ライフサイエンスコーパス: capsulatum

1 nfection by the dimorphic fungus Histoplasma capsulatum.

2 longed the survival of mice infected with H. capsulatum.

3 mperature-regulated morphologic switch in H. capsulatum.

4 ogens Coccidioides posadasii and Histoplasma capsulatum.

5 nity in an Ag-specific manner to Histoplasma capsulatum.

6 ogenicity in Blastomyces dermatitidis and H. capsulatum.

7 the genetics and regulatory mechanisms of A. capsulatum.

8 ion of the worldwide presence of Histoplasma capsulatum.

9 utes to host resistance to infection with H. capsulatum.

10 the lungs of mice infected with Histoplasma capsulatum.

11 a but not morphologically consistent with H. capsulatum.

12 ritical element of protective immunity to H. capsulatum.

13 ed host resistance to the fungus Histoplasma capsulatum.

14 e agents in host defense against Histoplasma capsulatum.

15 rotective and memory immunity to Histoplasma capsulatum.

16 ulfur metabolism influences morphology in H. capsulatum.

17 in vivo, mice were infected with Histoplasma capsulatum.

18 3) of heat-shock protein 60 from Histoplasma capsulatum.

19 ungs of naive mice infected with Histoplasma capsulatum.

20 or 6 organisms than with class 2 Histoplasma capsulatum.

21 e immunogen against pulmonary exposure to H. capsulatum.

22 wo yeast phase-specific genes in Histoplasma capsulatum.

23 hock protein 60 from the fungus, Histoplasma capsulatum.

24 mary infection with the pathogen Histoplasma capsulatum.

25 ined abundant yeast forms consistent with H. capsulatum.

26 hree families of siderophores excreted by H. capsulatum.

27 mation on the hydroxamate siderophores of H. capsulatum.

28 ary and secondary infection with Histoplasma capsulatum.

29 al for functional expression of a gene in H. capsulatum.

30 is by IFN-gamma and effective handling of H. capsulatum.

31 by transformation of an HAG1 plasmid into H. capsulatum.

32 studies of the dimorphic fungus Histoplasma capsulatum.

33 fection with the fungal pathogen Histoplasma capsulatum.

34 c oxide reductase (P450nor) from Histoplasma capsulatum.

35 e designed to amplify the Hcp100 locus of H. capsulatum.

36 His CSF culture also was positive for H capsulatum.

37 n CCR5(-/)(-) mice infected with Histoplasma capsulatum.

38 with the intracellular pathogen Histoplasma capsulatum.

39 erevisiae, Candida albicans, and Histoplasma capsulatum.

40 lates the yeast to mycelial transition in H. capsulatum.

41 100% specificity and 94% sensitivity for H. capsulatum.

42 tomyces dermatitidis and also in Histoplasma capsulatum.

43 fection with the fungal pathogen Histoplasma capsulatum.

44 latent infections of the fungus Histoplasma capsulatum.

45 antibody (MAb) raised against a Histoplasma capsulatum 80-kDa hsp showed cross-reactivity to the pur

46 s an extracellular pathogen, and Histoplasma capsulatum a facultative intracellular pathogen.

47 Histoplasma capsulatum, a fungal pathogen of humans, switches from a

48 se model of acute infection with Histoplasma capsulatum, a major human pathogenic fungus.

49 ost abundant protein secreted by Histoplasma capsulatum, a pathogenic fungus that causes histoplasmos

50 We describe a case in which the Histoplasma capsulatum AccuProbe test displayed cross-reactivity wit

51 demonstrated the ability of the Histoplasma capsulatum AccuProbe to accurately identify this organis

52 t immunoglobulin Gs (IgGs) to Hsp60 cause H. capsulatum aggregation dependent on the (i) concentratio

53 alpha protein, exceeding those induced by H. capsulatum, altered macrophage responses to this pathoge

54 ted a high mortality after infection with H. capsulatum, although TNFR1-/- mice were more susceptible

55 morphologic switch, which is exhibited by H. capsulatum and a group of evolutionarily related fungal

56 e the predominant infectious particle for H. capsulatum and are the first cell type encountered by th

57 tent antifungal activity against Histoplasma capsulatum and Cryptococcus neoformans by distinct mecha

58 s built with genomic elements of Histoplasma capsulatum and ESTs of Paracoccidioides brasiliensis tha

59 Tissues from mice infected with H. capsulatum and from biopsy specimens from a patient with

60 it has in-vitro activity against Histoplasma capsulatum and has shown success in case reports and sma

61 e suggests a direct link between Histoplasma capsulatum and presumed ocular histoplasmosis syndrome,

62 oth surface localized in the cell wall of H. capsulatum and released into the culture medium.

