ライフサイエンスコーパス: canonical

1 the Piccard hydrothermal field that span the canonical 122 degrees C limit to life, and thus provide

2 We identified and characterized a canonical 14-3-3-binding site (site 1) within the flexib

3 Transient Receptor Potential Canonical 4 (TRPC4) forms non-selective cation channels

4 In contrast, canonical ACE2 expression is unresponsive to IFN stimula

5 n of epithelial breast cancer cells, via non-canonical activation of GLI-signaling.

6 and integrin beta1, respectively, to reshape canonical Akt signaling within monocytes.

7 tension of the substrate scope of mTG beyond canonical amines thus substantially broadens the versati

8 bal degradation rates in tissues using a non-canonical amino acid and mass spectrometry.

9 dynamics simulations and state-dependent non-canonical amino acid cross-linking.

10 Here, we apply bioorthogonal non-canonical amino acid tagging (BONCAT) to visualize and q

11 itiate translation in vivo with aromatic non-canonical amino acids (ncAAs) bearing diverse sidechains

12 lling of newly synthesised proteins with non-canonical amino acids (NCAAs) by genetically restricting

13 expansion (GCE) technologies incorporate non-canonical amino acids (ncAAs) into proteins at amber sto

14 rect the incorporation of three distinct non-canonical amino acids into a single polypeptide.

15 otides than peptides composed exclusively of canonical amino acids.

16 tions capable of modifying almost all of the canonical amino acids.

17 cific incorporation of the azide-bearing non-canonical-amino-acid azidonorleucine (ANL) during protei

18 Further, canonical analysis of principal coordinates (CAP) analys

19 Non-canonical and C-to-U RNA-editing events are enriched ins

20 8 +/- 0.7 MPa) and that the dynamics of both canonical and CENP-A nucleosomes are preserved and parti

21 show that many key regulator proteins of the canonical and non-canonical NF-kappaB pathways, such as

22 nd trace the evolution of core components of canonical and non-canonical PRC1 complexes in animals.

23 orted an important role for Wnt5a acting via canonical and noncanonical signaling in spinal processin

24 n the small-molecule agonist eltrombopag and canonical and novel activating TpoR mutations that all d

25 NO receptor machinery includes both canonical and novel NIT-domain containing soluble guanyl

26 al traits of the many-body methods, in their canonical and reduced-scaling formulations, that underli

27 o has notable implications for understanding canonical and snRNA 3'-end processing.

28 otif in the Las1 subfamily and uncovered its canonical and specialized elements.

29 We demonstrate that DR3 engages the canonical and/or non-canonical NF-kappaB pathways, and t

30 se effect was found to be independent of the canonical androgen receptor pathway.

31 Our analysis shows that ERBs upregulate canonical antiviral genes typical of mammalian systems,

32 The BAD-BAX-caspase-3 cascade is a canonical apoptosis pathway.

33 ve of a particular visual sensitivity to the canonical appearance of facing bodies.

34 ose classes relate to generalizations of the canonical asymmetric vs. symmetric stem cell self-renewa

35 0 mediated substrate ubiquitination, and the canonical ATP cycle was required for HSP70's role: we ha

36 subset of atropisomers that differ from both canonical atropisomers (e.g., binaphthyls) and topoisome

37 insight into the molecular functions of non-canonical AUX/IAA proteins in auxin signaling transducti

38 nt via TIR1-dependent protein degradation of canonical AUX/IAA proteins, which normally repress the a

39 class of non-coding RNAs generated from non-canonical back-splicing events, have emerged to play key

40 ate site-specific incorporation of these non-canonical, backbone-extended monomers at the N- and C- t

41 fragilis UroS is functionally different from canonical bacterial UroS proteins.

42 ral model of the endogenously purified human canonical BAF complex bound to the nucleosome, generated

43 nd double-strand breaks (DSBs) by perturbing canonical base excision repair (BER).

44 glucose by beige adipocytes activated by the canonical beta3-adrenergic signaling pathway.

45 in/protein interaction in the absence of the canonical binding element.

46 DNA Ligase IV, XRCC4 and XLF, members of the canonical branch of NHEJ pathway (c-NHEJ).

47 ing sites that compete for the cA4 ligand, a canonical cA4-activated ribonuclease activity in the Csx

48 dopts an SGNH-hydrolase fold and possesses a canonical catalytic triad.

49 ogether with NCBP1, and to interact with the canonical CBC along with the protein SRRT.

