ライフサイエンスコーパス: candidate gene

1 ts in ten known deafness genes and one novel candidate gene.

2 tion (e.g., mutation or deletion) of a known candidate gene.

3 ere identified, including one at an a priori candidate gene.

4 diabetes (T1D), suggesting SKAP2 as a causal candidate gene.

5 h Factor Receptor 2 (VEGFR2), as a novel PAH candidate gene.

6 PR) protein family) as an extinction-related candidate gene.

7 nominated Egl-9 homolog 1 gene (EGLN1) as a candidate gene.

8 valuate protein expression of the identified candidate gene.

9 PRKN, SMARCAL1, SMAD7, which we refer to as candidate genes.

10 high-throughput sequencing of >300 potential candidate genes.

11 , GRB14, MAP3K1, FST, PEPD, and PDGFC as top candidate genes.

12 g lines generally results in fewer than five candidate genes.

13 q data and published literature to shortlist candidate genes.

14 ed TRAPPC9, MEF2C, and ST3GAL3 as novel ADHD candidate genes.

15 e a limitation for their usage in predicting candidate genes.

16 matics analyses were performed to prioritize candidate genes.

17 sses, and association analysis identified 22 candidate genes.

18 ch they classified 432 as high-priority ADHD candidate genes.

19 In 15 families, we delineated 12 candidate genes.

20 on chromosomes 3 and 7 for Mn containing six candidate genes.

21 e been associated with stillbirth and strong candidate genes.

22 es were significantly associated with top AD candidate genes.

23 identified rare genetic variants in several candidate genes.

24 e dominant signals in CPT2 and several other candidate genes.

25 ngle-nucleotide polymorphisms (SNPs) from 14 candidate genes.

26 he mapping interval, and identified the Pm5e candidate genes.

27 for highly significant mutational burden in candidate genes.

28 Among the above candidate genes, 36 genes were found to be associated wi

29 Using all positional candidate genes, a network was then constructed and comm

30 One of the candidate genes, Abscisic acid 8'-hydroxylase, is verifi

31 tly infer the specific functional effects of candidate genes across different tissues.

32 report the discovery of new Acrs by assaying candidate genes adjacent to a conserved Acr-associated (

33 Additionally, we identified 20 novel NOA candidate genes affecting 25 patients.

34 Our results implicate novel candidate genes affecting life span and suggest that var

35 t SET1 and two other SET QTLs each contain a candidate gene (AHG1, ANAC060, PDF1 respectively) closel

36 KD or polycystic liver disease to identify a candidate gene, ALG9, and in vitro cell-based assays of

37 Candidate gene analysis on MMTV-Cre;Vangl2(flox/flox) an

38 Interest in candidate gene and candidate gene-by-environment interac

39 o exercise and recovery, unveiling plausible candidate genes and biological mechanisms underlying ven

40 s of selection allowed the identification of candidate genes and candidate causal variants.

41 Associations between 68 candidate genes and cognitive impairment were assessed u

42 The authors discuss several candidate genes and environmental factors (for example,

43 These candidate genes and functional pathways may direct bHR/b

44 ng the chip to refine the list of positional candidate genes and identify potential causative mutatio

45 molecules but further provide a list of new candidate genes and pathways possibly implicated in inne

46 n-synonymous mutations in a set of plausible candidate genes and significant differences in their all

47 ity of rare-variant analyses for identifying candidate genes and the results highlight potential ther

48 of this study was to define ADHD-associated candidate genes and their associated molecular modules a

49 high-throughput platform to rapidly evaluate candidate genes and their interactions during heart deve

50 a highly heritable disorder with an array of candidate genes and unclear genetic architecture, remain

51 e integrated peach SV map and the identified candidate genes and variants represent valuable resource

52 ediate phenotypes for functional analysis of candidate genes and/or the development of novel traits.

