxyl terminus

170 The calcimimetic cinacalcet HCl acts on the calcium-sensing receptor to increase its sensitivity to

171 ecreased the sensitivity of cells expressing calcium-sensing receptors to changes in extracellular ca

172 n D additionally regulates the expression of calcium-sensing receptors to indirectly alter PTH secret

173 In the future, manipulation of the calcium-sensing receptor using calcimimetic or calcilyti

174 s, the vasopressin V2 receptor (V2R) and the calcium sensing receptor, using the novel V2R antagonist

175 the amount of biotinylated UT-A1 but not the calcium-sensing receptor was increased by forskolin.

176 racellular Ca(2+)-mediated activation of the calcium-sensing receptor was reduced by polyamines.

177 Candidate genes encoding the VDR and the calcium-sensing receptor were localized to regions on ra

178 ent of drugs targeting receptors such as the calcium-sensing receptor, which binds at least five calc

179 calcimimetics, allosteric modulators of the calcium-sensing receptor, would reduce cyst growth by in