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1 tures of human TDG bound to DNA with cadC (5-carboxyl-2'-deoxycytidine) flipped into its active site.
2 -hydroxymethyl (5hmC), 5-formyl (5fC), and 5-carboxyl (5caC) derivatives; thus, DNA elements with mul
5 The inhibitory domain has been mapped to the carboxyl acidic domain of TSPX, truncation of which rend
6 ation molecular functional groups, including carboxyl, amine, isopropyl, phenethyl, and tert-butylphe
7 neous modification of carbon electrodes with carboxyl-amine functionalities offers protection against
10 s, functionalized with multiple paired alpha-carboxyl and amino groups that bind to the large neutral
11 l-2-oxazoline as precursor to produce amine, carboxyl and oxazoline functional group rich surfaces.
12 r binding properties may, in addition to the carboxyl and phenolic groups, be influenced by the molec
14 five groups (i.e., amine, phenol, hydroxyl, carboxyl, and carbonyl) are found to be the dominant cla
16 Especially, the sequestration of OM (rich in carboxyl, aromatic, and/or carbonyl C) by Fe-rich minera
17 deposition had not altered the abundance of carboxyl, aryl, alkyl, or O/N-alkyl C in forest floor, b
18 deposition had not altered the abundance of carboxyl, aryl, alkyl, or O/N-alkyl C in forest floor, b
19 where hydroxyls (H), amines and phenols (A), carboxyls (C), and carbonyls or ketones/aldehydes (K) ar
22 constants (T(1) ) for the labeled acetyl and carboxyl carbonyls were approximately 30 seconds, suppor
24 tachment domain-containing (BADC) and biotin carboxyl carrier protein (BCCP) subunits from Arabidopsi
27 lved in the metabolism of cyclohex-1,5-diene carboxyl-CoA to acetyl-CoA were in high abundance in S.
29 nd slower rates were observed with increased carboxyl concentration and oxygen, heteroaliphatic, and
30 een eight characteristics (molecular weight, carboxyl concentration, and carbon, oxygen, nitrogen, al
31 of MWs (25 000-50 000 vs <200 Da) as well as carboxyl content (polygalacturonic acid (PGA) > citric a
32 A five amino acid stretch located at the carboxyl cytosolic region is essential for fibre formati
33 inuclear zirconium vertices and two flexible carboxyl-decorated tetraphenylethylene (TPE) spacers.
34 study revealed that graphitic sulfoxide and carboxyl dopants of graphene were the efficient binding
38 ble number of tandem repeat (VNTR) domain of carboxyl ester lipase (CEL) presents an opportunity to s
39 nes favoring the production of R-9-PAHSA and carboxyl ester lipase (CEL), a PAHSA degradative enzyme,
40 tic lipase-related protein 2 (PNLIPRP2), and carboxyl ester lipase (CEL), which may leak into the vis
41 n of the structure of AF-Est2 with the human carboxyl esterase 1, which has CoA thioesterase activity
42 rivative (DEAdcCE) for the protection of the carboxyl function at the side chain of the aspartic acid
46 nzoylglycine (H3L), which bears catechol and carboxyl functionalities in tandem, on to the surface of
47 on; thus, we propose that these nitrogen and carboxyl functionalities of aromatic compounds may also
48 tic approach, it is herein demonstrated that carboxyl functionalization of poly(lactic-co-glycolic ac
50 s with a core-shell structure and subsequent carboxyl functionalizations (CSD-PLNPs) were rationally
51 chemical sensor using polyaniline (PANi) and carboxyl functionalized multi-walled carbon nanotubes (f
53 work demonstrates the excellent potential of carboxyl-functionalized graphene oxide (GO-COOH) composi
57 ethylaminophenyl (4), 4-nitrophenyl (5), and carboxyl group (6) as substituents at the exocyclic doub
58 ric replacement of the tetrazole ring with a carboxyl group (60, IC(50) = 68 nM) gave a promising new
