ライフサイエンスコーパス: candidate

1 hin graphene membranes can serve as an ideal candidate.

2 udy was performed with MP0250, a DARPin drug candidate.

3 ntify SPy_2191 as a cross-protective vaccine candidate.

4 properties and being selected as an advanced candidate.

5 or disease at rank one is necessarily a good candidate.

6 eter used to accept or reject a living donor candidate.

7 ading malaria pre-erythrocytic-stage vaccine candidate.

8 ansplanted patient with all eligible control candidates.

9 .3 x 10(-4) S cm(-1) among the three new SSE candidates.

10 mework for discovering novel anticancer drug candidates.

11 therefore it is crucial to identify eligible candidates.

12 SPPB impairment was highly prevalent in KT candidates.

13 ian haplotype reveals eleven causal mutation candidates.

14 t-effective way to identify efficacious drug candidates.

15 odification of high-capacity Li-rich cathode candidates.

16 ss expensive steady-state anisotropy data of candidates.

17 to increase the solubility of ionizable drug candidates.

18 ing potency of hydrophobic/amphiphilic drugs candidates.

19 nces to KAT candidates prioritized below MOT candidates.

20 ainees, it is not routinely given to officer candidates.

21 inhibitor may be recommended for appropriate candidates.

22 zymes constitute new promising antimicrobial candidates.

23 ompounds, with some ending as promising drug candidates.

24 iding a rational method to compare different candidates.

25 rosurveillance and the evaluation of vaccine candidates.

26 broader access to the most medically urgent candidates.

27 d a number of saponin-based vaccine adjuvant candidates.

28 ells indicating that they are cancer vaccine candidates.

29 atient characteristics that define potential candidates.

30 s have become more accepting of hypertensive candidates: 65% in 2017% vs 41% in 2005 consider candida

31 The lead candidate (99m)Tc-FAPI-34 was applied for diagnostic sci

32 nd the cystic fibrosis C2-corrector clinical candidate ABBV-3221.

33 curately prioritize the potential neoantigen candidates according to their ability of activating the

34 ork, we designed a new chemotherapeutic drug candidate against cancer, namely, [Ru(DIP)(2)(sq)](PF(6)

35 to ensure appropriate selection of treatment candidates and identification of any concerns to address

36 gnatures yielded leads for possible new drug candidates and natural compounds upon bioinformatics dru

37 ed adult heart allocation to better stratify candidates and provide broader access to the most medica

38 kidney, liver, and cardiothoracic transplant candidates and recipients and explore potential interven

39 ated seven uncharged acetamido bis-oximes as candidate antidotes.

40 creased expression of NRF2, HMOX1, and other candidate antioxidant genes in cisplatin-resistant cells

41 elates of immune protection, and down-select candidate antivirals.

42 ion, and toxicity (ADMET) properties of drug candidates are important for their efficacy and safety a

43 Neurodevelopmental genes including autism candidates are vulnerable to environmental exposures and

44 te that 2-2c is a much improved in vivo lead candidate as compared to harmine for the treatment of di

45 ts for accessing the antigenicity of vaccine candidates, as well as developing antibody-based therape

46 ss balance, and have demonstrated that liver candidates awaiting transplant would benefit from a mode

47 epresented by the signal and then prunes the candidates based on the reference encoded within a Ferra

48 atric (age <18 years) kidney-only transplant candidates between December 31, 2012 to December 3, 2014

49 in parenchymal blood flow, itself a leading candidate biomarker of early neurodegenerative processes

50 miRNAs are considered efficient candidate biomarkers due to their high stability in tiss

51 Our analyses identify several candidate biomarkers of cellular senescence that overlap

52 The top candidate biomarkers were then tested in an independent

53 sis identifies several previously unexplored candidate blood biomarkers of neurological damage with p

54 ty and immunogenicity data about the vaccine candidate BNT162b1 in younger adults have been reported

55 ness defects, a critical step in identifying candidate cancer targets.