63 pecies, Cryptococcus neoformans, Histoplasma capsulatum, and Blastomyces dermatitidis from blood cult

64 America (Coccidioides posadasii, Histoplasma capsulatum, and Blastomyces dermatitidis), have soared r

65 duced resistance against B. dermatitidis, H. capsulatum, and C. posadasii.

66 on ancestor, Wor1 in C. albicans, Ryp1 in H. capsulatum, and Mit1 in S. cerevisiae are transcriptiona

67 gs of C57BL/6 mice infected with Histoplasma capsulatum, and the elimination of these cells impairs p

68 Blastomyces dermatitidis and Histoplasma capsulatum are dimorphic fungi that often cause self-lim

69 ved methods for the detection of Histoplasma capsulatum are needed in regions with limited resources

70 phic fungal pathogens, including Histoplasma capsulatum, are soil fungi that undergo dramatic changes

71 uding the subject of this study, Histoplasma capsulatum, are temperature-responsive organisms that ut

72 The success of Histoplasma capsulatum as an intracellular pathogen depends complete

73 ntify genes required for hyphal growth of H. capsulatum at RT and find that disruption of the signali

74 dimorphic probe hybridized with DNA from H. capsulatum, B. dermatitidis, C. immitis, P. brasiliensis

75 Specific probes for H. capsulatum, B. dermatitidis, C. immitis, P. brasiliensis

76 In H. capsulatum BAD1 transformants, yeast phase-specific expr

77 DPPIV homologs (HcDPPIVA and HcDPPIVB) in H. capsulatum based on a homology search with Aspergillus f

78 F-1alpha in the host response to Histoplasma capsulatum because granulomas induced by this pathogenic

79 A, were used to amplify DNA from Histoplasma capsulatum, Blastomyces dermatitidis, Coccidioides immit

80 intracellular pathogens such as Histoplasma capsulatum, but its mode of action remains elusive.

81 ous IL-4 modulates protective immunity to H. capsulatum by delaying clearance of the organism but doe

82 ts were generated in a virulent strain of H. capsulatum by optimization of Agrobacterium tumefaciens-

83 Chloroquine inhibits growth of H. capsulatum by pH-dependent iron deprivation, whereas it

84 Histoplasma capsulatum can efficiently survive within macrophages, f

85 However, H. capsulatum can establish persistent infections, indicati

86 The fungal pathogen Histoplasma capsulatum causes a spectrum of disease, ranging from lo

87 Except with Histoplasma capsulatum, chocolate agar incubated for only 3 days pro

88 ht, with the notable distinction that the H. capsulatum circuit responds to temperature.

89 n H protein expression levels between the H. capsulatum classes, with a correlation between secreted

90 t episodes, the isolated fungus (Histoplasma capsulatum, Coccidioides immitis/posadasii, Fusarium oxy

91 The endemic fungi Histoplasma capsulatum, Coccidioides spp, Blastomyces dermatitidis,

92 a Mycobacterium haemophilum and Histoplasma capsulatum coinfection occurring 21 years after a living

93 for B. dermatitidis and 100% and 73% for H. capsulatum compared with the results for culture.

94 r fusions analysed in B. dermatitidis and H. capsulatum confirmed that BAD1 is transcriptionally regu

95 These findings indicate that H. capsulatum conidia and yeast can produce melanin or mela

96 uced in macrophages during infection with H. capsulatum conidia but not H. capsulatum yeast cells.

97 H. capsulatum conidia were also cytotoxic to amoebae.

98 on of WGA-Fc fully protected mice against H. capsulatum, correlating with a reduction in lung, spleen

99 Substrate gels with H. capsulatum culture supernatants revealed beta-glucosidas

100 immunization with H antigen from Histoplasma capsulatum did not protect mice against an intravenous c

101 Because H. capsulatum displays a considerable array of virulence me

102 The fungus Histoplasma capsulatum displays an Hsp60 on its cell surface that is

103 Finally, H. capsulatum displays morphotype-specific expression of se

104 um isolates representing the three varieties capsulatum, duboisii, and farciminosum was evaluated usi

105 icantly impacted pathogenic mechanisms of H. capsulatum during macrophage infection, and the effect w

106 secreted proteolytic activity in Histoplasma capsulatum effective toward DppIV-specific substrates.

