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1 uptake; one of them encoded CaMK4, a calcium/calmodulin-dependent protein kinase.
2 crease its activity in BTICs, whereas Ca(2+)-calmodulin-dependent protein kinase 2 (CAMK2) inhibited
5 hanistically, CaMKK2 signals through Ca(2+) /calmodulin-dependent protein kinase 4 (CaMKIV) to contro
7 d dysregulation of Na and Ca handling and Ca/calmodulin-dependent protein kinase and are especially p
8 ined increase in cytosolic Ca(2+), activated calmodulin-dependent protein kinase and the calpain-casp
9 r new protein synthesis and required calcium/calmodulin-dependent protein kinases and the nuclear cal
10 by NMDA receptor activation, requires Ca2+ /calmodulin-dependent protein kinase, and is mediated by
11 cannabinoid type 1 (CB1) receptor and Ca(2+)/calmodulin-dependent protein kinase beta, activates AMP-
12 olerance, as did mutants in the gene calcium/calmodulin-dependent protein kinase (caki), encoding the
15 Psi Here, we characterize a role for calcium/calmodulin-dependent protein kinase (CaMK) I in the regu
16 f D-myo-inositol 1,4,5-trisphosphate/Ca(2+) /calmodulin-dependent protein kinase (CaMK) I. gamma-Amin
17 II could also induce the phosphorylation of calmodulin-dependent protein kinase (CaMK) II and cAMP r
18 ostretrieval bilateral inhibition of calcium/calmodulin-dependent protein kinase (CaMK) II in dorsal
19 +)-dependent binding of S100B to the calcium/calmodulin-dependent protein kinase (CaMK)-type domain o
20 2 model of Huntington disease and the Ca(2+)/calmodulin-dependent protein kinase (CaMK)/p25 double-tr
21 wn that the cytoplasmically oriented calcium/calmodulin-dependent protein kinase (CaMK)Ialpha regulat
22 gnaling in the inner ear is the type II Ca2+/calmodulin-dependent protein kinase (CaMK-II), which is
23 ore than 20 years, we have known that Ca(2+)/calmodulin-dependent protein kinase (CaMKII) activation
24 and the ensuing activation of the Ca(2+) and calmodulin-dependent protein kinase (CaMKII) are require
27 lation of RyR2 phosphorylation at the Ca(2+)/calmodulin-dependent protein kinase (CaMKII) site (S2814
29 prevent the arrhythmias induced by a Ca(2+) -calmodulin-dependent protein kinase (CaMKII)-dependent l
32 ral root development in Populus in a calcium/calmodulin-dependent protein kinase (CCaMK)-dependent ma
35 plex dephosphorylates and inactivates Ca2(+)/calmodulin-dependent protein kinase I (CaMKI), an upstre
38 sphorylation sites in Cx36 and evidence that calmodulin dependent protein kinase II (CaMKII) may pote
41 er brain regions, using Thy1-Cre and calcium/calmodulin dependent protein kinase II alpha-Cre for abl
42 is critically regulated by the alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII), a
46 sion of glutamate receptor 2 and beta Ca(2+)/calmodulin-dependent protein kinase II (betaCaMKII).
