ライフサイエンスコーパス: carbamyl

1 t protein kinase, (8R,9S, 11S)-(-)-9-methoxy-carbamyl-8-methyl-2,3,9,10-tetrahydro-8, 11-epoxy-1H,8H,

2 sed PKG inhibitors (8R,9S,11S)-(-)-9-methoxy-carbamyl-8-methyl-2,3,9,10-tetrahydro-8,11-epoxy -1H,8H,

3 t the ureido moiety of the DHOase substrate, carbamyl-aspartate (Ca-asp).

4 dimetal TnDhp in complexes with hydantoin, N-carbamyl-beta-alanine, and N-carbamyl-beta-amino isobuty

5 th hydantoin, N-carbamyl-beta-alanine, and N-carbamyl-beta-amino isobutyrate as well as apo-TnDhp in

6 The administration of carbamyl (c)-PAF caused preterm labor and fetal loss in

7 Both basal cytosolic [Ca2+]i and carbamyl choline-induced increases of [Ca2]i were unaffe

8 s(-)(1)), indicating hydrolysis of a common carbamyl-enzyme form.

9 of inhibitor cleavage to generate a covalent carbamyl-enzyme intermediate rather than a tetrahedral c

10 tion of a hydrazide-containing product and a carbamyl-enzyme intermediate that is sufficiently stable

11 activity is observed when the length of the carbamyl function is n = 6 and n = 7 for porcine and rat

12 termined from analysis of the N and C of the carbamyl group after hydrolysis.

13 loyl) GTP (mantGTP), 2'(3')-O-[(2-aminoethyl)carbamyl] GTP (edGTP), and adducts of fluorescein 5-isot

14 In the pyrimidine biosynthetic pathway, N-carbamyl-L-aspartate (CA-asp) is converted to L-dihydroo

15 ia coli ligated to products (phosphate and N-carbamyl-l-aspartate) has been determined at 2.37 A reso

16 plexed with products, phosphate (P(i)) and N-carbamyl-L-aspartate.

17 onaemia will allow specific treatment with N-carbamyl-l-glutamate and prevent neurological sequelae.

18 bolism and responds well to treatment with N-carbamyl-l-glutamate.

19 d by avibactam via formation of a reversible carbamyl linkage of the inhibitor with the catalytic ser

20 s PUs featuring fully substituted (tertiary) carbamyl nitrogen atoms, a structural motif that is almo

21 We show here that the rate of CAD (carbamyl-P synthetase/aspartate transcarbamylase/dihydro

22 as, and the tissue was incubated with 125 nM carbamyl PAF (cPAF), an analogue of PAF.

23 e incubated in organ culture with or without carbamyl PAF (cPAF, 100 nM).

24 nonhydrolyzable PAF receptor agonist methyl carbamyl PAF (mc-PAF) on the unidirectional in vitro mig

25 uterine or intraperitoneal administration of carbamyl PAF activates inflammation in gestational tissu

26 Pellets containing carbamyl-PAF (cPAF) were implanted in corneas of wild-ty

27 pecific (A23187) and specific (endothelin-1, carbamyl-PAF) stimulation, suggesting a role for this in

28 and the nonhydrolyzable PAF receptor agonist carbamyl-PAF.

29 Levels of carbamyl-palmitoyl transferase 1a and ATP synthase subun

30 distance is 45.2 A) when ATCase is bound to carbamyl phosphate (CP) and to L-alanosine (an analogue

31 at 5-N of glutamine is directly channeled to carbamyl phosphate (CP) synthesis.

32 roduction of L-citrulline and phosphate from carbamyl phosphate and L-ornithine in L-arginine biosynt

33 f this novel transcarbamylase complexed with carbamyl phosphate and N-succinyl-L-norvaline, as well a

34 e of Escherichia coli ATCase maintained with carbamyl phosphate and succinate, phosphonoacetamide and

35 ytic subunit (c3) and holoenzyme (c6r6) with carbamyl phosphate are different.

36 to the synthetase domain (CPS domain), where carbamyl phosphate formation is catalyzed in three conse

37 enzyme, was 2 mol of ATP utilized per mol of carbamyl phosphate formed.

38 sfers ammonia to the synthetase domain where carbamyl phosphate is formed in a three-step reaction se

39 other ligands (N-phosphonacetyl-L-aspartate, carbamyl phosphate plus malonate, phosphonoacetamide plu

40 nthesis reaction of biotin carboxylase where carbamyl phosphate reacted with ADP by holoBCCP87 was 5-

41 minimal medium and can suppress mutations in carbamyl phosphate synthase-aspartate carbamyl transfera

42 omains of CAD stimulates glutamine-dependent carbamyl phosphate synthesis and abolishes the ammonia-d

43 e enzyme can also catalyze ammonia-dependent carbamyl phosphate synthesis if provided with exogenous

44 utant not only catalyzed glutamine-dependent carbamyl phosphate synthesis, but was activated 10-fold

45 of reactions involved in glutamine-dependent carbamyl phosphate synthesis.

46 he E. coli enzyme was also found to catalyze carbamyl phosphate synthesis.

47 e 150-kDa band revealed sequence identity to carbamyl phosphate synthetase I (CPS I) and a high degre

48 rotein induced the activity of mouse hepatic carbamyl phosphate synthetase I (CpsI) 5-fold.

49 alogue of molecular changes in patients with carbamyl phosphate synthetase I (CPSI) deficiency to dev

50 Human carbamyl phosphate synthetase I (CPSI) is an essential h

51 In animals, UTP feedback inhibition of carbamyl phosphate synthetase II (CPSase) controls pyrim

52 on the hydrolysis of glutamine catalyzed by carbamyl phosphate synthetase of Escherichia coli.

53 lated trifunctional enzyme known as CAD (for carbamyl phosphate synthetase, aspartate transcarbamylas

54 d-Ala d-Ala ligase, glutathione synthetase, carbamyl phosphate synthetase, N(5)-carboxyaminoimidazol

55 However, ammonia-dependent synthesis of carbamyl phosphate was abolished, indicating that ammoni

56 The K(m) values for N-acetylornithine and carbamyl phosphate were 1.05 mM and 0.01 mM, respectivel

57 lyzes the conversion of metabolic ammonia to carbamyl phosphate, the rate-limiting step in urea biosy

58 In UV difference and 31P-NMR spectra, carbamyl phosphate-induced effects associated with wild-

59 l-L-citrulline from N-acetyl-L-ornithine and carbamyl phosphate.

60 o subunits that act in concert to synthesize carbamyl phosphate.

61 ate, whereas CPS.B uses a second ATP to form carbamyl phosphate.

62 nzymes, ornithine transcarbamylase (OTC) and carbamyl-phosphate synthase (CPS), as well as dibasic am

63 Escherichia coli carbamyl-phosphate synthetase consists of two subunits t

64 glutaminase domain (GLN domain) of mammalian carbamyl-phosphate synthetase II (CPSase II) catalyzes g

65 midotransferase domain (GLNase) of mammalian carbamyl-phosphate synthetase II hydrolyzes glutamine an

66 s was deleted and the sequences encoding the carbamyl-phosphate synthetase subunits were fused in fra

67 ammonia that arises by the action of PDG to carbamyl-phosphate synthetase.

68 ons in carbamyl phosphate synthase-aspartate carbamyl transferase within the pyrimidine pathway; the

69 ns catalytic specificity for hydrolysis of N-carbamyl versus the peptide bond in exopeptidases.