50 iodiniaceae species, and the presence of the canonical CDK motif, CDKB emerged as a likely candidate

51 re shared between many mice) that often have canonical CDR3s in the immunoglobulin heavy chain that,

52 ngiotensin-converting enzyme 2 (ACE2) is the canonical cell surface receptor for SARS-CoV-2.

53 across different ages and identified eleven canonical cell types, as well as six subpopulations of b

54 ow that the placenta minimally expresses the canonical cell-entry mediators for SARS-CoV-2.

55 Bacteria with these non-canonical cell-wall cross-links achieve a high optical d

56 potential target for HDT in TB in adjunct to canonical chemotherapy.

57 Whereas canonical chromothripsis profiles display oscillations b

58 Rhodopsin is a canonical class A photosensitive G protein-coupled recep

59 GGCC-transcription have identified specific, canonical complexes that may promote RNAPII-transcriptio

60 Mutagenesis of the single canonical conserved 3' UTR miR-290-binding site of Pfn2

61 fic promoters lack the previously identified canonical core promoter elements except for the Inr.

62 Both sparse partial least squares and kernel canonical correlation analysis captured two hidden dimen

63 This challenge might be met through canonical correlation analysis designed to model mutual

64 h as sparse partial least squares and kernel canonical correlation analysis, for identifying hidden d

65 Analysis of the survey results using canonical correspondence analysis explained 70.5% (horiz

66 ion and gates OD plasticity independent of a canonical cortical microcircuit.

67 Here we report a non-canonical cross-coupling approach for the construction o

68 he biological consequence of introducing non-canonical cross-links into the cell wall of Escherichia

69 l thickness and surface area had the highest canonical cross-loadings (|rho| = 0.31-0.61).

70 h natural and synthetic peptides fold into a canonical CSalphabeta motif stabilized by conserved disu

71 Notably, we identified a non-canonical cytochrome P450 that catalyses the remarkable

72 Although LRRC8A was dispensable for canonical DAMP-dependent NLRP3 activation, this was stil

73 content of retrieval) fell primarily within canonical default network regions.

74 esence of B(loc); ii) connection between the canonical definition of temperature and Gamma(mag); and

75 tin ligase FBW7 in a manner independent of a canonical degron.

76 al batteries is investigated through a grand canonical density functional theory (DFT) approach.

77 ytic efficiency for r8-oxo-GTP compared with canonical deoxyribonucleotides but that r8-oxo-GTP is in

78 s, to reveal how specificity is coded on the canonical DIP/Dpr interface.

79 GSCs have a non-canonical distribution of PRC2 activity and lack silence

80 letion of POT1B or BRD2 with TRF2 restores a canonical DNA damage response at telomeres, resulting in

81 ith heterozygous mutations, causing a focal, canonical DNA hypomethylation phenotype; this phenotype

82 change that mediates stable binding to a non-canonical DNA motif.

83 ng, establishing the subsequent alphabetaTCR canonical docking mode.

84 ethylation are stochastic and independent of canonical downstream effector signaling.

85 bases are accessible to alkylating agents in canonical dsDNA and that Hoogsteen base pairs increase t

86 a muscle-derived extrinsic factor that uses canonical dSmad2-mediated signaling to regulate wing siz

87 also generated independently of SGs and the canonical dsRNA-induced SG biogenesis pathway, because R

88 lls migrated to specialized sites within the canonical DZ that contained tingible body macrophages an

89 was reported that AspH substrates have a non-canonical EGFD disulfide pattern.

90 beta-fold domain, partially sequestering the canonical eIF4E-binding helix.

91 of degradation intermediates that map to the canonical EJC region.

92 Using grand-canonical electronic-structure calculations, we directly

93 or selenomethionine into proteins that lack canonical encoding for selenocysteine.

94 otein-tyrosine phosphatase 1B (PTP1B) is the canonical enzyme for investigating how distinct structur

95 mechanisms for NE sealing independent of the canonical ESCRT pathway.

96 To discover driver fusions beyond canonical exon-to-exon chimeric transcripts, we develop

97 of death receptor 5 (DR5) independent of its canonical extracellular ligand Apo2L/TRAIL; however, the

98 accuracy remains exceedingly high even when canonical face and place systems are removed from the da

99 nctional theory supports a Co(III)=N=Co(III) canonical form with significant pai-bonding between the

100 than half of the predicted targets with the canonical form.

