ライフサイエンスコーパス: carbocyclic

1 inhibitors built as conformationally locked, carbocyclic 1,3-diazepinone nucleosides to determine the

2 Asymmetric syntheses of L-carbocyclic 2',3'-didehydro-2',3'-dideoxy- and 2',3'-did

3 It was found that L-carbocyclic 2',3'-didehydro-2',3'-dideoxyadenosine (34)

4 -2',3'-dideoxy-3'-thiacytidine (3TC-TP), and carbocyclic 2',3'-didehydro-ddGTP (CBV-TP) indicated inc

5 imidine-2'-deoxyribose was synthesized using carbocyclic 2'-deoxyuridine as starting material.

6 te (T-dGTP), carbovir 5'-triphosphate, and D-carbocyclic-2'-deoxyguanosine 5'-triphosphate (D-CdG-TP)

7 As reported here, Carbocyclic 3-deazaadenosine is the first compound demon

8 Carbocyclic 4'-methyl and 4'-cyano nucleoside analogues

9 Carbocyclic 9-deazapurine nucleosides (1-4), a spiranic

10 (where X is the alpha- or beta-anomer of the carbocyclic abasic site analogue) were determined by NMR

11 exes having the alpha- or beta-anomer of the carbocyclic abasic site by human AP endonuclease showed

12 dition is more favored to give four-membered carbocyclic adducts, thereby precluding the requirement

13 2'-Fluoro-6'-methylene carbocyclic adenosine (FMCA) is a potent and selective i

14 2'-Fluoro-6'-methylene-carbocyclic adenosine (FMCA, 12) and its phosphoramidate

15 was inhibited by incubation of cells with a carbocyclic adenosine analog, 3-deazaaristeromycin, resu

16 The biological versatility of aristeromycin (carbocyclic adenosine) is limited by accompanying cytoto

17 tion that the side effects of aristeromycin (carbocyclic adenosine) were reduced by removing the meth

18 ng of the heterocyclic bases with the chiral carbocyclic alcohol 6 [(1R,2S,4R,5S)-1-[(benzyloxy)methy

19 d contrast to the reactions of the analogous carbocyclic allylic alcohols with tert-butyl hydroperoxi

20 This reaction is compatible with carbocyclic amides containing alpha-tertiary as well as

21 e 10 that was necessary for the synthesis of carbocyclic amine 15.

22 tyl analogue 5 was linearly constructed from carbocyclic amine 17, and the final target 6 was similar

23 rule constraint results in the production of carbocyclic amino ketones, key alkaloid building blocks.

24 enediyne is more reactive than corresponding carbocyclic analog and produces good yield of the Bergma

25 Duplexes containing a carbocyclic analog of dA were not cleaved.

26 Several carbocyclic analogs of glycinamide ribonucleotide, inclu

27 The carbocyclic analogue (C-BCNA) of the highly potent and s

28 The carbocyclic analogue had enhanced agonist efficacy, and

29 the ethylene glycol ketal of hydrocodone; a carbocyclic analogue of bisnorhydrocodone was also prepa

30 domain resulting in the identification of a carbocyclic analogue that possesses a KIapp value of 2.3

31 The carbocyclic analogues (26a,b) of D4FC demonstrated weak

32 stereoselective syntheses of the hydrindane carbocyclic analogues 95, 96, 100, and 104 are presented

33 Although these carbocyclic analogues appeared to be more stable than ze

34 s have been carried out then so as to access carbocyclic analogues of an important series of anticanc

35 gn and development of efficient syntheses of carbocyclic analogues of DPD, which are locked in the cy

36 Carbasugars, the carbocyclic analogues of sugars, constitute an important

37 A number of carbocyclic analogues of the fructose-derived ketone 1 h

38 cal compound 1 (BMS-986251) led to tricyclic-carbocyclic analogues represented by 3-7 and culminated

39 ic site repair has been examined using novel carbocyclic analogues.

