ライフサイエンスコーパス: calorie restriction

1 a function of aging, which was prevented by calorie restriction.

2 criptome persist regardless of two months of calorie restriction.

3 ke CREB-deficient mice, poorly responsive to calorie restriction.

4 e, augment stem-cell function in response to calorie restriction.

5 sed with the introduction of early postnatal calorie restriction.

6 d yet) result in reduced fat storage through calorie restriction.

7 is selectively activated during fasting and calorie restriction.

8 h dietary carbohydrate restriction than with calorie restriction.

9 ngival RAGE expression in rats is reduced by calorie restriction.

10 r expression of glucose-repressed genes upon calorie restriction.

11 important role in cell survival promoted by calorie restriction.

12 ing behavioral changes induced by short-term calorie restriction.

13 tal immobility in the forced swim test after calorie restriction.

14 reduced depression-like symptoms induced by calorie restriction.

15 hallmark of healthy AT and is upregulated by calorie restriction.

16 side to enhance life span does not depend on calorie restriction.

17 gene silencing, and extends lifespan without calorie restriction.

18 OR signaling mediates life span extension by calorie restriction.

19 extent than does similar weight loss through calorie restriction.

20 by Sir2 activity under conditions that mimic calorie restriction.

21 This process could be prevented by calorie restriction.

22 t deacetylase and may mediate the effects of calorie restriction.

23 gene mediates the life-extending effects of calorie restriction.

24 er certain environmental conditions, such as calorie restriction.

25 temperature and of energy expenditure during calorie restriction.

26 specific rewiring, which can be prevented by calorie restriction.

27 dent, with a mechanism most likely mimicking calorie restriction.

28 uction in energy expenditure associated with calorie restriction.

29 ation of IGF-1R prevented hypothermia during calorie restriction.

30 her parameters of adiposity independently of calorie restriction.

31 portant factor for the beneficial effects of calorie restriction.

32 onstrating replicative lifespan extension by calorie restriction.

33 by HPF1 was buffered by rapamycin but not by calorie restriction.

34 to study cells as they age in the absence of calorie restriction.

35 nimals is impaired but can be reactivated by calorie restriction.

36 fter ex vivo cytokine withdrawal and in vivo calorie restriction.

37 y increased bone mass in all cohorts despite calorie restrictions.

38 oups was as follows: controls, -1.0% (1.1%); calorie restriction, -10.4% (0.9%); calorie restriction

39 unchanged in controls, but decreased in the calorie restriction (-135 kcal/d [42 kcal/d]), calorie r

40 6 months: control (weight maintenance diet); calorie restriction (25% calorie restriction of baseline

41 When mice are subjected to 7-day calorie restriction (40% of normal food intake), body fa

42 iours (e.g. 88% would routinely advise about calorie restriction; 99.6% about increasing exercise) mo

43 activation of mTORC1 in Paneth cells during calorie restriction abolishes the ISC-augmenting effects

44 Calorie restriction acts by reducing mechanistic target

45 Whether prolonged calorie restriction affects biomarkers of longevity or m

46 and skeletal muscle metabolism; 48 hours of calorie restriction affects the liver (IHTG content, hep

47 Thus, calorie restriction affects the onset but not the progre

48 n-Y gastric bypass (RYGB) surgery than after calorie restriction alone has independent effects on glu

49 ter improvements than those that result from calorie restriction alone.

50 Whether dietary changes without calorie restriction also protect from diabetes has not b

51 Acute injections of GH after 7 d of calorie restriction also restored hepatic autophagy, but

52 doses of exercise or exercise combined with calorie restriction, although further work is required t

53 We previously showed that calorie restriction ameliorated Huntington's disease pat

54 In conclusion, 4-month dietary calorie restriction and aerobic exercise had significant

55 ses that have traditionally been linked with calorie restriction and aging in mammals.