53 otypic analysis of the mutants validated the candidate gene, and included intermediate phenotypes tha

54 ti-tissue methods focus on prioritization of candidate genes, and cannot directly infer the specific

55 egative phenotypic data to better prioritize candidate genes, and to stratify disease mapping using s

56 evealed coding and splice region variants in candidate genes, ANK1, EPHX2 and LOX2, implicated in dia

57 pproach led to the identification of a major candidate gene, any minor effect locus remained elusive

58 xternal knowledge of gene function to detect candidate genes, applied the method to an AD dataset, an

59 on linkage mapping, association mapping or a candidate gene approach) is relatively well supported.

60 Using a candidate gene approach, we tested the hypothesis that i

61 orders have been reported, all discovered by candidate gene approaches applied to at least one locus.

62 vation, extending previous reports that used candidate gene approaches.

63 enome complexity, functional analysis of the candidate genes are challenging in wheat.

64 favourable SNP markers for MAS and a list of candidate genes are provided.

65 We discovered that autism candidate genes are significantly enriched for bivalent

66 Candidate genes are still emerging, being identified whe

67 h larger samples using other methods than by candidate genes, are essential to developing methods tha

68 e-Histidine-type Transporter 1 (OsLHT1) as a candidate gene associated with the aspartate uptake trai

69 Pheno-RNA, a general approach to identifying candidate genes associated with a specific phenotype.

70 s were identified on BTA 2 and 14, harboring candidate genes associated with energy metabolism (IGFBP

71 nsden and Reute ecotype to identify a set of candidate genes associated with moss male infertility.

72 ncing and transcriptome analysis to identify candidate genes associated with the expression of the im

73 t analysis to identify constitutive QTLs and candidate genes associated with the grain Mn concentrati

74 within I. batatas, and identified promising candidate genes associated with this variation.

75 and predicated upon the findings of previous candidate gene association studies, a primary focus of t

76 Our candidate-gene association analyses of GWAS datasets sug

77 Candidate-gene association study in oilseed rape indicat

78 /CFS risk before concluding that most ME/CFS candidate gene associations are not replicated by the la

79 Other candidate genes at associated loci were also involved in

80 bioinformatics approaches can identify ADHD candidate genes at increased levels of credibility.

81 haracterization of the role of T1DM and T2DM candidate genes at the beta-cell level and the endoplasm

82 es in Malus germplasm collections and used a candidate gene-based association mapping approach to ide

83 of rose, was found to be colocalized with a candidate gene belonging to the 2-phenylethanol biosynth

84 t downregulation of known and most acylsugar candidate genes, but not defense genes.

85 o test the association of breast cancer with candidate genes by analyzing multi-omics data.

86 showed binding of MYC to the promoter of two candidate genes by chromatin immunoprecipitation.

87 for which we were able to identify credible candidate genes by combining multitrait association with

88 tization framework, POCKET (prioritizing the candidate genes by incorporating information on knowledg

89 sing a network propagation method, we ranked candidate genes by their similarity to known disease gen

90 Interest in candidate gene and candidate gene-by-environment interaction hypotheses reg

91 Knockdown of such candidate genes caused cilia elongation and ciliopathy-l

92 al risk factors, nor do they include obvious candidate genes, complicating their functional character

93 imary hematopoietic cells to interrogate 389 candidate genes contained in 75 loci associated with red

94 Our data suggest that GLI3 is a candidate gene contributing to KS etiology.

95 Some loci aligned with candidate genes controlling these traits.

96 s approach, we have identified five separate candidate genes (CREBBP, WDR24, ARL8A, PHLDA3, LAD1) tha

97 boosted scores may improve fine-mapping and candidate gene discovery for common disease.

98 the peanut genome sequence aids mapping and candidate-gene discovery for traits such as seed size an

99 lymorphism in the self-binding domain of the candidate gene DOG1.

100 About 30% of the candidate genes encode enzymes that work in lipid metabo

101 One of these regions contained a candidate gene encoding a beta-keto acyl carrier protein

102 iation in sulfatase activity we identified a candidate gene encoding an uncharacterized cytochrome P4

103 ding to avoid repeating some mistakes of the candidate gene era.