40 The preparation of acyclic, carbocyclic and azacyclic alpha-aminoboronic acid deriva

41 ates couple with enol triflates derived from carbocyclic and heterocyclic (i.e., piperidinones) beta-

42 e a series of chiral cis-2-alkyl-substituted carbocyclic and heterocyclic amine derivatives in excell

43 s with log(k(az)/k(s)) for a wide variety of carbocyclic and heterocyclic amine mutagens including Ph

44 tem for the N-alkylation of diverse aromatic carbocyclic and heterocyclic amines directly with carbox

45 iflate and reacted in situ with 21 different carbocyclic and heterocyclic aromatic compounds.

46 n is a valuable method for synthesis of both carbocyclic and heterocyclic bridged bicyclo[5.3.1]undec

47 Both carbocyclic and heterocyclic C2-aryl substituents have b

48 oieties should lead to highly functionalized carbocyclic and heterocyclic compounds.

49 own to be robust across a range of different carbocyclic and heterocyclic D-ring precursors, proceedi

50 rm a diverse array of omega-oxonitriles into carbocyclic and heterocyclic five- and six-membered alke

51 eveloped, approach to diverse functionalized carbocyclic and heterocyclic frameworks containing all-c

52 d to the synthesis of densely functionalised carbocyclic and heterocyclic frameworks that are otherwi

53 a broad substrate scope, providing access to carbocyclic and heterocyclic ring systems in good to exc

54 thesis of 1,3-indandione-fused five-membered carbocyclic and heterocyclic scaffolds.

55 zed as versatile methods for construction of carbocyclic and heterocyclic scaffolds.

56 The reaction affords carbocyclic and heterocyclic spirocycles bearing a quate

57 e of substituents and can be applied to both carbocyclic and heterocyclic substrates.

58 e of synthetically and medicinally important carbocyclic and heterocyclic systems.

59 Synthesis of stereodefined carbocyclic and heterocyclic tertiary boronic esters is

60 in the asymmetric hydrogenation of aliphatic carbocyclic and heterocyclic tetrasubstituted enamides,

61 A general and efficient synthesis of carbocyclic and hexenopyranosyl nucleosides has been dev

62 A variety of heterocyclic, carbocyclic, and acyclic alkenes react with good to exce

63 We tested cyclohexyl-substituted isochroman, carbocyclic, and chroman bicyclic dopamine analogs and f

64 synthesis of vicinally functionalized alkyl, carbocyclic, and heterocyclic compounds is described.

65 On the ribose moiety, 2'-hydroxy, 4'-thio, carbocyclic, and six-membered anhydrohexitol ring modifi

66 etal-free trifluoromethylation of activated, carbocyclic, and unactivated vinylcyclopropanes via a ri

67 cross-coupling between electron-rich hetero-/carbocyclic arenes and electron-poor arenes bearing rela

68 of the shikimate pathway for biosynthesis of carbocyclic aromatic compounds in plants, bacteria, fung

69 The reduction of a series of hetero- and carbocyclic aromatic compounds under ammonia free condit

70 nd pyrroles, as well as furan, thiophene and carbocyclic aromatics, further demonstrates the advantag

71 microm), aza-AdoMet (IC(50) 100 microm), and carbocyclic aza-AdoMet (IC(50) 35 microm).

72 arranges to incorporate the Si atom into the carbocyclic base to give an unprecedented cationic 5-sil

73 entane (BCP) and other related C(sp(3))-rich carbocyclic benzene bioisosteres from their correspondin

74 Mn(CF(3)-PDP) oxidations of carbocyclic bioisostere drug candidates (for example, HC

75 ilt from the corresponding benzoyl-protected carbocyclic bis-allyl ureas by ring-closing metathesis.

76 alkane carboxylic acids, which are essential carbocyclic building blocks in organic synthesis.

77 Newly prepared carbocyclic C-analog of tubercidine, profiled in MCF7 (b

78 The compounds 22 and (-)-53 (MU1656), carbocyclic C-nucleoside analogues of the natural nucleo

79 of new DOT1L inhibitors based on nonroutine carbocyclic C-nucleoside scaffolds.

80 Carbocyclic C-nucleosides are quite rare.

81 reduction with Bu3SnH and then converted to carbocyclic C-ribonucleosides 1, 3, and 4.

82 the phosphaethene TSs are much less than the carbocyclic cases.