50 tate (NMDA) receptor activation, and Calcium/calmodulin-dependent protein kinase II (CaMKII) activati
51 e Cl(-) currents can be attributed to Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) activati
52 stically, this effect was mediated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) activati
53 Ca(2+) oscillations and consequent Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) activati
55 tamine exposure transiently increases Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) alpha ex
56 y (SOCE) and sequential activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and Ca(2
59 reduced activation of PLCgamma-alpha-calcium/calmodulin-dependent protein kinase II (CaMKII) and PI3K
62 phorylated at serine 409 (Ser-409) by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and prot
63 hibitory peptide (mAIP) selective for Ca2+ / calmodulin-dependent protein kinase II (CaMKII) and U012
64 cription factor DeltaFosB and protein kinase calmodulin-dependent protein kinase II (CaMKII) are co-r
66 tein kinase A (PKA) at Ser(16) and by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) at Thr(1
70 ulation; (5) inhibiting either PKA or Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) during b
71 imulation; (5) inhibiting either PKA or Ca2+/calmodulin-dependent protein kinase II (CaMKII) during b
72 lum (SR) Ca(2+) release that involves Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) effects
73 activation of the multifunctional Ca(2+) and calmodulin-dependent protein kinase II (CaMKII) favors m
79 o signal neuronal cells and activate calcium calmodulin-dependent protein kinase II (CaMKII) in neuro
80 ctly associates with and targets the calcium/calmodulin-dependent protein kinase II (CaMKII) in pancr
81 iew, the functions of multifunctional Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in VSM p
88 e heart; however, the multifunctional Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is also
92 Here we show that the activity of calcium/calmodulin-dependent protein kinase II (CaMKII) is incre
93 w that Ca(2+)-dependent activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is requi
94 Considerable evidence suggests that calcium/calmodulin-dependent protein kinase II (CaMKII) overacti
96 ated Ca(2+) channels (VGCCs) leads to Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) phosphor
97 nhanced [(3) H]ryanodine binding and Ca(2+) /calmodulin-dependent protein kinase II (CaMKII) phosphor
102 nel activity reduced EGF receptor (EGFR) and calmodulin-dependent protein kinase II (CAMKII) signalin
103 is downstream of Dalpha7 nAChRs and Calcium/calmodulin-dependent protein kinase II (CaMKII) signalin
104 treated wild-type C57BL/6 mice with calcium/calmodulin-dependent protein kinase II (CaMKII) specific
107 esulted in compromised signaling from Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) to myosi
108 which in turn requires binding of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) to the N
109 protein GW182 increases expression of a Ca2+/calmodulin-dependent protein kinase II (CaMKII) translat
112 nificantly increased the activity of calcium/calmodulin-dependent protein kinase II (CaMKII) while re
113 ought to determine how activation of calcium/calmodulin-dependent protein kinase II (CaMKII), a centr
114 CaMK2N2 are endogenous inhibitors of calcium/calmodulin-dependent protein kinase II (CaMKII), a key s
115 reduces FRET between the NMDARcd and calcium/calmodulin-dependent protein kinase II (CaMKII), a proce
117 following: 1) that autophosphorylated Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), an impo
118 triggers the exchange of subunits in Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), an olig
119 embranes, synGAP is phosphorylated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), another
120 ono pentanoic acid; the inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII), autocam
121 vented by pharmacological blockade of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), it was
122 tream effector of WNT/Ca(2+) pathway, Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), led to
123 athway is a kinase cascade involving calcium/calmodulin-dependent protein kinase II (CaMKII), p38alph
125 d for activation of a MAPK cascade utilizing calmodulin-dependent protein kinase II (CaMKII), Raf, an
126 tors of transient spine expansion, including calmodulin-dependent protein kinase II (CaMKII), RhoA, a
127 ts depends on their interaction with calcium/calmodulin-dependent protein kinase II (CaMKII), which i
128 scular smooth muscle (VSM) expresses calcium/calmodulin-dependent protein kinase II (CaMKII)-delta an
129 ators of myocardial excitability, and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-dependen
