ライフサイエンスコーパス: carboxylesterase

1 genes, CYP2B1 and secreted human intestinal carboxylesterase.

2 t-related proteins such as chitinase and JHE-carboxylesterase.

3 cated that the isolated enzyme was rat serum carboxylesterase.

4 e IC50 for PPD compared to cells lacking the carboxylesterase.

5 ecently proposed mechanism for hydrolysis by carboxylesterases.

6 active site consensus sequence G-X-S-X-G of carboxylesterases.

7 several known and characterized lipases and carboxylesterases.

8 converted to the active metabolite SN-38 by carboxylesterases.

9 me is highly homologous with other rat liver carboxylesterases.

10 ode of plasticity within a specific class of carboxylesterases.

11 ered as a plant-specific TA clade in class I carboxylesterases.

12 oxaz carbamate prodrug that is hydrolyzed by carboxylesterases.

13 volves sequestration or hydrolysis of OPs by carboxylesterases.

14 A) was also characterized as an inhibitor of carboxylesterases.

15 sed proteomics approach, we identified liver carboxylesterase 1 (CES1) as a novel SORT1-interacting p

16 Here, we identified carboxylesterase 1 (CES1) as an essential NF-kB-regulate

17 se enzymes monoacylglycerol lipase (MGLL) or carboxylesterase 1 (CES1) confers resistance to the hist

18 The human carboxylesterase 1 (CES1) gene encodes for the enzyme ca

19 Here we investigated the role of hepatic carboxylesterase 1 (CES1) in regulating both normal and

20 Carboxylesterase 1 (CES1) is a serine hydrolase that met

21 for FGF-21 (beta=0.45, p =1.07x10 -18 ) and carboxylesterase 1 (CES1) protein (beta=0.66, p =4.91x10

22 Previous studies have demonstrated that carboxylesterase 1 (CES1) regulates hepatic triglyceride

23 y, we detected significant downregulation of carboxylesterase 1 (CES1), an enzyme that converts chole

24 xyl ester by human cathepsin A (CatA) and/or carboxylesterase 1 (CES1), is a stereospecific reaction.

25 (KISS1) related to reduced migration and low carboxylesterase 1 (CES1), to impaired survival in patie

26 fluenza drug, is hydrolytically activated by carboxylesterase 1 (CES1).

27 Carboxylesterase 1 (Ces1/Ces1g) has been shown to play a

28 Human carboxylesterase 1 (hCE1) exhibits broad substrate speci

29 The drug-metabolizing enzyme human carboxylesterase 1 (hCE1) is a candidate protein-based t

30 Human carboxylesterase 1 (hCE1) is a drug and endobiotic-proce

31 tal structures of the serine hydrolase human carboxylesterase 1 (hCE1), a broad-spectrum drug metabol

32 bition effect of PVC pellet extract on human carboxylesterase 1 (hCES1) activity.

33 Using carboxylesterase 1 knockout mice that were shown to mimi

34 ons in pharmacokinetics and drug response of carboxylesterase 1 substrates.

35 IC50, a decrease that was absent when human carboxylesterase 1 was added to prodrug treatment.

36 sterase 1 (CES1) gene encodes for the enzyme carboxylesterase 1, a serine esterase governing both met

37 approach, we identified a specific esterase, carboxylesterase 1, whose function had a clear impact no

38 ieved by prodrugs susceptible to cleavage by carboxylesterase 1.

39 Here we show that carboxylesterase 1/esterase-x (Ces1/Es-x) plays a regula

40 Human carboxylesterases 1 and 2 (CES1 and CES2) catalyze the h

41 inhibitors of the drug-metabolizing enzymes carboxylesterases 1 and 2 and demonstrate their pharmaco

42 .5 ppm lysosomal acid lipase, 0.14 ppm liver carboxylesterase, 1.8 ppm palmitoyl-protein thioesterase

43 Arabidopsis thaliana (At) carboxylesterase 15 (CXE15) and carboxylesterase 20 (CXE

44 protection is associated with superior UTRs [Carboxylesterase 1d (Ces1d)/adaptor protein-3beta (AP3B1