101 CD8 T cells and augmented the expression of canonical Foxo1 target genes such as Il7r and Sell In co

102 athogen Mycobacterium tuberculosis, lack the canonical FtsZ-membrane anchors and Z-ring regulators de

103 nthetase (LysRS), a moonlight protein with a canonical function in protein synthesis and a noncanonic

104 This role is in stark contrast with the canonical function of these two proteins in the maintena

105 ons of host proteins that deviate from their canonical functions thereby inducing cellular pathology.

106 erotrimeric G protein complex, consisting of canonical Galpha, Gbeta and Ggamma subunits, is involved

107 ET) occurs on timescales that are similar to canonical gene regulation and can respond to rapid envir

108 lification provides a generic alternative to canonical gene regulation.

109 mapping of unique gene symbol identifiers to canonical gene symbols allows for an ambiguous gene prop

110 he seven-member transient receptor potential canonical genes (TRPC1-7) encode cation channels linked

111 tabilizing compound, berberine, to these non-canonical genetic structures using UV-Vis and fluorescen

112 Here, we show in mice that activation of canonical Gli-dependent Hedgehog signaling by Gli1 gene

113 ut cannot be identified by the expression of canonical glial markers.

114 Departing from canonical gp130 signaling, SarA function is JAK-independ

115 e report that beta-arrestin 2 (beta-Arr2), a canonical GPCR signaling partner, localizes in SECs with

116 transmembrane helices have at least one non-canonical H-bond formed by a serine or threonine residue

117 we report that RNF168 ubiquitinates the non-canonical H2A variants H2AZ and macroH2A1/2 at the diver

118 Thus, IHH induces stromal activation of the canonical Hh signaling pathway to suppress tumor growth

119 upstream negative regulator of both FGFR and canonical Hh-GLI1 signaling, and additionally in the non

120 restoring Sox10 expression without affecting canonical HIF1a activity.

121 interaction toward nucleosomes with the non-canonical histone H2A.Z, thereby focusing the pathway on

122 span an AT-rich core and are depleted of the canonical histone H3.

123 of hundreds of shared and tumor-specific non-canonical HLA peptides, including an immunogenic peptide

124 12 forms stable periodic structures with non-canonical hydrogen bonds in some regions and non-canonic

125 k at the ionic interface, reminiscent of the canonical, hydrophobic air-water interface.

126 to the PSTN region that runs parallel to the canonical hyperdirect pathway from the isocortex to the

127 Small-molecule inhibitors of non-canonical IkappaB kinases TANK-binding kinase 1 (TBK1) a

128 this mechanobiology can be incorporated into canonical immunological models to improve how these mode

129 Prior studies identified the canonical inflammasome as the major pathway leading to i

130 5'-TOP/TCT initiation is intertwined with canonical initiation and used divergently in hundreds of

131 long non-coding (lnc) RNA that activates non-canonical innate immune signaling upon detection of the

132 While previous studies have observed canonical interactions between the globular domains of M

133 These observations indicate that the canonical IPCC range of ECS (1.5 to 4.5 degrees C per do

134 ns could be missed by solely focusing on the canonical isoform, and suggest that on- and off-target e

135 ndings suggest that JAZ4 participates in the canonical JA signaling pathway leading to plant defense

136 nt of the meiotic cohesin complex, via a non-canonical JAK/STAT pathway, and consequently promotes me

137 rate streams by which DMN couples with other canonical large-scale networks, including language and c

138 iption factor expression, and independent of canonical LPS-induced intercellular feedback in the tumo

139 y perturbations to crucial components of the canonical macroautophagy machinery and can occur in the

140 tion that influence clustering and a lack of canonical markers for certain cell types.

141 d clustering of gene expression profiles and canonical markers.

142 olo-WhiB1 regulates gene expression by a non-canonical mechanism relative to well-characterized sigma

143 indicates Kir channels are not gated by the canonical mechanism.

144 Papillar cytoplasm sharing does not employ canonical mechanisms such as incomplete cytokinesis or m

145 , indicating a functional departure from the canonical MEF2 corepressor function of class IIa HDACs.

146 Many canonical membraneless compartments within animal cells

147 n a negative feedback loop, affecting global canonical microRNA expression in erythrocytes.

148 icroRNA production, impacting populations of canonical microRNAs and mirtrons.CONCLUSIONWe identified

149 nucleotides at the 5' and/or 3' ends of the canonical miRNA sequence.