130 reased intracellular Ca(2+) through a Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-mediated
131 he hypotheses that (1) inhibition of Ca(2+) /calmodulin-dependent protein kinase II (CAMKII)-mediated
132 o the model reveal that inclusion of Ca(2+) /calmodulin-dependent protein kinase II (CAMKII)-mediated
133 lism regulates oocyte cell death via calcium/calmodulin-dependent protein kinase II (CaMKII)-mediated
134 Although many studies have focused on Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-mediated
145 tor DeltaFosB and the brain-enriched calcium/calmodulin-dependent protein kinase II (CaMKIIalpha) are
146 to principal or local-circuit cells, calcium/calmodulin-dependent protein kinase II (CAMKIIalpha) imm
149 ites by protein kinase A (Ser-7) and calcium-calmodulin-dependent protein kinase II (Ser-13) and at m
150 , PKA regulatory subunit type II, and Ca(2+)/calmodulin-dependent protein kinase II across cardiomyoc
152 id) receptor activation, calcium and calcium/calmodulin-dependent protein kinase II activity, but not
153 increase in oxidation-dependent calcium and calmodulin-dependent protein kinase II activity, which c
155 Alcohol-sensitive proteins included calcium/calmodulin-dependent protein kinase II alpha (CaMKIIalph
157 t mice devoid of IFNAR1 signaling in calcium/calmodulin-dependent protein kinase II alpha (CaMKIIalph
158 bunit, Rpt6, by the plasticity kinase Ca(2+)/calmodulin-dependent protein kinase II alpha (CaMKIIalph
159 ling molecules, calcineurin, Ras, and Ca(2+)/calmodulin-dependent protein kinase II and implicates Ca
160 ) currents were dependent in part on calcium/calmodulin-dependent protein kinase II and IP(3) pathway
161 mic the calmodulin binding domain of calcium/calmodulin-dependent protein kinase II and its 1-amino-a
162 itive deficits via altered levels of calcium/calmodulin-dependent protein kinase II and N-methyl-D-as
163 ociated with reduced levels of total calcium/calmodulin-dependent protein kinase II and N-methyl-D-as
164 lated to higher activation of nuclear Ca(2+)/calmodulin-dependent protein kinase II and nuclear expor
165 o be independent of their effects on calcium/calmodulin-dependent protein kinase II and PKA, respecti
167 rrhythmic manifestations, related to Ca(2+) /calmodulin-dependent protein kinase II and ryanodine rec
168 , cardiac stress protein biomarkers, such as calmodulin-dependent protein kinase II and the transcrip
169 it that mediates dephosphorylation of Ca(2+)/calmodulin-dependent protein kinase II and tyrosine hydr
170 es and Thr-287 autophosphorylation of Ca(2+)/calmodulin-dependent protein kinase II beta (CaMKIIbeta)
171 However, double knockdown of pygo and Ca2+/calmodulin-dependent protein kinase II caused additional
172 , inhibitors, and a dominant negative Ca(2+)/calmodulin-dependent protein kinase II construct block A
174 nt and function, including Titin and calcium/calmodulin-dependent protein kinase II delta (Camk2d).
175 he mechanical effects of the kinases calcium/calmodulin-dependent protein kinase II delta (CaMKIIdelt
177 myocytes from arrhythmia-susceptible calcium calmodulin-dependent protein kinase II delta C (CaMKIIde
179 the LTP kinase dependency from PKA to Ca2(+)/calmodulin-dependent protein kinase II during synapse ma
183 tracellular signal-regulated kinase, calcium/calmodulin-dependent protein kinase II gamma, and CREB2,
184 A null mutation of the Drosophila calcium/calmodulin-dependent protein kinase II gene (CaMKII) was
185 ion and subsequent activation of calcium and calmodulin-dependent protein kinase II has a causal role
186 eam signaling protein, PKC-alpha, and Ca(2+)/calmodulin-dependent protein kinase II in endothelial ce
187 2B, also referred to as Pyk2) and of calcium/calmodulin-dependent protein kinase II in wild-type brai
188 rolled firing rate adaptation whereas Ca(2+)/Calmodulin-dependent protein kinase II induced a delayed
189 ia inhibition of ryanodine receptors, Ca(2+)/calmodulin-dependent protein kinase II inhibition, or by
191 Development of organ-specific calcium and calmodulin-dependent protein kinase II inhibitors may re
192 ignal-regulated kinase activators and Ca(2+)/calmodulin-dependent protein kinase II inhibitors showed
194 rom transgenic mice expressing a calcium and calmodulin-dependent protein kinase II inhibitory peptid
197 es including JNK, GSK3alpha/beta, and Ca(2+)/calmodulin-dependent protein kinase II is increased sign
199 on synapsin I, two of which are known Ca(2+)/calmodulin-dependent protein kinase II phosphorylation s
200 xygen species signaling, and oxidized Ca(2+)/calmodulin-dependent protein kinase II signaling were in
202 ignaling kinases protein kinase C and Ca(2+)/Calmodulin-dependent protein kinase II to AngII-mediated
204 as phosphorylation of substrates for calcium/calmodulin-dependent protein kinase II was unchanged.