56 The effect of early-onset calorie restriction and aging on the accumulation of ele

57 through improvements in macroautophagy (eg, calorie restriction and calorie restriction mimetics) ar

58 Core body temperature was reduced in the calorie restriction and calorie restriction with exercis

59 tested the hypothesis that weight loss from calorie restriction and exercise combined (CREX) improve

60 We show that calorie restriction and exercise-mediated weight loss in

61 the physiological changes in mammals during calorie restriction and how they may lead to the observe

62 ary and sufficient for lifespan extension by calorie restriction and low-intensity stress.

63 esponses to a variety of stresses, including calorie restriction and metabolic stress.

64 Calorie restriction and rapamycin extended life span in

65 or cyclic ADP ribose-mediates the effects of calorie restriction and rapamycin on ISC function.

66 cally the Ames dwarf Prop1 (df/df) mutation, calorie restriction and rapamycin.

67 a key transcriptional target and mediator of calorie restriction and stress-induced life span extensi

68 When subjected to calorie restriction and then fasted for 23 hours, the L-

69 Lack of Sir2 along with calorie restriction and/or mutations in the yeast AKT ho

70 malian sirtuins as regulators of physiology, calorie restriction, and aging.

71 levels were elevated by fasting or prolonged calorie restriction, and declined with feeding.

72 ercise 5 d/wk for 16 wk combined with modest calorie restriction ( approximately 0.84 MJ/d).

73 Moreover, if metabolic syndrome and calorie restriction are opposite extremes of the same me

74 ed to an enhanced starvation response during calorie restriction as evidenced by increased plasma ghr

75 tiveness of 2 wk of dietary carbohydrate and calorie restriction at reducing hepatic triglycerides in

76 with the changes in ARC expression observed, calorie restriction attenuated the increases in cytosoli

77 longer duration are required to determine if calorie restriction attenuates the aging process in huma

78 ine systems and propose that Sirt1 regulates calorie restriction by sensing low calories and triggeri

79 ocus on mitochondrial-targeted antioxidants, calorie restriction, calorie restriction mimetics, and e

80 neth cells, and the ISC-enhancing effects of calorie restriction can be mimicked by rapamycin.

81 Calorie restriction can extend life span in a variety of

82 Calorie restriction can inhibit or delay carcinogenesis,

83 Calorie restriction caused a persistent and significant

84 Excessive calorie restriction causes malnutrition and has adverse

85 Moderate calorie restriction causes temporal changes in liver and

86 Mice were subjected to 1 wk of 60% calorie restriction, causing them to lose nearly all bod

87 Both chronic calorie restriction (CCR) and intermittent calorie restr

88 Presently, we demonstrate that 10 d of calorie restriction, corresponding to a 20-25% weight lo

89 o of exercise training (EX group; n = 18) or calorie restriction (CR group; n = 18)] or to a healthy

90 Calorie restriction (CR) (consumption of a diet with few

91 Calorie restriction (CR) and alternate-day fasting (ADF)

92 Calorie restriction (CR) and alternate-day fasting (ADF)

93 Calorie restriction (CR) and conserved nutrient-sensing

94 Mammalian life span can be extended by both calorie restriction (CR) and mutations that diminish som

95 Weight loss from calorie restriction (CR) and/or endurance exercise train

96 It is not known if long-term calorie restriction (CR) can ameliorate this relationshi

97 Calorie restriction (CR) delays aging and affects the ci

98 Dietary methionine restriction (MR) and calorie restriction (CR) each improve metabolic health a

99 Calorie restriction (CR) enhances health span (the lengt

100 Calorie restriction (CR) extends life span and ameliorat

101 Calorie restriction (CR) extends life span in a wide var

102 Calorie restriction (CR) extends life span in diverse sp

103 Calorie restriction (CR) extends the life span of numero

104 It has been reported that 30% calorie restriction (CR) for 3 mo results in large incre

105 Calorie restriction (CR) has been reported to increase S

106 Calorie restriction (CR) improves health and extends lif

107 ulators in the lifespan extending effects of calorie restriction (CR) in a number of species.