56 Objective: To identify candidate causal genes for IR, we screened regional and

57 and mice, and shed light on the consistency, candidate causes, and potential functional corollaries o

58 ing limb, single-cell RNA data identified 25 candidate cell types that included progenitor and differ

59 Candidate cerebral palsy risk genes overlapped with neur

60 dem mass spectrometry, we sought to identify candidate chemicals of interest in serum samples from 83

61 We mapped candidate cis-regulatory elements (cCREs) and linked the

62 The marks serve as sites for candidate cis-regulatory elements (cCREs) that may serve

63 of ALS-related Ubqln2 mutants and identifies candidate client proteins that are altered in vivo in di

64 iled analyses of selective sweeps containing candidate cognition loci reveal multiple cases of hard s

65 mong African American (AA) kidney transplant candidates compared to other races.

66 ify CEP112 as a basal foot protein and other candidate components of this assembly, aiding future inv

67 ain inhibitors that could progress to viable candidate compounds to treat Chagas disease and human sl

68 human challenge trials of SARS-CoV-2 vaccine candidates could accelerate the testing and potential ro

69 ll transcriptomes identified 15 gene-protein candidates (data set 3).

70 with target affinities that are superior to candidates derived from phage display panning experiment

71 have been commonly used when evaluating new candidate disease variants, despite not having been deve

72 ion with a replication-defective HSV vaccine candidate, dl5-29, leads to transfer of virus-specific a

73 We identified hundreds of candidate domestication genes with drastically lowered g

74 ene product should be prioritized as a novel candidate drug target for treating dyslipidemia and asso

75 not only for relapse prevention but also as candidate drugs for a faster resolution of such episodes

76 ndardised approach for the identification of candidate drugs for repurposing in the treatment of prog

77 DT protein to provide glycoconjugate vaccine candidates (DT-Hexa, DT-Hepta, and DT-Octa) that were us

78 In the cases that went undiagnosed, candidate dystonia-causing genes were prioritised in a s

79 re child BMI and sum of skinfolds (SSF), and candidate eating behavior moderators were portion size,

80 e status of young elephants and responses to candidate EEHV vaccines in the future.IMPORTANCE Whether

81 d is incorporated for determining transplant candidate eligibility.

82 one to testosterone identifies HSD17B12 as a candidate enzyme capable of driving basal testosterone p

83 ment (QMRA) is a tool to evaluate the use of candidate fecal indicators to signify a health risk from

84 anonical CDK motif, CDKB emerged as a likely candidate for a Saccharomyces cerevisiae Cdc28/Pho85-lik

85 fruit should be considered a promising fruit candidate for a sustainable healthy diet.

86 e of 16 x 10(6) Hz/Oe, making it a potential candidate for a wide range of magnetic sensing applicati

87 Thus, 2B04 is a promising candidate for an effective antiviral that can be used to

88 (Taxol C side chain), and TmAAE4 as suitable candidate for esterification of benzoic acid with CoA (T

89 ified wheat gene WFhb1-1 (aka WFhb1-c1) as a candidate for FHB resistance gene.

90 id (Taxol D side chain), TmAAE13 as the best candidate for generating a CoA ester of tiglic acid (Tax

91 l side chain), TmAAE15 as a highly efficient candidate for hexanoic acid activation (Taxol C side cha

92 ive specks (HRS); we identified a histologic candidate for HRS.

93 Therefore, pravastatin may be a candidate for human clinical translation to rescue fetal

94 y5-mas(3)) yielded the most promising tracer candidate for imaging of PSMA.

95 environments, making this system a powerful candidate for investigating acclimatization and local ad

96 The one outstanding candidate for large-scale functional HGT is the holopara

97 e identify CHD7, a chromatin remodeler, as a candidate for mediating the repressive function of let-7

98 of monolayer hBN, which makes it a desirable candidate for novel electromechanical and stretchable op

99 Thus, it can be used as an excellent candidate for periodontitis treatment.

100 ation, renders NPA101.3 a potential clinical candidate for RET-driven cancers.