107 , cathepsin G, and BPI are the major anti-H. capsulatum effector molecules in the azurophil granules

108 The adverse effects of IL-4 on H. capsulatum elimination were not observed during the earl

109 The YPS3 gene of Histoplasma capsulatum encodes a protein that is both surface locali

110 We report a case of Histoplasma capsulatum endocarditis in which Histoplasma antigen ass

111 The pathogenic fungus Histoplasma capsulatum escapes innate immune defenses and colonizes

112 The fungal pathogen Histoplasma capsulatum evades the innate and adaptive immune respons

113 A "dimorphic" fungus, H. capsulatum exists as a saprophytic mold in soil and conv

114 This finding suggested that H. capsulatum exploited an autophagic process to survive.

115 H. capsulatum expresses several iron acquisition mechanisms

116 Here, we report H. capsulatum ferric reduction activities in whole yeast ce

117 for the detection of B. dermatitidis and H. capsulatum from culture isolates and directly from clini

118 ect and differentiate B. dermatitidis and H. capsulatum from culture isolates and directly from clini

119 bilizer significantly reduced recovery of H. capsulatum from macrophages and produced a decrement in

120 T cells (Tregs) using a model of Histoplasma capsulatum fungal infection.

121 esenting 10-fold coverage of the Histoplasma capsulatum G217B genome was used to construct a restrict

122 In a screen to identify H. capsulatum genes required for lysis of bone marrow-deriv

123 Here, we detail mapping the Histoplasma capsulatum genome comprehensively in fosmids, resulting

124 In addition, the relationships of H. capsulatum genotypes with clinically relevant phenotypes

125 ighteen of 19 blood cultures positive for H. capsulatum grew in both IS and MFL, although the time to

126 H. capsulatum grows as a multicellular hypha in the soil th

127 Wild-type H. capsulatum grows as filaments at room temperature and as

128 The human fungal pathogen Histoplasma capsulatum grows in a sporulating filamentous form in th

129 lony-stimulating factor (GM-CSF), inhibit H. capsulatum growth in macrophages.

130 Interestingly, H. capsulatum growth was restricted in mice lacking the typ

131 The Histoplasma capsulatum H antigen is a major secreted glycoprotein of

132 intracellular pathogenic fungus Histoplasma capsulatum has increased dramatically.

133 l pathogens Candida albicans and Histoplasma capsulatum have been reported to protect against the oxi

134 Ten cases of Histoplasma capsulatum (HC) infection were reported: 9 associated wi

135 Histoplasma capsulatum (Hc) is a facultative intracellular fungal pa

136 Histoplasma capsulatum (Hc) is a facultative intracellular fungus th

137 Histoplasma capsulatum (Hc) is a facultative, intracellular parasite

138 Histoplasma capsulatum (Hc) is a pathogenic fungus that replicates i

139 econdary infection by the fungus Histoplasma capsulatum (HC) is multifactorial, requiring cells of th

140 he intracellular fungal pathogen Histoplasma capsulatum (Hc) resides in mammalian macrophages and cau

141 Cryptococcus neoformans (CN) and Histoplasma capsulatum (HC) to external gamma-radiation and to the o

142 Histoplasma capsulatum (Hc), is a facultative intracellular fungus t

143 se against the pathogenic fungus Histoplasma capsulatum (Hc).

144 with observations in other organisms, the H. capsulatum hcl1 mutant was unable to grow on leucine as

145 cus neoformans (cryptococcosis), Histoplasma capsulatum (histoplasmosis), and Talaromyces (Penicilliu

146 fied an insertion mutation disrupting the H. capsulatum homolog of 3-hydroxy-methylglutaryl coenzyme

147 ) isotype monoclonal antibodies (MAbs) to H. capsulatum Hsp60.

148 his drove IL-10 production in response to H. capsulatum IL-10 inhibited Mvarphi control of fungal gro

149 Treatment of naive and H. capsulatum-immune mice with caspase inhibitors decreased

150 n (BPI) also mediated fungistasis against H. capsulatum in a concentration-dependent manner.

151 fungal isolates tested and also detected H. capsulatum in clinical specimens from three patients tha

152 A real-time PCR assay to detect Histoplasma capsulatum in formalin-fixed, paraffin-embedded (FFPE) t

153 clearance of the fungal pathogen Histoplasma capsulatum in mice lacking the chemokine receptor CCR2.

