ライフサイエンスコーパス: cap structure

1 f a transcript independent of its 5' end and cap structure.

2 lent enzyme-GMP intermediate to generate the cap structure.

3 iation and separately formation of the GpppA cap structure.

4 r by competing with eIF4E for binding to the cap structure.

5 are induced to fold upon recognition of the cap structure.

6 on factor (eIF) 4G, bridging the 5' terminal cap structure.

7 nding of an initiation factor, eIF4E, to the cap structure.

8 anslation of cellular mRNAs utilizing the 5' cap structure.

9 ite that is a considerable distance from the cap structure.

10 ranslated efficiently in the absence of a 5' cap structure.

11 was contributed by the interaction with the cap structure.

12 position 10-15 nucleotides downstream of the cap structure.

13 he 5' diphosphate end of RNA to form a GpppN cap structure.

14 in the affinity of eIF4E for the mRNA m7GTP cap structure.

15 in a heterodimeric complex to bind the mRNA cap structure.

16 p in vitro due to its ability to bind the 5' cap structure.

17 in (PAB1) gene deletion, stabilizes the mRNA cap structure.

18 F4F (of which eIF4G is a subunit) for the 5' cap structure.

19 ay that is stimulated by removal of the mRNA cap structure.

20 synthesized BTV ssRNA transcripts to form a cap structure.

21 GTP to the 5' end of mRNA to form the GpppN cap structure.

22 y require a 3' OH or interaction with the 5' cap structure.

23 hotoreactive moiety is brought closer to the cap structure.

24 ) into either the m(7)G or G moieties of the cap structure.

25 2'-O-Me), creating part of the mammalian RNA cap structure.

26 5'-end of the mRNA 7-methylguanosine (m(7)G) cap structure.

27 -CoV-2 catalyzes the formation of the 5' RNA cap structure.

28 bypassing the host cell requirement of a 5' cap structure.

29 hich are involved in the modification of RNA cap structure.

30 Y14 is critical for its binding to the mRNA cap structure.

31 ric, coiled coil with a small, alpha-helical cap structure.

32 in synthesis by binding the 5' terminal mRNA cap structure.

33 at eIF4F binds mRNAs primarily at the 5' m7G cap structure.

34 protein in 2'-O and G-N-7 methylation of the cap structure.

35 is responsible for methylating the viral RNA cap structure.

36 oth eIF4E-2 and eIF4E-3 can bind to the mRNA cap-structure.

37 on of higher order PIMs that possess mannose cap structures.

38 nd increases interactions of eIF4E with mRNA cap structures.

39 es then add methyl groups to form functional cap structures.

40 was developed for the two distinct types of cap structures.

41 o synthesize viral mRNAs methylated at their cap structures.

42 of which is covered by a novel T:A:T triple capping structure.

43 at the distal end, often with the help of a capping structure.

44 r loop arrangements, strand orientations and capping structures.

45 iolate protecting layer, consisting of Ag2S5 capping structures.

46 ase-paired thymines that are involved in the capping structures.

47 m(7)GDP; however, it did not function on the cap structure alone.

48 itiation factor 4E (eIF4E) also binds to the cap structure, an interaction that is critical for initi

49 Communication between the 5' cap structure and 3' poly(A) tail of eukaryotic mRNA res

50 n of a reporter mRNA lacking the 5' (7)mGppp cap structure and 3' poly(A) tail.

51 e consistent with ribosomal tethering at the cap structure and clustering at internal sites.

52 viral RNAs that are capped by binding to the cap structure and depurinating the RNAs downstream of th

53 at the barbed end are intimately related to cap structure and dynamics.

