ライフサイエンスコーパス: cardiac valve

1 e endocardial cushion, the primordium of the cardiac valves.

2 perspectives on transcatheter replacement of cardiac valves.

3 of pathological microfractures in calcified cardiac valves.

4 tribution were found both between and within cardiac valves.

5 as myocardial fibrosis and calcification of cardiac valves.

6 al cushions that ultimately develop into the cardiac valves.

7 and function and detailed evaluation of all cardiac valves.

8 and for its adhesion to the vessel wall and cardiac valves.

9 rt development necessary to the formation of cardiac valves.

10 ralization of the arterial blood vessels and cardiac valves.

11 potentially therapeutic regeneration of the cardiac valves.

12 cal event for the embryonic morphogenesis of cardiac valves.

13 ibomian glands, and defects in the semilunar cardiac valves.

14 e impact of potential residual CPAs on human cardiac valves.

15 Cs are a constituent of the normal aorta and cardiac valves.

16 perties, and pathobiological behavior of the cardiac valves.

17 M), predominates in the supporting tissue of cardiac valves.

18 pproaches to therapeutic regeneration of the cardiac valves.

19 ncluding the intima and media of vessels and cardiac valves.

20 tissue remodeling formed the leaflets of the cardiac valves.

21 gies to guide tissue formation in engineered cardiac valves.

22 ocardial Nfatc1 expression within developing cardiac valves.

23 scription factor required for development of cardiac valves.

24 Although patients with certain cardiac valve abnormalities have increased risk of infec

25 ents (53 of 233) met the case definition for cardiac-valve abnormalities (odds ratio, 22.6; 95 percen

26 There were no cases of idiopathic cardiac-valve abnormalities among the subjects who had n

27 After case reports of cardiac-valve abnormalities related to the use of appeti

28 The odds ratio for such cardiac-valve abnormalities was 12.7 (95 percent confide

29 ween the use of any appetite suppressant and cardiac-valve abnormalities was analyzed in a final matc

30 The presence of cardiac-valve abnormalities, defined by the Food and Dru

31 was used to identify factors associated with cardiac-valve abnormalities.

32 of papillary muscles, the fibrous tissue of cardiac valve and chordae tendineae and the course of co

33 echocardiography (TEE) is used frequently in cardiac valve and proximal aortic surgical procedures, b

34 correlated with severity of disease, causing cardiac valve and septal disease in the neonate that was

35 Cs proved to be particularly abundant in the cardiac valves and aortic sinus.

36 r arrhythmias, and percutaneous placement of cardiac valves and closure devices will also be discusse

37 realistic and unique comprehensive views of cardiac valves and congenital abnormalities.

38 cells and is necessary for formation of the cardiac valves and for complete cardiac septation.

39 docardial cushions are the precursors of the cardiac valves and form by a process of epithelial-mesen

40 riable morphology, were detected in all four cardiac valves and in some tendinous cords.

41 Hyperplasia of the cardiac valves and outflow tract septation defects indic

42 e macrophages required for the remodeling of cardiac valves and septa.

43 Abnormal development of the cardiac valves and septae is the most frequent form of b

44 formation exists on the innervation of human cardiac valves and the relationship of nerve fibers and

45 s prevalent, such as in the formation of the cardiac valves and trabeculae.

46 ed endocardium and fail to form identifiable cardiac valves and trabeculae.

47 c surgery, including coronary artery bypass, cardiac valve, and aortic procedures, is among the most

48 Keywords: CT, Cardiac, Valves, Aortic Stenosis (C) RSNA, 2025.

49 Cardiac valves are essential to direct forward blood flo

50 Cardiac valves arise from endocardial cushions, speciali

51 h mineralization can occur at various sites (cardiac valves, arterial intima or media, capillaries),

52 c OPN and Msx2 expression >50% and decreased cardiac valve calcification 80% (8.3 +/- 1.5% versus 1.4

53 Furthermore, adult mutant mice exhibit cardiac valve calcifications associated with abnormal ma

54 nges in coronary artery, thoracic aorta, and cardiac valve calcium scores and pulse wave velocity wer

55 on of the pathomorphological features of the cardiac valves compared with previously used sparse arra

56 development of the embryonic outflow tract, cardiac valves, conducting system, and the developing co

57 heumatic heart disease (RHD) with persistent cardiac valve damage.

58 -/-) embryos as well as additional semilunar cardiac valve defects and a double-outlet right ventricl

59 Cardiac valve defects are a common congenital heart malf

60 ogical approaches show that NS mutants cause cardiac valve defects by increasing Erk MAPK activation,

61 who presented predominantly with congenital cardiac valve defects.

62 hisms in a patient population suffering from cardiac valve defects.