154 ssary for macrophage-mediated immunity to H. capsulatum in mice.

155 esponse is required for full virulence of H. capsulatum in mice.

156 used to expedite culture confirmation of H. capsulatum in regions in which PDH is endemic.

157 V-ATPase function in the pathogenicity of H. capsulatum, in iron homeostasis and in fungal dimorphism

158 The production of H. capsulatum-induced interferon-gamma and TNF-alpha was as

159 Histoplasma capsulatum induces a cell-mediated immune response in lu

160 at shock protein 60 (Hsp60) from Histoplasma capsulatum induces a protective immune response in mice.

161 her Blastomyces dermatitidis and Histoplasma capsulatum-infected canine and feline lungs and airway e

162 ation of excess interleukin-4 in lungs of H. capsulatum-infected CCR2(-/-) mice is at least partially

163 H. capsulatum-infected CCR2(-/-) mice manifested defects in

164 Apoptosis was diminished in H. capsulatum-infected gld/gld and TNF-alpha-deficient mice

165 ations in the metal homeostasis of murine H. capsulatum-infected macrophages that were exposed to act

166 Rising rates of Histoplasma capsulatum infection are an emerging problem among the r

167 hat CCR5 controls the outcome of Histoplasma capsulatum infection by dictating thymic and lymph node

168 erleukin (IL)-17 and IL-23 on immunity to H. capsulatum infection in mice.

169 n vivo, Zn supplementation and subsequent H. capsulatum infection supressed MHCII on DCs, enhanced PD

170 ce that received methamphetamine prior to H. capsulatum infection were immunologically impaired, with

171 specifically limits iron during Histoplasma capsulatum infection, and fungal acquisition of iron is

172 aive and immune mice during the course of H. capsulatum infection.

173 of Tregs in the lungs prior to and during H. capsulatum infection.

174 he balance between Treg and Th17 cells in H. capsulatum infection.

175 ns-mediated mutagenesis, and screened for H. capsulatum insertional mutants that were unable to survi

176 ce were infected by injection of Histoplasma capsulatum into the subarachnoid space.

177 Histoplasma capsulatum is a dimorphic fungal pathogen that survives

178 Histoplasma capsulatum is a dimorphic fungus that causes respiratory

179 Histoplasma capsulatum is a dimorphic fungus that is endemic in the

180 Histoplasma capsulatum is a fungal pathogen that causes respiratory

181 Histoplasma capsulatum is a fungal pathogen that requires the induct

182 Histoplasma capsulatum is a fungal respiratory pathogen that survive

183 Histoplasma capsulatum is a respiratory pathogen that infects phagoc

184 Histoplasma capsulatum is a significant respiratory and systemic fun

185 Histoplasma capsulatum is a successful intracellular pathogen of mam

186 Acidobacterium capsulatum is an acid-tolerant, encapsulated, Gram-negat

187 Histoplasma capsulatum is an effective intracellular parasite of mac

188 Histoplasma capsulatum is an infrequent but serious cause of endocar

189 the immune response during infection with H. capsulatum is controlled via mechanisms independent of t

190 importance to its success or failure, and H. capsulatum is good at finding or making the right enviro

191 cteria; however, the time to detection of H. capsulatum is increased.

192 l feature of the fungal pathogen Histoplasma capsulatum is its ability to shift from a mycelial phase

193 Histoplasma capsulatum is the best-studied of the primary pathogens

194 esis of the respiratory pathogen Histoplasma capsulatum is the conversion from the mold form (found i

195 Histoplasma capsulatum is the most common cause of fungal respirator

196 Histoplasma capsulatum is the most common endemic mycosis in the Uni

197 The yeast phase of Histoplasma capsulatum is the virulent form of this thermally dimorp

198 sition in pathogenic organisms, including H. capsulatum, is a highly regulated process.