150 since genomic analysis indicates suboptimal canonical miRNAs are enriched in operons, and we validat

151 Mirtrons are non-canonical miRNAs arising by splicing and debranching fro

152 ciated with a switch of IL6 signaling from a canonical mode (myeloid cells) to a noncanonical trans-s

153 The canonical model of RB regulation is that cyclin-CDKs pho

154 noncanonical mechanism is distinct from the canonical modes of chromatin remodelers that directly en

155 the cell with regulatory capabilities beyond canonical molecular regulatory mechanisms.

156 as estimated to be 422 m(2) g(-1) from grand canonical Monte Carlo simulations.

157 ed with oscillating chemical potential Grand Canonical Monte Carlo/molecular dynamics simulations are

158 myelofibrosis patients, respectively, have "canonical" MPL exon 10 driver mutations W515L/K/R/A or S

159 can eliminate most of the incomplete and non-canonical NAD caps through their decapping, deNADding an

160 a stable heterodimeric complex that accepts canonical NatB-type substrates in vitro.

161 MLKL is the final executioner of canonical necroptosis; however, in axonal necroptosis, M

162 e show that such tracking can be achieved by canonical network architectures and dynamics, and that t

163 ing spatial patterns of task activation-than canonical networks.

164 tics or sensory stimulation appear to engage canonical neurocircuits that encompass excitatory and in

165 Deleting the canonical NF-kappaB kinase, IKKbeta, in Scx-lineage cell

166 (a) a scaffold to recruit components of the canonical NF-kappaB machinery and (b) a protease to clea

167 wn for its pivotal role as a mediator of the canonical NF-kappaB pathway, which has important functio

168 te that DR3 engages the canonical and/or non-canonical NF-kappaB pathways, and thus stimulates naive

169 regulator proteins of the canonical and non-canonical NF-kappaB pathways, such as Nfkb2, and its dow

170 Here we show that activation of the non-canonical NF-kappaB signalling pathway by AZD5582 result

171 f NFkappaB p65, suggesting activation of the canonical NFkappaB signaling pathway.

172 TOH1, including genes that encode Delta-like canonical Notch ligand and other secretory-specific tran

173 s-either via the synthesis of ribose and the canonical nucleobases and then joining them together or

174 ing possible prebiotic syntheses of the four canonical nucleotides of coding RNA.

175 vate transcription in a manner distinct from canonical ones.

176 In addition to canonical open reading frames (ORFs), thousands of trans

177 Earlier studies indicate that either the canonical or non-canonical pathways of inflammasome acti

178 e and epithelial cells are thought to be the canonical orchestrators of this complex equilibrium, her

179 located in the 5' mRNA leaders, and amongst canonical ORFs during the activation of the zygotic tran

180 ependent decay (RIDD) without activating its canonical output mediated by the transcription factor XB

181 ssion and activity in obesity, however, only canonical p53 functions (i.e. senescence and apoptosis)

182 damage is sufficient to induce activation of canonical p53 target genes in NEFs.

183 L) depletion also modulated transcription of canonical p53 target genes, suppressing p53-induced expr

184 ponses to a peptide library derived from the canonical PAR4-agonist peptide, AYPGKF-NH(2), and we mon

185 The ubiquitin-proteasome system is the canonical pathway for protein degradation in eukaryotic

186 The canonical pathway of eicosanoid production in most mamma

187 Although the canonical pathway remained unchanged, autocrine SHH inte

188 l pathway of ILV formation, secondary to the canonical pathway, and that this pathway controls the ta

189 ampus revealed that stress increased several canonical pathways (TREM1, NF-kappaB, complement, IL-6 s

190 es indicate that either the canonical or non-canonical pathways of inflammasome activation have a lim

191 T cells restrained effector T cells via the canonical PD-L1-PD-1 axis and were sufficient to acceler

192 NFaT transcription factors, rather than the canonical PDX1 enhancer complex, are predicted to drive

193 Some have canonical pepsin-like aspartic protease features, wherea

194 are required to robustly identify these non-canonical peptides.

195 While the PmMDV VP sequence lacks a canonical phospholipase A2 domain, the structure of an E

196 tients without affecting their vision or the canonical phototransduction cascade.

197 In contrast to the canonical picture of transport by direct attachment to m

198 The CLC exchangers, unlike canonical 'ping-pong' antiporters, simultaneously bind a

199 ng the upstream and downstream regulators of canonical PINK1/parkin-mediated mitophagy, alongside non

200 on strains at ambient CO(2) We find that the canonical plant-like C(2) cycle does not operate in this

201 nts that might play an important role in non-canonical poly(A) site choice in response to abiotic str

202 ue, likely off-pathway, intermediates in the canonical polymerization cycle.