54 anslation of HPV-18 E6 largely relies on the cap structure and eIF4E and eIF4AI, two key translation

55 r by a mechanism which is independent of the cap structure and in this case ribosomes are directed to

56 f many positive strand RNA viruses lack a 5' cap structure and instead rely on cap-independent transl

57 endoplasmic reticulum, colocalizing with the cap structure and interacting with the ribosomal protein

58 of stable snRNPs, hypermethylation of the 5' cap structure and nuclear import of the resultant partic

59 ise our current knowledge on the role of the cap structure and of the cap-binding protein complex in

60 The 5'-cap structure and poly(A) tail of eukaryotic mRNAs funct

61 esis, the mRNA 5'-terminal 7-methylguanosine cap structure and several recognition proteins play a pi

62 mRNA requires direct interaction between the cap structure and the eukaryotic translation initiation

63 L-BC Gag also covalently binds to the cap structure and the mutation H156R, which corresponds

64 Although the cap structure and the poly(A) tail are on opposite ends

65 The 5'-terminal cap structure and the poly(A) tail at the 3' terminus se

66 accharomyces cerevisiae is stimulated by the cap structure and the poly(A) tail through the binding o

67 Both the cap structure and the spliced leader (SL) sequence affec

68 The VHS RNase binds both to mRNA cap structure and to tristetraprolin, an inducible host

69 We probed a variety of non-native synthetic cap structures and found that an unmethylated guanosine

70 RNAs into Xenopus oocytes and examined their cap structures and translational activities during meiot

71 e loop plays a central role for the specific capping structures and in stabilizing the most favored f

72 We also show that the m(7)G cap structure, and not the poly(A) tail, is the primary

73 The distinct capping structures appear to be crucial for the favored

74 Thus, changes in the telomere cap structure are sufficient to affect the rate of senes

75 5' Cap structures are ubiquitous on eukaryotic mRNAs, essen

76 First, as cap structures are usually required for translation of m

77 the identification of the absence of the 5' cap structure as a primary molecular determinant of part

78 contain an unusual 2,2,7-trimethylguanosine cap structure as a result of trans-splicing onto the 5'

79 The dual role of the cap structure as a target of mRNA degradation and as the

80 reaction with free GDP, yielding the same 5'-capped structure as is formed by protein GTP:RNA guanyly

81 The 7-methylguanosine cap structure at the 5' end of eukaryotic messenger RNAs

82 CBC) associates cotranscriptionally with the cap structure at the 5' end of nascent mRNA to protect i

83 ic mRNA turnover is the removal of the m(7)G cap structure at the 5' end of the message.

84 ly degraded, presumably due to the lack of a cap structure at the 5' end of the mRNA.

85 ctors recruit the 40S ribosomal subunit to a cap structure at the 5' end of the mRNA.

86 ly dependent upon the presence of an m7GpppN cap structure at the 5' end of the transcript.

87 ) has been based on methods that require the cap structure at the 5' end of transcripts derived from

88 ncer RNAs did not appear to contain a normal cap structure at the 5' ends.

89 g protein synthesis independent of the m(7)G cap structure at the 5'-end of an mRNA molecule.

90 initiation factor 4E (eIF4E) binds the m7GTP cap structure at the 5'-end of mRNAs, stimulating the tr

91 of a triphosphate or a 7-methyl 3'G5'ppp5' G cap structure at the 5'-end of the RNA does not affect c

92 mation of the 2,2,7-trimethylguanosine (TMG) cap structure at the human telomerase RNA 5' end by the

93 Rotavirus mRNAs contain a type 1 cap structure at their 5' end that is added by the viral

94 ase (L) protein of VSV methylates viral mRNA cap structures at the guanine-N-7 (G-N-7) and ribose-2'-

95 ellum and three constituents of the axonemal capping structure at the tips of both assembling and mat

96 The assembly is closed by specific capping structures at either end, which we propose to pl

97 We propose that mRNAs lacking a cap structure become exposed to RdRp to initiate or main

98 ith a natural competition existing at the 5' cap structure between PARN and eIF4E that may be regulat

99 y ISG15 and ISGylated 4EHP has a much higher cap structure-binding activity.

100 4EHP is an mRNA 5' cap structure-binding protein and acts as a translation

101 terminal Strep tag appears buried within the cap structure, blocking effector transport even in Y. pe

102 , like L-A viral mRNA, lack 3'-poly(A) or 5'-cap structures but can normally express mRNA with both c

103 etoplastid mRNA acquire a hypermethylated 5'-cap structure, but its function has been unclear.

104 RNA virus furnishes its transcript with a 5' cap structure by a novel cap-snatching mechanism in whic

105 ic activity and subsequent hydrolysis of the cap structure by a scavenger decapping activity.