60 ree arginines that accommodates the terminal carboxyl group and a dedicated cavity that facilitates b
61 involves 2-phenylisopropyl protection of the carboxyl group and does not require excesses of commerci
63 ly attached biotin as a vector to transfer a carboxyl group between donor and acceptor molecules duri
65 imethylamino)propyl)carbodiimide activates a carboxyl group followed by nucleophilic attack by benzhy
66 protein-binding sites, we implemented a new carboxyl group footprinter, benzhydrazide, and refined i
67 dation of proteins (FPOP), and site-specific carboxyl group footprinting to investigate the HOS of pr
68 ast photochemical oxidation of proteins, and carboxyl group footprinting with glycine ethyl ester, we
70 tem, such as the biphenyl system, and a free carboxyl group leads to highly potent and selective GIVA
71 residue is enzymatically linked to the gamma-carboxyl group of a glutamate in the primary sequence of
72 on requires a direct interaction between the carboxyl group of allosteric effectors and Arg-120 of Ea
77 sol side-chain cleavage by reducing the C-20 carboxyl group on cortisol, yielding 20beta-dihydrocorti
79 antiradical moieties (catechol, guaiacyl and carboxyl group) and molecular conformation in antioxidat
80 profloxacin had peaks related to the ionised carboxyl group, i.e., at 1576 and 1392 cm(-1), which wer
81 ce of a receptor to bind the C-terminal free carboxyl group, the C-terminal amidated group, or the N-
83 iwalled carbon nanotubes functionalized with carboxyl groups (MWCNTf) was developed to modify glassy
84 nalized polystyrene nanospheres with surface carboxyl groups (PPs and QPs, respectively) were fabrica
85 -1) corresponded to methyl esterified uronic carboxyl groups and confirmed the higher equivalent weig
86 bination of readily functionalized amine and carboxyl groups attached to a chiral central core along
87 ectroscopy (TRLFS) identified phosphoryl and carboxyl groups from bacterial envelopes, among other re
89 solubilize amino acid derivatives with free carboxyl groups in CDCl(3) and to mediate their interact
91 fers functionalized products with acetyl and carboxyl groups in one step, in good yields, and with sh
92 ves as a "stinger" and penetrates a triad of carboxyl groups in the S3-S4 linker of the voltage senso
95 enefited from the reactive functional groups-carboxyl groups of Alb NPs, p19 protein, a viral protein
96 mutants revealed that catalysis requires the carboxyl groups of Glu362 and Asp426, and not of Asp383,
97 groups of N-terminal residues but also gamma-carboxyl groups of internal (non-N-terminal) Asp and Glu
98 cium-driven electrostatic interactions among carboxyl groups of the AGPs and the pectic acids give ri
101 of Asp383, confirming the enzyme employs two carboxyl groups to degrade lippopolysaccharide using an
104 d range of substrates (e.g. metabolites with carboxyl groups) for various applications, including bio
105 on nanotubes (CNTs; with and without surface carboxyl groups) into polyacrylonitrile (PAN) and polyst
106 lectronic effects from the 2-thio- and the 6-carboxyl groups, a lability that could, in turn, be usef
107 yl-aliphatic ketones, aliphatic and aromatic carboxyl groups, phenol, and methoxy phenyl ethers.
115 egradation activities, while deletion of the carboxyl GT-1 domain that is unique to the plant RNAse J
116 imilar carbon chain structure while SA has a carboxyl head group and GMS has two free hydroxyl groups
117 ower activation energies in the formation of carboxyl intermediate, in line with their higher activit
122 ster carbonyl hydration, suggesting that the carboxyl is linked to more extended H-bond clusters than
124 amates are then sequentially added via alpha-carboxyl-linkages to the growing glutamate side chain.