101 aride is the minimal epitope and a potential candidate for the vaccine against the K2 sero group of K

102 gical outcomes and that losartan is a viable candidate for translational studies.

103 ntum dots (PQDs) are regarded as a promising candidate for various optoelectronics applications.

104 mone receptor-positive breast cancer who are candidates for adjuvant endocrine therapy should be offe

105 ase associations and provide highly credible candidates for biological experiments.

106 le-allele DHCR7 mutations might not be ideal candidates for CAR use, especially if they are nursing,

107 of these monoclonal antibodies are promising candidates for clinical development as potential therape

108 which erythrocyte antibodies would likely be candidates for clinical use in ITP.

109 d CL fibrous gel platforms appear to be good candidates for controlled drug release based wound dress

110 the antibodies described here are promising candidates for COVID-19 treatment and prevention.

111 pathways, have the potential to become drug candidates for distinct central nervous system pathologi

112 ollow HEA nanoparticles makes them promising candidates for energy and electrocatalysis applications.

113 lts indicate that FC predicts promising gene candidates for further study of disease-disease interact

114 in manipulating microglia, making them ideal candidates for future studies investigating microglial f

115 th at least one anti-CD20 therapy), were not candidates for high-dose chemotherapy and subsequent aut

116 erovskites have been identified as potential candidates for hosting the quantum-spin-liquid state at

117 non-clinical models to select promising drug candidates for human evaluation, and to use dynamic clin

118 Neither are obvious candidates for involvement in the brain processes that u

119 t dual PMIX and PMX inhibitors are promising candidates for malaria treatment and prevention.

120 was a nationwide, population-based study of candidates for military service in Israel attending the

121 to predict disease genes for humans and gene candidates for molecular functions, but they are rarely

122 Some of them were candidates for neurodevelopmental disorders in humans in

123 lled carbon nanotubes (SWCNTs) are promising candidates for next-generation computing as a result of

124 articularly older male patients, may be good candidates for OSA evaluation following a CSC diagnosis.

125 illbirth and six disease genes that are good candidates for phenotypic expansion.

126 nverting nanoparticles (UCNPs) are promising candidates for photon-driven reactions, including light-

127 e computation of marker sequences or finding candidates for probe design by identifying approximate k

128 ified here have no defined phenotype and are candidates for severe dominant disorders.

129 LN metastases on PSMA PET/CT were considered candidates for SN biopsy with indocyanine green-(99m)Tc-

130 a genome-wide approach to identify potential candidates for such interventions.

131 s adverse effect-prone type III IFN are good candidates for the management of COVID-19.

132 ify antiferromagnetic insulators as suitable candidates for the manipulation of magnetic and topologi

133 This makes metal-free perovskites novel candidates for the next generation of optoelectronics.

134 benzoxime group (EWG = CHNOBn) are very good candidates for the subsequent highly stereoselective Gri

135 d the molecules bufalin and lycorine as drug candidates for therapeutic applications in cardiac fibro

136 The cPRA per titer also risk-stratified candidates for trial inclusion.

137 ned all nonstatus one adult liver transplant candidates from 2010 to 2014.

138 From 832 high-LD variants, we identify 39 candidate functional variants from 14 loci displaying al

139 ap-filling method that computes the costs of candidate gap-filling reactions from a universal reactio

140 ate cancer gene (HOXB13), as well as a novel candidate gene (ILDR1), which encodes a receptor highly

141 e-Histidine-type Transporter 1 (OsLHT1) as a candidate gene associated with the aspartate uptake trai

142 n, while more than half of them are from our candidate gene group, which would otherwise go unidentif

143 According to evaluations of candidate gene prediction performance tested under four

144 sing four main approaches: linkage analysis, candidate gene sequencing and most recently, exome and g

145 e led by knowledge in the field (through the candidate gene strategy), now they often lead the scient

146 SP6 has also been implicated as an AI candidate gene through its study in rodent models.

147 Our candidate-gene association analyses of GWAS datasets sug

148 ed that expression levels of known and novel candidate genes (putatively encoding beta-ketoacyl-(acyl

149 o exercise and recovery, unveiling plausible candidate genes and biological mechanisms underlying ven

150 These candidate genes and functional pathways may direct bHR/b

151 n-synonymous mutations in a set of plausible candidate genes and significant differences in their all

152 ity of rare-variant analyses for identifying candidate genes and the results highlight potential ther

153 t analysis to identify constitutive QTLs and candidate genes associated with the grain Mn concentrati

154 bioinformatics approaches can identify ADHD candidate genes at increased levels of credibility.