45 conversion of Irinotecan (CPT-11) to SN-38, carboxylesterase 2 (CES2) is a significant predictive bi

46 Here, we show that hepatic carboxylesterase 2 (CES2) is markedly reduced in NASH pa

47 ) is a prodrug of Doxaz that is activated by carboxylesterase 2 (CES2), which is expressed by liver,

48 Human carboxylesterase 2 (hCES2) converts anticancer prodrugs,

49 lity of polymer-drug conjugates by the human Carboxylesterase 2, for a targeted drug activation.

50 l (ASC) clone that expresses secretory human carboxylesterase-2 (shCE2) enzyme extracellularly and ye

51 eered to express recombinant secretory human carboxylesterase-2 and nanoluciferase genes for simultan

52 haliana (At) carboxylesterase 15 (CXE15) and carboxylesterase 20 (CXE20) have been shown to deplete s

53 Carboxylesterase 3 (Ces3) is a hydrolase with a wide ran

54 Carboxylesterase 3/triacylglycerol hydrolase (Ces3/TGH)

55 3c) be named caeA and caeB respectively, for carboxylesterase A and B.

56 ived from sixteen different environments for carboxylesterase activity and identified 714 positive hi

57 Plasma carboxylesterase activity and SN-38 levels in mice recei

58 We identified tumor permeability and carboxylesterase activity needed for prodrug activation

59 Simulations varying tumor permeability and carboxylesterase activity predicted a concave increase i

60 with a panel of hydrolase assays revealed a carboxylesterase activity with a preference for short ac

61 f this superfamily possess phospholipase and carboxylesterase activity with diverse substrate specifi

62 holly or partly the consequence of intrinsic carboxylesterase activity, as indicated by high-performa

63 nt for more than 95% of rat liver microsomal carboxylesterase activity.

64 ling, especially through inhibition of Notum carboxylesterase activity.

65 no-/picomolar boronic acid inhibitors of the carboxylesterase alphaE7 from the agricultural pest Luci

66 ld) activities, but was relatively devoid of carboxylesterase and all-trans REH activities.

67 Members of the carboxylesterase and cytochrome P450 monooxygenase super

68 nstrated reduced activity of alpha- and beta-carboxylesterase and elevated levels of detoxification e

69 The sixth isoenzyme was a novel carboxylesterase and its complete cDNA was cloned and se

70 Both enzymes possess significant carboxylesterase and S-formylglutathione thioesterase ac

71 Murine carboxylesterases and hormone sensitive lipase have been

72 the ADC even in the presence of enzymes like carboxylesterases and human neutrophil elastase, indicat

73 Both carboxylesterases and P450 enzymes have been shown to be

74 Enzyme markers for ER (such as carboxylesterase), and PM (such as 5'-nucleotidase [5'-N

75 l activity, do not require interactions with carboxylesterases, and do not inhibit human acetylcholin

76 nes, est30 and est55, encoding two different carboxylesterases, and genetic rearrangement in the est5

77 Carboxylesterases are enzymes that catalyze the hydrolys

78 Carboxylesterases are important enzymes responsible for

79 Together, our results show that lipases and carboxylesterases are involved in tuning Lepidoptera phe

80 ome-wide association studies have identified carboxylesterases as the key enzymes mediating modular a

81 cts upon hydrolysis was evaluated for use in carboxylesterase assays.

82 lesterase form 2 (73%) and the hamster liver carboxylesterase AT51p (67%).

83 was due to variation in the concentration of carboxylesterase between cell types.

84 terase (BChE) and structurally close to them carboxylesterase (CaE), as well their binding to NMDA-re

85 a structurally related enzyme, porcine liver carboxylesterase (CaE).