83 The isolation of carbocyclic coformycin as the herbicidally active compon

84 we report that the primary mode of action of carbocyclic coformycin has been identified as inhibition

85 tic radiolabeled marker, rapid conversion of carbocyclic coformycin to the 5'-phosphate analog could

86 The 5'-phosphate analog of the carbocyclic coformycin was synthesized and shown to be a

87 um L. var Onward) seedlings are treated with carbocyclic coformycin, there is a very rapid and dramat

88 ine nucleosides (1-4), a spiranic pyrimidone carbocyclic compound (5), and an unusual carbocyclic iso

89 cope, thus offering an opportunity to access carbocyclic compounds from simple precursors even in an

90 Carbocyclic compounds with high stereochemical and funct

91 es of natural and unnatural heterocyclic and carbocyclic compounds.

92 ntaining a tetrahydropyran ring (1a) and its carbocyclic congener (1b).

93 ons to set the key quaternary centers in the carbocyclic core and the use of biocatalytic oxidation a

94 rmolecular Diels-Alder reaction to forge the carbocyclic core in a concise and stereoselective manner

95 rated in the synthesis of the seven-membered carbocyclic core of resveratrol-based natural products (

96 The resulting 6-step synthesis of the carbocyclic core of the berkeleyone natural products has

97 With access to the carbocyclic core of the family of natural products, wilf

98 ployed to construct the fused [5-6-7] linear carbocyclic core of the molecule and complete the total

99 This sequence generates the fused carbocyclic core of the natural product in short order.

100 A flexible strategy toward the carbocyclic core of the naturally occurring sphingomyeli

101 The key steps en route to the carbocyclic core of these targets were a [2,3]-sigmatrop

102 The carbocyclic core structure was assembled using a tandem

103 Initial attempts to access the carbocyclic core were surprisingly challenging and in re

104 conditions, expediently generated its [7,5]-carbocyclic core, afforded a unique sequence for dihydro

105 and ring-closing metathesis to construct its carbocyclic core.

106 reacted somewhat less efficiently than their carbocyclic counterparts, the fragmentation provided 11-

107 Carbocyclic decalin is a ubiquitous bicyclic structural

108 ontaining a 2',3'-unsaturation in its planar carbocyclic deoxyribose ring that acts on HIV-1 reverse

109 al analysis of organic ring systems, and the carbocyclic diastereomers have highly divergent conforma

110 To address carbocyclic fatty acid synthesis in plants, a cDNA libra

111 nd the pathway in higher plants that produce carbocyclic fatty acids was defined as by transfer of C(

112 represent the first enantiopure non-natural carbocyclic fenestranes isolated to date.

113 uct of cumbiasin B that possesses an unusual carbocyclic framework named seco-cumbiane.

114 ployed, for the first time, to construct the carbocyclic framework of aminoyclitols, while bis-Wittig

115 The carbocyclic framework of daphnepapytone A was formed by

116 that possesses a unique tetracyclic 7/5/6/5 carbocyclic framework that is punctuated with numerous s

117 t peripheral but embedded within the complex carbocyclic framework.

118 c cycloadducts that map onto the alternative carbocyclic frameworks of both himandravine and GB17.

119 underwent cyclizations to provide different carbocyclic frameworks.

120 oxides, achieved through the combination of carbocyclic-fused di-Grignard reagents and readily avail

121 ethod was used to synthesize three different carbocyclic[g]indole scaffolds as inhibitors of human no

122 However, the O-phosphonate analog of carbocyclic glycinamide ribonucleotide did support enzym

123 ide, including the phosphonate derivative of carbocyclic glycinamide ribonucleotide, did not serve as

124 erted to the conformationally locked (north)-carbocyclic guanosine (+)-17 identical to the one obtain

125 on alterations of macrocycles, made of four carbocyclic/heterocyclic subunits, which resemble the st

126 ign of chimeric proline-based amino acids as carbocyclic hydroxyethylene isosteres of inhibitor molec

127 Several carbocyclic ions show similar behavior.

128 one carbocyclic compound (5), and an unusual carbocyclic isonucleoside (6) were prepared as enantiome

129 or stereospecific preparation of a versatile carbocyclic key intermediate, D-2'-fluoro-6'-methylene c

130 (ProTide) technology to the antiviral agent carbocyclic L-d4A (L-Cd4A).