63 lish the cellular and molecular signature of cardiac valve delamination in vivo and demonstrate the c

64 zebrafish atrioventricular canal (AVC) where cardiac valves develop.

65 eously suppresses elements that could hinder cardiac valve development and homeostasis.

66 ndocardium is a crucial signaling center for cardiac valve development and maturation.

67 light on the function of Nfatc1 in zebrafish cardiac valve development and reveals its role in VIC fo

68 d that many key genetic pathways involved in cardiac valve development are also implicated in disease

69 Defining molecular factors in cardiac valve development has facilitated identification

70 ulates the release of active TGF-beta during cardiac valve development in the avian heart.

71 protein) activity in the endocardium during cardiac valve development.

72 to better understand its mechanistic role in cardiac valve development.

73 ry pathways that control normal and abnormal cardiac valve development.

74 sly to play important and selective roles in cardiac valve development.

75 Patients with cardiac valve disease (CVD) frequently have congestive h

76 The pathogenesis of cardiac valve disease correlates with the emergence of m

77 f TNF and inflammation in the development of cardiac valve disease in man.

78 Mitral valve prolapse (MVP) is a common cardiac valve disease that affects nearly 1 in 40 indivi

79 cytopenia, 1, 1, 2, and 0, respectively; for cardiac valve disease, 0, 0, 3, and not analyzed, respec

80 r C. burnetii in antiphospholipid-associated cardiac valve disease, and performing early echocardiogr

81 In some persons, particularly those with cardiac valve disease, infection with C. burnetii can ca

82 carotid artery disease, atrial fibrillation, cardiac valve disease, obesity, dyslipidemia, hypertensi

83 aPL-positive patients with thrombocytopenia, cardiac valve disease, skin ulcer, aPL nephropathy, and/

84 Mitral valve prolapse (MVP) is a common cardiac valve disease, which affects 1 in 40 in the gene

85 etiology of both degenerative and rheumatic cardiac valve diseases.

86 trating the role of cilia function in common cardiac valve disorders, including mitral valve prolapse

87 five-year cumulative incidence of idiopathic cardiac-valve disorders was 0 per 10,000 subjects among

88 ed with an increased risk of newly diagnosed cardiac-valve disorders, particularly aortic regurgitati

89 in abundantly expressed in great vessels and cardiac valves during embryogenesis, and in many adult t

90 f cell phenotypes and matrix architecture in cardiac valves during fetal maturation and postnatal ada

91 microRNA 21 (miR-21), which is expressed in cardiac valve endothelium during development, in order t

92 E416D mutant enzymes were unable to restore cardiac valve formation and could only partially rescue

93 hese results suggest that FOG-2 functions in cardiac valve formation as an attenuator of EMT by repre

94 To gain mechanistic understanding of cardiac valve formation at single-cell resolution and in

95 h signaling pathway is crucial for primitive cardiac valve formation by epithelial-mesenchymal transi

96 Cardiac valve formation is a complex process that involv

97 During cardiac valve formation, Dll4-Notch1 signaling leads to

98 e gene expression in lymphocytes and control cardiac valve formation.

99 l-transduction processes required for normal cardiac valve formation.

100 in early cardiac morphogenesis as well as in cardiac valve formation.

101 Several gene mutations are known to affect cardiac valve formation.

102 rophages were abundant in inflamed/rheumatic cardiac valves from both mice and humans.

103 Human cardiac valves have distinct patterns of innervation tha

104 comitant inflammation of synovial joints and cardiac valves in disorders such as rheumatic fever and

105 alpha interaction as a key driver of chronic cardiac valve inflammation and suggest these molecules a

106 is specifically prevented the development of cardiac valve inflammation.

107 clinical sequelae, such as life-threatening cardiac valve involvement.

108 and that renal stones developed at 64 years, cardiac-valve involvement at 54 years, and coronary-arte

109 lopment of the extracellular matrix (ECM) of cardiac valves is necessary for proper heart function.

110 r, these results suggest a role of FGF-4 for cardiac valve leaflet formation through proliferative ex

111 Cardiac valve leaflets and large conduit arteries have b

112 Cardiac valve leaflets develop from rudimentary structur

113 , which confer biomechanical strength to the cardiac valve leaflets.

114 diovascular development in the maturation of cardiac valve leaflets.

115 activation may be an important mechanism in cardiac valve maintenance and function by enhancing endo

116 tor to transduce reverse signals involved in cardiac valve maturation and axon pathfinding.

117 predominantly by valvular endocardium during cardiac valve maturation, exhibited enlarged valves.

118 Defects in cardiac valve morphogenesis and septation of the heart c

119 ial-mesenchymal transformation (EnMT) during cardiac valve morphogenesis.