108 Calorie restriction (CR) in the absence of malnutrition

109 While moderate calorie restriction (CR) in the absence of malnutrition

110 Calorie restriction (CR) increases life span in yeast in

111 Calorie restriction (CR) increases longevity in many spe

112 Calorie restriction (CR) increases the lifespan of C57Bl

113 Calorie restriction (CR) influences aging processes and

114 Calorie restriction (CR) is a dietary intervention that

115 Calorie restriction (CR) is a feeding paradigm known to

116 ring genetic manipulation, the diet known as calorie restriction (CR) is currently the only way to sl

117 Calorie restriction (CR) is neuroprotective in Parkinson

118 in human WAT under conditions of obesity and calorie restriction (CR) is not fully understood yet.

119 Calorie restriction (CR) is often described as the most

120 cardiovascular and chronic kidney diseases; calorie restriction (CR) is the most studied means to de

121 idence suggesting weight maintenance through calorie restriction (CR) may limit risk of HER2-positive

122 Because calorie restriction (CR) modulates age-related renal dis

123 Despite initial success, weight loss by calorie restriction (CR) often fails because of rebound

124 Here we examined the effects of aging and calorie restriction (CR) on expression of the oxidative

125 deacetylase mediates many of the effects of calorie restriction (CR) on organismal lifespan and meta

126 We previously showed that calorie restriction (CR) reduced brain Abeta deposition

127 Clinical trials involving calorie restriction (CR) require an assessment of adhere

128 Calorie restriction (CR) retards aging and increases lon

129 er protection observed in NRF2 KO mice under calorie restriction (CR) suggests that most of the benef

130 tion, wild-type NAD+ salvage is required for calorie restriction (CR) to extend replicative lifespan.

131 ion of circadian clock genes are affected by calorie restriction (CR), a dietary paradigm known to in

132 Determining how calorie restriction (CR), a prolongevity metabolic inter

133 Calorie restriction (CR), a reduction of 10-40% in intak

134 Calorie restriction (CR), a robust intervention shown to

135 rce or experimentally reduced such as during calorie restriction (CR), endotherms can reduce energy e

136 including reduced life span under stress and calorie restriction (CR), G1 arrest defects, dedifferent

137 Calorie restriction (CR), the reduction of dietary intak

138 multiple long-lived mouse models, including calorie restriction (CR), which led us to hypothesize th

139 concomitant decrease in NADH levels mediate calorie restriction (CR)-induced life span extension.

140 span and the antiaging effects conferred by calorie restriction (CR).

141 icient in SIRT4 or on the dietary regimen of calorie restriction (CR).

142 ogic features mimicking animals living under calorie restriction (CR).

143 m cells (ISCs) is instead upregulated during calorie restriction (CR).

144 or, CRTC1 mediates anti-steatotic effects of calorie restriction (CR).

145 Reduced intake of nutrients [calorie restriction (CR)] extends longevity in organisms

146 he hypothesis that the gingiva of rats fed a calorie-restriction (CR) diet expresses lower levels of

147 evaluate the clinical effects of a long-term calorie-restriction (CR) diet on periodontitis in an ani

148 Weight control by exercise and dietary calorie restriction (DCR) has been associated with reduc

149 Calorie restriction delays brain senescence and prevents

150 e a potentially conserved mechanism by which calorie restriction delays the ageing process.

151 iled to further increase life span and, like calorie restriction, deletion of either SCH9 or TOR1 inc

152 s revealed that IGF signaling also modulates calorie restriction-dependent Tb regulation in regions r

153 Calorie restriction did not prevent muscle mass loss wit

154 were randomly assigned to and started a 25% calorie restriction diet (n=143, 66%) or an ad libitum c

155 ic risk factor responses to a prescribed 25% calorie restriction diet for 2 years were evaluated (sys

156 ipants were randomly assigned (2:1) to a 25% calorie restriction diet or an ad libitum control diet.