155 sing a network propagation method, we ranked candidate genes by their similarity to known disease gen

156 genomic regions containing several plausible candidate genes for grain chalkiness.

157 Additionally, we highlight variants in candidate genes for obesity warranting further investiga

158 We analyzed 84 candidate genes in 4,649 patients and 4,982 controls by

159 We developed a new method to detect such candidate genes in large multi-omic case-control studies

160 These associated SNPs and candidate genes paved a path to understand the genetic a

161 semicombinatorial approach yielded multiple candidate genes that, upon further analysis, revealed an

162 sion set, we identify individual significant candidate genes to which we assign direction of expressi

163 Many candidate genes underlying herbivory and specialization

164 Eight putative candidate genes were identified for three QTLs that enha

165 Four candidate genes were overexpressed in Escherichia coli B

166 The high-priority ADHD candidate genes were significantly coexpressed in the br

167 Candidate genes were validated by independent gene mutat

168 We identified 45 candidate genes with ancient polymorphisms maintained by

169 Among the above candidate genes, 36 genes were found to be associated wi

170 xternal knowledge of gene function to detect candidate genes, applied the method to an AD dataset, an

171 h larger samples using other methods than by candidate genes, are essential to developing methods tha

172 Three homologous candidate genes, glycogen synthase (glys), atp-binding c

173 e been associated with stillbirth and strong candidate genes.

174 on chromosomes 3 and 7 for Mn containing six candidate genes.

175 ngle-nucleotide polymorphisms (SNPs) from 14 candidate genes.

176 Candidate genetic variants were identified by whole-exom

177 builds three-dimensional atomic models from candidate graphs generated by RAG Sampler, and (c) RAG D

178 Candidate GSi-responder patients were characterized by d

179 Nevertheless, candidate HIV interventions for men advance to clinical

180 ect in the evaluation of living kidney donor candidates; however, data on performance of commonly use

181 Among the new candidates identified in blood cells, 655 CpG sites, loc

182 The leading dengue virus vaccine candidates in clinical testing are all based on live-vir

183 Conducting polymers are promising material candidates in diverse applications including energy stor

184 Potential candidates include batteries, fuel cells, energy harvest

185 Suitable candidates include patients who are at high immunologic

186 raise doubts about others and identify novel candidates, including point mutations in the 5' region o

187 Identification of appropriate candidates, indications and contraindications, medical a

188 BACKGROUNDThe live attenuated BPZE1 vaccine candidate induces protection against B. pertussis and pr

189 tes in Babraham pigs, using the single cycle candidate influenza vaccine S-FLU.

190 In a prospective context, nearly all candidate inhibitors from a screen against acetylcholine

191 and immunobiology is advancing novel vaccine candidates into human trials.

192 The planet candidate is roughly the same size as Jupiter and is no

193 ds into high-quality chemical probes or drug candidates is an ongoing challenge in biomedical researc

194 g the target proteins of small-molecule drug candidates is important for determining their molecular

195 shock requirements for some heart transplant candidates listed with specific types of treatments.

196 s to match pieces of equipment with a set of candidate locations based on wireless signal measurement

197 g influenza model will be useful for testing candidate mAbs and emerging delivery platforms prior to

198 These candidate markers of disease activity need to be replica

199 in, which is the basis for different vaccine candidates, matches optimized vaccine inserts, being ide

200 A potential candidate mechanism reflecting such idiosyncratic biases

201 Cellular senescence is a candidate mechanism that might be important for this con

202 t of rapamycin (mTOR) signaling pathway as a candidate mechanism.