120 PFE occurred most commonly on cardiac valves (n = 400 [78%]).

121 tations comprised of fibrin and platelets on cardiac valves, NBTE poses a diagnostic challenge due to

122 Cardiac valves of transgenic mice expressing human TNF d

123 This results in excess Collagen within cardiac valves of uninjured hearts.

124 ic surgery, it now is apparent that standard cardiac valve operations can be performed through very s

125 acement, or a previous operation involving a cardiac valve or ascending aorta.

126 clinical outcomes among patients undergoing cardiac valve or proximal aortic surgery with vs without

127 Among adults undergoing cardiac valve or proximal aortic surgery, intraoperative

128 was receipt of intraoperative TEE during the cardiac valve or proximal aortic surgery.

129 (64.6%) were male, 39 (30.0%) had prosthetic cardiac valve or valve repair, 21 (16.2%) cardiac implan

130 rdiogenic emboli in patients with mechanical cardiac valves or nonvalvular atrial fibrillation.

131 es in either initial adherence of strains to cardiac valves or vegetation weights.

132 Cardiac valves originate from endocardial cushions (EC)

133 ighly expressed in the embryonic periosteum, cardiac valves, placenta, and periodontal ligament as we

134 Cardiac valve procedures are commonly performed concurre

135 an and GAS proteins triggers proinflammatory cardiac valve-reactive T cells.

136 mine is associated with an increased risk of cardiac-valve regurgitation.

137 at endocardial hematopoiesis is critical for cardiac valve remodeling as a source of tissue macrophag

138 aled that these macrophages are essential in cardiac valve remodeling.

139 e impacted by the findings of these studies: cardiac valve repair and replacement, assessment of vent

140 aving coronary artery bypass grafting and/or cardiac valve repair or replacement from 2009 to 2011.

141 ients aged at least 18 years undergoing open cardiac valve repair or replacement surgery and/or proxi

142 of US kidney transplantation patients after cardiac valve replacement and to compare associations of

143 Although some patients who require cardiac valve replacement clearly benefit more from one

144 Allograft valves have been used in cardiac valve replacement for 35 years.

145 142 women; mean age 68 years) who underwent cardiac valve replacement surgery between 1994 and 1998.

146 portion pulmonary hypertension who underwent cardiac valve replacement surgery.

147 rence in survival of dialysis patients after cardiac valve replacement with tissue versus nontissue p

148 Seventeen patients, who underwent cardiac valve replacement, completed a neuropsychologica

149 hip fracture repair, lung cancer resection, cardiac valve replacement, coronary angioplasty, pancrea

150 scheduled for coronary artery bypass graft, cardiac valve replacement, or both.

151 o underwent coronary artery bypass grafting, cardiac valve replacement, or total joint arthroplasty (

152 on patients hospitalized in 1991 to 2004 for cardiac valve replacement.

153 r findings, including abnormalities of other cardiac valves, septal defects, persistent left superior

154 lopmental defects in the endocardial-derived cardiac valve, septum, and vasculature.

155 , Pannus, Paravalvular Leak, CT Angiography, Cardiac, Valves Supplemental material is available for t

156 nd short-axis imaging readily disclosed each cardiac valve, support structures and chamber, as well a

157 nomorphic ventricular tachycardia (VT) after cardiac valve surgeries have not been studied extensivel

158 In patients with both cardiac valve surgery and dialysis treatment (n = 197),

159 gery, percutaneous coronary intervention, or cardiac valve surgery between January 1, 2009 and Septem

160 more comorbidities and more often underwent cardiac valve surgery compared with nondialysis patients

161 Cardiac valve surgery has seen a rapid and ongoing evolu

162 Cardiac valve surgery is, consequently, becoming much mo

163 post-operative conduction disturbances after cardiac valve surgery requiring a permanent pacemaker (P

164 ing, percutaneous coronary intervention, and cardiac valve surgery were most strongly associated with

165 Among patients referred for cardiac valve surgery, age does not appear to limit the

166 ans for percutaneous coronary interventions, cardiac valve surgery, and pediatric cardiac surgery (on

167 ong-term survival of dialysis patients after cardiac valve surgery.

168 e review the evolution of minimally invasive cardiac valve surgery.

169 oaches have become increasingly important in cardiac valve surgery.

170 laces both native cardiac ventricles and all cardiac valves, thus eliminating problems commonly seen

171 es, we developed a tissue model using rabbit cardiac valves to investigate the interaction of A. acti

172 acterial adhesion to the vessel wall and the cardiac valves under flow.

173 in zebrafish embryos leads to hypercellular cardiac valves, whereas Notch inhibition prevents valve

174 This is exemplified by EndMT in cardiac valves, which are lined with a specialized endot

175 opmental valve anomalies and have myxomatous cardiac valves with 100% penetrance.