199 psulatum that correctly identified the 34 H. capsulatum isolates in a battery of 107 fungal isolates

200 eny of 46 geographically diverse Histoplasma capsulatum isolates representing the three varieties cap

201 The zoopathogenic fungus Histoplasma capsulatum, like other eukaryotic aerobic microorganisms

202 cate we have cloned the gene encoding the A. capsulatum major sigma factor and the gene product is ac

203 gap, we identified the gene encoding the A. capsulatum major sigma factor, rpoD, which encodes a 597

204 nsidered a resident of the phagolysosome, H. capsulatum may also reside in a modified phagosome witho

205 lu) and amphotericin B (AmB) for Histoplasma capsulatum meningitis, MICs were determined for 10 clini

206 The fungal pathogen Histoplasma capsulatum minimizes detection of beta-glucan by host ce

207 hich the primary fungal pathogen Histoplasma capsulatum multiplies and disseminates from the lung to

208 H. capsulatum must compete with the host to acquire the ess

209 this hypothesis has not been tested since H. capsulatum mutants that experience decreased phagosomal

210 Growth of H. capsulatum mycelia in chemically defined minimal medium

211 nly (three Candida albicans, one Histoplasma capsulatum, one Candida glabrata, and one Fusarium speci

212 A, they did not necessarily correspond to H. capsulatum open reading frames.

213 with heat shock protein 60 from Histoplasma capsulatum or a polypeptide from the protein designated

214 t shock protein 60 (rHsp60) from Histoplasma capsulatum or a region of the protein designated fragmen

215 F bottle did not recover M. tuberculosis, H. capsulatum, or C. neoformans isolates.

216 the site preference measured for purified H. capsulatum P450nor was not constant, increasing from app

217 , IgG1 and IgG2a MAbs to Hsp60 can modify H. capsulatum pathogenesis in part by altering the intracel

218 mic mycosis caused by the fungus Histoplasma capsulatum, primarily affects immune-suppressed patients

219 e used against C. immitis DNA and for the H. capsulatum probe used against Candida albicans DNA.

220 fungal pathogen Histoplasma capsulatum var. capsulatum produced melanin or melanin-like compounds in

221 The fungus, Histoplasma capsulatum, produces a persistent infection.

222 of cells from mice immunized with either H. capsulatum recombinant Hsp70 or bovine serum albumin.

223 dicate the importance of Hcl1 function in H. capsulatum replication in the harsh growth environment o

224 ial effector nitric oxide (*NO) restricts H. capsulatum replication.

225 In response to excess iron, H. capsulatum represses transcription of genes involved in

226 Host defenses against Histoplasma capsulatum require the action of several cytokines.

227 The pathogenic fungus Histoplasma capsulatum requires iron for its survival during macroph

228 on against the pathogenic fungus Histoplasma capsulatum requires Th1 cytokines.

229 ehydrogenase genes of B. dermatitidis and H. capsulatum, respectively.

230 To understand how H. capsulatum responds to RNS, we determined the transcript

231 ed beta-glucosidase activities from three H. capsulatum restriction fragment length polymorphism (RFL

232 A. capsulatum RpoD restored normal growth to E. coli strain

233 nd calcium and its prevalence as Histoplasma capsulatum's most abundant secreted protein.

234 tical disease occurring in the absence of H. capsulatum seropositivity.

235 Histoplasma capsulatum should be considered in the differential diag

236 The H. capsulatum siderophore dimerum acid and the structurally

237 , the capacity of IgG MAbs to agglutinate H. capsulatum significantly impacted pathogenic mechanisms

238 ' sera of a 69- to 70-kDa H. capsulatum var. capsulatum-specific antigen which appears to be useful i

239 eneral DNA binding proteins from Histoplasma capsulatum strain G217B.

240 n and is also expressed differentially in H. capsulatum strains of different virulence levels.

241 erated monoclonal antibodies (MAbs) to an H. capsulatum surface-expressed heat shock protein of 60 kD

242 ere we show that a 250-fold difference in H. capsulatum susceptibility between inbred mouse strains i

243 or the dimorphic fungal pathogen Histoplasma capsulatum, susceptibility to echinocandins differs for

244 e complication of infection with Histoplasma capsulatum that can lead to obstruction of pulmonary and

245 nce of infection with the fungus Histoplasma capsulatum that can lead to occlusion of large pulmonary

246 selected for, or induced, a phenotype of H. capsulatum that caused a persistent murine lung infectio

247 l-time LightCycler PCR assay for Histoplasma capsulatum that correctly identified the 34 H. capsulatu

248 al in response to a sublethal inoculum of H. capsulatum The absence of myeloid HIF-1alpha did not alt

249 rophages to limit intracellular growth of H. capsulatum Thus, enhancement of HIF-1alpha creates a hos

250 revealed an important mechanism by which H. capsulatum thwarts the host immune system.