131 With related but less symmetrical carbocyclic ligands, however, the magnetic properties of

132 1c)] by a formal 4-electron oxidation of the carbocyclic ligands.

133 inding affinity and biological activity with carbocyclic LNA (cLNA) analogs by replacing the 2'-oxyge

134 yielding hydroxylation products analogous to carbocyclic lyxosides.

135 Hirocidin A is an unusual nine-membered carbocyclic maleimide and hirocidins B and C are relativ

136 Here we report the synthesis of a new carbocyclic mechanism-based covalent inhibitor of an alp

137 We report the first structural analysis of a carbocyclic mechanism-based GH inactivator, the results

138 We report that a carbocyclic modification of the ribose moiety incorporat

139 The methods for synthesising the carbocyclic moiety mainly focus on the construction of t

140 ond to the pyrrole rings on each side of the carbocyclic moiety, gave 4J(Me,H) = 0.9-1.0 Hz.

141 ether moiety and the [2.2.1] camphor-derived carbocyclic moiety.

142 o-annulation, leading to five-membered spiro-carbocyclic motifs essentially as single diastereomers (

143 A carbocyclic N(6)-methyl-2'-deoxyadenosine bisphosphate a

144 s of theory for 45 (single-ring, multi-ring, carbocyclic, N,O-heterocyclic) molecules across the arom

145 t in the total synthesis of heterocyclic and carbocyclic natural products.

146 By virtue of its carbocyclic nature, N-MCD4T (2) is a more robust molecul

147 y follow patterns previously established for carbocyclic nitrenium ions, but the reactions with AcO(-

148 are comparable to those of highly selective carbocyclic nitrenium ions.

149 assembly of five- and six-membered oxa- and carbocyclic nitriles demonstrating the utility of omega-

150 For the preparation of a carbocyclic nitrogen analogue of S-adenosylmethionine (c

151 d the preparation of an undescribed class of carbocyclic nucleoside analogues and provided a proof of

152 Carbocyclic nucleoside analogues are catabolically stabl

153 Two new families of enantiomerically pure carbocyclic nucleoside analogues based on a cyclohexane

154 A new class of carbocyclic nucleoside analogues built on a bicyclo[4.1.

155 clopentylamine precursors for 5'-substituted carbocyclic nucleoside analogues was developed.

156 xane scaffold can lock the conformation of a carbocyclic nucleoside into one of the two antipodal (no

157 of a carboxyl group at the alpha position of carbocyclic nucleoside phosphonate analogues leads to a

158 the efficient conversion of 3 into the novel carbocyclic nucleoside spironoraristeromycin 4.

159 D-carba T is a carbocyclic nucleoside that has a 3' hydroxyl on the pse

160 ficient asymmetric synthesis of an antiviral carbocyclic nucleoside, noraristeromycin 5.

161 rba-T, 13) was used as a reference, flexible carbocyclic nucleoside.

162 A series of four structurally related carbocyclic nucleosides (6a, 6b, 10a, and 10b) were synt

163 nd L-2',3'-dideoxy-2',3'-didehydro-2'-fluoro-carbocyclic nucleosides (D- and L-2'F-C-d4Ns) were synth

164 Carbocyclic nucleosides are nucleoside analogues in whic

165 [reaction: see text] Carbocyclic nucleosides are of considerable interest for

166 The triphosphates (27a,b) of the carbocyclic nucleosides demonstrated potent inhibitory a

167 oro substitution on the 2',3'-double bond in carbocyclic nucleosides has provided biologically intere

168 Carbocyclic nucleosides have received much attention due

169 rivileged rigid template for sculpting other carbocyclic nucleosides to meet the demands of specific

170 The syntheses of target carbocyclic nucleosides were accomplished via a converge

171 The target D- and L-carbocyclic nucleosides were both stereospecifically syn

172 agents, D- and L-2',3'-unsaturated 3'-fluoro carbocyclic nucleosides were synthesized and evaluated a

173 s of synthesis of 3-, 4- and 6-membered ring carbocyclic nucleosides, a selection of the more relevan

174 versatile intermediates for the synthesis of carbocyclic nucleosides, have been developed via a ring-

175 itution reactions after the synthesis of the carbocyclic nucleosides.