106 at the 3' end and promotes hydrolysis of the cap structure by Dcp1/Dcp2 at the 5' end through an unkn

107 Remodeling of the glycan cap structures by the cocktail enabled enhanced GP bindi

108 Chemical modifications of the mRNA cap structure can enhance the stability, translational p

109 ation of clustered lesions in the chromosome capping structure can result in the unfolding of existin

110 conversion of GpppRNA ends to the m7GpppRNA cap structure characteristic of eukaryal mRNAs.

111 Telomeres form protective capping structures composed of telomeric DNA complexed w

112 Telomeres are protected by capping structures consisting of core protein complexes

113 tro indicated that the 7-methyl group of the cap structure contributes to the enzyme's substrate spec

114 tail, followed either by cleavage of the 5' cap structure (decapping) and 5'->3' exonucleolytic dige

115 lation of 4EHP may play an important role in cap structure-dependent translation control in immune re

116 U3 and U8 RNAs containing alternative cap structures did not localize in nucleoli nor did U3 o

117 ase activity that can also remove the entire cap structure dinucleotide from an mRNA.

118 tion factor eIF4E with the universal mRNA 5' cap structure, dominated by steric effects on barrier-he

119 les during phagocytosis and to the posterior cap structure during surface receptor shedding for immun

120 ry, most eukaryotic cellular mRNAs have a 5' cap structure [e.g. m7G(5')ppp(5')N].

121 ught to be required for interaction with the cap structure, eIF4G, and 4E-BPs, it fails to interact w

122 The 5' messenger RNA (mRNA) cap structure enhances translation and protects the tran

123 The deRNAylation/capping structure explains why GDP is a preferred substr

124 e methyltransferases sequentially modify the cap structure, first at the guanine-N-7 (G-N-7) position

125 pyrophosphatase that hydrolyzes the residual cap structure following 3' to 5' decay of an mRNA.

126 g enzyme DcpS functions to clear the cell of cap structure following decay of the RNA body by catalyz

127 cpS is known for its role in hydrolyzing the cap structure following mRNA degradation.

128 ecular dynamics simulations showing how BNNT cap structures form during Ni-catalyzed chemical vapor d

129 as an adenine bulge and a G.G.T base triple capping structure formed between the central edgewise lo

130 x with only two G-tetrads but multiple-layer capping structures formed by loop residues.

131 In addition, the capping structures formed by the extended flanking segme

132 ed decapping enzyme Dcp2 that removes the 5' cap structure from eukaryotic mRNA and thereby efficient

133 DCPS decaps the cap structure generated by 3' to 5' exonucleolytic degra

134 a selective HDAC6 inhibitor with a bisected cap structure, generating 26 analogs with comparable or

135 n transfers the RNA to GDP, forming the core cap structure GpppA-RNA.

136 nt enzyme-pRNA intermediate to generate a 5'-cap structure (GpppA).

137 hate end of poly(A) to form a tetraphosphate cap structure, GppppA.

138 eport that the L protein produces an unusual cap structure, guanosine(5')tetraphospho(5')adenosine (G

139 esence of translational control elements and cap structures has not been carefully investigated for m

140 The cap structures have the potential to be of considerable

141 hat T. vaginalis mRNAs are protected by a 5' cap structure, however, contrary to that typical for euk

142 lves three mRNA structural features: (i) the cap structure, (ii) the context of the Kozak sequences t

143 d woodchuck, behaved as if it contained a 5'-cap structure; (ii) in the infected liver there were add

144 be controlled by access of the enzyme to the cap structure in a competition with the translation init

145 These results define an additional 5' RNA cap structure in eukaryotes and raise the possibility th

146 er IRES domains substitute for a 5' terminal cap structure in protein synthesis.

147 ndings underscore the importance of a proper cap structure in the synthesis of functional messenger R

148 The SL RNA cap structure in Trypanosoma brucei is unique among euka

149 The only known RNA cap structure in unicellular protists is the unusual Cap

150 tissues, and human cells, we discovered new cap structures in humans and mice (FAD, UDP-Glc, UDP-Glc

151 iruses, FluB PB2 recognizes a wider range of cap structures including m(7)GpppGm-, m(7)GpppG-, and Gp

152 Addition of a 12-nucleotide chain to the cap structure increased affinity at high ionic strength

153 les increase, the stability of the spherical cap structure increases with respect to the alternative

154 Direct analysis of the mRNA cap structure indicated no alteration of cap processing

155 Picornaviruses, whose RNA genome lacks a cap structure, inhibit cap-dependent mRNA translation, a

156 te-terminated substrates shows that that the cap structure inhibits the action of the enzyme.