104 performed to assess the diagnostic value of candidate gene expression signatures.

105 Within this QTL, we detected three putative candidate genes, fgfa8, cyp17a1 and an uncharacterised p

106 y results do not support previous depression candidate gene findings, in which large genetic effects

107 Semibalanus balanoides has been studied as a candidate gene for balancing selection for more than two

108 port that the transcription factor TBX1, the candidate gene for DiGeorge syndrome, is expressed in me

109 sceptibility and suggest KIAA0930 as a novel candidate gene for lung cancer risk.

110 tyrosine-protein kinase 1 gene as a putative candidate gene for Sbwm1.

111 omic and quality traits revealed a promising candidate gene for seed weight, BjA.TTL, as well as addi

112 AGAMOUS paralog, FhAG2, was identified as a candidate gene for sex determination in F. hispida.

113 by retroviral capture and de facto provide a candidate gene for the endotheliochorial to hemochorial

114 Tnfrsf9 (encoding CD137) is a candidate gene for the Idd9.3 type 1 diabetes (T1D) susc

115 ility and that PAX8 could be considered as a candidate gene for the study of GDM.

116 These findings support that PAX8 could be a candidate gene for the study of gestational DM (GDM).

117 we detected relevant tissues/cell types and candidate genes for 45 economically important traits in

118 These correlations were used to identify candidate genes for a reaction in histidine biosynthesis

119 n accuracy and optimized them for predicting candidate genes for anatomical entities.

120 eractions and is better optimized to predict candidate genes for anatomical entities.

121 association studies allowed prediction of 17 candidate genes for association with nitrogen use effici

122 We identified strong candidate genes for asthma hospitalizations in adults in

123 Screening 46 candidate genes for astrocyte diversity across the mouse

124 uss how novel genomic resources can identify candidate genes for biofortification, integrating knowle

125 architecture of terpene yield and we provide candidate genes for breeding or engineering of crops for

126 tive sweeps across the Arabian breed contain candidate genes for combating oxidative damage during ex

127 elationships, variability in resistance, and candidate genes for defence response within the ash genu

128 This facilitates prioritization of candidate genes for functional follow-up studies.

129 uld be used in cassava breeding programs and candidate genes for functional validation.

130 r trichomes and thereby seem to be potential candidate genes for future studies in connection to the

131 genomic regions containing several plausible candidate genes for grain chalkiness.

132 ased pipeline to systematically characterize candidate genes for HRV in live zebrafish embryos.

133 chers to directly rank potential anti-CRISPR candidate genes for increased speed in testing and valid

134 s) confirmed the relevance of the key driver candidate genes for insulin responsiveness.

135 is the identification and prioritization of candidate genes for manipulation.

136 rriers during speciation and identify strong candidate genes for mate and host plant choice behaviors

137 Additionally, we highlight variants in candidate genes for obesity warranting further investiga

138 ysis across numerous tissues revealed strong candidate genes for obesity-related traits.

139 ith neurological or psychiatric disorders as candidate genes for PNES.

140 as newborn ovary homeobox gene (NOBOX), are candidate genes for primary ovarian insufficiency in wom

141 corded between the two cultivars to identify candidate genes for resistance.

142 Four candidate genes for self-incompatibility were linked in

143 With lists of candidate genes for sex determination containing fewer t

144 ng of two trichomes preferentially expressed candidate genes for straight-chain fatty acid biosynthes

145 No candidate genes for SUDEP in Chinese people have been id

146 Little is known about candidate genes for SUDEP in people of Chinese origin as

147 non-epilepsy controls, to identify potential candidate genes for SUDEP.

148 of P. axillaris petals revealed three strong candidate genes for sympetaly based on functional annota

149 ilial function, revealing new mechanisms and candidate genes for syndromic human disease.