157 using terms encompassing various aspects of calorie restriction, dietary restriction, aging, longevi

158 ication of the orexin gene promoter, whereas calorie restriction enhances the activation of orexin ce

159 ead us to propose a genetic pathway by which calorie restriction extends life span and provides a fra

160 Calorie restriction extends lifespan and produces a meta

161 Calorie restriction extends lifespan in organisms rangin

162 It is not known whether calorie restriction extends maximum life span or life ex

163 r PP (mainly legume protein; n = 19) without calorie restriction for 6 weeks.

164 When mice are subjected to 60% calorie restriction for several days, they lose nearly a

165 Thus, when body fat is reduced by calorie restriction, ghrelin stimulates growth hormone s

166 Individuals in the calorie restriction group achieved a mean reduction in c

167 Calorie restriction has been reproducibly shown to prolo

168 Calorie restriction has been shown to have neuroprotecti

169 Calorie restriction has been shown to inhibit epithelial

170 However, calorie restriction has not been as successful as expect

171 2 can extend life span, but a direct link to calorie restriction has not been demonstrated.

172 osis in rat brain with age and evidence that calorie restriction has the ability to attenuate this.

173 Dietary restriction (DR; sometimes called calorie restriction) has profound beneficial effects on

174 association with the anti-ageing effects of calorie restriction, has received particular attention,

175 Regular exercise and calorie restriction have long been known to increase ins

176 RT1, is a mediator of life span extension by calorie restriction; however, SIRT1 may paradoxically in

177 c calorie restriction (CCR) and intermittent calorie restriction (ICR) have shown anticancer effects.

178 They also show that calorie restriction, IGF-1R signaling, and body temperat

179 Weight loss induced by exercise training or calorie restriction improves glucose tolerance and insul

180 Calorie restriction improves life span whereas nutrient

181 Calorie restriction in adult men and women causes benefi

182 However, calorie restriction in adult men and women causes many o

183 roved BAT tracer uptake was identified after calorie restriction in diabetic rats (ZDF-CR).

184 body temperature) are decreased by prolonged calorie restriction in humans and support the theory tha

185 hanisms underlying the beneficial effects of calorie restriction in humans and to characterize new ma

186 activator, mimics the anti-ageing effects of calorie restriction in lower organisms and in mice fed a

187 irtuin 1), activates a critical component of calorie restriction in mammals; that is, fat mobilizatio

188 at mediate the life-span-extending effect of calorie restriction in metazoans.

189 During calorie restriction in mice, increased expression of FGF

190 required for the induction of a phenotype by calorie restriction in mice.

191 state of knowledge regarding the effects of calorie restriction in modulating metabolism and aging.

192 response to exercise training combined with calorie restriction in obese and overweight women (n = 7

193 AA diet promotes rapid fat mass loss without calorie restriction in obese mice.

194 Recent studies of calorie restriction in several organisms demonstrate an

195 In this review, we discuss SIR2 genes and calorie restriction in the lower organisms yeast and Dro

196 Thus, like calorie restriction in the mouse, nicotinamide riboside

197 nt deacetylase required for longevity due to calorie restriction in yeast and Drosophila.

198 o be involved in life span determination and calorie restriction in yeast mother cells.

199 cardiovascular health of practicing moderate calorie restriction in young and middle-aged healthy ind

200 has been associated with various effects of calorie restriction, including an increase in lifespan.

201 In obese individuals, calorie restriction increased AT APOM expression and sec

202 Calorie restriction increases life span in many organism

203 Prolonged calorie restriction increases life span in rodents.

204 Previously, we showed that calorie restriction increases the replicative life span

205 balanced NmR salvage cycle is essential for calorie restriction-induced life span extension and stre

206 Sirtuin 1 is required for calorie restriction-induced lifespan extension in mice,

207 deprivation-induced SIRT1 transcription, and calorie restriction-induced SIRT1 expression.