157 The N7-methylguanine portion of the mRNA cap structure interacts with cap-binding proteins via an

158 y (lipid-rich necrotic core content, fibrous cap structure, intraplaque hemorrhage), complementing th

159 The mRNA cap structure is a major site of dynamic mRNA methylatio

160 The 2,2,7-trimethylguanosine (TMG) cap structure is characteristic of certain eukaryotic sm

161 The decapping enzyme that removes the 5' cap structure is encoded by the DCP1 gene.

162 For coronaviruses, RNA cap structure is first methylated at the guanine-N-7 (G-

163 The cap structure is formed by several activities and comple

164 formation of the 5' 7-methylguanosine (m7G) cap structure is known to require a guanylyltransferase

165 A cis-diol containing cap structure is present at the 5' end of the U2 homolog

166 ts argue that dissociation of eIF4E from the cap structure is required before decapping.

167 g mechanism in which m(7)Gp from a host mRNA cap structure is transferred to the 5'-diphosphate termi

168 the mature viral particles are modified by a cap structure is unknown.

169 the PCIF1-dependent modification of VSV mRNA cap structures is inert with regard to mRNA stability, t

170 f how the flavivirus MTase protein binds RNA cap structures is presented.

171 In eukaryotes, the 5'-methylguanosine (cap) structure is principally removed by the Nudix famil

172 bonding and hydrophobic interactions in this capping structure is -1.2 kcal/mol, evaluated from therm

173 NA-binding motif no longer binds to the mRNA cap structure, is localized in the cell nucleus, does no

174 The SL cap is the most elaborate cap structure known in nature and has been shown to cons

175 ing protein that binds to capped RNA but not cap structure lacking an RNA.

176 The presence of the 5' cap structure m(7)G(5')ppp(5')Nm is a general feature of

177 e only plant mRNAs known to naturally lack a cap structure (m(7)GpppN) are viral in origin.

178 Eukaryotic mRNA bears a cap structure (m(7)GpppX-) at the 5' terminus crucial fo

179 eIF4F (4F) complex that assembles at the 5' cap structure (m(7)GTP) of mRNA to initiate ribosomal sc

180 d of the mRNA can affect the state of the 5' cap structure, m7G(5')ppp(5')G.

181 eIF4E linkage to cap structures mediates the recruitment of other transla

182 A polymerase synthesizes viral mRNAs with 5'-cap structures methylated at the guanine-N7 and 2'-O-ade

183 However, cap structure modification is challenging because of the

184 this and the 38-year-old cartilage the three capping structures: NeuAc(alpha2-3)-Gal-GlcNAc6S-Gal-Glc

185 forms the distinctive gamma-methylphosphate cap structure of 7SK, a noncoding RNA that regulates Cdk

186 MTases and can target only the N7-methylated cap structure of adenylate-primed RNA substrates.

187 Binding of the cap structure of AlMV4 by the polymerase activated RNA s

188 iral heterotrimeric RNA polymerase binds the cap structure of cellular pre-mRNA to promote its cleava

189 The m7GpppN cap structure of eukaryotic mRNA is formed cotranscripti

190 nd of three steps in the synthesis of the 5'-cap structure of eukaryotic mRNA.

191 he enzyme responsible for methylating the 5' cap structure of eukaryotic mRNA.

192 nformational change after the binding of the cap structure of host cell heterogeneous nuclear RNA by

193 degradation, and TGS1, which modifies the 5'-cap structure of hTR to enhance degradation, as possible

194 vaccinia virus enzymes, determination of the cap structure of messenger RNA, and development of poxvi

195 The 5'-cap structure of most spliceosomal small nuclear RNAs (s

196 initiation factor 4E (eIF4E) binds to the 5' cap structure of mRNA and is critical for cap-dependent

197 plants have two complexes that bind the m7G-cap structure of mRNA and mediate interactions between m

198 eIF4E, eIF4G, and eIF4A, binds to the m(7)G cap structure of mRNA and stimulates recruitment of the

