ライフサイエンスコーパス: cardiac progenitor cell

1 and the self-renewal and differentiation of cardiac progenitor cells).

2 tion of dmiR-1 in regulating the polarity of cardiac progenitor cells.

3 s, suggesting that GSK-3beta-MSCs upregulate cardiac progenitor cells.

4 tly higher activation of endogenous c-kit(+) cardiac progenitor cells.

5 fied disease of disrupted differentiation of cardiac progenitor cells.

6 protein (Bmp) signaling regulates miRNAs in cardiac progenitor cells.

7 fied a family of closely related multipotent cardiac progenitor cells.

8 ain survival of proliferating populations of cardiac progenitor cells.

9 cted intramyocardially to stimulate resident cardiac progenitor cells.

10 ymmetry, cardiac evolution, and isolation of cardiac progenitor cells.

11 nd heart field (SHF), an important source of cardiac progenitor cells.

12 ften result from improper differentiation of cardiac progenitor cells.

13 reMer and the MLC-2v promoters are active in cardiac progenitor cells.

14 esult from disruption of discrete subsets of cardiac progenitor cells(1), but the transcriptional cha

15 cell [FhCPC]) and adult failing (adult human cardiac progenitor cell [AhCPC]) hearts, as well as youn

16 hat the local trophic effects of MSC require cardiac progenitor cell and CM-CXCR4 expression and are

17 it(+) cell populations yielding a mixture of cardiac progenitor cells and endothelial progenitor cell

18 ISL1 is expressed in cardiac progenitor cells and plays critical roles in car

19 eacetylation of Gata4, which is expressed by cardiac progenitor cells and plays critical roles in the

20 ine the transcriptional profile of mammalian cardiac progenitor cells and provide insight into the mo

21 can improve the engraftment of transplanted cardiac progenitor cells and therapeutic efficacy for tr

22 ecify fate and differentiation in individual cardiac progenitor cells, and exposes mechanisms of disr

23 Nkx2-5 marks the earliest recognizable cardiac progenitor cells, and is activated in response t

24 After cardiac injury, cardiac progenitor cells are acutely reduced and are rep

25 RATIONALE: Cardiac progenitor cells are an attractive cell type for

26 Cardiac progenitor cells are an attractive cell type for

27 Multipotent cardiac progenitor cells are found in the fetal and adul

28 Cardiac progenitor cells are multipotent and give rise t

29 From a clinical perspective, the ideal cardiac progenitor cells are those that can proliferate,

30 cessary and sufficient to specify a field of cardiac progenitor cells as the heart-valve-inducing reg

31 gle-cell RNA sequencing to interrogate early cardiac progenitor cells as they become specified during

32 smooth muscle alpha-actin gene expression in cardiac progenitor cells, as an agonist of myofibroblast

33 ed imatinib, sunitinib or sorafenib to human cardiac progenitor cells, assessing cell viability, prol

34 Remarkably, ablation of up to 60% of cardiac progenitor cells at embryonic day 7.5 was well t

35 rentiation of a subset of second heart field cardiac progenitor cells at the epicardium to adipocytes

36 at therapies targeting this axis may enhance cardiac-progenitor cell-based regenerative therapy.

37 The role played by the Notch pathway in cardiac progenitor cell biology remains to be elucidated

38 s at the transition from cardiac mesoderm to cardiac progenitor cells but is preserved on a subset of

39 ription factor gene Six1, which functions in cardiac progenitor cells but is stably silenced upon car

40 Percentages of cardiac progenitor cells (c-kit+ cells) and mononucleate

41 humans has identified the presence of adult cardiac progenitor cells, capable of cardiomyogenic diff

42 rentiating into cardiomyocytes like proposed cardiac progenitor cells, cardiac SP cells fuse with pre

43 on of freshly isolated, c-kit-enriched human cardiac progenitor cells confirmed frequent coexpression

44 During mammalian embryogenesis, cardiac progenitor cells constituting the second heart f

45 Endogenous cardiac progenitor cell (CPC) activation may partially o

46 sults from clinical trials support expanding cardiac progenitor cell (CPC) based therapies.

47 ction and mechanisms of SWI/SNF in mediating cardiac progenitor cell (CPC) differentiation during car

48 with diabetes and oxygen toxicity may alter cardiac progenitor cell (CPC) function resulting in defe

49 ) mice arises as a consequence of defects in cardiac progenitor cell (CPC) function, and that neonata

50 aging myopathy dictated by depletion of the cardiac progenitor cell (CPC) pool is unknown.