176 es a group of analogues known generically as carbocyclic nucleosides.

177 zed for the synthesis of biologically active carbocyclic nucleosides.

178 of unnatural five-membered ring heterocyclic carbocyclic nucleosides.

179 ed a central spirocyclobutanone scaffold for carbocyclic nucleosides.

180 s of carbocycles related to the synthesis of carbocyclic nucleosides.

181 Thus, we identified uncharged carbocyclic nucleotide analogues that represent potentia

182 Thus, we have greatly expanded the range of carbocyclic nucleotide analogues that represent potentia

183 bicyclic cyclopentenones fused with either a carbocyclic or a heterocyclic ring system in good yield.

184 Kabachnik-Fields reactions of various carbocyclic or heterocyclic acetylenic aldehydes togethe

185 demonstrating how covalently bonding, soft, carbocyclic organometallic ligands provide an excellent

186 metric epoxidation of various styrenes using carbocyclic oxazolidinone-containing ketone 3 has been i

187 where phosphorylation occurs, derivatives of carbocyclic oxetanocin A (4a), oxetanocin G (4b), and 2-

188 ydrolyzable phosphatidic acid and LPA analog carbocyclic phosphatidic acid (ccPA) also inhibits PIEZO

189 f cyclopentane and cyclopentene and a chiral carbocyclic phosphonate.

190 an convert symmetrical ketoesters to complex carbocyclic products bearing multiple stereocentres with

191 nes or alkynes and diaryliodonium salts form carbocyclic products in a single step.

192 lic product is distinct from the more common carbocyclic products of synthetic and biosynthetic [4+2]

193 e array of different heterocyclic as well as carbocyclic products.

194 NRTIs based on the carbocyclic pseudosugar may offer an effective approach

195 s with dicarbonyls provides rapid entry into carbocyclic reaction products.

196 ucts that can be converted into analogues of carbocyclic ribosides.

197 that allow the construction of more than one carbocyclic ring at a time have proven valuable, in part

198 Modifications of the substituents on the carbocyclic ring did not perturb the inhibition pattern

199 acrocyclic ring reduction, lactamization and carbocyclic ring formation.

200 a Mur ligase homolog forms the six-membered carbocyclic ring in the final step of the pathway.

201 The conformation of the carbocyclic ring in these nucleosides was found to be le

202 ng phosphorylation at the 5' hydroxyl on the carbocyclic ring in vivo.

203 Indole fused with a seven-membered carbocyclic ring is a commonly observed structural featu

204 or beta-hydroxyl substituent at C-5' of the carbocyclic ring is detailed.

205 In these products, the size of the carbocyclic ring is varied widely (5-12 membered); howev

206 The presence of a carbocyclic ring on the new drug, cis-amminedichloro(2-m

207 (tetracyclic molecules with a linear 6-6-6-5 carbocyclic ring system) ring systems and properly subst

208 ricyclic compounds with a linear 6-6-5 fused carbocyclic ring system.

209 ave all evolved pathways to incorporate this carbocyclic ring system.

210 rovides a new method for the construction of carbocyclic ring systems bearing versatile organoboronic

211 carbon bonds, thus providing these important carbocyclic ring systems in a single synthetic step.

212 e generation of quaternary carbon centers in carbocyclic ring systems is sparse.

213 can be controlled to afford a range of novel carbocyclic ring systems through an intramolecular allyl

214 useful route to a number of heterocyclic and carbocyclic ring systems.

215 placing the ribose moiety with a constrained carbocyclic ring.

216 epoxide moieties and an electron-rich indole carbocyclic ring.

217 carbaporphyrin that is unsubstituted on the carbocyclic ring.

218 es that depend intimately on the size of the carbocyclic ring: 5-membered oxonitriles generate magnes

219 We have introduced constrained carbocyclic rings (to explore the role of sugar puckerin

220 rected into the hydrophobic pocket and small carbocyclic rings accessing the ribose-binding pocket.

221 Fatty acids containing three-member carbocyclic rings are found in bacteria and plants.

222 Nonbenzenoid carbocyclic rings are postulated to serve as important s

223 ive cyclizations to form 10- and 12-membered carbocyclic rings in the key steps of the biosynthesis o

224 , two new C-C bonds, and establishes two new carbocyclic rings is also described.