203 The findings reveal novel candidate mechanisms involved in the protective effects

204 The identified QTL regions suggest candidate meiotic genes that could be manipulated in ord

205 We identify candidate members of the gut microbiome that elicit a Sm

206 Thus, SB based matching rules for LT candidates might improve the survival of the LT populati

207 d across three age groups, we identified one candidate (miR-216a) implicated in beta cell proliferati

208 After characterization, we quantified 11 candidate miRNAs associated with vascular performance an

209 However, the bonobo is often overlooked as a candidate model.

210 Two candidate modules featuring voltage-dependent Ca2+-chann

211 We found anacardic acid as a candidate molecule to serve as a therapeutic agent to pr

212 also guides the design and selection of drug candidate molecules.

213 with a measles-vectored chikungunya vaccine candidate, MV-CHIK, were analyzed.

214 icogenesis and therefore represents a strong candidate neurodevelopmental disorder gene.

215 a (5 mm diameter) to assess penetration of a candidate neuroprotective siRNA.

216 The lead nanobody candidate, NIH-CoVnb-112, blocks SARS-CoV-2 spike pseudo

217 ds that allow for both the identification of candidate non-coding pathogenic variants and their funct

218 The common marmoset is envisioned as a candidate nonhuman primate species for comprehensive mod

219 ol TMUV infection, a live-attenuated vaccine candidate of TMUV was developed in our previous study, b

220 l investigation was performed into the other candidates of cyclobutadiene-fused troponimines by subst

221 nd minimizing risks associated with new drug candidates on given populations.

222 e, Sm(2) Co(17) -based magnets are excellent candidates owing to their high-temperature stability.

223 itize the typically long lists of genes with candidate pathogenic variants.

224 hotgun sequencing and reveals both known and candidate pathways associated with host colonization.

225 nockout kidneys, which were used to identify candidate pathways dysregulated in kidneys destined to f

226 Twelve candidate peptides were selected as potential authentica

227 ch led to the identification of the clinical candidate PF-06826647 (22).

228 43 of which resolve to TM7, a member of the Candidate Phyla Radiation, forming six monophyletic clad

229 source of valuable information, composed of candidate phylogenies and associated clonal prevalence.

230 pproach (BeviMed(4)) identified multiple new candidate PID-associated genes, including IVNS1ABP.

231 mong the four selected market available drug candidates, Pralatrexate and Azithromycin were confirmed

232 itization, and potential consequences to KAT candidates prioritized below MOT candidates.

233 these proteins reveals that phase-separated candidate proteins exhibit higher IDR contents, higher m

234 arkers, especially when they have identified candidate proteins for analyzing diseased tissues near o

235 iption factors are also enriched among these candidate proteins.

236 us validating our approach; plus, many other candidate RA target genes were found.

237 n and colleagues recently identified several candidate RAN translation inhibitors from a high-through

238 e transcriptional regulator LMO4 is one such candidate regulator.

239 Using genome editing to delete candidate REs, we showed that a strong intronic bipartit

240 a library of 2024 FDA-approved drugs or drug candidates, revealing UMI-77 as an unexpected mitophagy

241 A distal candidate Runx1 enhancer exhibits high chromatin accessi

242 d 24-hour urine concentrations of endogenous candidate secretory solutes at baseline, using targeted

243 inal chemists optimizing their compounds for candidate selection: (1) What are the important clearanc

244 case with evaluation of the significance of candidate signals by extensive simulations.

245 Perhaps the most well established candidate signature is the P3b event-related potential,

246 The predicted candidate silencers exhibit characteristics expected of

247 in which edited loci are deep sequenced, and candidate sites are prioritized based on apparent select

248 determine the relative affinities of PLB for candidate sites on SERCA.

249 Functional roles of the prioritized candidate SNPs were examined with chromatin immunoprecip

250 iological techniques used to test these drug candidates, some of the most important screens performed

251 le, provided the collagen sequences for each candidate species are available.