150 The third stage identifies candidate genes for the remaining lines by sequencing mu

151 tion to evaluate gene-burden associations of candidate genes from European genome-wide association st

152 o significant enrichment of rare variants in candidate genes (genes encoding components of the comple

153 very of vitiligo susceptibility loci through candidate gene, genomewide linkage, and genomewide assoc

154 Through candidate gene, genomewide linkage, and genomewide assoc

155 novel network-based approach for predicting candidate genes/genomic regions utilising the knowledge

156 Three homologous candidate genes, glycogen synthase (glys), atp-binding c

157 s whole-genome approach introduces potential candidate genes governing the link between metabolic str

158 n, while more than half of them are from our candidate gene group, which would otherwise go unidentif

159 Seven of the candidate genes have putative roles connected to the phe

160 ysis of SNPs on chromosome 4D identified two candidate gene hits, TraesCS4D02G352200 (TaNox8; an NADP

161 his locus identified a number of polymorphic candidate genes, however only one, beta haemoglobin, was

162 AS analysis, such as haploblock analysis and candidate gene identification, is lacking.

163 ellular phenotypes following perturbation of candidate genes identified by genome-wide studies.

164 Candidate genes identified by WES were sequenced in an a

165 rapidly model loss-of-function mutations in candidate genes identified from SCLC sequencing studies.

166 ed a network analysis approach to prioritize candidate genes identified from whole-exome sequencing a

167 fic visualization that will aid in analyzing candidate genes identified in genome-wide association st

168 ome-wide DNA polymorphisms and the promising candidate genes identified in this study represent a val

169 ate cancer gene (HOXB13), as well as a novel candidate gene (ILDR1), which encodes a receptor highly

170 identified a LINE-1 insertion in the retinal candidate gene IMPG2 that is associated with a form of P

171 ociated protein 1 (DAP1) was implicated as a candidate gene in a previous familial linkage study of S

172 plicated follistatin gene, which is a strong candidate gene in the minimal mapped interval to cause t

173 We analyzed 84 candidate genes in 4,649 patients and 4,982 controls by

174 , has also assisted in the identification of candidate genes in families with consanguinity.

175 We developed a new method to detect such candidate genes in large multi-omic case-control studies

176 tool for variants of unknown significance in candidate genes in patients with non-specific phenotypes

177 function from other organisms, we identified candidate genes in publicly available transcriptome data

178 We detected 104 candidate genes in sweep regions involved in different p

179 date has incorporated the ohnolog status of candidate genes in the analysis.

180 Stability values were < 1.5 for the 20 candidate genes in the prospective cohort.

181 iated with heart rate variability (HRV), but candidate genes in these loci remain uncharacterized.

182 ffect of tissue sampling and preservation on candidate genes included in a renal transplant diagnosti

183 reviously reported resting QT interval loci; candidate genes included KCNQ4 and KIAA1755.

184 The expression patterns of seven candidate genes, including beta-catenin, Notch1, GATA6,

185 e for selection in highly estrogen-dependent candidate genes, including those for the estrogen recept

186 ling results converged to implicate multiple candidate genes, including two previously associated wit

187 sin cohesin subunit REC8 was identified as a candidate gene influencing crossover number and patterni

188 evidence has emerged from statin trials and candidate gene investigations suggesting that lower LDL

189 Here, we employed RNA-seq to identify candidate genes involved exclusively or shared by C(4) o

190 , we identified and validated multiple novel candidate genes involved in circadian period determinati

191 ptome analysis allowed the identification of candidate genes involved in lipid metabolism and the ass

192 The present experiment targeted candidate genes involved in serotonin production, metabo

193 analysis has led to the elucidation of hemp candidate genes involved in the syntheses of specialized

194 regulatory effects of non-coding variants on candidate genes is a key step in evaluating their clinic

195 Potential candidate genes (LEPR, FANCC, COL1A1, and PCCA) influenc

196 r of associations reported in the depression candidate gene literature are likely to be false positiv

197 Loss-of-function mutants of the NOP2A candidate gene located inside the largest effect QTL and

198 Of these, 27, including two candidate genes located within the QTL associated with C

199 ns, which can guide future studies to assess candidate genes necessary for downy mildew resistance in

200 ant SNP for each trait-locus combination and candidate genes occurring within the GWAS hits.