225 e ability of PikC to hydroxylate a series of carbocyclic rings linked to the desosamine glycoside via

226 beta-methylene C(sp(3) )-H bonds of various carbocyclic rings were also successfully alkynylated.

227 ively functionalized within each of the four carbocyclic rings, a synthetic ent-steroid has been prep

228 s secondary C(sp(3))-H bonds in a variety of carbocyclic rings, including cyclopropanes, cyclobutanes

229 on an analysis of over 70 neutral or charged carbocyclic rings, we compare the HOMA indices based on

230 ), three compounds with incrementally larger carbocyclic rings.

231 topological alteration of various classes of carbocyclic scaffolds bearing diverse functional groups.

232 rbon (C-C) single bonds in readily available carbocyclic scaffolds can yield uniquely substituted car

233 ust path to synthesize highly versatile rare carbocyclic scaffolds under transition-metal- and additi

234 ns are powerful tools for rapidly assembling carbocyclic scaffolds.

235 Extensions toward the synthesis of carbocyclic sinefungin 7 document the importance of real

236 bled various natural alterations to both the carbocyclic skeleton and the side chain.

237 s work describes a synthetic approach to the carbocyclic skeleton of isospongian diterpenes that uses

238 Hosomi-Sakurai cyclizations to construct the carbocyclic skeleton of the targets.

239 The carbocyclic skeleton was efficiently constructed from tw

240 ative containing the 2,8-ethanonoradamantane carbocyclic skeleton, whose key-step consists of an intr

241 The carbocyclic skeletons of the cumbiasins are unprecedente

242 or-diterpenoid, all of which possess unusual carbocyclic skeletons, were isolated from the hexane sol

243 ne (PCP) analogues possessing a highly rigid carbocyclic structure and an attached piperidine ring wh

244 The replacement of aryl rings with saturated carbocyclic structures has garnered significant interest

245 a unique family of fundamental [n]-membered carbocyclic structures with radiating alkenes, which hav

246 place in a single operation to access novel carbocyclic structures.

247 While simple carbocyclic substitution of adenosine agonists greatly d

248 og, while another duplex contains a central, carbocyclic substrate analog (carba-8-oxo-dG).

249 Subtle changes in the carbocyclic substrate led to the discovery of a heretofo

250 th DNA containing a south-constrained abasic carbocyclic sugar at the target site in the presence of

251 nd treatment of organotypic slices with this carbocyclic sugar increased the number and size of posts

252 ion of a macrocycle between the base and the carbocyclic sugar moiety, via ring-closing metathesis, a

253 across global populations, we identified the carbocyclic sugar myo-inositol as a component that promo

254 A key intermediate for carbocyclic sugar production, (1S,2S,3R, 4R,5S)-1-(tert-

255 A synthesis of carbocyclic sugars from carbohydrate-derived dialdehydes

256 We compare a pyridine-2-sulfinate with a carbocyclic sulfinate and establish different catalyst r

257 For the carbocyclic sulfinate, the aryl bromide oxidative additi

258 substitution; and a variety of aromatic and carbocyclic surrogates for phenyl.

259 Formal expansion of (4n + 2)-pi carbocyclic systems by insertion of NSN motifs in every

260 mistry is also extended from heterocyclic to carbocyclic systems, with computational guidance used to

261 itu generated nitrosoalkenes to form bridged carbocyclic systems.

262 tionality amenable to the preparation of the carbocyclic target molecule by suitable postrearrangemen

263 (cPGI(2); a stable prostacyclin analog), and carbocyclic thromboxane (cTXA(2)) were administered at c

264 We use carbocyclic thromboxane A2 (CTA2) to convert the TXAS he

265 Carbocyclic thymidine (carba-T, 13) was used as a refere

266 showed that DPTL binds with high affinity to carbocyclic TXA(2), TXA(2) mimetic (U-46619), TXB(2), PG

267 Carbocyclic uracil polyoxin C (+)-2 and its alpha-epimer

268 Carbocyclic uracil polyoxin C analogs are prepared from

269 However, stable carbocyclic versions of these analogues are less effecti