86 r substrate specificity from the human liver carboxylesterase called hCE-1, which hydrolyzes the meth

87 Carboxylesterase (CE) activity was detected in human gut

88 luate the concept that transfer of the human carboxylesterase (CE) gene will overcome the drug resist

89 We identified a rabbit liver carboxylesterase (CE) that was very efficient at CPT-11

90 We chose the prodrug converting enzyme carboxylesterase (CE), which converts the camptothecin d

91 We have isolated a cDNA encoding a rabbit carboxylesterase (CE; EC 3.1.1.1) that converts the camp

92 Carboxylesterases (CE) are ubiquitous enzymes responsibl

93 Carboxylesterases (CE) are ubiquitous enzymes responsibl

94 Carboxylesterases (CE) are ubiquitous enzymes that hydro

95 Carboxylesterases (CE) are ubiquitous enzymes thought to

96 ) or direct conversion of CPT-11 to SN-38 by carboxylesterases (CE) in the small intestine.

97 s an antitumor prodrug that is hydrolyzed by carboxylesterases (CE) to yield SN-38, a potent topoisom

98 onyloxycamptothecin (CPT-11) is activated by carboxylesterases (CE) to yield the potent topoisomerase

99 0 enzymes, which are homologous to mammalian carboxylesterase (CES) enzymes, and show that a number o

100 be completely inhibited with the nonspecific carboxylesterase (CES) inhibitor bis(4-nitrophenyl) phos

101 mall peptide precursors as the substrates of carboxylesterase (CES).

102 Carboxylesterases (CEs) are a class of enzymes that cata

103 Carboxylesterases (CEs) are ubiquitous enzymes that are

104 Because CPT-11 is activated by carboxylesterases (CEs), we assessed the relative contri

105 dentified as a potent selective inhibitor of carboxylesterases (CEs).

106 vivo to the topoisomerase I poison SN-38 by carboxylesterases (CEs).

107 ivating irinotecan (CPT-11) with recombinant carboxylesterases (CEs).

108 the growth of cancer cells that overexpress carboxylesterase CES1 (hCE1) and CES2 (hiCE).

109 ecific inhibitor loperamide, indicating that carboxylesterase Ces2a, which was appropriately up-regul

110 eptidic precursors as the substrates of both carboxylesterases (CESs) and alkaline phosphatases (ALPs

111 n the worm body and further modified via the carboxylesterase CEST-4.

112 Est30 is a thermophilic carboxylesterase cloned from Geobacillus stearothermophi

113 nce (Cyp9K1, Cyp6P3, and Cyp6M2), and also a carboxylesterase (COEAE1F) as major candidates.

114 The carboxylesterase Coeae6g was selected for further functi

115 Inhibiting carboxylesterases could, therefore, restore the effectiv

116 The described adenovirus/rabbit carboxylesterase/CPT-11 (irinotecan, 7-ethyl-10[4-(1-pip

117 Prodrug 12b showed rapid activation in a carboxylesterase (CPY) enzymatic assay and favorable ADM

118 Three carboxylesterase (CXE)-like enzymes from Catharanthus ro

119 uentially in both liver and tumor tissues by carboxylesterases, cytidine deaminase, and thymidine pho

120 defense molecules and insecticides, such as carboxylesterases, cytochrome P450, gluthathione S-trans

121 e families for glutathione S-transferase and carboxylesterase detoxification enzymes.

122 A carboxylesterase domain was found within the amino acid

123 Loss of yvaK (carboxylesterase E) or rnr (RNase R) caused no obvious p

124 Serum carboxylesterase enzymes (CE) can partially hydrolyze th

125 030120 and Sopen05g030130) encoding putative carboxylesterase enzymes of the alpha/beta-hydrolase sup

126 rinotecan; CPT-11) is a prodrug activated by carboxylesterase enzymes.

127 The purified protein was identified as carboxylesterase ES-10 (EC 3.1.1.1) by N-terminal Edman

128 Taken together these data indicate that carboxylesterase ES-10 plays a major role in the hydroly

129 dition to previously characterized rat liver carboxylesterases ES10, ES4, ES3, the protein products f

130 The carboxylesterase Est55 has been cloned and expressed in

131 cids total) were identical to those of a rat carboxylesterase expressed in the liver.