126 CCP5, we confirmed that it metabolized gamma-carboxyl-linked glutamate of synthetic substrates and tu
127 ereas most CCPs catalyze hydrolysis of alpha-carboxyl-linked glutamates, CCP5 uniquely metabolizes th
128 nmethylated phosphatases to show that PP6 is carboxyl-methylated and that LCMT-1 is the major methylt
132 he results of in vitro characterization of a carboxyl methyltransferase encoded in the cluster, Her8,
133 terminal half of Opi3 and isoprenyl cysteine carboxyl methyltransferases with a solved crystal struct
134 0, which makes a direct interaction with the carboxyl modification and the phosphate backbone of the
136 th environmentally-sensitive probes Laurdan, carboxyl-modified Laurdan (C-Laurdan), Di-4-ANEPPDHQ, an
139 on radical efficiently substitutes the three carboxyl moieties of Finland trityl with a high rate con
142 ditions where a ureido group is added to the carboxyl moiety to form a cyclic amide, regenerating SP
143 valuated the potential for poly(lactic acid)/carboxyl-multiwalled carbon nanotube (PLA/ f-MWCNT) comp
144 and amine groups NDandante or amine NDamine, carboxyl NDvox or hydroxyl groups NDH and drop-casted or
146 onjugation of L-glutamate primarily to the 8-carboxyl of isochorismate and yields the key SA biosynth
149 action because only compounds that contain a carboxyl or hydroxyl group and have moderate steric hind
150 ectra revealed Sb in untreated peat bound to carboxyl or phenol groups with average Sb-carbon distanc
151 well as the elongation of either the Mo-O5 (carboxyl) or Mo-O7 (hydroxyl) distance that switches the
153 to the anti-fouling effect conferred by the carboxyl-PEG layer, we could directly detect as little a
154 nsformations were less inhibited than in the carboxyl poor Fh-GA, and a crystalline lepidocrocite "sh
156 poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-dodecanol) (mPEG-b-PC
157 poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-dodecanol; PEG-PCD) t
158 oly (ethylene glycol)-block-poly (2-methyl-2-carboxyl-propylene carbonate-graft-SMART-graft-dodecanol
160 decarboxylation of 1: transfer of the second carboxyl proton to the adjacent phenyl carbon and C-C cl
163 lution, and spectroscopic observation of the carboxyl radical confirm its formation as a reaction int
165 the lifetime (520 +/- 120 ns) of a reactive carboxyl radical in solution, and spectroscopic observat
166 insights on how truncation of the amino and carboxyl regions of alphasyn may modulate the propensity
168 the amide group is flanked by two catalytic carboxyls, reveals key mechanistic information: (a) Gene
169 tionated permafrost thaw DOM directly showed carboxyl-rich alicyclic molecules, while the same compon
171 thetic polymers have been shown to mimic the carboxyl-rich surface motifs of non-collagenous proteins
172 ree-energy simulations, we observed that the carboxyl side chain of Glu89 (located along the arch mot
175 uction of a second IQ domain to the Ca(V)1.3 carboxyl tail switched the apparent functional stoichiom
177 structure of the beta2AR in complex with the carboxyl terminal 14 amino acids from Galphas along with
178 tically, ARID1A interacted with EZH2 via its carboxyl terminal and antagonized EZH2-mediated IFN resp
179 ssociates with CPL2, a plant-specific Pol II carboxyl terminal domain (CTD) phosphatase, to form the
181 se 9 (CDK9)-that phosphorylates NELF and the carboxyl terminal domain of Pol II-and enrichment of the
183 slational termination impairment and protein carboxyl terminal extension), which mechanistically link
185 ive EF-hand-like Ca(2+) binding motif in the carboxyl terminal region of BTV nonstructural phosphopro
186 5-associated seven transmembrane full-length carboxyl terminal variants, MOR-1B1, MOR-1B2, MOR-1B3, M
188 aking place at the amino-terminal (FERM) and carboxyl-terminal (FAT) domains and that both domains ar
190 modifies the nascent polypeptide by adding a carboxyl-terminal alanine and threonine (CAT) tail throu
191 nnels are characterized by the presence of a carboxyl-terminal cyclic nucleotide-binding domain (CNBD
192 pendent kinase 12 (CDK12) phosphorylates the carboxyl-terminal domain (CTD) of RNA polymerase II (pol
193 In endoplasmic reticulum (ER) membranes, the carboxyl-terminal domain (CTD) of SREBPs binds to the CT
195 oes not absolutely require the non-conserved carboxyl-terminal domain (CTD), which is necessary for r
196 ivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) as a critical intrin
197 ding and catalytic motifs, the isolated TlyA carboxyl-terminal domain exhibits no detectable affinity
199 ally occurring DLX3 mutant that disrupts the carboxyl-terminal domain leading to tricho-dento-osseous
204 ts revealed that the Ssu72 RNA polymerase II carboxyl-terminal domain phosphatase, a critical determi
206 me interface includes the RNAP subunit alpha carboxyl-terminal domain, which is required for RNAP-rib
209 served common docking (CD) domain within the carboxyl-terminal domains of ERK3 and ERK4 and the conse