51 diac-specific Pim-1 kinase expression on the cardiac progenitor cell (CPC) population were examined t

52 -function hESCs had a profound impairment in cardiac progenitor cell (CPC) specification and cardiomy

53 KEY POINTS: Autologous cardiac progenitor cell (CPC) therapy is a promising app

54 of donor age and hypoxia of human pediatric cardiac progenitor cell (CPC)-derived exosomes in a rat

55 both neonatal rat cardiomyocytes (NRCM) and cardiac progenitor cells (CPC) upon exposure to doxorubi

56 Administration of cardiac progenitor cells (CPCs) 4 hours after reperfusio

57 MITO cells, which is cardiac progenitor cells (CPCs) activated by the mitocho

58 We report that c-kit-positive cardiac progenitor cells (CPCs) activated with insulin-l

59 and perform side-by-side comparison between cardiac progenitor cells (CPCs) and cardiomyocytes (CMs)

60 An analysis of the clonality of cardiac progenitor cells (CPCs) and myocyte turnover in

61 Cardiac progenitor cells (CPCs) and other stem cell type

62 Cardiac progenitor cells (CPCs) and skin fibroblasts fro

63 Autologous c-kit(+) cardiac progenitor cells (CPCs) are currently used in th

64 Cardiac progenitor cells (CPCs) are thought to different

65 cally with FGF to stimulate the migration of cardiac progenitor cells (CPCs) during cardiac jogging -

66 s in the mouse heart tube are hypoxic, while cardiac progenitor cells (CPCs) expressing islet 1 (ISL1

67 rived from mouse ES (mES) cells, we isolated cardiac progenitor cells (CPCs) from differentiating mES

68 of ischemic myocardium and whether c-kit(+) cardiac progenitor cells (CPCs) function can be enhanced

69 However, the role of CaMKIIdelta in cardiac progenitor cells (CPCs) has not been previously

70 Cardiac progenitor cells (CPCs) have been shown to promo

71 We tested whether cardiac progenitor cells (CPCs) implanted in proximity o

72 Transfer of cardiac progenitor cells (CPCs) improves cardiac functio

73 Cardiac progenitor cells (CPCs) in the niches express No

74 We recently identified a population of cardiac progenitor cells (CPCs) in zebrafish expressing

75 e a versatile population of Sca-1(+)/CD45(-) cardiac progenitor cells (CPCs) into endothelial cells a

76 ABSTRACT: Therapeutic use of c-kit(+) cardiac progenitor cells (CPCs) is being evaluated for r

77 T) and PG(TR) were expressed in c-Kit+:Sca1+ cardiac progenitor cells (CPCs) isolated from the hearts

78 Cardiac progenitor cells (CPCs) must control their numbe

79 Cardiac progenitor cells (CPCs) possess the insulin-like

80 We now show that Nkx2-5(+) cardiac progenitor cells (CPCs) that express the Sry-typ

81 In vertebrate embryos, cardiac progenitor cells (CPCs) undergo long-range migra

82 nerative potential of adoptively transferred cardiac progenitor cells (CPCs) via genetic engineering

83 Cardiac progenitor cells (CPCs) were isolated from trans

84 Here, we hypothesize that codelivery of cardiac progenitor cells (CPCs) with a nonviral minicirc

85 teome of human embryonic stem cells (hESCs), cardiac progenitor cells (CPCs), and cardiomyocytes duri

86 tent stem cells (hPSCs), adult heart-derived cardiac progenitor cells (CPCs), and reprogrammed fibrob

87 c characteristics and the secretome of human cardiac progenitor cells (CPCs), and their potential to

88 f aged stem cells and in particular c-kit(+) cardiac progenitor cells (CPCs).

89 tential mechanisms by which diabetes affects cardiac progenitor cells (CPCs).

90 ssociated with cellular senescence in c-kit+ cardiac progenitor cells (CPCs).

91 the transition from mesodermal precursors to cardiac progenitor cells (CPCs).

92 d recent therapeutic application of resident cardiac progenitor cells (CPCs).

93 from the second heart field, a population of cardiac progenitors cells (CPCs).

94 Human cardiac progenitor cells, cultured as cardiospheres (CSp

95 yoblasts, HL-1 atrial myocytes, and c-kit(+) cardiac progenitor cells demonstrated higher expression

96 uring cardiac development and morphogenesis, cardiac progenitor cells differentiate into cardiomyocyt

97 Although transcription factors involved in cardiac progenitor cell differentiation have been descri

98 in a Notch1-independent manner, and regulate cardiac progenitor cell differentiation in an endocytosi

99 Numb regulated cardiac progenitor cell differentiation in an endocytosi

100 itional depletion of JMJD3 leads to impaired cardiac progenitor cell differentiation, phenocopying th

101 MiRNAs have also been implicated in resident cardiac progenitor cell differentiation.

102 mammalian heart develops from two fields of cardiac progenitor cells distinguished by their spatiote

103 d genes also mediate all three categories of cardiac progenitor cell division or a subset thereof.