208 Calorie restriction-induced weight loss is accompanied b

209 of its expression in AT and secretion during calorie restriction-induced weight loss.

210 sion, and could have a significant impact on calorie restriction-induced, SIRT1-mediated, changes in

211 In mammals, calorie restriction induces a complex pattern of physiol

212 Calorie restriction lengthens lifespan, in part, due to

213 p53 activity may mediate a component of the calorie-restriction life span-extending pathway in flies

214 report that Sir2 is directly involved in the calorie-restriction life-span-extending pathway in Droso

215 supplementation with resveratrol may produce calorie restriction-like effects on metabolic and longev

216 oration of GH by infusion during the week of calorie restriction maintained autophagy in the Goat(-/-

217 addition, it is possible that even moderate calorie restriction may be harmful in specific patient p

218 ting IGF-I levels which occur as a result of calorie restriction may lead to the inhibition of skin t

219 her important metabolic pathways that affect calorie restriction may serve as entry points for drugs

220 Circadian clocks govern calorie restriction-mediated life span extension through

221 ed in various biological processes including calorie restriction-mediated life span extension.

222 biomarkers for brite formation and show that calorie-restriction-mediated weight loss in women dynami

223 lyphenol in red wine, has been reported as a calorie restriction mimetic with potential antiaging and

224 ryotes and has been suggested as a potential calorie restriction mimetic.

225 This has led to the development of calorie restriction mimetics and other pharmacological i

226 ite extremes of the same metabolic spectrum, calorie restriction mimetics might provide another thera

227 macroautophagy (eg, calorie restriction and calorie restriction mimetics) are also presented.

228 -targeted antioxidants, calorie restriction, calorie restriction mimetics, and exercise training.

229 this parameter has only been estimated under calorie restriction, mimicked by starvation.

230 We have previously shown that under calorie restriction, mitochondrial deacetylase Sirt3 dea

231 ollowing carbohydrate restriction (n = 7) or calorie restriction (n = 7).

232 CNTF(Ax15); 0.1 mg x kg(-1) per day; n = 11) calorie-restriction (n = 9), or feeding ad libitum (n =

233 cited other hallmark changes associated with calorie restriction, namely bradycardia and decreased bo

234 bradycardia and hypothermia associated with calorie restriction occur through mechanisms unaffected

235 maintenance diet); calorie restriction (25% calorie restriction of baseline energy requirements); ca

236 for IUGR studies using a moderate 30% global calorie restriction of pregnant mothers and used cardiac

237 Calorie restriction of tor1D or sch9D cells failed to fu

238 has begun to identify important mediators of calorie restriction, offering the hope of new drugs to i

239 ith trial data showing beneficial effects of calorie restriction on aging biomarkers.

240 We report that effects of calorie restriction on neuronal plasticity, memory and s

241 k was to determine the effect of early-onset calorie restriction on sarcopenia in the aging rat.

242 ic and complex effects of fasting and severe calorie restriction on the levels and localization of di

243 Similar effects occur during long-term calorie restriction or a high protein diet.

244 life span in wild-type yeast require severe calorie restriction or additional mutations to extend li

245 conditions, including Prop1(df/df) dwarfism, calorie restriction or dietary rapamycin.

246 Weight loss, through calorie restriction or increases in energy expenditure v

247 , on the benefits or hazards associated with calorie restriction or overeating, respectively.