199 einitiation complex to eIF4F bound at the 5'-cap structure of mRNA are necessary for preventing eIF5-

200 Recognition of the 5'-cap structure of mRNA by eIF4E is a critical step in the

201 plex, Eu(THED)3+, effectively cleaves the 5' cap structure of mRNA in solution by nucleophilic attack

202 The 5' cap structure of mRNA is a N7 methylated guanosine resid

203 Binding of the 5' -terminal cap structure of mRNA to eIF4E is a critical event durin

204 The cap-binding complex (CBC) binds to the cap structure of mRNA to protect it from exonucleases as

205 es contain a small subunit that binds the 5'-cap structure of mRNA, and a large subunit, eIF4G or eIF

206 Through its interaction with the 5' cap structure of mRNA, eIF4E functions to recruit mRNAs

207 Recognition of the cap structure of mRNA, m(7)GpppN, where N is any nucleot

208 Moreover, Y14 binds the cap structure of mRNAs and inhibits the activity of the

209 ly with the decapping factor Dcp2 and the 5' cap structure of mRNAs via different but overlapping dom

210 AD-box protein family that recognizes the 5' cap structure of mRNAs, allows mRNA to bind to the ribos

211 in vitro, specifically interacts with the 5' cap structure of RNA substrates, and this interaction is

212 Consequently, the cap structure of the gammaTuRC is distal to the base of

213 t role in mRNA translation by binding the 5'-cap structure of the mRNA and facilitating the recruitme

214 karyotic initiation factor 4E (eIF4E) to the cap structure of the mRNA.

215 incorporates the GDP moiety of GTP into the cap structure of transcribing mRNAs.

216 Methylation of the 5'-cap structure of viral RNAs plays important roles in gen

217 We further demonstrate that the mRNA cap structures of rabies and measles viruses are also mo

218 ine RNA caps to the 2,2,7-trimethylguanosine cap structures of small nuclear and small nucleolar RNAs

219 ntose is linked to a terminal mannose in the cap structures of these oligosaccharides as evidenced by

220 her 5' capping or 2'-O-methylation of the 5' cap structures of viral transcripts, and in this way pro

221 poly(A)-specific ribonuclease, binds the 5' cap-structure of mRNA and initiates deadenylation-depend

222 y to integrate into telomeres, the essential capping structures of chromosomes that play roles in can

223 ecognition of the methyl-7-guanosine (m(7)G) cap structure on mRNA is an essential feature of mRNA me

224 s the formation of a N7-methylated guanosine cap structure on the 5' end of nascent RNA polymerase II

225 ylation-independent repression requires a 5' cap structure on the mRNA; however, deadenylation does n

226 The effects of the cap structure on these different processes is mediated b

227 ron microscopy revealed the formation of new cap structures on broken filaments that re-grew.

228 biosensor designed to detect the presence of cap structures on mRNAs that is also sensitive to mRNA d

229 rase domain of L sequentially methylated the cap structure only when pre-mRNAs of 40 nucleotides or l

230 uiting the 40S ribosomal subunit to the mRNA cap structure or internal ribosome entry site (IRES) ele

231 ut did not block translation mediated by the cap structure or other viral IRESs.

232 d as the high-affinity substrate but not the cap structure or RNA alone.

233 ion from RIG-I, explaining the complexity of cap structures over evolution.

234 s pathway is decapping, since removal of the cap structure permits 5'-->3' exonucleolytic digestion.

235 Since the cap structure plays a critical role in the assembly of t

236 the critical role a fully methylated 5' mRNA cap structure plays in the recognition and recruitment o

237 ne residue closely resembles the 5' terminal cap structure present on all eukaryotic mRNA molecules.

238 transcript, thus forming on it an authentic cap structure (referred to as cap0) in the budding yeast

239 The mRNA 5'-cap structure removal by the decapping enzyme DCP2 is a

240 Analysis of the mRNA cap structure revealed that alterations to the predicted

241 ification of the diverse range of beta-helix cap structures reveals subtle commonalities in structura

242 Unlike the cap structures seen in U-snRNAs and mRNAs it is neither

243 ture in miRNA cleavage by developing the new CAP-STRUCTURE-seq method to capture the intact mRNA stru

244 and their initial 7-methylguanosine (m7G) 5' cap structures subsequently become converted to 2,2,7-tr

245 their poly(A) tail but contain an intact 5' cap structure, suggesting that Dhh1 is required for effi

246 more distal, toward the tip of the gammaTuRC-cap structure, than that of gamma-tubulin.