104 e jumeau (jumu) controls three categories of cardiac progenitor cell division-asymmetric, symmetric,

105 ed for only two categories of jumu-regulated cardiac progenitor cell division: symmetric and cell div

106 By arresting the cardiac progenitor cell divisions at different developin

107 CHES-1-like) and Jumeau (Jumu), which govern cardiac progenitor cell divisions by regulating Polo kin

108 ent of a jumu-regulated subnetwork mediating cardiac progenitor cell divisions.

109 khead domain TFs and Polo kinase to regulate cardiac progenitor cell divisions.

110 olved image data show that a subset of these cardiac progenitor cells do not overlap with the express

111 In the absence of SHP-2 signaling, cardiac progenitor cells downregulate genes associated w

112 alized phenotypic properties consistent with cardiac progenitor cells, endothelial progenitor cells,

113 ying enzyme histone deacetylase 3 (Hdac3) in cardiac progenitor cells exhibit precocious cardiomyocyt

114 erentiation or significant contribution from cardiac progenitor cell expansion and differentiation in

115 erived CDCs demonstrated increased number of cardiac progenitor cells expressing c-kit(+), flk-1, and

116 rt-derived cell subpopulations that included cardiac progenitor cells expressing c-kit(+), Islet-1, a

117 report the existence of adult heart-derived cardiac progenitor cells expressing stem cell antigen-1.

118 CPCs isolated from human fetal (fetal human cardiac progenitor cell [FhCPC]) and adult failing (adul

119 differentiation of mouse and human PSCs into cardiac progenitor cells, followed by intramyocardial de

120 ppearing to be more suitable than c-kit(POS) cardiac progenitor cells for widespread clinical therape

121 Primary cardiac progenitor cells formed new human cardiac myocyt

122 tly by a strategy that implements the use of cardiac progenitor cells from the recipient to repopulat

123 elivery, engraftment, and differentiation of cardiac progenitor cells from the recipient.

124 d enhancer with genes that play key roles in cardiac progenitor cell function and cardiovascular deve

125 ic link between this surface transporter and cardiac progenitor cell function.

126 The isolation and culturing of cardiac progenitor cells has demonstrated that growth fa

127 c-kit-expressing cardiac progenitor cells have been reported as the prima

128 Human cardiac progenitor cells have demonstrated great potenti

129 , the mechanisms underlying ISL1 function in cardiac progenitor cells have not been fully elucidated.

130 was to demonstrate the enhancement of human cardiac progenitor cell (hCPC) reparative and regenerati

131 ) reporter gene imaging for monitoring human cardiac progenitor cell (hCPC) transplantation in a mous

132 Human cardiac progenitor cells (hCPC) improve heart function a

133 2+ initiate division of c-kit-positive human cardiac progenitor cells (hCPCs) and determine their fat

134 Human cardiac progenitor cells (hCPCs) are a promising cell so

135 harmacological/genetic modification of human cardiac progenitor cells (hCPCs) are necessary intervent

136 on is enhanced by adoptive transfer of human cardiac progenitor cells (hCPCs) into a pathologically c

137 ogous stem cell therapy using human c-Kit(+) cardiac progenitor cells (hCPCs) is a promising therapeu

138 Human cardiac progenitor cells (hCPCs) may promote myocardial

139 Cardiac progenitor cells hold great potential for clinic

140 generate expandable and multipotent induced cardiac progenitor cells (iCPCs) from mouse adult fibrob

141 er, reprogramming into proliferative induced cardiac progenitor cells (iCPCs) remains to be accomplis

142 ons for proliferation and differentiation of cardiac progenitor cells, implicate Su(H) in regulating

143 c positional fate maps resolve the origin of cardiac progenitor cells in amniotes.

144 kx2.5, an evolutionarily conserved marker of cardiac progenitor cells in both fields.

145 d abundance and cardiac myogenic capacity of cardiac progenitor cells in failing human hearts, the ne

146 The identification of cardiac progenitor cells in mammals raises the possibili

147 naling leads to premature differentiation of cardiac progenitor cells in mice.

148 muscles share a gene regulatory network with cardiac progenitor cells in pharyngeal mesoderm of the s

149 Resident cardiac progenitor cells in ScaKI mice do not respond to

150 on factor essential for the specification of cardiac progenitor cells in the second heart field, as a

151 estigated these inhibitors' effects on human cardiac progenitor cells in vitro and rat heart in vivo.

152 ons of impaired growth and survival of ScaKI cardiac progenitor cells in vitro.