251 determined the transcriptional profile of H. capsulatum to *NO-generating compounds using a shotgun g

252 sure of an avirulent laboratory strain of H. capsulatum to A. castellanii selected for, or induced, a

253 Although the ability of H. capsulatum to prevent acidification of the macrophage ph

254 was sufficient to increase resistance of H. capsulatum to RNS in culture.

255 patterns ranging from circular (Histoplasma capsulatum) to punctate (Cryptococcus neoformans) to lab

256 survive within macrophages, facilitating H. capsulatum translocation from the lung into the lymphati

257 Detection of the Histoplasma capsulatum urinary antigen (UAg) is among the most sensi

258 H. capsulatum uses different host receptors for binding to

259 We propose that H. capsulatum uses the pathways identified here to cope wit

260 we designed a strategy to disrupt CBP1 in H. capsulatum using a telomeric linear plasmid and a two-st

261 rmally dimorphic fungal pathogen Histoplasma capsulatum var. capsulatum produced melanin or melanin-l

262 tion in patients' sera of a 69- to 70-kDa H. capsulatum var. capsulatum-specific antigen which appear

263 The presence of H. capsulatum var. farciminosum DNA was confirmed by sequen

264 first reports of the direct detection of H. capsulatum var. farciminosum in equine blood and at high

265 he 29 horses with suspected cases of EZL, H. capsulatum var. farciminosum was confirmed by extraction

266 Histoplasma capsulatum var. farciminosum, the causative agent of epi

267 nce for the existence of two subgroups of H. capsulatum var. farciminosum.

268 acil auxotrophy due to a ura5 mutation on H. capsulatum virulence in both cell culture and whole-anim

269 of the dimorphic fungal pathogen Histoplasma capsulatum was first described over 40 years ago.

270 es and alveolar macrophages infected with H. capsulatum was inhibited by the addition of physiologic

271 Intracellular proliferation of H. capsulatum was measured in alveolar macrophages and peri

272 r intranasal exposure of mice to Histoplasma capsulatum was necessary for control of primary or secon

273 Consequently, H. capsulatum was selectively deprived of Zn, thereby halti

274 To identify phase-regulated genes of H. capsulatum, we carried out expression analyses by using

275 ants of Francisella novicida and Histoplasma capsulatum, we confirmed the applicability of these host

276 tidis, Sporothrix schenckii, and Histoplasma capsulatum were each ingested by amoebae and macrophages

277 of rRNA genes of 24 isolates of Histoplasma capsulatum were examined.

278 Two isolates of Histoplasma capsulatum were recovered from the Isolator tube only.

279 more diverged pathogenic fungus, Histoplasma capsulatum, were sequenced and compared with those of 13

280 ure-responsive transcriptional network in H. capsulatum, which switches from a filamentous form in th

281 eminated Coccidioides immitis or Histoplasma capsulatum with heterozygous missense mutations in the S

282 of infected mice, aberrant processing of H. capsulatum within macrophages, and immobilization of MAC

283 portant for survival and proliferation of H. capsulatum within macrophages.

284 was associated with delayed clearance of H. capsulatum yeast and increased fungal burden.

285 nt in the outermost layer of the Histoplasma capsulatum yeast cell wall and contributes to pathogenes

286 ion effects of the antibodies to Hsp60 on H. capsulatum yeast cells by light microscopy, flow cytomet

287 ing MAb and were similar in appearance to H. capsulatum yeast cells.

288 ection with H. capsulatum conidia but not H. capsulatum yeast cells.

289 Growth of H. capsulatum yeast in chemically defined minimal medium wi

290 long-lasting fungistasis against Histoplasma capsulatum yeasts and that all of the fungistatic activi

291 at human dendritic cells (DC) phagocytose H. capsulatum yeasts and, unlike human macrophages (Mo) tha

292 tivity were identified by incubation with H. capsulatum yeasts for 24 h and by quantifying the subseq

293 HNP-2, and HNP-3 inhibited the growth of H. capsulatum yeasts in a concentration-dependent manner wi

294 infection of the mammalian host, Histoplasma capsulatum yeasts survive and reside within macrophages

295 an override one of the strategies used by H. capsulatum yeasts to survive intracellularly within Mo.

296 estored in the presence of wild-type (WT) H. capsulatum yeasts, or the hydroxamate siderophore, rhodo

297 ed the capacity of DC to kill and degrade H. capsulatum yeasts.

298 inst sublethal and lethal challenges with H. capsulatum yeasts.

299 ted additive fungistatic activity against H. capsulatum yeasts.

300 ibited no significant fungistasis against H. capsulatum yeasts.