211 that the HD together with the DLX3 amino- or carboxyl-terminal domains was required for maximal inhib
212 imerization is stimulated by the lysine-rich carboxyl-terminal extension of UBE2S that is also requir
214 with Astn2 TM2 leads to the appearance of a carboxyl-terminal fragment consistent with intramembrane
216 al analysis, and CRISPR editing identified a carboxyl-terminal fragment of thrombospondin-1 as an une
217 ino-terminal domains of NLRP1B, liberating a carboxyl-terminal fragment that is a potent caspase-1 ac
218 ulting metabolites, both alpha- and beta-APP carboxyl-terminal fragments and APP intracellular domain
219 pensable for the interaction with P, and the carboxyl-terminal half of P is sufficient for the intera
221 immunosensors for the detection of Ubiquitin carboxyl-terminal hydrolase (UCHL-1) biomarker of brain
222 oleucine, l-valine, l-aspartic and ubiquitin carboxyl-terminal hydrolase involved in protein degradat
223 e the serum levels of tau protein, ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), neurofilament l
228 e Golgi is the pH-dependent recognition of a carboxyl-terminal Lys-Asp-Glu-Leu (KDEL) signal by the K
229 ifference between the isoforms with the same carboxyl-terminal microtubule-binding domain repeats, is
234 trates via phosphopeptide recognition by its carboxyl-terminal polo-box domain (PBD) is poorly unders
235 study, the data demonstrate that within the carboxyl-terminal portion of mouse TG, T3 is formed de n
237 luding an extended transmembrane helix 5 and carboxyl-terminal receptor tail that interacts with G pr
239 mong known TRP structures, together with the carboxyl-terminal region, forms a large two-layered cyto
242 e of S generates a polybasic Arg-Arg-Ala-Arg carboxyl-terminal sequence on S1, which conforms to a C-
243 r phosphorylation occurred primarily at four carboxyl-terminal serine (Ser) and threonine (Thr) resid
245 enhanced the interaction of PTPN22 with the carboxyl-terminal Src kinase (CSK), an interaction that
246 he amino-terminal region of the protein, and carboxyl-terminal tail identity both contribute to MLO a
248 todomain, a transmembrane helix, and a short carboxyl-terminal tail, or as a soluble ectodomain that
251 % (95% CI: 0% to 6%; p = 0.04) and increased carboxyl-terminal telopeptide of collagen type I by 4% (
252 sue inhibitor of matrix metalloproteinase 1, carboxyl-terminal telopeptide of collagen type I, and so
253 Recent research has demonstrated that the carboxyl-terminal transmembrane domain (TMD) of some Bcl
256 oth hydroxyl-terminated 'neutral' (D-OH) and carboxyl-terminated 'anionic' (D-COOH) Polyamidoamine (P
257 groups and the relative concentration of the carboxyl-terminated alkanethiols in a binary self-assemb
258 t across self-assembled monolayers (SAMs) of carboxyl-terminated monoterpenoids (O(2) C(C(9) HX)) and
261 nine dimer spokes radiate, placing the Sas-6 carboxyl termini at the outer edge of the approximately
262 a decreased interaction between the amino to carboxyl termini in the functional tagged murine TRPC6 t
263 imately 4-5 nm, revealing that the amino and carboxyl termini of Ana2 are located in the outer cartwh
264 The results indicate that the amino and carboxyl termini of PHO1 are both oriented toward the cy
265 cted cells, we determined that the amino and carboxyl termini reside in the extracellular space and a
269 y receptor phosphorylation, primarily in the carboxyl terminus but also in the cytoplasmic loops, and
270 ocess is initiated by phosphorylation of its carboxyl terminus by G protein-coupled receptor kinase 1
273 either as fused domains (IbetaH(Asp)) at the carboxyl terminus of a nonribosomal peptide synthetase (
275 molecular interaction assay reveals that the carboxyl terminus of APC interacts with the matrix regio
276 in bacterial proteasomal ATPases, buries the carboxyl terminus of each protomer in the central channe
280 he tryptophan-rich lipid-binding loop in the carboxyl terminus of LPL prevents homodimer formation an
284 MD), which leads to partial unwinding of the carboxyl terminus of transmembrane helix 6 and induces a
286 h the exclusion of exon 3 generates a unique carboxyl terminus with specific anti-apoptotic functions
287 e identify the HECT (homologous to the E6-AP carboxyl terminus) family E3 ubiquitin ligase, UBR5, as
288 g new gene) and HECT (homologous to the E6AP carboxyl terminus) types shed light on their enzymatic a
291 p53 is subject to lysine methylation at its carboxyl terminus, which has been shown to repress p53's
295 sackievirus-adenovirus receptor fused to the carboxyl-terminus of human IgG) efficiently neutralizes
298 nt that truncation of alphasyn, particularly carboxyl truncation that can be augmented by dysfunction
299 d proton delivery to the amide nitrogen by a carboxyl, while the other carboxylate engages in nucleop
300 2-phenylisopropyl group can be cleaved from carboxyl with 2-3% (v/v) of TFA in acetonitrile (0-10 de