153 The molecular basis of the defect in ScaKI cardiac progenitor cells is associated with increased ca

154 Understanding the origins and roles of cardiac progenitor cells is important for elucidating th

155 enitor cells, but the expression of CXCR4 in cardiac progenitor cells is very low.

156 s, with selective increases in expression of cardiac progenitor cell markers and reduced differentiat

157 apparently distinct populations of resident cardiac progenitor cells may have the potential to regen

158 ac progenitor cell [YCPC]) and old mice (old cardiac progenitor cell [OCPC]), were studied for senesc

159 t the cXin gene is specifically expressed in cardiac progenitor cells of chick embryos as early as st

160 ), which profoundly reduces FGF signaling in cardiac progenitor cells of the second heart field.

161 influence of hypoxia on CXCR4 expression in cardiac progenitor cells, on the recruitment of intraven

162 rine embryos that exhibit a full spectrum of cardiac progenitor cell or cardiomyocyte ablation.

163 congenital malformation, the consequences of cardiac progenitor cell or embryonic cardiomyocyte loss

164 rnative strategies using autologous resident cardiac progenitor cells or embryonic stem cell-derived

165 ining induced pluripotent stem cells-derived cardiac progenitor cells or mesenchymal stem cells-deriv

166 d the cellular mechanisms that maintain this cardiac progenitor cell pool in vivo remain unknown.

167 l infarction rapidly depletes the endogenous cardiac progenitor cell pool, and the inefficient recrui

168 of Akt promotes expansion of the presumptive cardiac progenitor cell population as assessed by immuno

169 /Sca1+ cardiac SP cells represent a distinct cardiac progenitor cell population, capable of cardiomyo

170 -population (CSP) cells represent a distinct cardiac progenitor cell population, capable of in vitro

171 es exhibiting differential expression in the cardiac progenitor cell population.

172 the molecular identities of these different cardiac progenitor cell populations appear to be distinc

173 , conclude that following myocardial injury, cardiac progenitor cell populations are acutely depleted

174 ebrafish embryos, Bmp signaling is active in cardiac progenitor cells prior to their differentiation

175 ion via proliferation and differentiation of cardiac progenitor cells, proliferation of pre-existing

176 epair consistent with impairment of resident cardiac progenitor cell proliferative capacity associate

177 beling positive CM (-44%, P<0.01), increased cardiac progenitor cell recruitment (100.9%, P<0.01), an

178 Infarct size, cardiac function, cardiac progenitor cells recruitment, fibrosis, and card

179 Deletion of Hdac3 in cardiac progenitor cells releases genomic regions from t

180 regeneration by differentiation of recipient cardiac progenitor cells restored a significant portion

181 re we uncover a hierarchical role of ISL1 in cardiac progenitor cells, showing that ISL1 directly reg

182 However, there are no obvious defects in cardiac progenitor cell specification, proliferation or

183 scored the importance of Gata4 in regulating cardiac progenitor cells specification and differentiati

184 Receptor tyrosine kinase inhibitors reduce cardiac progenitor cell survival, proliferation, differe

185 se studies suggest that ISO injury activates cardiac progenitor cells that can differentiate into new

186 ow that Hoxb1 plays a key role in patterning cardiac progenitor cells that contribute to both cardiac

187 ), Fgf10 promotes the proliferation of these cardiac progenitor cells that form the arterial pole of

188 whether the heart in large mammals contains cardiac progenitor cells that regulate organ homeostasis

189 ABSTRACT: Autologous cardiac progenitor cell therapy is a promising alternati

190 Among cardiac progenitor cells, there is a distinct subpopulat

191 s reveal that Hdac3 plays a critical role in cardiac progenitor cells to regulate early cardiogenesis

192 tion of addition of second heart field (SHF) cardiac progenitor cells to the poles of the heart tube

193 nger transcription factor expressed in early cardiac progenitor cells, to activate the alphaCA promot

194 onist or antagonist or deleting Ppargamma in cardiac progenitor cells using Mesp1-Cre reveals that Pp

195 The abundance of these cardiac progenitor cells was increased nearly 4-fold in

196 cKit+ cardiac progenitor cells were BrdU labeled during injury

197 Pure populations of cardiac progenitor cells were isolated from the cardiac

198 central regulator of genome organization in cardiac progenitor cells, which is crucial for cardiac l

199 n hearts contain myocytes derived from extra-cardiac progenitor cells, which may have originated from

200 rotein 3 (ltbp3) transcripts mark a field of cardiac progenitor cells with defining characteristics o

201 sk or during the integration of donor (e.g., cardiac progenitor) cells with native cardiomyocytes in

202 ell [AhCPC]) hearts, as well as young (young cardiac progenitor cell [YCPC]) and old mice (old cardia