203 990M mutation affected the gating of the non-canonical pore of TRPM3, resulting in large inward catio

204 Here, we apply the recently developed grand canonical potential kinetics (GCP-K) formulation of quan

205 tion of core components of canonical and non-canonical PRC1 complexes in animals.

206 n in cancer cells in a context distinct from canonical PRC2.

207 Here, we identify a non-canonical promoter element that plays a key role.

208 These similarities represent conserved, canonical properties of the functional circuits and comp

209 vitamin B12, or genetic perturbation of the canonical propionate breakdown pathway results in propio

210 , which form stable complexes with the main, canonical protein encoded on the same messenger RNA, the

211 This effect is not mediated by the canonical protein kinase A pathway but rather, through d

212 orrection of pathological mutations with non-canonical protospacer-adjacent motifs.

213 ermediates in the prebiotic synthesis of the canonical pyrimidine ribonucleosides (cytidine and uridi

214 s of brain-behavior-environment covariation (canonical r(discovery) = .21 to .49, canonical r(test) =

215 iation (canonical r(discovery) = .21 to .49, canonical r(test) = .10 to .39, p(false discovery rate c

216 e electrochemistry to seamlessly combine two canonical radical reactions-cobalt-mediated hydrogen-ato

217 Catalysis by canonical radical S-adenosyl-l-methionine (SAM) enzymes

218 the pro-angiogenic factor SDF1alpha via its canonical receptor CXCR4 and the MAP kinase ERK5.

219 HH ligands signal through the canonical receptor PTCH1, and three co-receptors: GAS1,

220 ys large variability and complexity, yet the canonical regularities of the cortex suggest that such w

221 -GLI1 signaling, and additionally in the non-canonical regulation of GLI1 through pERK1/2.

222 Instead of utilizing a canonical replication fork, BIR is driven by a migrating

223 to the NEL_INST group (i.e. Peak VOR > 2.0); canonical resting-state networks preferentially engaged

224 Mammalian genomes encode 20 canonical RGS and 16 Galpha genes with key roles in phys

225 DNN) to predict toehold switch function as a canonical riboswitch model in synthetic biology.

226 In summary, our work identifies a non-canonical role of caspase-8 exploited by cancer cells to

227 growth inhibition does not, however, involve canonical roles as part of the RISC; rather, AGO1 contro

228 addition, oligodendrocytes play diverse non-canonical roles including axonal metabolic support and a

229 er place complosome activities among the non-canonical roles of other intracellular innate danger sen

230 nd unfolded state for ETR-3 RRM-3, which has canonical RRM fold.

231 ut half of the backbone NH sites exhibited a canonical scenario, where local opening/closing was asso

232 ne family have largely remained conserved in canonical sequence motifs and copy numbers as in E. macl

233 enus flytrap domain, which is connected to a canonical seven-transmembrane domain.

234 le, NHR-23/NR1F1 functions downstream of the canonical sex-determination pathway.

235 natal fibroblasts (HFFs) mainly via TGF-beta canonical signaling and Smad2/3 activation; RAP, an inhi

236 dynamic changes of core liver functions and canonical signaling pathways governing development at bo

237 Blockage of canonical signaling using Sfrp1, Dkk1, or fibroblast-spe

238 forming growth factor-beta (TGFbeta)-induced canonical signaling with the noncanonical kinase cascade

239 e reveals the presence of ATP and GMP at the canonical sites of the Bateman domains, the latter in a

240 pic phase behavior and provide access to non-canonical soft matter Frank-Kasper A15 and sigma phases.

241 erozygous variant (c.1995delA) truncates the canonical Sp1 molecule in the highly conserved C-termina

242 Germline nonsense and canonical splice site variants identified in disease-cau

243 nical hydrogen bonds in some regions and non-canonical stacking in others, whereas (CG)12 forms a sta

244 of mature IL-1beta and IL-18 in response to canonical stimuli initiated by NOD-like receptor (NLR),

245 ered that soluble endorepellin activates the canonical stress signaling pathway consisting of PERK, e

246 Non-canonical structures are linked to this expansion.

247 ors as initiating substrates, instead of its canonical substrate ATP.

248 and have similar affinities for S7P and the canonical substrate fructose 6-phosphate (F6P).