206 Pharmacologic inhibition of calcium and calmodulin-dependent protein kinase II with 2.5 microM o
208 nd is accompanied by altered CaMKII (calcium/calmodulin-dependent protein kinase II) and flotillin-1
209 stabilization of postsynaptic CaMKII (Ca(2+)/calmodulin-dependent protein kinase II) at inhibitory sy
210 1 pathway, phospho-alphaCaMKII (alpha Ca2(+)/calmodulin-dependent protein kinase II) level in the hip
211 mitochondrial recruitment of CaMKII (Ca(2+)/calmodulin-dependent protein kinase II), which decreases
212 phosphorylation at Ser16 and CaMKII (Ca(2+)/calmodulin-dependent protein kinase II)-dependent phosph
214 ng protein, but not the activation of Ca(2+)/calmodulin-dependent protein kinase II, Akt or mitogen-a
215 mitogen-activated protein kinase, and Ca(2+)/calmodulin-dependent protein kinase II, and activators o
216 in cAMP, light-induced activation of Ca(2+) /calmodulin-dependent protein kinase II, and dopamine-ind
217 kinases, including protein kinase C, Ca(2+)/calmodulin-dependent protein kinase II, and extracellula
218 ellular protein mediators Homer1b/c, calcium/calmodulin-dependent protein kinase II, and the Alzheime
219 c activation of protein kinase A and calcium/calmodulin-dependent protein kinase II, as well as synap
220 a(2+) must first mobilize actin-bound Ca(2+)/calmodulin-dependent protein kinase II, freeing it for s
221 glutamate-mediated Ca(2+) signaling (Ca(2+)/calmodulin-dependent protein kinase II, PPP3CA, and VISL
223 turn, led to the phosphorylation of calcium/calmodulin-dependent protein kinase II, which promoted b
224 ice using the CaMKIIalpha-Cre (alpha-calcium/calmodulin-dependent protein kinase II-Cre) system to KD
225 2 expression can be upregulated in a calcium/calmodulin-dependent protein kinase II-dependent manner
226 at have the ryanodine receptor 2 calcium and calmodulin-dependent protein kinase II-dependent phospho
227 l fragment of HDAC4 but also promoted Ca(2+)/calmodulin-dependent protein kinase II-mediated phosphor
228 ent of HDAC4, which was attenuated by Ca(2+)/calmodulin-dependent protein kinase II-mediated phosphor
230 used 1 Hz optogenetic stimulation of calcium/calmodulin-dependent protein kinase II-positive principa
231 lease channel-ryanodine receptor-2, PKA, and calmodulin-dependent protein kinase II-were activated in
237 FTO interacts with three isoforms of calcium/calmodulin-dependent protein kinase II: alpha, beta and
240 pines, (3) required activation of the Ca(2+)/calmodulin-dependent protein-kinase II, (4) was restrict
244 ms like those associated with CaMKII (Ca(2+)/calmodulin-dependent protein kinase-II), NLRP3 (NACHT, L
245 A protein with similarities to the Ca(2+)/ calmodulin dependent protein kinase II_association domai
246 rotein (alphakap) encoded within the calcium/calmodulin-dependent protein kinase IIalpha (CAMK2A) gen
248 AT-C24 DAT) and thereby contained the Ca(2+)-calmodulin-dependent protein kinase IIalpha (CaMKIIalpha
249 a synapse-enriched protein kinase, Ca(2)(+)/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha
250 is study, we investigated the role of Ca(2+)/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha
251 ization of beta-actin mRNA but not of Ca(2+)/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha
252 ceptors, p600 associates with the calmodulin.calmodulin-dependent protein kinase IIalpha complex.