201 mass and obesity-associated (FTO) gene is a candidate gene of obesity.

202 ysis to estimate risk of mortality for major candidate genes of aging and longevity and their cohort

203 ge on PCR amplification and co-expression of candidate genes on apparent expression stability.

204 Additional lesions in these candidate genes or pathway components associate variant

205 he knockdown of the three strongest selected candidate genes (ORP3, GJB3, and RXFP1) enhances the mal

206 We found strong evidence for new candidate genes, particularly Rhbdf2, whose close associ

207 These associated SNPs and candidate genes paved a path to understand the genetic a

208 a series of preregistered analyses examining candidate gene polymorphism main effects, polymorphism-b

209 Novel candidate genes potentially involved in the control of s

210 I networks via anatomy ontology improved the candidate gene prediction accuracy and optimized them fo

211 oped an integrative framework to improve the candidate gene prediction accuracy for anatomical entiti

212 According to evaluations of candidate gene prediction performance tested under four

213 pared the performance of their network-based candidate gene predictions.

214 ellitus Knowledge Portal to evaluate whether candidate genes prioritized by our in vitro studies were

215 ed that expression levels of known and novel candidate genes (putatively encoding beta-ketoacyl-(acyl

216 wide association analyses identified several candidate genes related to animal resilience to environm

217 QTL regions were annotated in 11 positional candidate genes related to osteogenesis, skeletal muscle

218 Candidate genes related to plant cell wall modification

219 amilies with the same genetic condition) and candidate gene (relying on previous knowledge on the gen

220 We think the genomic resource and the candidate genes reported here set the foundation to full

221 dentified adenosine receptor (AdoR) as a top candidate gene required for ISC proliferation.

222 Candidate genes required for reovirus to cause cell deat

223 f valuable quantitative trait loci (QTL) and candidate genes responsible for the concentration of gra

224 Six potential candidate genes (RPS4X, SEPT6, NKRF, CX0rf57, NAA10, and

225 Of 31 candidate genes selected for investigation, the effects

226 SNPs within 36 "candidate" genes, selected for their involvement in estr

227 sing four main approaches: linkage analysis, candidate gene sequencing and most recently, exome and g

228 genes (TNC, MMPs), we have identified novel candidate genes (SFRP2, SPP1, CCR1, C2, MSR1, C4A, PLA2G

229 Knockdown assays found that seven candidate genes significantly changed mosquitoes' suscep

230 p = 3.9 x 10(- 2)) for valeric acid, and 17 candidate genes significantly clustered in olfactory rec

231 We show that a top-ranked miR-137 candidate gene, Sorl1, has a tumor suppressor function i

232 e led by knowledge in the field (through the candidate gene strategy), now they often lead the scient

233 transcriptome analyses of animal models, and candidate gene studies have advanced our understanding o

234 Prior candidate gene studies have shown tumor suppressor DNA m

235 nkage analysis suited to strong-effect loci, candidate gene studies prone to false positives, and und

236 investigated by genome-wide association and candidate gene studies, which indicate that a number of

237 association studies, and the remaining were candidate gene studies.

238 ny genes were originally identified based on candidate-gene studies that did not adequately account f

239 provide a synthesis of published evidence of candidate-gene studies.

240 hows that the dsi-RNA knockdown of all three candidate genes suppressed glycogen and lipid biosynthes

241 identify overlaps between new and known PTB candidate gene systems.

242 identified in both approaches and is a good candidate gene that could be controlling grain Mn concen

243 the genetic risk variant rs17066096 and the candidate gene that encodes IL-22 binding protein (IL-22

244 an exon skipping event in HDAC7, which is a candidate gene that is important in the parasite's cell

245 We identified multiple methylation sites and candidate genes that can be further evaluated for their

246 de future transcriptome analyses to identify candidate genes that confer HM tolerance in wheat.