132 Some members of nonspecific carboxylesterase family (EC 3.1.1.1) have been shown to

133 r, the 20(S)-glycinate esters do not require carboxylesterase for conversion to their active forms.

134 characterized Silicibacter sp. protein was a carboxylesterase for short fatty acyl chains, similar to

135 hest sequence identity with the rabbit liver carboxylesterase form 2 (73%) and the hamster liver carb

136 Insect carboxylesterases from the alphaEsterase gene cluster, s

137 al and functional study of a novel bacterial carboxylesterase (FTT258) from F. tularensis, a homologu

138 A second carboxylesterase gene (NCBI accession number NM_133960),

139 uggest that local gene transfer of the human carboxylesterase gene and concomitant local administrati

140 novirus vector (AdCMV.CE) carrying the human carboxylesterase gene driven by the cytomegalovirus (CMV

141 e concept that in vivo transfer of the human carboxylesterase gene will confer sensitivity of a solid

142 n as few as 10% of cells expressed the human carboxylesterase gene, there was bystander growth suppre

143 strong selective sweep tied to a CNV in the carboxylesterase genes Coeae2g - Coeae6g.

144 bers of the three major enzyme families- the carboxylesterases, glutathione transferases, and cytochr

145 expression levels of key biomarker enzymes (carboxylesterase, GST, and CYP450) exhibited a consisten

146 s of CPT-11 by two recently identified human carboxylesterase (hCE) enzymes, hCE-1 and hCE-2.

147 A human liver carboxylesterase (hCE-2) that catalyzes the hydrolysis o

148 Here, we identify human intestinal carboxylesterase (hiCE) as the agent of activation for P

149 Further exploration of LRO function and carboxylesterase homologs in C. elegans and other animal

150 etabolomics, and synthesis, we show that the carboxylesterase homologue Cel-CEST-1.2 is responsible f

151 Carboxylesterases hydrolyze many pharmaceuticals and agr

152 atment of the cells with inhibitors of human carboxylesterase I and II, both in terms of total number

153 yl-10-hydroxycamptothecin) by a rabbit liver carboxylesterase in vitro and growth-inhibitory activity

154 study provides insight into the mechanism of carboxylesterase inhibition and raises the possibility t

155 ith esterase inhibition data for a series of carboxylesterase inhibitors.

156 These data indicate that the carboxylesterase inhibits AvrBsT-triggered phenotypes in

157 The expression of this carboxylesterase is developmentally regulated.

158 Ester hydrolysis by extracellular carboxylesterases is considered the rate-limiting step i

159 f expression of any one of the six different carboxylesterase isoenzymes will regulate the metabolism

160 ates were observed, suggesting that multiple carboxylesterase isozymes are responsible for the array

161 recessive mutation predicted to inactivate a carboxylesterase known to hydrolyze lysophospholipids an

162 steryl ester hydrolase (hncCEH) and rat lung carboxylesterase (LCE), proteins differing by only 4 res

163 ry mechanism by which Iw1 acts to suppress a carboxylesterase-like protein gene, W1-COE, within the W

164 Cytochrome P450s, carboxylesterases, major facilitator superfamily transpo

165 Rat serum carboxylesterase may have applications for the site-spec

166 Inhibition of intestinal carboxylesterases may allow modification of the pharmaco

167 tically coupled complex, but which undergoes carboxylesterase mediated transformation to a mononuclea

168 tically coupled complex, but which undergoes carboxylesterase mediated transformation to a mononuclea

169 protein], NOTUM [notum, palmitoleoyl-protein carboxylesterase], METAP1 [methionyl aminopeptidase 1],

170 ypermethrin and subsequently identified as a carboxylesterase (NCBI accession number BAC36707).

171 The carboxylesterase Notum hydrolyzes a palmitoleate moiety

172 Carboxylesterase Notum is a negative regulator of the Wn

173 Recently, carboxylesterase Notum was shown to act as a negative re

174 Notum, palmitoleoyl-protein carboxylesterase (NOTUM), a negative regulator of canoni

175 Carboxylesterases occur in Streptomyces species, but in

176 in class C beta-lactamases, peptidases, and carboxylesterases of family VIII.