252 Establishing methods to identify candidate structures that can lead to native folds or de

253 s live-attenuated tetravalent dengue vaccine candidate (TAK-003).

254 This discovery sets HR3 as a new candidate target for antiviral strategies for NiV and li

255 posed and applied to identify potential drug candidates targeting RdRp from 1906 approved drugs.

256 A leading vaccine candidate targets 30 of the > 200 emm types of GAS.

257 and novelty parameters to select 5 top lead candidate targets.

258 tensin-II antagonist losartan is a promising candidate that has enhanced extinction in a post-traumat

259 ein networks could identify synthetic lethal candidates that are more reproducible than those previou

260 Drug candidates that form covalent linkages with their target

261 LGG molecular mutations types and identifies candidates that may be considered potential predictive b

262 seful for generating live attenuated vaccine candidates that prevent disease and fecal spread of ente

263 n (FDA)-approved small molecules to identify candidate therapeutic drugs for COVID-19.

264 enomic and epigenomic landscape and identify candidate therapeutic targets for this dismal cancer.

265 overed anaplastic lymphoma kinase (ALK) as a candidate thinness gene.

266 an trials is crucial for advancing a vaccine candidate to clinics.

267 s suggest that ME materials are an excellent candidate to enable miniature bioelectronics for clinica

268 becoming mandatory to properly evaluate the candidate to liver transplantation for alcoholic liver d

269 ggests that muscle MRI is a strong biomarker candidate to predict prognosis and treatment efficacy.

270 that LS measurement may be helpful to select candidates to be withdrawn from surveillance programs.

271 locus was discovered that narrowed the Ptr1 candidates to eight nucleotide-binding leucine-rich repe

272 syndrome and highlight new targets and drug candidates to facilitate the development of a treatment

273 3B-dependent NMD target transcripts that are candidates to mediate the functions of NMD in mOSNs were

274 Testing of vaccine candidates to prevent infection with severe acute respir

275 -doped carbon (Fe-N-C) materials are leading candidates to replace platinum catalysts for the oxygen

276 ure-outcome analysis due to pathways through candidate traits.

277 Using tREX, we test 243 candidate tRNAs in Escherichia coli and identify 71 orth

278 sing the CRISPR-Cas9 system to model loss of candidate tumor suppressor genes in SCLC, and we anticip

279 The candidate type III effector TarP, which localized to foc

280 ata suggest that further development of this candidate vaccine for prevention of EBOV disease is warr

281 ance immune responses to vaccines, including candidate vaccines for HIV.

282 rmed at BSL-2 and also has applications as a candidate vectored vaccine to elicit protective immunity

283 sed an artificial neural network to identify candidate viral capsid proteins, several of which formed

284 Among candidates, we estimated time to listing, waitlist morta

285 The candidates were also produced on pilot scale to investig

286 Subsequently, LPV and selected prodrug candidates were evaluated for their in vivo pharmacokine

287 Several candidates were independently validated and included mem

288 nd relevant pharmacological parameters of 15 candidates were investigated.

289 provided greater instrumental support to the candidates were most likely to receive a request: odds r

290 The adjuvant-free vaccine candidates were orally administered to mice and generate

291 Positive candidates were treated with levofloxacin.

292 antibody [CDC PRA+], C1q+) heart transplant candidates were treated with the combination of belatace

293 Candidates who accepted had a brief perioperative risk p

294 identify 92 081 adult kidney transplantation candidates who were offered a DCD50 kidney that was even

295 compound 15 stands out as the most promising candidate with potent inhibitory activities against both

296 to access a range of fluorinated therapeutic candidates with distinct physicochemical properties rela

297 idates: 65% in 2017% vs 41% in 2005 consider candidates with hypertension well controlled with 1 medi

298 hosts (1) a compendium of M. truncatula SSP candidates with putative function and family annotations

299 nt change was successful in >50% of eligible candidates, with C-peptide >252 pmol/L emerging as the b

300 Experimental testing of 62 screening candidates yielded the discovery of 10 new agonist chemo