248 tors such as high osmolarity and heat shock, calorie restriction, or inhibitors of TOR and phosphatid

249 Additionally, calorie restriction partially restored the impaired BAT

250 n addition, several longevity factors in the calorie restriction pathway, including the NADH shuttle

251 s); calorie restriction with exercise (12.5% calorie restriction plus 12.5% increase in energy expend

252 Calorie restriction prevented fiber loss with age, and t

253 lomerulosclerosis did not develop if dietary calorie restriction prevented weight gain and glomerular

254 Calorie restriction prevents both oxidant injury and glo

255 n levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepres

256 We also found that calorie restriction promotes lifespan extension at least

257 iator of the beneficial metabolic effects of calorie restriction, protects neurons against mutant HTT

258 We report here that fasting or calorie restriction protocols in C57BL6 mice promote a m

259 Although calorie restriction reduced the number of ETS abnormalit

260 There is some evidence that calorie restriction reduces or delays many of the age-re

261 Calorie restriction reprograms diurnal rhythms in protei

262 charomyces cerevisiae, lifespan extension by calorie restriction requires the NAD+-dependent histone

263 In addition, calorie restriction resulted in a significant improvemen

264 n the social defeat model of chronic stress, calorie restriction reverses the behavioral deficits see

265 hormonal adaptations related to longevity in calorie restriction rodents.

266 2 years of moderate calorie restriction significantly reduced multiple cardi

267 In diverse organisms, calorie restriction slows the pace of ageing and increas

268 ent sensitivity of the promoter and impaired calorie restriction-stimulated tissue expression of SIRT

269 By using data from a 24-wk calorie-restriction study, we tested the validity of the

270 ith metformin mimics some of the benefits of calorie restriction, such as improved physical performan

271 a key mediator of the pathways downstream of calorie restriction that have been shown to delay the on

272 rincipal modulator of pathways downstream of calorie restriction that produce beneficial effects on g

273 idol; juvenile enrichment; sucrose drinking; calorie restriction; the serotonin selective reuptake in

274 mice is elevation of GH levels during severe calorie restriction, thereby preserving blood glucose an

275 circumference, and body fat, independent of calorie restriction, through a systematic review and met

276 These results imply that the ability of calorie restriction to inhibit or delay cancer incidence

277 vide a possible molecular pathway connecting calorie restriction to life extension in mammals.

278 onsidered to be required in combination with calories restriction to allow an effective decrease of i

279 stration of exogenous betaOHB, or fasting or calorie restriction, two conditions associated with incr

280 rading off against longevity, with trials of calorie restriction underway.

281 tion-induced lifespan extension in mice, and calorie restriction upregulates sirtuin 1 in humans.

282 Life span extension induced by calorie restriction was not affected by the loss of CL.

283 n protein, vinegar, fish oil, tea, cinnamon, calorie restriction, weight loss, exercise, and low-dose

284 is syndrome are often oppositely affected by calorie restriction, which extends lifespan and prevents

285 Calorie restriction, which increases life span and insul

286 In rodent models, calorie restriction with adequate nutrient intake decrea

287 e physiological and clinical implications of calorie restriction with adequate nutrient intake.

288 axa in individuals either practicing chronic calorie restriction with adequate nutrition (CRON) or wi

289 hough it is currently not known if long-term calorie restriction with adequate nutrition extends maxi

290 gate the short-term and long-term effects of calorie restriction with adequate nutrition on these ris

291 Moreover, calorie restriction with adequate nutrition protects aga

292 determined the effects of acute and chronic calorie restriction with either a low-fat, high-carbohyd

293 lorie restriction (-135 kcal/d [42 kcal/d]), calorie restriction with exercise (-117 kcal/d [52 kcal/

294 estriction of baseline energy requirements); calorie restriction with exercise (12.5% calorie restric

295 e was reduced in the calorie restriction and calorie restriction with exercise groups (both P<.05).

296 (1.1%); calorie restriction, -10.4% (0.9%); calorie restriction with exercise, -10.0% (0.8%); and ve

297 Long-term calorie restriction without malnutrition and reduced fun

298 ifespan in humans, we do know that long-term calorie restriction without malnutrition results in some

299 When subjected to 60% calorie restriction, WT and Goat(-/-) mice both lost 30%

300 ed into a no-restriction (ZDF-ND) and a mild calorie restriction (ZDF-CR) group.