177 rolysed to salicylic acid by the cytoplasmic carboxylesterase OSD4.

178 ers, was shown previously to bind the murine carboxylesterase promoter in chromatin immunoprecipitati

179 del in which E2F1-specific regulation of the carboxylesterase promoter requires both E2F1/DNA interac

180 Rather, E2F1 could no longer bind to the carboxylesterase promoter that contained the consensus E

181 uired for E2F1-mediated transcription of the carboxylesterase promoter.

182 ecessary for E2F1-mediated activation of the carboxylesterase promoter.

183 AdCMV.CE produced a functional carboxylesterase protein in A549 cells in vitro and in v

184 protein is, in fact, a cell wall-associated carboxylesterase rather than a proteinase, as initially

185 the cDNA encoding a secreted form of rabbit carboxylesterase (rCE) to disseminated neuroblastoma tum

186 he presence of high levels of a rabbit liver carboxylesterase (rCE), which can efficiently activate t

187 s of two model polyesters by eight different carboxylesterases revealed increasing hydrolysis with in

188 Alterations in carboxylesterase sequences could lead to variability in

189 ly investigated the effects of polyester and carboxylesterase structure on the hydrolysis of nanomete

190 hlights the importance of both polyester and carboxylesterase structure to enzymatic polyester hydrol

191 smic reticulum (ER) via interaction with two carboxylesterases (termed gp60a and gp60b), which themse

192 aptoglobin, serum amyloid protein (SAP), and carboxylesterase that bear oligosaccharides with termina

193 to deliver the cDNA encoding a rabbit liver carboxylesterase that efficiently activates the prodrug

194 lyses of human proteins show that Notum is a carboxylesterase that removes an essential palmitoleate

195 discovery of a yield-boosting "missing link" carboxylesterase that selectively deprotects a late-stag

196 We show that HSR203J encodes a carboxylesterase that specifically hydrolyzes benzyl sal

197 Notum is a carboxylesterase that suppresses Wnt signaling through d

198 a form suitable for further cleavage by the carboxylesterases that also contribute to tau-fluvalinat

199 We further show that carboxylesterases that localize to intestinal organelles

200 n a prodrug structure susceptible to hepatic carboxylesterases that release active drug.

201 If the probe is pre-activated by carboxylesterases, the tricyclic core becomes electron-r

202 that is hydrolyzed by hepatic and intestinal carboxylesterase to form SN-38, which in turn is detoxif

203 the molecular basis for the ability of alpha-carboxylesterases to confer OP resistance to insects is

204 or selective hydrolysis by one or more human carboxylesterases to release doxazolidine (Doxaz), the f

205 plification conferring metabolic resistance (carboxylesterase) to organophosphates and carbamates in

206 ophoretic mobility indicating that the liver carboxylesterase was a glycoprotein of the high mannose

207 Using cavity comparisons, the human carboxylesterase was successfully identified, which is a

208 For HeLa cells, 20 nM of the 50 nM total carboxylesterases was unaffected by NDGA.

209 general characteristics of the family of rat carboxylesterases, we hypothesized that one member, ES-4

210 Six different carboxylesterases were identified and purified from rat

211 Arylesterases and carboxylesterases were identified as the main metabolic

212 Several mammalian carboxylesterases were shown to activate the prodrug iri

213 e that MT2282 encodes a cell wall-associated carboxylesterase, which is required for full virulence o

214 However, the potential use of bacterial carboxylesterases, which have the advantage of high stab

215 erse enzymes and novel families of microbial carboxylesterases, whose activity could not have been pr

216 Carboxylesterases with high sequence identity to hCE-2 h

217 Est30 is a member of a new family of carboxylesterases with representatives in other Gram-pos

218 this enzyme, and showed that it is a serine carboxylesterase, with a catalytic triad formed by S117,