253 essing Cre-recombinase driven by the calcium/calmodulin-dependent protein kinase IIalpha promoter.
254 d cardiomyocyte apoptosis, fibrosis, calcium/calmodulin-dependent protein kinase IIdelta phosphorylat
255 as a direct inhibitor of CaMKIIdelta (Ca(2+)/calmodulin-dependent protein kinase IIdelta) activity, a
256 Because SN inhibits CaMKIIdelta (Ca(2+)/calmodulin-dependent protein kinase IIdelta) activity, w
257 se II inhibitor KN93, suggesting that Ca(2+)/calmodulin-dependent protein kinase IIdelta, a target of
258 n vascular smooth muscle (VSM) cells, Ca(2+)/calmodulin-dependent protein kinase IIdelta2 (CaMKIIdelt
259 he mechanistic role of the family of calcium/calmodulin-dependent protein kinases in mediating these
260 gh saturated fat diet activates CaMK (Ca(2+)/calmodulin-dependent protein kinase) in the heart, which
262 Here, we present evidence that the calcium/calmodulin-dependent protein kinase IV (CaMK4) is increa
264 sponse to membrane depolarization and Ca(2+)/calmodulin-dependent protein kinase IV (CaMKIV) activati
265 ive oxygen species (ROS) production, calcium/calmodulin-dependent protein kinase IV (CaMKIV) activati
267 describe a novel mechanism in which calcium/calmodulin-dependent protein kinase IV (CaMKIV), through
269 KN93, a small-molecule inhibitor of calcium/calmodulin-dependent protein kinase IV, targeted to CD4(
270 is regulated by the classical nuclear Ca(2+)/calmodulin-dependent protein kinase IV-CREB/CREB-binding
272 ersely, the DOR effect was reduced by Ca(2+)/calmodulin-dependent protein kinase kinase (CaMKK) inhib
273 alian target of rapamycin (mTOR) via calcium calmodulin-dependent protein kinase kinase (CaMKK).
275 re, we report that the expression of Ca(2+) /calmodulin-dependent protein kinase kinase 2 (CaMKK2) is
276 ally reduced by the application of a calcium/calmodulin-dependent protein kinase kinase 2 inhibitor (
277 istic target of rapamycin complex 1, calcium/calmodulin-dependent protein kinase kinase 2, and protei
279 e expression of constitutively active Ca(2+)/calmodulin-dependent protein kinase kinase alpha (caCaMK
280 PK kinases liver kinase B1 (LKB1) and Ca(2+)/calmodulin-dependent protein kinase kinase beta (CaMKKbe
281 AMPK activation by aa is mediated by Ca(2+)/calmodulin-dependent protein kinase kinase beta (CaMKKbe
284 events were blocked by inhibition of Ca(2+)/calmodulin-dependent protein kinase kinase beta, an upst
286 altered calcium signaling, transduced by the calmodulin-dependent protein kinase kinase cascade, medi
289 y AMPA-type glutamate receptors and required calmodulin-dependent protein kinase-mediated phosphoryla
290 ngation factor 2 kinase (eEF2K), an atypical calmodulin-dependent protein kinase, phosphorylates and
291 or somatostatin-positive interneurons and of calmodulin-dependent, protein kinase-positive, principal
293 alcineurin, Akt/protein kinase B, and Ca(2+)/calmodulin-dependent protein kinase signaling pathways i
294 O)-1, glutathione reductase (GSR)-1, calcium/calmodulin-dependent protein kinase type (CAMK)-IV, cAMP
296 ger, phospholamban, calcineurin, and calcium/calmodulin-dependent protein kinase type II (CaMKII) wer
298 -bisphosphate binding, protein kinase C- and calmodulin-dependent protein kinase type II phosphorylat
299 to remodeling pathways (e.g., Akt and Ca(2+)/calmodulin-dependent protein kinase type II) and develop