249 valent acyl-enzyme intermediates of PGA with canonical substrates (L-Asp and L-Glu) and an opportunis

250 lasmic domain of BRI1 contains five putative canonical surface-exposed Tyr-based endocytic motifs.

251 synapse configurations are less-studied, non-canonical synapse types that are prevalent throughout th

252 Prima-1(Met) activity was independent of its canonical target, mutant p53, and was better associated

253 Cs), we demonstrate that HIF1a activates non-canonical targets to impair generation of oligodendrocyt

254 cture revealed that sarecycline binds at the canonical tetracycline binding site located in the decod

255 at in oocytes TBPL2 does not assemble into a canonical TFIID complex.

256 ptor (BMPR) signaling cascade, distinct from canonical TGF-beta signaling.

257 eration; suggesting the involvement of a non-canonical Tgfb signaling pathway.

258 According to the now canonical theory, reward predictions are represented as

259 at-specific cold mimetics via activating non-canonical thermogenesis protect against obesity.

260 ading to tumorous overproliferation when the canonical TIR1 auxin signaling is disrupted.

261 r findings highlight the need to move from a canonical to a context-specific view of GPCR signalling

262 nse to inflammation, MDS HSPCs switched from canonical to noncanonical NF-kappaB signaling, a process

263 nt antagonist, we assessed beta-catenin, the canonical transducer of Wnt signaling, and found increas

264 Canonical transient receptor potential channels (TRPC) a

265 chanistic principles surprisingly similar to canonical translation elongation.

266 In G0 cells, canonical translation initiation is inhibited; yet we fi

267 omics and bioinformatics, both signaling and canonical translation pathways show significant downregu

268 No satisfactory canonical treatment is available for post-kala-azar derm

269 e-exported by Crm1 and Mex67, but not by the canonical tRNA exporters Los1 or Msn5.

270 We show that the non-canonical tubulin Tuba8, transiently expressed in cortic

271 Recent studies suggest that non-canonical tumor-specific HLA peptides derived from annot

272 iograms are typically categorized into a few canonical types, each thought to reflect distinct pathol

273 ts WD40 domain, bypassing the requirement of canonical upstream autophagy machinery.

274 aberrant and inconsequential variant of the canonical V(D)J recombination.

275 unogens, and live mutants lead the design of canonical vaccines aimed at disrupting infection in the

276 A canonical variate analysis using 95% confidence regions

277 Across cohorts, canonical variates did not relate to specific resting-st

278 We identified seven canonical variates in the discovery and five in the repl

279 Canonical vertebrate epithelial Na(+) channel (ENaC) for

280 sterol movement from STRIC is independent of canonical vesicular trafficking but requires Arp2/3, sug

281 evaluated on 57 different Atari games(3)-the canonical video game environment for testing artificial

282 We discuss the inconsistencies with the canonical view that glucagon is primarily a hyperglycemi

283 us to accurately quantify the expression of canonical viral open reading frames (ORFs) and to identi

284 ctroencephalographic (EEG) "microstates" are canonical voltage topographies that reflect brief activa

285 tering to study magnetic fluctuations in the canonical weak itinerant ferromagnet MnSi.

286 the current study, we show that Wnt5A, a non-canonical Wnt ligand that drives a metastatic, therapy-r

287 w that Sox17 functionally interacts with the canonical Wnt pathway to specify and pattern the endoder

288 ulators to inhibit BMP, TGF-beta (SMAD), and canonical Wnt pathways that reduced variability between

289 ng Wnt4 expression with consequent paracrine canonical Wnt signaling activation.

290 Inhibitors of either Notch or canonical Wnt signaling block WBR and reduce proliferati

291 We demonstrate that EHMT2 suppresses canonical Wnt signaling by activating expression of the

292 ther, we provide evidence that activation of canonical Wnt signaling has a profound effect on melanom

293 D8(+) T cell-conditioned medium (CM) induced canonical Wnt signaling in infected recipient cells whil

294 Here we show that canonical Wnt signaling in mesoderm is critical to confe

295 a played a minor, if any, role in regulating canonical Wnt signaling in the oligodendroglial lineage

296 actor 1 (LEF1), a downstream effector in the canonical Wnt signaling pathway.

297 ular bodies (MVBs) is required for sustained canonical Wnt signaling.

298 of the crypts and up-regulation of Axin2, a canonical Wnt target gene, and SRY-box transcription fac

299 The canonical Wnt target gene, Axin2, is also a direct trans

300 pproaches have been used to characterize the canonical X-shape conformers under specific ionic condit