247 lerated through the discovery of markers and candidate genes that could be used in cassava breeding p

248 im of these studies is the identification of candidate genes that demonstrate congruent disease-relat

249 Among 23 candidate genes that differentiated patients with active

250 We also identify some candidate genes that may play a role in ivermectin resis

251 (SNPs) were located in regulatory regions of candidate genes that may serve as major regulators of th

252 gene expression in interneurons, as well as candidate genes that might execute tonotopic plasticity.

253 resistance genes, but we uncovered a set of candidate genes that warrant further study.

254 semicombinatorial approach yielded multiple candidate genes that, upon further analysis, revealed an

255 g epithelial membrane protein 3 (EMP3), as a candidate gene, then demonstrate inactivating mutations

256 SP6 has also been implicated as an AI candidate gene through its study in rodent models.

257 Several of these contain candidate genes (TINF2, PARP1, TERF1, ATM and POT1) with

258 With this work, we provide a list of candidate genes to study for improving rice stress toler

259 sion set, we identify individual significant candidate genes to which we assign direction of expressi

260 e, IRF2 was identified as the most promising candidate gene underlying resistance and susceptibility

261 tly improves detection and identification of candidate genes underlying a QTL, solidifying the founda

262 Many candidate genes underlying herbivory and specialization

263 Candidate genes underlying these QTL suggest pathogen ef

264 egy represents an important tool for finding candidate genes underlying traits of interest and potent

265 biological layers to identify and prioritize candidate genes, understand pathogenic pathways, and elu

266 We functionally assessed the effects of 15 candidate genes using RNA interference (RNAi): all affec

267 foundation for large-scale QTL fine mapping, candidate gene validation, and developing functional mar

268 Candidate gene variants derived from a prespecified set

269 These major candidate gene variants function in distinct pathways, i

270 s was followed by WES in selected cases if a candidate gene was not found.

271 To validate the gene functions, each candidate gene was silenced by injecting the target dsi-

272 Prior knowledge of candidate genes was extracted from both experimental and

273 Furthermore, a list of 23 candidate genes was identified and predicted to be benef

274 dentified, and region-specific expression of candidate genes was mapped in human tissues.

275 With the aim of identifying new candidate genes, we examined early-onset breast cancer p

276 Deletions encompassing this candidate gene were present in awned mutants of an awnle

277 eported that common DNA variants in specific candidate genes were associated with altered neural acti

278 As a result, 284 and 279 candidate genes were found to be significantly associate

279 Five candidate genes were identified based on the linkage dis

280 Candidate genes were identified by measuring growth as a

281 Eight putative candidate genes were identified for three QTLs that enha

282 ggest that early hypotheses about depression candidate genes were incorrect and that the large number

283 Four candidate genes were overexpressed in Escherichia coli B

284 e ontology (GO) term analysis, six promising candidate genes were significantly clustered in organell

285 The high-priority ADHD candidate genes were significantly coexpressed in the br

286 About 61 candidate genes were successfully cloned from Anopheles

287 Nine zebrafish orthologues of six human candidate genes were targeted simultaneously in eggs fro

288 Candidate genes were validated by independent gene mutat

289 Candidate genes were validated with functional data.

290 Sequence information of the predicted candidate genes will permit development of molecular mar

291 We identified 45 candidate genes with ancient polymorphisms maintained by

292 Candidate genes with biological function related to tran

293 d the Wilcoxon rank-sum test, and visualizes candidate genes with dynamic APA.

294 ng in both populations implicates over 2,000 candidate genes with sex- and environment-specific or an

295 ction mutation in forkhead box I3 (FOXI3), a candidate gene within the common deleted region found in

296 ubjects, and haploinsufficiency for FOXI3, a candidate gene within the deleted region, is the likely

297 led with previously established roles of the candidate genes within identified risk loci in periderm

298 enetic interactions between BMPR1A and other candidate genes within linkage region 1 which may provid

299 We identified candidate genes within quantitative trait loci for HLB t

300 ted transcript level of biological plausible candidate gene ZFP90 via expression quantitative trait l