247 a reverse turn that is consistent with the C-cap structure that has been previously reported for the

248 The cap structure that is characteristic of all polymerase-I

249 sential step in the formation of the m7GpppN cap structure that is characteristic of eukaryotic mRNA

250 Their plus-strand RNA genome contains a 5'-cap structure that is methylated at the guanine N-7 and

251 and demonstrate that mMBs have a specialized cap structure that is orientated toward polar bodies.

252 hat Xgrip210 is a component of the gammaTuRC cap structure that is required for the assembly of the g

253 e with a deep cavity for binding the m7GpppN cap structure that is required for viral RNA transcripti

254 Eukaryotic RNAs typically contain 5' cap structures that have been primarily studied in yeast

255 glec-5, bind to NeuAcalpha2,3Gal, a terminal capping structure that can also be displayed on the lipo

256 Telomeres are chromosome-capping structures that protect ends of the linear genom

257 In addition to lacking a cap structure, the full-length I transcripts synthesized

258 Defect-free BNNT cap structures then form perpendicular to the catalyst s

259 o utilize GTP to produce an authentic 5' RNA cap structure, though the GTP-mediated mechanism is uncl

260 Given the functions of the 5' cap structure throughout mRNA metabolism, antisense olig

261 d histidine in nsP1 and the transfer of this cap structure to a diphosphate RNA.

262 , and act independently of a 7mG(5')ppp(5')G cap structure to deadenylate an exogenous mRNA substrate

263 s use 5' caps or other mechanisms to mimic a cap structure to limit detection of viral RNAs by intrac

264 rity of eukaryotic mRNAs is mediated by a 5' cap structure to which the eukaryotic initiation factor

265 ate that PCIF1 efficiently modifies VSV mRNA cap structures to m(7)Gpppm(6)A(m) and define the substr

266 The lack of a cap structure typical of eukaryotic mRNA and absence of

267 scribe two methods to synthesize C8-modified cap structures using the Suzuki-Miyaura cross-coupling r

268 e distinctive 2,2,7-trimethylguanosine (TMG) cap structure usually found on snRNAs and snoRNAs is pro

269 examined decapping of 30 chemically distinct cap structures varying the state of methylation, sugar,

270 ) tail complex on mRNA can interact with the cap structure via eIF-4G.

271 cell sorter analysis confirmed that the 7mG cap structure was critical for efficient infectivity, al

272 BioServe Fluid Processing Apparatus and root cap structure was examined at both light and electron mi

273 A unique capping structure was shown to form in this 1:4:1 G-quad

274 nded to reduce the ability of PB2 to bind to cap structures, was stable in all three assays, whereas

275 on of existing repeats and de novo design of capping structures, we designed leucine-rich repeats (LR

276 RNAs lacking 2'-O-methylated 5' cap structures were also detected in the in vivo 6 hr la

277 Human U3 and U8 RNAs with various cap structures were generated by in vitro transcription,

278 The ManLAM mannose cap structures were necessary in limiting P-L fusion, an

279 ation of N-glycans in EBs, whereas alpha-Gal-capped structures were more prevalent in ExE cells.

280 tidic acid can be induced to reversibly form cap structures when exposed to an asymmetry in ionic str

281 ols the half-life of mRNA by cleaving the 5' cap structure, which exposes a monophosphate that is eff

282 The N7-methylated guanosine (m7G) cap structure, which is found at the 5' ends of mature e

283 the MTE despite the absence of an m(7)GpppN cap structure, which is normally required for eIF4E to b

284 ses, such as VSV, possess a fully methylated cap structure, which is required for mRNA stability, eff

285 -3' mRNA decay pathways is removal of the 5' cap structure, which precedes and permits digestion of t

286 structure derived from the standard m7GpppN cap structure, with 2'-O methylations on the first four

287 neously self-enrich into discreet islet-like cap structures within in vitro cultures, independent of

288 each thymine position provided evidence of a capping structure within the top loop region of the i-mo